372,134 results match your criteria core


In-situ X-ray analysis of misfit strain and curvature of bent polytypic GaAs-InxGa1-xAs core-shell nanowires.

Nanotechnology 2021 Sep 24. Epub 2021 Sep 24.

Department of Physics, University of Siegen, Walter-Flex Straße 3, Siegen, Nordrhein-Westfalen, 57072, GERMANY.

Misfit strain in core-shell nanowires can be elastically released by nanowire bending in case of asymmetric shell growth around the nanowire core. In this work, we investigate the bending of GaAs nanowires during the asymmetric overgrowth by an In(x)Ga(1-x)As shell caused by avoiding substrate rotation. We observe that the nanowire bending direction depends on the nature of the substrate's oxide layer, demonstrated by Si substrates covered by native and thermal oxide layers. Read More

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September 2021

Machine-learning insights into nitrate-reducing communities in a full-scale municipal wastewater treatment plant.

J Environ Manage 2021 Sep 21;300:113795. Epub 2021 Sep 21.

Department of Civil Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, Republic of Korea. Electronic address:

This study carried out machine-learning (ML) modeling using activated sludge microbiome data to predict the operational characteristics of biological unit processes (i.e., anaerobic, anoxic, and aerobic) in a full-scale municipal wastewater treatment plant. Read More

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September 2021

Pitfalls in international benchmarking of energy intensity across wastewater treatment utilities.

J Environ Manage 2021 Sep 21;300:113613. Epub 2021 Sep 21.

School of Engineering, University of Limerick, Limerick, Ireland.

The collection, treatment and disposal of wastewater is estimated to consume more than 2% of the world's electrical energy, whilst some wastewater treatment plants (WWTPs) can account for over 20% of electrical consumption within municipalities. To investigate areas to improve wastewater treatment, international benchmarking on energy (electrical) intensity was conducted with the indicator kWh/m and a quality control of secondary treatment or better for ≥95% of treated volume. The core sample included 321 companies from 31 countries, however, to analyse regional differences, 11 countries from an external sample made up of various studies of WWTPs was also used in places. Read More

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September 2021

Neuroscientific approaches to study prosociality.

Curr Opin Psychol 2021 Aug 31;44:38-43. Epub 2021 Aug 31.

Department of Social Neuroscience and Social Psychology, University of Bern, Switzerland. Electronic address:

Prosociality is a core feature of human functioning and has been a topic of interest across disciplinary boundaries for decades. In this review, we highlight different neuroscientific approaches that have enriched traditional psychological methods for studying prosocial behavior among individuals and groups. First, we outline findings from task-based neuroimaging studies that provide correlational evidence for the involvement of different neural mechanisms in prosocial behavior. Read More

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Sex-based differences in body core temperature response across repeat work bouts in the heat.

Appl Ergon 2021 Sep 21;98:103586. Epub 2021 Sep 21.

School of Exercise and Nutrition Science, Queensland University of Technology, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; Defence Science and Technology Group, Department of Defence, Melbourne, Victoria, Australia. Electronic address:

Objective: To investigate the effects of repeated work bouts in the heat on peak body core temperature and to explore sex-based differences in body core temperature responses.

Methods: Fourteen males and fifteen females performed four work bouts (two heavy and two moderate, alternating) in 32.5 °C Wet Bulb Globe Temperature (WBGT), each separated by 30-min seated rest in 28. Read More

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September 2021

Imaging in Osteoarthritis.

Osteoarthritis Cartilage 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiology, New York University Grossmann School of Medicine, 550 1(st) Avenue, 3nd Floor, New York, NY 10016, USA.

Osteoarthritis (OA) is the most frequent form of arthritis with major implications on both individual and public health care levels. The field of joint imaging, and particularly magnetic resonance imaging (MRI), has evolved rapidly due to the application of technical advances to the field of clinical research. This narrative review will provide an introduction to the different aspects of OA imaging aimed at an audience of scientists, clinicians, students, industry employees, and others who are interested in OA but who do not necessarily focus on OA. Read More

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September 2021

Assessing Dentists' Knowledge and Experience in Restoring Endodontically Treated Teeth Using Post & Cores.

J Dent 2021 Sep 21:103815. Epub 2021 Sep 21.

UCL Eastman Dental Institute, Rockefeller Building, 20 University Street, London WC1E 6DE, United Kingdom. Electronic address:

Objectives: The restoration of endodontically, heavily filled teeth has been a challenge for the dental profession for decades. The aims of this study were to investigate dentists' experience and knowledge in the use of post & core when restoring endodontically treated teeth.

Method: This was a mixed method study incorporating quantitative and qualitative data collection. Read More

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September 2021

Insight into Shenqi Jiangtang Granule on the improved insulin sensitivity by integrating in silico and in vivo approaches.

J Ethnopharmacol 2021 Sep 21:114672. Epub 2021 Sep 21.

Department of Endocrinology, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China; Institute for Chronic Disease Management, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China. Electronic address:

Ethnopharmacological Relevance: Presently, insulin resistance has been a growing concern that urgently needs to be addressed, because it not only places patients at risk of developing type 2 diabetes mellitus but also results in metabolic syndrome and different aspects of cardiovascular diseases. Shenqi Jiangtang Granule (SJG) is a classic traditional Chinese medicine (TCM) prescription that is widely used to treat diabetes mellitus and its complications in clinical practice. While studies have revealed that SJG with multi-ingredients and multi-targets characteristics possesses potential anti-insulin resistance pharmacological properties, its mechanisms of action and molecular targets for the treatment of insulin resistance are still obscure, which prompt us to conduct an in-depth research. Read More

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September 2021

Orthogonal Characterization and Pharmacokinetic Studies of Polylactide-Polyethyleneglycol Polymeric Nanoparticles with Different Physicochemical Properties.

Int J Pharm 2021 Sep 21:121120. Epub 2021 Sep 21.

Department of Biopharmaceutics, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.

To optimize prolonged and sustained delivery of polylactide-block-polyethyleneglycol polymeric nanoparticles (PLA-PEG NPs), in terms of the PLA isomer and molecular weight, we performed orthogonal physicochemical characterization and evaluated the pharmacokinetics of tamoxifen (TAM)-loaded PLA-PEG NPs. DL-lactide- (DL-PEG NP), L-lactide- (L-PEG NPs), and stereocomplex-based (SC-PEG NPs) PLA-PEGs, with two different PLA to PEG ratios (12k-5k and 5k-5k Da) were synthesized, and NPs were prepared by anti-solvent precipitation. Size exclusion chromatography, multi-angle light scattering, dynamic light scattering, and H nuclear magnetic resonance studies revealed that SC-PEG NPs (12k-5k) had a compact structure and the highest PEG density, followed by L-PEG NPs (12k-5k), DL-PEG NPs (12k-5k), and all PLA-PEG NPs (5k-5k). Read More

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September 2021

Dual-modified starch nanospheres encapsulated with curcumin by self-assembly: Structure, physicochemical properties and anti-inflammatory activity.

Int J Biol Macromol 2021 Sep 21. Epub 2021 Sep 21.

College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.

Pullulanase debranching and subsequent hydroxypropylation were applied to prepare a series of dual-modified starches (Hydroxypropylated debranched starch, HPDS) with different degrees of hydroxypropyl substitution. Their structural and physicochemical properties varied with the degree of hydroxypropyl substitution, and all HPDS exhibited the ability to self-assemble into well-shaped nanospheres (100-150 nm, PDI < 0.2). Read More

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September 2021

Gesture errors in left and right hemisphere damaged patients: a behavioural and anatomical study.

Neuropsychologia 2021 Sep 21:108027. Epub 2021 Sep 21.

NPSY.Lab-VR, Department of Human Sciences, University of Verona, Italy. Electronic address:

Objective: Erroneous gesture execution is at the core of motor cognition difficulties in apraxia. While a taxonomy of errors may provide important information about the nature of the disorder, classifications are currently often inconsistent. This study aims to identify the error categories which distinguish apraxic from non-apraxic patients. Read More

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September 2021

Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage.

J Biol Chem 2021 Sep 21:101224. Epub 2021 Sep 21.

Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany and Center for Biochemistry, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany. Electronic address:

Energy metabolism and extracellular matrix function together orchestrate and maintain tissue organization, but crosstalk between these processes is poorly understood. Here, we used single cell RNA-seq (scRNA-seq) analysis to uncover the importance of the mitochondrial respiratory chain for extracellular matrix homeostasis in mature cartilage. This tissue produces large amounts of a specialized extracellular matrix to promote skeletal growth during development and maintain mobility throughout life. Read More

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September 2021

Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey.

Lancet Oncol 2021 Sep 15. Epub 2021 Sep 15.

Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, ON, Canada; Departments of Oncology, Queen's University, Kingston, ON, Canada; Public Health Sciences, Queen's University, Kingston, ON, Canada. Electronic address:

Background: The WHO Essential Medicines List (EML) identifies priority medicines that are most important to public health. Over time, the EML has included an increasing number of cancer medicines. We aimed to investigate whether the cancer medicines in the EML are aligned with the priority medicines of frontline oncologists worldwide, and the extent to which these medicines are accessible in routine clinical practice. Read More

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September 2021

iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome.

Stem Cell Reports 2021 Sep 14. Epub 2021 Sep 14.

Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany. Electronic address:

Therapeutic application of induced pluripotent stem cell (iPSC) derivatives requires comprehensive assessment of the integrity of their nuclear and mitochondrial DNA (mtDNA) to exclude oncogenic potential and functional deficits. It is unknown, to which extent mtDNA variants originate from their parental cells or from de novo mutagenesis, and whether dynamics in heteroplasmy levels are caused by inter- and intracellular selection or genetic drift. Sequencing of mtDNA of 26 iPSC clones did not reveal evidence for de novo mutagenesis, or for any selection processes during reprogramming or differentiation. Read More

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September 2021

Funneling and Enhancing Upconversion Emission by Light-Harvesting Molecular Wires.

J Phys Chem Lett 2021 Sep 24:9525-9530. Epub 2021 Sep 24.

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Triplet-triplet annihilation (TTA) upconversion has shown promising potentials in the augmentation of solar energy conversion. However, challenging issues exist in improving TTA upconversion efficiencies in solid-states, one of which is the back energy transfer from upconverted singlet annihilators to sensitizers, resulting in decreasing upconversion emission. Here we present a light-harvesting molecular wire consisting of dendrons with 9,10-diphenylanthracene derivatives (DPAEH) at the periphery and -phenylene ethynylene oligomers (PPE) as the wire core. Read More

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September 2021

Core-Doped [(CdCo)S(SPh)] Clusters from a Self-Assembly Route.

Inorg Chem 2021 Sep 24. Epub 2021 Sep 24.

Department of Chemistry, University of Massachusetts Amherst, 710 N Pleasant Street, Amherst, Massachusetts 01003, United States.

The incorporation of substitutional Co impurities in [CdS(SPh)] (Cd) molecular clusters prepared by the self-assembly method where NaS is the sulfur precursor and a redox method where elemental S is the sulfur precursor is studied. The Co ions provide unique spectroscopic and chemical handles to monitor dopant speciation during cluster formation and determine what role, if any, other cluster species play during Cd cluster formation. In contrast to the redox method that produces exclusively surface-exchanged Co-doped Cd (Co:Cd), the preparation of Cd by the self-assembly method in the presence of Co ions results in Co incorporation at both the surface and core sites of the Cd cluster. Read More

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September 2021

The association between hepatocarcinogenesis and intracellular alterations due to hepatitis B virus infection.

Authors:
Masataka Tsuge

Liver Int 2021 Sep 24. Epub 2021 Sep 24.

Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan.

Chronic hepatitis B virus (HBV) infection is a worldwide health problem leading to severe liver dysfunction, including liver cirrhosis and hepatocellular carcinoma. Although current antiviral therapies for chronic HBV infection have been improved and can lead to a strong suppression of viral replication, it is difficult to completely eliminate the virus with these therapies once chronic HBV infection is established in the host. Furthermore, chronic HBV infection alters intracellular metabolism and signaling pathways, resulting in the activation of carcinogenesis in the liver. Read More

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September 2021

Preparation of core-shell microporous organic polymer-coated silica microspheres for chromatographic separation and N-glycopeptides enrichment.

J Sep Sci 2021 Sep 24. Epub 2021 Sep 24.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian, 116023, China.

Through a "one-pot" strategy, a layer of microporous organic polymer was coated onto the surface of monodisperse amino-functionalized silica microsphere via amino-aldehyde condensation reaction with core-shell structure. The change in chemical structure of material before and after modification was determined by Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy. Due to existence of a large number of amino and aldehyde groups in microporous organic polymer shell, the water contact angle decreased from 56. Read More

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September 2021

Homoleptic Alkynyl-protected Ag15 Nanocluster with Atomic Precision: Structural Analysis and Electrocatalytic Performance toward CO2 Reduction.

Authors:
Rongchao Jin

Angew Chem Int Ed Engl 2021 Sep 24. Epub 2021 Sep 24.

Carnegie Mellon University, Department of Chemistry, 4400 Fifth Avenue, 15213, Pittsburgh, UNITED STATES.

Atomically precise Ag nanoclusters provide an ideal platform to correlate the structure and electrocatalytic performance at the atomic level. Herein, we report the fabrication of homoleptic alkynyl-protected Ag15(C≡CtBu)12+ (abbreviated as Ag15) nanocluster and its electrocatalytic properties toward CO2 reduction reaction. Crystal structure analysis reveals that, Ag15 possesses a body-centered-cubic (BCC) structure with an [email protected]@Ag6 metal core configuration. Read More

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September 2021

Differential DNA methylation and transcriptional signatures characterize impairment of muscle stem cells in pediatric human muscle contractures after brain injury.

FASEB J 2021 Oct;35(10):e21928

Shirley Ryan AbilityLab, Chicago, Illinois, USA.

Limb contractures are a debilitating and progressive consequence of a wide range of upper motor neuron injuries that affect skeletal muscle function. One type of perinatal brain injury causes cerebral palsy (CP), which affects a child's ability to move and is often painful. While several rehabilitation therapies are used to treat contractures, their long-term effectiveness is marginal since such therapies do not change muscle biological properties. Read More

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October 2021

Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma.

PLoS Pathog 2021 Sep 24;17(9):e1009958. Epub 2021 Sep 24.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Cross-reactive epitopes (CREs) are similar epitopes on viruses that are recognized or neutralized by same antibodies. The S protein of SARS-CoV-2, similar to type I fusion proteins of viruses such as HIV-1 envelope (Env) and influenza hemagglutinin, is heavily glycosylated. Viral Env glycans, though host derived, are distinctly processed and thereby recognized or accommodated during antibody responses. Read More

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September 2021

Development of a novel ALK rearrangement screening test for non-small cell lung cancers.

PLoS One 2021 24;16(9):e0257152. Epub 2021 Sep 24.

Molecular Diagnosis Laboratory, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan.

Approximately 5-7% of non-small cell lung cancer (NSCLC) cases harbor an anaplastic lymphoma kinase (ALK) fusion gene and may benefit from ALK inhibitor therapy. To detect ALK fusion genes, we developed a novel test using reverse transcription polymerase chain reaction (RT-PCR) for the ALK kinase domain (KD). Since ALK expression is mostly silenced in the adult with the exception of neuronal tissue, the normal lung tissue, mesothelial lining, and inflammatory cells are devoid of ALK transcript, making ALK KD RT-PCR an ideal surrogate test for ALK fusion transcripts in lung or pleural effusion. Read More

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September 2021

The Pandemic`s Unresolved Infectious Psycho-Neuro-Immunologies: Myeloid Cells, Vessels, Nasal Cross-Roads.

Psychiatr Danub 2021 Sep;33(Suppl 9):88-101

BipoSuisse - Psychiatrische Praxis, Vereinsweg 11, CH 3012 Berne, Switzerland,

Unresolved infectious psycho-neuro-endocrino-inflammation (PNEI) denotes an area of tragically accelerated interest because of SARS-CoV-2`s capacity to meddle with the immune responses in a stage-wise fashion. Its pandemic, interacting with antecedent further deteriorating health and living conditions, takes a direct toll of million human lives. In order to withstand the plethora of slowly or never easing ailments labeled "Post-acute Sequelae of Covid-19 (PASC)" a comprehensive understanding from the intrusions up to its emerging aftermaths is paramount. Read More

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September 2021

Healthy People 2030 Leading Health Indicators and Overall Health and Well-being Measures: Opportunities to Assess and Improve the Health and Well-being of the Nation.

J Public Health Manag Pract 2021 Nov-Dec 01;27(Suppl 6):S235-S241

Office of Disease Prevention and Health Promotion, Office of the Assistant Secretary for Health, Office of the Secretary, US Department of Health and Human Services, Washington, District of Columbia (Ms Ochiai, Ms Kigenyi, and Ms Blakey); Secretary's Advisory Committee on National Health Promotion and Disease Prevention Objectives for 2030 (former) (Dr Sondik, Dr Pronk, and Dr Kleinman); NORC at the University of Chicago, Bethesda, Maryland (Ms Fromknecht and Ms Heffernan); and Health ConTexts, LLC, Silver Spring, Maryland (Ms Brewer).

Context: Released by the US Department of Health and Human Services (HHS) every decade since 1980, Healthy People identifies science-based objectives with targets to monitor progress and motivate and focus action. Healthy People 2030 is the current iteration of the Healthy People initiative.

Program: Healthy People 2030 includes 3 sets of measures-Healthy People 2030 objectives, Leading Health Indicators (LHIs), and Overall Health and Well-being Measures (OHMs). Read More

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September 2021

Ultrasound-guided Procedures Allow Delay of Definitive Treatment for Core Muscle Injuries.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

Vincera Institute, Philadelphia, PA Thomas Jefferson University Hospital, Department of Radiology, Philadelphia, PA.

Introduction: Core muscle injuries (CMI) are common in every sport. To minimize lost playing time, providers apply various non-surgical treatments including platelet-rich plasma (PRP), corticosteroids, ultrasound (US)-guided percutaneous tenotomy, and prolotherapy. Limited data exists with regards to their effectiveness. Read More

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September 2021

Learning to Match Anchor-Target Video Pairs with Dual Attentional Holographic Networks.

IEEE Trans Image Process 2021 Sep 24;PP. Epub 2021 Sep 24.

Video hyperlinking is the task of linking two video fragments/clips based on their multi-modal contents. Specifically, given an anchor video as a query, machine techniques automatically generate links between the anchor and target videos by modeling and comparing their content aboutness. The term "aboutness" specifically refers to contextually relevant multimedia content, i. Read More

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September 2021

Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.

J Am Chem Soc 2021 Sep 24. Epub 2021 Sep 24.

RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

The extant complex proteins must have evolved from ancient short and simple ancestors. The double-ψ β-barrel (DPBB) is one of the oldest protein folds and conserved in various fundamental enzymes, such as the core domain of RNA polymerase. Here, by reverse engineering a modern DPBB domain, we reconstructed its plausible evolutionary pathway started by "interlacing homodimerization" of a half-size peptide, followed by gene duplication and fusion. Read More

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September 2021

Zwitterionic Nanocapsules with Salt- and Thermo-Responsiveness for Controlled Encapsulation and Release.

ACS Appl Mater Interfaces 2021 Sep 24. Epub 2021 Sep 24.

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.

Intelligent polymer nanocapsules that can not only encapsulate substances efficiently but also release them in a controllable manner hold great potential in many applications. To date, although intensive efforts have been made to develop intelligent polymer nanocapsules, how to construct the well-defined core/shell structure with high stability via a straightforward method remains a considerable challenge. In this work, the target novel zwitterionic nanocapsules (ZNs) with a stable hollow structure were synthesized by inverse reversible addition fragmentation transfer (RAFT) miniemulsion interfacial polymerization. Read More

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September 2021

High-Resolution Mapping of Amino Acid Residues in DNA-Protein Cross-Links Enabled by Ribonucleotide-Containing DNA.

Anal Chem 2021 Sep 24. Epub 2021 Sep 24.

Department of Chemistry, University of California, Riverside, Riverside, California 92521, United States.

DNA-protein cross-links have broad applications in mapping DNA-protein interactions and provide structural insights into macromolecular structures. However, high-resolution mapping of DNA-interacting amino acid residues with tandem mass spectrometry remains challenging due to difficulties in sample preparation and data analysis. Herein, we developed a method for identifying cross-linking amino residues in DNA-protein cross-links at single amino acid resolution. Read More

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September 2021

Inside-Out/Outside-In Tunability in Nanosized Lanthanide-Based Molecular Cluster-Aggregates: Modulating the Luminescence Thermometry Performance via Composition Control.

ACS Appl Mater Interfaces 2021 Sep 24. Epub 2021 Sep 24.

Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.

Modulating the optical property of a material via structural modification is a powerful tool for obtaining the desired optical output. If a material can be tuned inside (core) and outside (outer shell), then the degree of control is greater toward application. Herein, we present a lanthanide-based nanosized molecular cluster aggregate (MCA) that allows fine-tuning of the inner core via composition control akin to nanoparticles. Read More

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September 2021