7,110 results match your criteria corneal haze


Congenital aniridia: clinical profile of children seen at the University College Hospital, Ibadan, South-West Nigeria.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211019513. Epub 2021 May 31.

Department of Ophthalmology, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.

Purpose: To describe the clinical features of patients younger than 16 years with aniridia presenting to the Paediatric Ophthalmology unit of the Eye Clinic, University College Hospital, Ibadan, Nigeria.

Methods: The is a retrospective review of children with aniridia seen between May 2015 and April 2019 at the Paediatric Ophthalmology unit of the Eye Clinic, University College Hospital in Ibadan. Data on demographic characteristics, presenting complaints, ocular and systemic examination findings, and interventions were collected and descriptively summarised. Read More

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[Deep learning based lesion detection from anterior segment optical coherence tomography images and its application in the diagnosis of keratoconus].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):447-453

Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To developed an image analysis system of anterior segment optical coherence tomography (AS-OCT) examination results based on deep learning technology, and to evaluate its effect in identifying various types of corneal pathologies and quantified indices. A total of 4 026 patients (5 617 eyes), including 1 977 males and 2 049 females, aged (45±23) years, were enrolled in Qingdao Eye Hospital from January 2011 to August 2019. The AS-OCT images were used as a training dataset, which were labeled with location information of 16 corneal pathologies (including corneal epithelial defect, corneal epithelial thickening, corneal thinning and so on) by clinical experts, as well as the tissue stratification of the corneal epithelium and stroma. Read More

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Conversion of mouse embryonic fibroblasts into neural crest cells and functional corneal endothelia by defined small molecules.

Sci Adv 2021 Jun 4;7(23). Epub 2021 Jun 4.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.

Reprogramming of somatic cells into desired functional cell types by small molecules has vast potential for developing cell replacement therapy. Here, we developed a stepwise strategy to generate chemically induced neural crest cells (ciNCCs) and chemically induced corneal endothelial cells (ciCECs) from mouse fibroblasts using defined small molecules. The ciNCCs exhibited typical NCC features and could differentiate into ciCECs using another chemical combination in vitro. Read More

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An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.

Exp Anim 2021 Jun 2. Epub 2021 Jun 2.

Institute of Comparative Medicine, Yangzhou University.

In this study, we describe an N-ethyl-N-nitrosourea-induced mouse model with a corneal opacity phenotype that was associated with "eye open at birth" (EOB). Histological and immunohistochemistry staining analysis showed abnormal differentiation of the corneal epithelial cells in the mutant mice. The EOB phenotype was dominantly inherited on a C57BL/6 (B6) background. Read More

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Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility.

Pharmaceutics 2021 May 27;13(6). Epub 2021 May 27.

Institute of Chemistry, St. Petersburg State University, Universitetskii Pr. 26, Peterhoff, 198504 St. Petersburg, Russia.

A plethora of micro- and nanoparticle types are currently investigated for advanced ocular treatment due to improved drug retention times, higher bioavailability and better biocompatibility. Yet, comparative studies of both physicochemical and toxicological performance of these novel drug delivery systems are still rare. Herein, poly(L-lactic acid)- and poly(ε-caprolactone)-based micro- and nanoparticles were loaded with prednisolone as a model drug. Read More

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The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model.

PLoS One 2021 1;16(6):e0245406. Epub 2021 Jun 1.

Department of Mechanical, Manufacturing and Biomedical Engineering, School of Engineering, Trinity College Dublin, University of Dublin, Dublin, Ireland.

Decellularized porcine corneal scaffolds are a potential alternative to human cornea for keratoplasty. Although clinical trials have reported promising results, there can be corneal haze or scar tissue. Here, we examined if recellularizing the scaffolds with human keratocytes would result in a better outcome. Read More

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Diagnosing Paraproteinemic Keratopathy: A Case Report.

Case Rep Ophthalmol 2021 May-Aug;12(2):337-343. Epub 2021 May 7.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, New Territories, Hong Kong, Hong Kong, China.

A 65-year-old man presented with bilateral, painless, progressive blurring of vision over 9 years. Slit-lamp examination revealed bilateral subepithelial corneal opacities in clusters located at the mid-periphery. Anterior segment optical coherence tomography, in vivo confocal microscopy (IVCM), serum protein electrophoresis, and molecular genetic testing were performed to evaluate the cause of corneal opacities. Read More

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Accidental Corneal Intrastromal Intraocular Lens Implantation with the Wound-Assisted Technique and Clinical Course with Anterior Segment Optical Coherence Tomography.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):283-287. Epub 2021 Apr 30.

Department of Ophthalmology, Jichi Medical University, Tochigi, Japan.

Accidental intraocular lens (IOL) implantation into the corneal stroma is a rare clinical entity that can occur during the wound-assisted technique. In this report, we describe a case of an 81-year-old man who underwent cataract surgery in which the IOL was implanted into the corneal stroma with the wound-assisted technique, and we present changes in anterior segment optical coherence tomography. The IOL was removed and reinserted after widening the incision. Read More

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Comprehensive phenotypic and functional analysis of dominant and recessive FOXE3 alleles in ocular developmental disorders.

Hum Mol Genet 2021 May 27. Epub 2021 May 27.

Department of Pediatrics and Children's Research Institute at the Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA.

The forkhead transcription factor FOXE3 is critical for vertebrate eye development. Recessive and dominant variants cause human ocular disease but the full range of phenotypes and mechanisms of action for the two classes of variants are unknown. We identified FOXE3 variants in individuals with congenital eye malformations and carried out in vitro functional analysis on selected alleles. Read More

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Recombinant IL-22 promotes protection in a murine model of Aspergillus flavus keratitis and mediates host immune responses in human corneal epithelial cells.

Cell Microbiol 2021 May 24:e13367. Epub 2021 May 24.

Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.

Aspergillus flavus is a leading cause of corneal infections in India and worldwide, resulting in severe visual impairment. We studied the host immune response towards A. flavus in immortalised human corneal epithelial cells (HCEC) and found increased expression of Toll-like receptors, antimicrobial peptides and proinflammatory cytokines like IL-6 and IL-8. Read More

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Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs.

Commun Biol 2021 May 21;4(1):608. Epub 2021 May 21.

Centre de recherche, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.

The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection is heightened. Here, we show that bioengineered, fully synthetic, and robust corneal implants can be manufactured from a collagen analog (collagen-like peptide-polyethylene glycol hybrid, CLP-PEG) and inflammation-suppressing polymeric 2-methacryloyloxyethyl phosphorylcholine (MPC) when stabilized with the triazine-based crosslinker 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. Read More

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Vaccination inhibits the human adenoviral transduction in a mouse keratoconjunctivitis model.

Vaccine 2021 Jun 17;39(26):3498-3508. Epub 2021 May 17.

Department of Molecular Biodefense Research, Graduate School of Medicine, Yokohama City University, Yokohama 236-0004, Japan. Electronic address:

Adenovirus infections are a major cause of epidemic keratoconjunctivitis (EKC), which can lead to corneal subepithelial infiltrates and multifocal corneal opacity. In the current study, we investigated the use of an E1/E3-deleted adenovirus serotype 5 (Ad5) vector as a vaccine administered intramuscularly (IM) or intranasally (IN) against subsequent challenges with a luciferase-expressing Ad5 (Ad5-Luci) vector via eyedrop. We evaluated the adaptive immune response to Ad5 vector vaccination and confirmed a robust polyfunctional CD8 T cell response in splenic cells. Read More

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Application of two-part glue technique in epithelial ingrowth after laser keratomileusis flap dislocation.

Indian J Ophthalmol 2021 06;69(6):1614-1617

Department of Ophthalmology, National Cheng Kung University Hospital; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

A 59-year-old woman who underwent uneventful laser in situ keratomileusis surgery 16 years ago presented with traumatic flap dislocation complicated by an epithelial ingrowth in the right eye. The epithelial ingrowth was managed with re-lifting the flap, mechanical debridement, soaking with 70.0% alcohol, and irrigation. Read More

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Fusarium infection complicating rheumatic keratitis that acutely progressed to endophthalmitis during regular infusion of tocilizumab: a case report.

BMC Ophthalmol 2021 May 19;21(1):224. Epub 2021 May 19.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background: Filamentous fungi are ubiquitous in plants, water, and soil. The predominant fungi that infect the human cornea include Fusarium and Aspergillus species. The onset of fungal endophthalmitis is indolent, and typically takes weeks to months to develop after corneal infection. Read More

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Longitudinal Assessment of Alkali Injury on Mouse Cornea Using Anterior Segment Optical Coherence Tomography.

Transl Vis Sci Technol 2021 Mar;10(3)

Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA.

Purpose: Chemical burns due to alkalis cause extensive damage to the ocular surface leading to blindness. Assessment of ocular burn could be challenging due to severe opacity, inflammation, and angiogenesis. Anterior segment optical coherence tomography (AS-OCT) and OCT angiography (OCTA) may provide fast, non-invasive deep tissue visualization of pathology with high sensitivity in conjunction with slit-lamp analysis. Read More

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Current Diagnosis and Management of Tangier Disease.

J Atheroscler Thromb 2021 May 14. Epub 2021 May 14.

Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute.

Tangier disease is a genetic disorder characterized by an absence or extremely low level of high-density lipoprotein (HDL)-cholesterol (HDL-C). It is caused by a dysfunctional mutation of the ATP-binding cassette transporter A1 (ABCA1) gene, the mandatory gene for generation of HDL particles from cellular cholesterol and phospholipids, and it appears in an autosomal recessive hereditary profile. To date, 35 cases have been reported in Japan and 109 cases outside Japan. Read More

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Protective effects of citicoline-containing eye drops against UVB-Induced corneal oxidative damage in a rat model.

Exp Eye Res 2021 May 13;208:108612. Epub 2021 May 13.

Kocaeli University, Ford Otosan Ihsaniye Automotive Vocational School, Department of Motor Vehicles and Transportation Technologies, Kocaeli, Turkey.

It has been reported that citicoline increases antioxidant activity in some tissues. However, the effect of citicoline on corneal wound-healing has not yet been demonstrated. The aim was to investigate the protective effects of citicoline on ultraviolet B (UVB) radiation-induced corneal oxidative damage in a rat model. Read More

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An intact complement system dampens cornea inflammation during acute primary HSV-1 infection.

Sci Rep 2021 May 13;11(1):10247. Epub 2021 May 13.

Departments of Ophthalmology, The University of Oklahoma Health Sciences Center (OUHSC), 608 Stanton L. Young Blvd., DMEI PA415, Oklahoma City, OK. 73104, USA.

Corneal transparency is an essential characteristic necessary for normal vision. In response to microbial infection, the integrity of the cornea can become compromised as a result of the inflammatory response and the ensuing tissue pathology including neovascularization (NV) and collagen lamellae destruction. We have previously found complement activation contributes to cornea pathology-specifically, denervation in response to HSV-1 infection. Read More

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Compound heterozygous missense mutations in a Chinese mucopolysaccharidosis type VI patient: a case report.

BMC Ophthalmol 2021 May 13;21(1):214. Epub 2021 May 13.

Department of Ophthalmology, Affiliated Hospital of Yunnan University, Second People's Hospital of Yunnan Province, Kunming, China.

Background: Mucopolysaccharidosis type VI (MPS VI) is a rare autosomal recessive inherited disease caused by mutations in the arylsulfatase B (ARSB) gene. MPS VI is a multisystemic disease resulting from a deficiency in arylsulfatase B causing an accumulation of glycosaminoglycans in the tissues and organs of the body. In this report, we present the case of a 16-year-old Chinese male who presented with vision loss caused by corneal opacity. Read More

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Penetrating Keratoplasty - Indications in a tertiary care center in Nepal.

Nepal J Ophthalmol 2020 Jul;12(24):252-261

B. P. Koirala Centre for Ophthalmic Studies (BPKLCOS), Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Introduction: Penetrating keratoplasty has become one of the most commonly performed transplant procedures where full thickness diseased host corneal tissue is replaced with healthy donor corneal tissue. Aims of penetrating keratoplasty include improvement in visual acuity, removal of infectious load, alleviate pain or even to simply save the anatomy of the eye. Visual improvement and removal of infection is the prime objective of majority of corneal grafts. Read More

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Ocular tuberculosis in a calf.

BMC Vet Res 2021 May 8;17(1):187. Epub 2021 May 8.

Laboratorio de Investigación en Tuberculosis Bovina, Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico city, Mexico.

Background: Bovine tuberculosis is a chronic inflammatory disease that causes granuloma formation mainly in retropharyngeal, tracheobronchial, mediastinal lymph nodes and lungs of bovines. The presence of these lesions in other tissues such as the eyeball is very rare and difficult to diagnose. This study describes macroscopic and microscopic pathological findings in a calf with ocular and meningeal tuberculosis. Read More

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Penetrating Keratoplasty in Infants With Peters Anomaly: Visual and Graft Outcomes.

Cornea 2021 Jun;40(6):720-725

Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: To determine the prevalence of survival of corneal grafts and visual outcomes of primary penetrating keratoplasty (PK) in infants with Peters anomaly (PA) in Beijing, China.

Methods: Twenty-nine patients (37 eyes) with PA who underwent PK before the age of 1 year were included. Optical correction for all eyes and occlusion therapy of amblyopia for a unilateral opacity were performed 2 weeks after suture removal. Read More

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Long term results of accelerated 9 mW corneal crosslinking for early progressive keratoconus: the Siena Eye-Cross Study 2.

Eye Vis (Lond) 2021 May 1;8(1):16. Epub 2021 May 1.

Departmental Ophthalmology Unit, USL Toscana Sud-Est, Campostaggia, Siena, Italy.

Purpose: To assess clinical results of the 9 mW/5.4 J/cm accelerated crosslinking (ACXL) in the treatment of progressive keratoconus (KC) over a span of 5 years.

Methods: The prospective open non-randomized interventional study (Siena Eye-Cross Study 2) included 156 eyes of 112 patients with early progressive KC undergoing the Epi-Off 9 mW/5. Read More

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Improvement of Vision and Ocular Surface Symptoms With a Scleral Lens After Microbial Keratitis.

Eye Contact Lens 2021 Apr 27. Epub 2021 Apr 27.

Clinical and Experimental Optometry Research Lab (CEORLab) (R.J.M.-d.-A., J.M.G.-M.), Center of Physics, University of Minho, Braga, Portugal; Department of Ophthalmology (C.M.), Singleton Hospital, Swansea Bay University Health Board, Swansea, United Kingdom; School of Ophthalmology and Optometry and Eye Hospital (C.M.), Wenzhou Medical University, Wenzhou, China; and Eye-Contact-Lens Research and Education (E.v.d.W.), Amsterdam, the Netherlands.

Abstract: A 38-year-old woman, previous daily disposable soft contact lens wearer, reported an episode of microbial keratitis positive for Pseudomonas aeruginosa 11 months before contacting the investigators. After acute treatment, she was left with a degree of opacity in the pupillary area, corneal scar, and an irregular corneal profile, with a best spectacle visual acuity of +0.48 logarithm of the minimum angle of resolution. Read More

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Two-step keratoplasty for deep vascularized corneal opacity with severe peripheral thinning following Acanthamoeba keratitis.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 27. Epub 2021 Apr 27.

Cornea and Ocular Surface Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Purpose: In cases of corneal opacity with vascularization and peripheral thinning, traditional keratoplasty techniques have several risks and drawbacks. We report the results of a two-step surgical strategy consisting in performing a large diameter tectonic lamellar keratoplasty (TLK) to restore appropriate corneal thickness and an avascular recipient bed, followed by central optical PK within the lamellar graft at a later date.

Methods: This single-institution study analyzes the results of 7 eyes of 7 patients who received PK after large diameter TLK. Read More

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Falsely high rebound tonometry.

J AAPOS 2021 Apr 24. Epub 2021 Apr 24.

Pediatric Ophthalmology and Ocular Genetics, Wills Eye Hospital, Philadelphia, Pennsylvania; Department of Ophthalmology, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Background: Rebound tonometry (RBT) can be used to measure intraocular pressure (IOP) in children unable to tolerate measurement with applanation tonometry (AT) while awake. RBT readings are often 2-3 mm Hg higher than AT. We have experienced children with a repeatedly higher difference between RBT and AT measurements (≥6 mm Hg). Read More

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A simplified index to quantify the irritation/corrosion potential of chemicals - Part II: Eye.

Regul Toxicol Pharmacol 2021 Apr 24;123:104935. Epub 2021 Apr 24.

KREATiS, 23 Rue du Creuzat, 38080, L'Isle d'Abeau, France. Electronic address:

Eye irritation is a key human health endpoint assessed by in vitro and in vivo methods. One of the commonly used scoring methods to quantify the eye irritation potential of chemicals is the Modified Maximum Average Score (MMAS). It is dependent on the eye irritation effects (e. Read More

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Predictors of Vision-Related Quality of Life After Endothelial Keratoplasty in the Descemet Endothelial Thickness Comparison Trials.

Cornea 2021 Apr;40(4):449-452

*F. I. Proctor Foundation, University of California, San Francisco, CA; †Casey Eye Institute, Oregon Health Sciences University, Portland, OR; ‡Byers Eye Institute, Stanford University, Palo Alto, CA; §Lions VisionGift, Portland, OR; ¶Department of Ophthalmology, University of California, San Francisco, CA; ‖Department of Epidemiology and Biostatistics, University of California, San Francisco, CA; and **Department of Research, Kaiser Permanente Northern California.

Purpose: To determine which baseline characteristics are associated with vision-related quality of life (QOL) after endothelial keratoplasty.

Methods: A patient- and outcome-masked randomized clinical trial. Consecutive patients presenting with isolated endothelial disease requiring endothelial keratoplasty at Oregon Health Sciences University and Stanford University. Read More

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Comparison of cumulative dispersed energy between conventional phacoemulsification and femtosecond laser-assisted cataract surgery with two different lens fragmentation patterns.

Lasers Med Sci 2021 Apr 19. Epub 2021 Apr 19.

Universal Eye Center, Taipei, Taiwan.

The purpose of the study is to compare the total ultrasound power used between eyes undergoing different lens fragmentation patterns of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS). A total of 506 patient eyes underwent preoperative grading of lens opacity using the Lens Opacity Classification System III (LOCSIII). The eyes were divided into two subgroups: subgroup 1 had a LOCSIII grade of 1-3, and subgroup 2 had a LOCSIII grade of 4-6. Read More

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[Crosslinking and Keratoconus].

Klin Monbl Augenheilkd 2021 Apr 19. Epub 2021 Apr 19.

Keratoconus leads to a progressive protrusion and thinning of the cornea. In order to stop this, corneal crosslinking can be performed if the progression of the disease is proven. Crosslinking according to the "Dresden protocol" includes abrasion of the corneal epithelium, application of riboflavin eye drops and irradiation with UV-A light of an intensity of 3 mW/cm² for 30 minutes. Read More

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