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Thorac Cardiovasc Surg 2022 Jun 25. Epub 2022 Jun 25.

Department of Cardiac Surgery, University Clinical Hospital Center Zagreb, University of Zagreb, Zagreb, Croatia.

Background:  Diabetic patients tend to have increased platelet reactivity after coronary artery bypass grafting (CABG). The aim of this study was to determine the association between hemoglobin A1c (HbA1c) values and platelet reactivity and to evaluate the consequent impact on clinical outcomes in patients undergoing CABG.

Methods:  This prospective observational trial consecutively enrolled 225 diabetic patients undergoing CABG, between February 2014 and October 2018. Read More

Phytomedicine 2022 Jun 15;104:154277. Epub 2022 Jun 15.

Department of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Nanfang Hospital (ZengCheng Branch), Southern Medical University, Guangzhou 510515, China. Electronic address:

Background: Excessive myocardial fibrosis is the pathological basis of heart failure following myocardial infarction (MI). Although calycosin improves cardiac function, its effect on cardiac fibrosis and cardiac function after MI in mice and its precise mechanism remain unclear.

Purpose: Here, we firstly investigated the effects of calycosin on cardiac fibrosis and ventricular function in mice after MI and the role of transforming growth factor-beta receptor 1 (TGFBR1) signaling in the amelioration of cardiac fibrosis and ventricular function. Read More

J Pharm Biomed Anal 2022 Jun 11;219:114888. Epub 2022 Jun 11.

Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:

In recent years, the development and optimization of biodegradable coronary stents have become the research focus of many medical device manufacturers and scientific research institutions since they can be completely degraded and absorbed, and they restore vascular function. However, there is a lack of in situ quantification of these stents spatially in tissue in vivo. In this study, matrix-assisted laser desorption/ionization (MALDI) Fourier transform ion cyclotron resonance (FT ICR) and time-of-flight (TOF) mass spectrometric imaging (MSI) were used to analyze the time-dependent distributions of a biodegradable vascular scaffold, which consisted of copolymers of lactic acid and glycolic acid (PLGA) and its degradation products in cross-sections and longitudinal sections of blood vessels. Read More

Br J Pharmacol 2022 Jun 25. Epub 2022 Jun 25.

Department of Medicine, Karolinska Institutet.

Background And Purpose: Tyrosine kinase inhibitors (TKI) used to treat chronic myeloid leukemia (CML) have been associated with cardiovascular side effects, including reports on calcific aortic valve stenosis. The aim of this study was to establish the effects of first and second generation TKIs in aortic valve stenosis, and to determine the associated molecular mechanisms EXPERIMENTAL APPROACH: Treatment of APOE*3Leiden.CETP transgenic mice with nilotinib, imatinib or vehicle. Read More

Echocardiography 2022 Jun 25. Epub 2022 Jun 25.

Washington State University/Elson S. Floyd College of Medicine, Spokane, Washington, USA.

COVID-19 related multisystem inflammatory syndrome in children (MIS-C) can present with cardiovascular complications like shock, arrhythmias, pericardial effusion, and coronary artery dilatation. The majority of MIS-C associated coronary artery abnormalities are dilation or small aneurysms which are transient and resolve in a few weeks. We present here a case of a 3-month-old child who was noted to have giant aneurysms of her coronary arteries (LAD and RCA) 26 days after testing positive for COVID-19. Read More

Endocrine 2022 Jun 25. Epub 2022 Jun 25.

Kidney and Hypertension Unit, Joslin Diabetes Center, Boston, MA, USA.

Purpose: Adipokines have been associated with increased risk of cardiovascular disease. Our aim was to determine if adipokine levels are associated with coronary artery calcification (CAC) as well as all-cause mortality in incident dialysis patients.

Methods: In patients new to dialysis, we prospectively investigated the association of adiponectin, leptin and resistin with coronary artery calcification measured by ECG-gated computer tomography. Read More

Eur J Drug Metab Pharmacokinet 2022 Jun 25. Epub 2022 Jun 25.

Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, People's Republic of China.

Background And Objectives: Guanxinshutong capsules (GXST) are usually used to treat acute myocardial infarction (AMI), and the clinical effect of GXST is significant. However, there have been only a few studies on the pharmacokinetics of GXST against AMI injury. The objective of this study was to investigate the pharmacokinetics of nine bioactive compounds of GXST in normal and AMI rats. Read More

Eur J Nucl Med Mol Imaging 2022 Jun 25. Epub 2022 Jun 25.

Departments of Medicine (Division of Artificial Intelligence in Medicine), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Suite Metro 203, Los Angeles, CA, 90048, USA.

Purpose: We sought to evaluate inter-scan and inter-reader agreement of coronary calcium (CAC) scores obtained from dedicated, ECG-gated CAC scans (standard CAC scan) and ultra-low-dose, ungated computed tomography attenuation correction (CTAC) scans obtained routinely during cardiac PET/CT imaging.

Methods: From 2928 consecutive patients who underwent same-day Rb cardiac PET/CT and gated CAC scan in the same hybrid PET/CT scanning session, we have randomly selected 200 cases with no history of revascularization. Standard CAC scans and ungated CTAC scans were scored by two readers using quantitative clinical software. Read More

Eur Heart J 2022 Jun 25. Epub 2022 Jun 25.

McMaster University, Hamilton, Ontario, Canada.

Aims: It is unknown whether Asian and non-Asian patients with atherosclerotic vascular disease derive similar benefits from long-term antithrombotic therapy.

Methods And Results: In patients with chronic coronary artery disease (CAD) and/or peripheral artery disease (PAD) enrolled in The Cardiovascular Outcomes for People Using Anticoagulation Strategies trial, the effects of rivaroxaban 2.5 mg b. Read More

Echocardiography 2022 Jun 24. Epub 2022 Jun 24.

Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Three-dimensional (3D) echocardiography is an important tool in the evaluation of mitral valve anatomy. We illustrate a case of a 67-year-old female who was admitted for non-ST-elevation myocardial infarction (NSTEMI) and underwent two-vessel coronary artery bypass grafting for surgical disease. Her two-dimensional (2D) echocardiographic images intraoperatively demonstrated a mass on the posterior mitral valve leaflet which created a diagnostic challenge; 3D transesophageal imaging was crucial in identifying the true nature of the pathology to be mitral annular calcification with supra-annular extension. Read More

J Pak Med Assoc 2022 Jun;72(6):1137-1141

Dr. A. Q. Khan Institute of Biotechnology & Genetic Engineering, University of Karachi.

Objective: To investigate the correlation of Adenine-1012-Guanine (rs4516035) promoter region polymorphism of vitamin-D receptor gene with serum levels of omentin-1, vitamin-D and vitamin-D receptor protein in patients with coronary artery disease.

Methods: The case-control study was conducted from January to June 2020 at the cardiac unit of Civil hospital Karachi (CHK), and comprised coronary artery disease patients and controls. The tetra-primer amplification refractory mutation system polymerase chain reaction method was used to genotype Adenine-1210Guanine polymorphism in the vitamin D receptor gene. Read More

J Pak Med Assoc 2022 Jun;72(6):1114-1117

Department of Cardiovascular Medicine, Baoji Hospital of Traditional Chinese Medicine, China.

Objective: To explore the combined application value of serum monocyte chemoattractant protein-1 and lipoprotein-associated phospholipase A2 in the diagnosis of hypertension and coronary heart disease.

Methods: The cross-sectional case-control study was conducted at Baoji Hospital of Traditional Chinese medicine, Shaanxi, China, from April 2018 to May 2020, and comprised patients with suspected hypertension and coronary heart disease. Patients with both hypertension and coronary heart disease formed Group A, and those with simple hypertension formed Group B. Read More

BMC Cardiovasc Disord 2022 Jun 24;22(1):286. Epub 2022 Jun 24.

Medical Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.

Background: Circulating microRNAs (miRNAs) are considered a hot spot of research that can be employed for monitoring and/or diagnostic purposes in coronary artery disease (CAD). Since different disease features might be reflected on altered profiles or plasma miRNAs concentrations, a combination of miRNAs can provide more reliable non-invasive biomarkers for CAD.

Subjects And Methods: We investigated a panel of 14-miRNAs selected using bioinformatics databases and current literature searching for miRNAs involved in CAD using quantitative real-time PCR technique in 73 CAD patients compared to 73 controls followed by function and pathway enrichment analysis for the 14-miRNAs. Read More

Angiology 2022 Jun 24:33197221110723. Epub 2022 Jun 24.

Department of Cardiology, Siverek State Hospital, Sanliurfa 63600, Turkey.

This study investigated the role of atherogenic index of plasma (AIP) in predicting contrast induced nephropathy (CIN) in patients who underwent percutaneous coronary intervention due to non-ST elevated myocardial infarction. Of these, 1644 patients were included in the study. Retrospective data of patients were obtained from hospital records. Read More

Open Heart 2022 Jun;9(1)

UOC UTIC Emodinamica e Cardiologia, Ospedale Santa Maria Goretti, Latina, Lazio, Italy.

Chin J Nat Med 2022 Jun;20(6):432-442

Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction (MI), by far, there are few preventive and therapeutic options for ischemic heart failure (IHF) after MI. Qi-Tai-Suan (QTS) is an oleanolic acid (OA) derivative which once underwent a clinical trial for treating hepatitis. In this study, we investigated the potential cardioprotective effect of QTS on IHF. Read More

J Adv Res 2022 Jun 21. Epub 2022 Jun 21.

State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Introduction: Acute myocardial infarction (AMI) accounts for the majority of deaths caused by coronary artery disease (CAD). Early warning of AMI, especially for patients with stable coronary artery disease (sCAD), is urgently needed. Our previous study showed that alterations in the gut microbiota were correlated with CAD severity. Read More

Anim Biotechnol 2022 Jun 24:1-18. Epub 2022 Jun 24.

Laboratory Animal Center, Chinese PLA General Hospital, Beijing, China.

In the past twenty years, the number of adults with diabetes has tripled. Most studies have been conducted using rodent models of type 2 diabetes mellitus (T2DM), and the developed drugs have low clinical conversion efficiency. Therefore, it is urgent to establish a more human-like large animal model to explore T2DM pathogenesis and formulate new disease prevention and control strategies. Read More

CVIR Endovasc 2022 Jun 24;5(1):29. Epub 2022 Jun 24.

Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore.

Sirolimus-coated balloons (SCB) have demonstrated much promise as an alternative drug eluting device to the existing paclitaxel coated balloon platforms for the treatment of peripheral arterial disease (PAD). They have been well tested pre-clinically and have demonstrated anti-restenotic effects as well as clinical safety in its use for treatment of coronary artery disease. The existing approved SCBs have thus far demonstrated good short-term patency (12-months) and did not exhibit any major adverse events or device related shortcomings in its use for treatment of PAD. Read More

Swiss Med Wkly 2022 May 26;152:w30171. Epub 2022 May 26.

Division of Pediatric Cardiology, Department of women-mother-child, Lausanne University Hospital, Lausanne, Switzerland.

Aim Of The Study: Kawasaki disease is a febrile illness which can lead to significant coronary artery lesions. Its incidence varies among countries and is highest in Japan (330.2 children under 5 years old/100,000 per year). Read More

Liver Int 2022 Jun 24. Epub 2022 Jun 24.

AP-HP, Hôpital Necker Enfants Malades, Service d'Imagerie Adulte, Paris, France.

Cases of coronary and pulmonary artery pseudoaneurysms secondary to COVID-19 have been reported in the literature and are supposed to be secondary to inflammatory and vasculitis processes linked to a viral multisystem inflammatory syndrome. Although the incidence of COVID-19-associated liver injury ranges from 14% to 53% in hospitalized patients [5], COVID-19-associated hepatic artery pseudoaneurysms have never been reported so far. We present the case of a patient whose follow-up CT after cryoablation of renal cell carcinoma revealed seven fusiform pseudoaneurysms of the two hepatic arteries secondary to COVID-19. Read More

Acta Paediatr 2022 Jun 24. Epub 2022 Jun 24.

Department of Pediatrics, University Hospital Heraklion, School of Medicine, University of Crete, Greece.

Aim: We studied the incidence and time course of any coronary artery changes in children up to 2 years of age who were hospitalised with mild COVID-19.

Methods: This was a single centre prospective study of 29 children (19 males) with a median age of 3.0 months and interquartile range (IQR) of 1. Read More

Diabetes 2022 Jun 24. Epub 2022 Jun 24.

Department of Medicine, University Health Network, Toronto & University of Toronto.

Mendelian randomization (MR) suggests post-prandial hyperinsulinemia (unadjusted for plasma glucose) increases body mass index (BMI) but its impact on cardiometabolic disease (CMD), a leading cause for mortality and morbidity in people with obesity is not established. Fat distribution i.e. Read More

Biomark Med 2022 Jun 24. Epub 2022 Jun 24.

Department of Cardiology, Ankara City Hospital, University of Health Sciences, Ankara, 06800, Turkey.

To assess the correlation between the ratio of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and slow coronary flow (SCF). A total of 119 patients with SCF and 121 age- and sex-matched patients with normal coronary flow were included in this retrospective cross-sectional study. Thrombolysis in myocardial infarction frame count of angiography images was marked by two interventionalists. Read More

Comput Intell Neurosci 2022 14;2022:6184061. Epub 2022 Jun 14.

Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, China.

This study aimed to explore the clinical application of computed tomographic angiography (CTA) and standardized rehabilitation nursing in patients with coronary artery bypass grafting (CABG). CTA image was segmented by reconstruction algorithm and finally assembled into a whole image. Three-dimensional reconstruction of the coronary artery was then performed. Read More

Br J Cardiol 2021 1;28(3):39. Epub 2021 Sep 1.

Fellow in Interventional Cardiology Department of Cardiology, St. George's University Hospitals NHS Foundation Trust, London, SW17 0QT.

Radial artery access has transformed cardiac catheterisation, allowing it to be performed in a daycase setting, saving both hospital beds, and nursing care costs. However, there are two common and seemingly diametrically opposite complications. These are radial artery occlusion and forearm haematoma; the former could be reduced by heparin, but at the expense of precipitating the latter. Read More

Br J Cardiol 2021 1;28(3):37. Epub 2021 Sep 1.

Consultant Cardiologist Department of Cardiology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, G51 4TF.

Transcatheter aortic valve implantation (TAVI) is a routine procedure for patients with symptomatic severe aortic stenosis who are deemed inoperable or high-risk surgical candidates. The aim of this study was to examine real-world data on death and readmission rates in patients following the procedure. Electronic health records for patients who underwent TAVI between April 2015 and November 2018 were reviewed. Read More

Br J Cardiol 2021 2;28(3):30. Epub 2021 Jun 2.

House Officer (Postgraduate Year 1) Department of Internal Medicine, Singapore General Hospital, Outram Road, Singapore 169608.

Exercise prevents and aids treatment of coronary heart disease, hypertension, heart failure, diabetes mellitus, obesity and depression, reduces cardiac events and improves survival. However, evidence suggests that the relationship between exercise and mortality may be curvilinear, with modest additional benefit at higher levels. Intensive exercise has also been associated with increased atrial fibrillation risk, although its clinical implications are not well understood. Read More

Arthrosc Sports Med Rehabil 2022 Jun 28;4(3):e975-e988. Epub 2022 May 28.

Midwest Orthopedics at Rush, Chicago, Illinois, U.S.A.

Purpose: To compare the early postoperative outcomes of patients undergoing inpatient versus outpatient hip arthroscopy and identify any characteristics that may serve as predictors of these complications.

Methods: The PearlDiver Mariner insurance database was queried for all patients who underwent hip arthroscopy from 2010 to 2019. Patients were matched based on Charlson Comorbidity Index, age, and sex. Read More

Br J Cardiol 2021 9;28(1). Epub 2021 Mar 9.

Consultant Acute Medicine and Cardiology Ealing Hospital, London NorthWest University Healthcare NHS Trust, London, UB1 3HW.

A round 7.4 million people in the UK have heart and cardiovascular disease, coronary artery disease (CAD) being the most common type. The Driving and Vehicle Licensing Agency (DVLA) has guidance for medical professionals to aid assessment of cardiac patients with respect to driving. Read More