7,093 results match your criteria core collection

Cleavage-Resistant Protein Labeling With Hydrophilic Trityl Enables Distance Measurements .

J Phys Chem B 2021 May 13. Epub 2021 May 13.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

Sensitive distance measurements in proteins using pulsed-electron spin resonance (ESR) require reduction-resistant and cleavage-resistant spin labels. Among the reduction-resistant moieties, the hydrophilic trityl core known as OX063 is promising due to its long phase-memory relaxation time (). This property leads to a sufficiently intense ESR signal for reliable distance measurements. Read More

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[Discussion on traditional Chinese medicine properties of Myrtus communis leaves based on literature analysis and Chinese medicine theory].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(8):1935-1942

School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.

Myrtus communis is a traditional medicinal aromatic plant in the Mediterranean. At present, the plant has been introduced and cultivated in the southern part of China, and it is mostly used for ornamental or cosmetic purposes. Based on literature analysis and the theory of Chinese medicine, we discussed the medicinal parts and properties of M. Read More

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Practical publication metrics for academics.

Clin Transl Sci 2021 May 13. Epub 2021 May 13.

Professor of Medicine, David Geffen School of Medicine, Division of General Internal Medicine and Health Services Research, University of California, 1100 Glendon Ave, Suite 1820-1838, Los Angeles, California, 90024-3503, USA.

Research organizations are becoming more reliant on quantitative approaches to determine how to recruit and promote researchers, allocate funding, and evaluate the impact of prior allocations. Many of these quantitative metrics are based on research publications. Publication metrics are not only important for individual careers, but also affect the progress of science as a whole via their role in the funding award process. Read More

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Bibliometric analysis of zerovalent iron particles research for environmental remediation from 2000 to 2019.

Environ Sci Pollut Res Int 2021 May 12. Epub 2021 May 12.

Affiliation State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

Zerovalent iron (ZVI) has been a major focus of research and has attracted great attention during the last 2 decades by international researchers because of its excellent pollutant removal performance and several other merits in environmental remediation. Based on Web of Science Core Collection data, we present a comprehensive bibliometric analysis of ZVI research from 2000 to 2019. We analyze 4472 publications assuming three stages of growth trend of annual publication totals. Read More

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Decision Aids for Shared Decision-making in Uro-oncology: A Systematic Review.

Eur Urol Focus 2021 May 9. Epub 2021 May 9.

Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.

Context: Decision aids (DAs) aim to support patients in the process of shared decision-making for complex treatment decisions. To improve patient-centered care in uro-oncology, it is essential to evaluate the availability and quality of existing DAs.

Objective: To assess the quality of existing DAs for patients across the most prevalent uro-oncological entities. Read More

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DICOM-MIABIS integration model for biobanks: a use case of the EU PRIMAGE project.

Eur Radiol Exp 2021 May 12;5(1):20. Epub 2021 May 12.

Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

PRIMAGE is a European Commission-financed project dealing with medical imaging and artificial intelligence aiming to create an imaging biobank in oncology. The project includes a task dedicated to the interoperability between imaging and standard biobanks. We aim at linking Digital imaging and Communications in Medicine (DICOM) metadata to the Minimum Information About BIobank data Sharing (MIABIS) standard of biobanking. Read More

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Evolutions in the Management of Hepatocellular Carcinoma over Last 4 Decades: An Analysis from the 100 Most Influential Articles in the Field.

Liver Cancer 2021 Apr 2;10(2):137-150. Epub 2021 Feb 2.

Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.

Introduction: Over the past 4 decades, the management of hepatocellular carcinoma (HCC) has changed dramatically. The publications that have had the most significant impact on HCC management have not been quantitatively analyzed. In this article, we analyzed the 100 most influential articles over the past 4 decades using bibliometric citation analysis to characterize the evolution in HCC treatment. Read More

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A core outcome set for genitourinary symptoms associated with menopause: the COMMA (Core Outcomes in Menopause) global initiative.

Menopause 2021 May 10. Epub 2021 May 10.

Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University. Melbourne, Australia School of Nursing, Indiana University, Indianapolis, IN Department of Obstetrics and Gynaecology, University of Chicago, Chicago, IL Red Hot Mamas North America, Inc., New York, NY Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY Department of Obstetrics and Gynaecology, University Hospitals Dorset NHS Trust, Poole, Dorset, UK Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University London, UK Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Department of Obstetrics and Gynaecology, Fortis Escort Hospital, Jaipur, India Department of Gynaecology and Obstetrics, University of Muenster, Muenster, Germany Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia Department of Reproductive and Maternal Medicine, School of Medicine, University of Glasgow, Glasgow, UK Departments of Psychiatry, Psychology and Obstetrics and Gynecology, University of Illinois at Chicago, Chicago IL Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, University of Pavia, Pavia, Italy Department of Urology, UIC College of Medicine, Chicago IL Queen Charlotte's and Chelsea and Westminster Hospitals, Imperial College London, London, UK Auckland District Health Board, Auckland, New Zealand Department of Obstetrics and Gynecology, Midlife Women's Health Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Obstetrics and Gynecology, George Washington University, Washington, DC Department of Obstetrics and Gynecology, University Clinic Inselspital Bern, Bern, Switzerland Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada.

Objective: Genitourinary symptoms, such as vaginal dryness and pain with sex, are commonly experienced by postmenopausal women. Comparing treatments for these genitourinary symptoms are restricted by the use of different outcome measures in clinical trials and the omission of outcomes, which may be relevant to women. The aim of this project was to develop a Core Outcome Set (COS) to be reported in clinical trials of treatments for genitourinary symptoms associated with menopause. Read More

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Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity.

Angew Chem Int Ed Engl 2021 May 10. Epub 2021 May 10.

University of Illinois, Department of Chemistry, 600 S. Mathews, 61801, Urbana, UNITED STATES.

Structurally complex natural products have been a fruitful source for the discovery and development of new drugs.  In an effort to construct a compound collection populated by architecturally complex members with unique scaffolds, we have used the natural product limonin as a starting point.  Limonin is an abundant triterpenoid natural product and, through alteration of its heptacyclic core ring system using short synthetic sequences, a collection of 98 compounds was created, including multiple members with novel ring systems. Read More

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The use of electronic PROMs provides same outcomes as paper version in a spine surgery registry. Results from a prospective cohort study.

Eur Spine J 2021 May 10. Epub 2021 May 10.

IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.

Background And Purpose: Patient-Reported Measured Outcomes (PROMs) are essential to gain a full understanding of a patient's condition, and in spine surgery, these questionnaires are of help when tailoring a surgical strategy. Electronic registries allow for a systematic collection and storage of PROMs, making them readily available for clinical and research purposes. This study aimed to investigate the reliability between the electronic and paper form of ODI (Oswestry Disability Index), SF-36 (Short Form Health Survey 36) and COMI-back (Core Outcome Measures Index for the back) questionnaires. Read More

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High spatial resolution imaging of the dynamics of cuticular lipid deposition during Arabidopsis flower development.

Plant Direct 2021 Apr 29;5(4):e00322. Epub 2021 Apr 29.

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology Iowa State University Ames IA USA.

The extensive collection of () and () mutants of maize and Arabidopsis have proven invaluable in dissecting the branched metabolic pathways that support cuticular lipid deposition. This bifurcated pathway integrates a fatty acid elongation-decarbonylative branch and a fatty acid elongation-reductive branch, which collectively has the capacity to generate hundreds of cuticular lipid metabolites. In this study, a combined transgenic and biochemical strategy was implemented to explore and compare the physiological function of three homologous genes, , , and , in the context of this branched pathway. Read More

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Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field.

Front Pharmacol 2021 22;12:646626. Epub 2021 Apr 22.

Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.

Microbubbles are widely used as highly effective contrast agents to improve the diagnostic capability of ultrasound imaging. Mounting evidence suggests that ultrasound coupled with microbubbles has promising therapeutic applications in cancer, cardiovascular, and neurological disorders by acting as gene or drug carriers. The aim of this study was to identify the scientific output and activity related to ultrasound microbubble through bibliometric approaches. Read More

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Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.

Genomics 2021 May 6. Epub 2021 May 6.

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Background: Recent reports have established the emergence and dissemination of extensively drug resistant (XDR) H58 Salmonella Typhi clone in Pakistan. In India where typhoid fever is endemic, only sporadic cases of ceftriaxone resistant S. Typhi are reported. Read More

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EMS blood collection from patients with acute chest pain reduces emergency department length of stay.

Am J Emerg Med 2021 Apr 26;47:248-252. Epub 2021 Apr 26.

Department of Emergency Medicine, Wake Forest School of Medicine, USA.

Background: Expediting the measurement of serum troponin by leveraging EMS blood collection could reduce the diagnostic time for patients with acute chest pain and help address Emergency Department (ED) overcrowding. However, this practice has not been examined among an ED chest pain patient population in the United States.

Methods: A prospective observational cohort study of adults with non-traumatic chest pain without ST-segment elevation myocardial infarction was conducted in three EMS agencies between 12/2016-4/2018. Read More

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The role of eHealth, telehealth, and telemedicine for chronic disease patients during COVID-19 pandemic: A rapid systematic review.

Digit Health 2021 Jan-Dec;7:20552076211009396. Epub 2021 Apr 19.

Center for Information Systems & Technology, Claremont Graduate University, Claremont, USA.

Objective: To summarize the current status of, and the current expert opinions, recommendation and evidence associated with the use and implementation of electronic health (eHealth), telemedicine, and/or telehealth to provide healthcare services for chronic disease patients during the COVID-19 pandemic.

Materials And Methods: We searched four electronic databases (PubMed, Google Scholar, Science Direct, and Web of Science Core Collection) to identify relevant articles published between 2019 and 2020. Searches were restricted to English language articles only. Read More

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Role of Indices Incorporating Power, Force and Time in AF Ablation: A Systematic Review of Literature.

Heart Lung Circ 2021 May 3. Epub 2021 May 3.

Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia; Lyell McEwin Hospital, Adelaide, SA, Australia. Electronic address:

Introduction: Successful pulmonary vein isolation (PVI) for atrial fibrillation (AF) depends on the formation of durable transmural lesions. Recently, novel indices have emerged to guide lesion delivery. The aim of the systematic review of literature was to determine AF recurrence following ablation guided by indices incorporating force, power and time, and compare acute procedural outcomes and 12-month AF recurrence with ablation guided by contact force (CF) guided only. Read More

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Genome-wide association analysis for yield-related traits at the R6 stage in a Chinese soybean mini core collection.

Genes Genomics 2021 May 6. Epub 2021 May 6.

National Center for Soybean Improvement, Key Laboratory of Biology and Genetics and Breeding for Soybean, Ministry of Agriculture, State Key Laboratory for Crop Genetics and Germplasm Enhancement, College of Agriculture, Nanjing Agricultural University, Weigang No. 1, Nanjing, 210095, Jiangsu, China.

Background: Soybean (Glycine max (L.) Merr.) is an economically important crop for vegetable oil and protein production, and yield is a critical trait for grain/vegetable uses of soybean. Read More

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Evaluation of Trials Comparing Single-Enantiomer Drugs to Their Racemic Precursors: A Systematic Review.

JAMA Netw Open 2021 May 3;4(5):e215731. Epub 2021 May 3.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut.

Importance: Chiral switching, a strategy in which drug manufacturers develop a single-enantiomer formulation of a drug to be substituted for a racemic formulation, allows manufacturers to maintain market exclusivity for drugs losing patent protection, even without demonstrating superior efficacy or safety.

Objective: To identify and characterize all randomized clinical trials (RCTs) directly comparing a Food and Drug Administration (FDA)-approved single-enantiomer drug against a previously approved racemic drug for 1 or more efficacy or safety end points.

Evidence Review: Drugs were identified using the Drugs@FDA database. Read More

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Hepatitis B virus prevalence in first-time blood donors in Flanders, Belgium: Impact of universal vaccination and migration.

Transfusion 2021 May 6. Epub 2021 May 6.

Blood Service, Belgian Red Cross, Mechelen, Belgium.

Background: Transfusion-transmissible infections such as hepatitis B virus (HBV) remain a major concern for the safety of blood transfusion. This cross-sectional study aimed to assess the trend of HBV prevalence and associated risk factors among a first-time donor population in a low endemic country.

Study Design And Methods: Between 2010 and 2018, blood samples were collected from first-time donors presented at donor collection sites of Belgian Red Cross-Flanders. Read More

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Scientometric Analysis of Dental Implant Research over the Past 10 Years and Future Research Trends.

Biomed Res Int 2021 13;2021:6634055. Epub 2021 Apr 13.

Department of Periodontics, Stomatological Hospital of Tianjin Medical University, Tianjin, China.

Background: We conducted a bibliometrics analysis to explore the recent trends in dental implant research which could help researchers have a clear grasp of the relevant research hotspots and prospects. . Altogether, 15,770 articles on dental implants, from January 1, 2010, to October 31, 2019, were selected from the Web of Science Core Collection. Read More

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The Process of Managing the Children with Type 1 Diabetes in the Family: A Grounded Theory Study.

Iran J Nurs Midwifery Res 2021 Jan-Feb;26(1):25-33. Epub 2021 Jan 18.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes is a disease that affects all family members. Parents of children with type 1 diabetes are always concerned about all aspects of children's life. The aim of this study was to elucidate the process of managing children with diabetes in the family. Read More

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January 2021

Application of Andersen's behavioural model of health services use: a scoping review with a focus on qualitative health services research.

BMJ Open 2021 May 5;11(5):e045018. Epub 2021 May 5.

Public Health and Health Education, Pädagogische Hochschule Freiburg, Freiburg im Breisgau, Germany.

Introduction: Qualitative methods have become integral in health services research, and Andersen's behavioural model of health services use (BMHSU) is one of the most commonly employed models of health service utilisation. The model focuses on three core factors to explain healthcare utilisation: predisposing, enabling and need factors. A recent overview of the application of the BMHSU is lacking, particularly regarding its application in qualitative research. Read More

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A collection of toolkit strains reveals distinct localization and dynamics of membrane-associated transcripts in epithelia.

Cell Rep 2021 May;35(5):109072

Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China. Electronic address:

Visualizing mRNA in real time in vivo at high resolution is critical for a full understanding of the spatiotemporal dynamics of gene regulation and function. Here, using a PP7/PCP-based mRNA-tagging approach, we construct a collection of tissue-specific and differentially expressed toolkit strains for visualizing mRNAs encoding apical, basolateral, and junctional proteins in Caenorhabditis elegans epithelia. We precisely delineate the spatiotemporal organization and dynamics of these transcripts across multiple subcellular compartments and tissues. Read More

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A cloud-based bioinformatic analytic infrastructure and Data Management Core for the Expanded Program on Immunization Consortium.

J Clin Transl Sci 2020 Sep 22;5(1):e52. Epub 2020 Sep 22.

Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.

The Expanded Program for Immunization Consortium - Human Immunology Project Consortium study aims to employ systems biology to identify and characterize vaccine-induced biomarkers that predict immunogenicity in newborns. Key to this effort is the establishment of the Data Management Core (DMC) to provide reliable data and bioinformatic infrastructure for centralized curation, storage, and analysis of multiple de-identified "omic" datasets. The DMC established a cloud-based architecture using Amazon Web Services to track, store, and share data according to National Institutes of Health standards. Read More

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September 2020

Assessing clinical investigators' perceptions of relevance and competency of clinical trials skills: An international AIDS Malignancy Consortium (AMC) study.

J Clin Transl Sci 2020 Aug 7;5(1):e28. Epub 2020 Aug 7.

University of Texas Health Sciences Center, San Antonio, TX, USA.

Introduction: The AIDS Malignancy Consortium (AMC) conducts clinical trials of therapeutic and prevention strategies for cancer in people living with HIV. With its recent expansion to Sub-Saharan Africa and Latin America, there was a need to increase the competence of clinical investigators (CIs) to implement clinical trials in these regions.

Methods: AMC CIs were invited to complete a survey to assess role-relevance and self-perceived competence based on the Joint Task Force for Clinical Trials Competency domains. Read More

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The DIAMOND portal: An innovative platform for sharing translational research workforce training and assessment resources.

J Clin Transl Sci 2020 Jul 6;4(6):480-484. Epub 2020 Jul 6.

Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI, USA.

Although several initiatives have produced core competency domains for training the translational science workforce, training resources to help clinical research professionals advance these skills reside primarily within local departments or institutions. The Development, Implementation, and AssessMent of Novel Training in Domain (DIAMOND) project was designed to make this training more readily and publicly available. DIAMOND includes a digital portal to catalog publicly available educational resources and an ePortfolio to document professional development. Read More

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Quo Vadis Metabolomics-A Review of Current Methods and Applications to Explore Metabolism in the Nematode.

Metabolites 2021 Apr 29;11(5). Epub 2021 Apr 29.

Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

Metabolomics and lipidomics recently gained interest in the model organism (). The fast development, easy cultivation and existing forward and reverse genetic tools make the small nematode an ideal organism for metabolic investigations in development, aging, different disease models, infection, or toxicology research. The conducted type of analysis is strongly depending on the biological question and requires different analytical approaches. Read More

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Research trends in rabies vaccine in the last three decades: a bibliometric analysis of global perspective.

Hum Vaccin Immunother 2021 May 4:1-9. Epub 2021 May 4.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

: Rabies is an infectious zoonotic viral disease which mainly occurs in Africa and Asia. Dogs are predominantly responsible for rabies transmission contributing up to 99% of all human rabies cases. Rabies is a vaccine preventable disease in both animals and humans. Read More

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Analytical Cryo-Scanning Electron Microscopy of Hydrated Polymers and Microgels.

Acc Chem Res 2021 May 4. Epub 2021 May 4.

Stevens Institute of Technology Hoboken, New Jersey 07030, United States.

ConspectusDespite the fact that scanning electron microscopes (SEM) coupled with energy-dispersive X-ray microanalysis (EDS) has been commercially available for more than a half-century, SEM/EDS continues to develop and open new opportunities to study the morphology of advanced materials. This is particularly true in applications to hydrated soft matter. Developments in field-emission electron sources that enable low-voltage imaging of uncoated polymers, silicon-drift detectors that enable high-efficiency collection of X-rays characteristic of light elements, and cryogenic methods to effectively cryo-fix hydrated samples have opened new opportunities to apply techniques relatively well established in hard-materials applications to challenging new problems involving synthetic polymers. Read More

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