16,740 results match your criteria cord syndrome

Altered effect of killer immunoglobulin-like receptor-ligand mismatch by graft versus host disease prophylaxis in cord blood transplantation.

Bone Marrow Transplant 2021 Sep 24. Epub 2021 Sep 24.

Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.

The role of killer immunoglobulin-like receptor-ligand mismatch (KIR-ligand mismatch) between donors and recipients undergoing cord blood transplantation (CBT) is controversial. If each immunosuppressant differently affects natural killer (NK) cell function, the effect of KIR-ligand mismatch may be altered depending on the type of graft versus host disease (GVHD) prophylaxis. To verify this hypothesis, the difference in the effect of KIR-ligand mismatch was retrospectively assessed between patients who received CBT for acute leukemia, myelodysplastic syndrome, or chronic myeloid leukemia, as well as GVHD prophylaxis comprising tacrolimus plus methotrexate (MTX) or mycophenolate mofetil (MMF). Read More

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September 2021

Delayed postoperative cervical spinal cord ischemic lesion after a thoracolumbar fusion for syndromic scoliosis: a case report and systematic review of the literature.

Childs Nerv Syst 2021 Sep 24. Epub 2021 Sep 24.

Spine Surgery Unit III-Scoliosis, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.

Introduction: We report a case and a literature review of delayed postoperative cervical spinal cord injury after thoraco-lumbar spine surgery.

Case Report: A 13-year-old Prader-Willi Syndrome female was treated by a T3-L5 posterior spine fusion for progressive scoliosis. Intraoperative neuromonitoring and immediate postoperative neurological examination were normal. Read More

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September 2021

[Effect of moxibustion on the expression of microglia and brain-derived neurotrophic factor protein in the spinal cord of rats with myofascial pain syndrome].

Zhen Ci Yan Jiu 2021 Sep;46(9):769-74

School of Acupuncture and Moxibustion, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.

Objective: To observe the effect of moxibustion at myofascial trigger points on microglia activation and the expression of brain-derived neurotrophic factor (BDNF) in the spinal cord of rats with myofascial pain syndrome (MPS), so as to explore the central mechanism of the analgesic effect of moxibustion.

Methods: Twenty-four male SD rats were randomly divi-ded into control, model and moxibustion groups (=8 in each group). The MPS model was established by strinking on fascia musculares and eccentric exercise. Read More

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September 2021

Agreement between commercially available ELISA and in-house Luminex SARS-CoV-2 antibody immunoassays.

Sci Rep 2021 Sep 23;11(1):18984. Epub 2021 Sep 23.

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain.

Serological diagnostic of the severe respiratory distress syndrome coronavirus 2 (SARS-CoV-2) is a valuable tool for the determination of immunity and surveillance of exposure to the virus. In the context of an ongoing pandemic, it is essential to externally validate widely used tests to assure correct diagnostics and epidemiological estimations. We evaluated the performance of the COVID-19 ELISA IgG and the COVID-19 ELISA IgM/A (Vircell, S. Read More

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September 2021

Case report of restless anal syndrome as restless legs syndrome variant after COVID-19.

BMC Infect Dis 2021 Sep 23;21(1):993. Epub 2021 Sep 23.

Tokyo Medical University Hospital, Tokyo, Japan.

Background: Coronavirus disease 2019 (COVID-19) has a broad spectrum from respiratory and nasopharyngeal symptoms, cerebrovascular diseases, impaired consciousness, and skeletal muscle injury. Emerging evidence has indicated the neural spread of this novel coronavirus. Restless legs syndrome (RLS) is a common neurological, sensorimotor disorder, but highly under diagnosis disorder. Read More

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September 2021

24-month Real-World Study of Spinal Cord Stimulation in Failed Back Surgery Patients with Refractory Pain.

Pain Physician 2021 Sep;24(6):479-488

Pain Unit, La Princesa University Hospital, Madrid, Spain; Clinical Pharmacology, La Princesa University Hospital, Madrid, Spain.

Background: Failed Back Surgery Syndrome (FBSS) causes disability and lowers health-related quality of life (HRQoL) for patients. Many patients become refractory to Conventional Medical Management (CMM) and Spinal Cord Stimulation (SCS) is advised. However, comparative effectiveness research of both clinical approaches still lacks further evidence. Read More

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September 2021

Transcranial Direct Current Stimulation for the Management of Neuropathic Pain: A Narrative Review.

Pain Physician 2021 Sep;24(6):E771-E781

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Korea.

Background: Neuropathic pain (NP) is common and often resistant to conventional analgesics. Among different types of noninvasive brain stimulation techniques, transcranial direct current stimulation (tDCS) has been widely used to mitigate pain in patients with NP.

Objective: The aim of this study was to review the effects of tDCS on the management of various types of NP. Read More

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September 2021

Microencapsulated Wharton Jelly-derived adult mesenchymal stem cells as a potential new therapeutic tool for patients with COVID-19 disease: an in vitro study.

Am J Stem Cells 2021 15;10(3):36-52. Epub 2021 Aug 15.

Division of Internal Medicine and Endocrine and Metabolic Sciences (MISEM), Laboratory for Endocrine Cell Transplants and Biohybrid Organs, Department of Medicine and Surgery, University of Perugia Piazzale Gambuli I-06132, Perugia, Italy.

Background: The recent newly appeared Coronavirus disease (COVID-19), caused by an enveloped RNA virus named "severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)", is associated with severe respiratory morbidity and mortality. Recent studies have shown that lymphopenia and a cytokine mass release represent important pathogenic features, with clinical evidence of dyspnea and hypoxemia, often leading to acute respiratory distress syndrome (ARDS), in severely ill patients, with a high death toll. Currently, stem cells are actively being investigated for their potential use in many "untreatable" diseases. Read More

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Non-pharmacological treatments for chronic orchialgia: A systemic review.

Arab J Urol 2021 4;19(3):401-410. Epub 2021 Aug 4.

Department of Urology, Hamad Medical Corporation, Doha, Qatar.

Objective: : To review the outcomes of various therapeutic modalities that can be offered to patients with chronic orchialgia (CO) after failed conservative treatment.

Methods: : A literature search was conducted using the PubMed and MEDLINE databases searching for articles exploring different CO treatment modalities. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach was used to report the results of the literature search. Read More

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Differentiation of immortalized human multi-lineage progenitor to alveolar type 2-like cells: angiotensin-converting enzyme 2 expression and binding of severe acute respiratory syndrome coronavirus 2 spike and spike 1 proteins.

Cytotherapy 2021 Aug 17. Epub 2021 Aug 17.

Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Department of Genetics, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Along with the nasal epithelium, the lung epithelium is a portal of entry for sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and many other respiratory viruses. In the case of SARS-CoV-2, the virus surface spike proteins bind to the angiotensin-converting enzyme 2 (ACE-2) receptor to facilitate entry into the respiratory epithelium. Alveolar type 2 (AT2) cells are committed respiratory progenitor cells responsible for the integrity and regeneration of the respiratory epithelium and production of respiratory surfactant proteins. Read More

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Retinal optical coherence tomography and magnetic resonance imaging in neuromyelitis optica spectrum disorders and MOG-antibody associated disorders: an updated review.

Expert Rev Neurother 2021 Sep 23. Epub 2021 Sep 23.

Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Introduction: Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein IgG antibody associated disorders (MOGAD) comprise two groups of rare neuroinflammatory diseases that cause attack-related damage to the central nervous system (CNS). Clinical attacks are often characterized by optic neuritis, transverse myelitis, and to a lesser extent, brainstem encephalitis/area postrema syndrome. Retinal optical coherence tomography (OCT) is a non-invasive technique that allows for in vivo thickness quantification of the retinal layers. Read More

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September 2021

Clinical heterogeneity of low flow spinal arteriovenous fistulas; a case series.

BMC Neurol 2021 Sep 21;21(1):366. Epub 2021 Sep 21.

Department of Neurology, Hospital Kuala Lumpur, Jalan Pahang, 50586, Kuala Lumpur, Malaysia.

Background: Spinal AVF (SAVF), a potentially treatable cause of myelopathy, remains a challenging diagnosis. Its rarity and non-specific imaging findings often result in misdiagnosis despite a high index of clinical suspicion. The classically described high T2 signal in the spinal cord or prominent vascular flow voids in the intradural space were not infrequently missed on initial imaging, only to be picked up at follow-up imaging after progression of symptoms. Read More

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September 2021

Pathogenesis, Etiology and Treatment of Failed Back Surgery Syndrome.

Neurochirurgie 2021 Sep 17. Epub 2021 Sep 17.

Department of Orthopedic Surgery, School of Medicine, AJA University of Medical Science, Tehran, Iran. Electronic address:

Failed back surgery syndrome (FBSS) is associated with persistent lower back pain after and despite one or more surgical interventions. A number of factors underlie and maintain FBSS and successful management of pain chiefly depends on identifying them. Pharmacological, surgical, and non-surgical therapeutic measures are taken to treat the pain. Read More

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September 2021

Spread of vimentin-immunoreactive cells within the plaque-like lesion in the spinal anterior horn of a patient with post-poliomyelitis syndrome.

Neuropathology 2021 Sep 19. Epub 2021 Sep 19.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

A Japanese man in the present study experienced acute weakness in his right leg as a two year old. The strength in his leg gradually recovered and developed, and he could play golf and climb mountains up to around the age of 50. From approximately 55 years of age, he became unable to stand up from a stooped position. Read More

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September 2021

High Frequency 10 kHz Spinal Cord Stimulation as a First Line Programming Option for Patients With Chronic Pain: A Retrospective Study and Review of the Current Evidence.

Cureus 2021 Aug 16;13(8):e17220. Epub 2021 Aug 16.

Department of Neurosurgery, Rutgers New Jersey Medical School, Newark, USA.

Introduction Neuromodulation is an evolving and increasingly popular therapy for chronic pain management. Recent data suggest that novel waveforms have demonstrated greater benefit over traditional spinal cord stimulation (SCS). The authors conducted a retrospective review of patients undergoing high-frequency 10 kHz SCS at a single tertiary medical center for the purpose of contributing further evidence to this growing body of data. Read More

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Decompression Illness in Repetitive Breath-Hold Diving: Why Ischemic Lesions Involve the Brain?

Front Physiol 2021 3;12:711850. Epub 2021 Sep 3.

Faculty of Sport Sciences, University of Rouen, Mont-Saint-Aignan, France.

Nitrogen (N) accumulation in the blood and tissues can occur due to breath-hold (BH) diving. Post-dive venous gas emboli have been documented in commercial BH divers (Ama) after repetitive dives with short surface intervals. Hence, BH diving can theoretically cause decompression illness (DCI). Read More

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September 2021

The Central Cord Score: A Novel Classification and Scoring System Specific to Acute Traumatic Central Cord Syndrome.

World Neurosurg 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Banner University of Arizona Medical Center - Tucson, Tucson, AZ.

Background: Acute traumatic central cord syndrome (ATCCS) remains the most common form of spinal cord injury (SCI) in the United States. Its treatment remains controversial and is a consequence of ATCCS having an inherently different natural history from conventional SCI, thus requiring a separate classification system. We devised a novel Central Cord Score (CCscore) that both guides treatment and tracks improvement over time with symptoms specific to ATCCS. Read More

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September 2021

Human Acellular Amniotic Matrix with Previously Seeded Umbilical Cord Mesenchymal Stem Cells Restores Endometrial Function in a Rat Model of Injury.

Mediators Inflamm 2021 3;2021:5573594. Epub 2021 Sep 3.

Peking University People's Hospital, Reproductive Medicine Center, Beijing 100044, China.

Background: Abnormal endometrial repair after injury results in the formation of intrauterine adhesions (IUA) and a thin endometrium, which are key causes for implantation failure and infertility. Stem cell transplantation offers a potential alternative for some cases of severe Asherman's syndrome that cannot be treated with surgery or hormonal therapy. Umbilical cord-derived mesenchymal stem cells (UCMSCs) have been reported to repair the damaged endometrium. Read More

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September 2021

A case of paraplegia due to asymptomatic varicella-zoster virus infection in AIDS patient unexpectedly diagnosed by CSF metagenomic next-generation sequencing.

BMC Infect Dis 2021 Sep 16;21(1):963. Epub 2021 Sep 16.

Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, 530021, Guangxi, China.

Background: Varicella-zoster virus (VZV) infection may induce central nervous system complications in HIV/AIDS patients. However, it is rare to have paraplegia caused by VZV infection but no herpes zoster clinically. Asymptomatic VZV infection in HIV/AIDS patient increased the difficulty of diagnosis. Read More

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September 2021

Horner's syndrome secondary to heart surgery in a pediatric patient.

Saudi J Ophthalmol 2020 Oct-Dec;34(4):303-305. Epub 2021 Jul 29.

Department of Ophthalmology, Sütcü Imam University, Faculty of Medicine KSU Faculty of Medical, Kahramanmaraş, Turkey.

Horner's Syndrome (HS) is a disease characterized by miosis, ptosis, and ipsilateral lack of sweating. It can occur with any injury at the level of the ocular sympathetic system neurons from the hypothalamus to the cervical postganglionic fibers. We present here a case of HS that developed after heart surgery in a 9-year-old boy. Read More

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Models and Processes to Extract Drug-like Molecules From Natural Language Text.

Front Mol Biosci 2021 30;8:636077. Epub 2021 Aug 30.

Department of Computer Science, University of Chicago, Chicago, IL, United States.

Researchers worldwide are seeking to repurpose existing drugs or discover new drugs to counter the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A promising source of candidates for such studies is molecules that have been reported in the scientific literature to be drug-like in the context of viral research. However, this literature is too large for human review and features unusual vocabularies for which existing named entity recognition (NER) models are ineffective. Read More

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Medical management of heavily exposed victims: An experience at the Tokaimura criticality accident.

J Radiol Prot 2021 Sep 15. Epub 2021 Sep 15.

Harada Hospital, Irima, Saitama, JAPAN.

A criticality accident occurred at the uranium conversion plant in Tokaimura, Ibaraki Prefecture, Japan on September 30, 1999. When uranyl nitrate was overloaded to a critical mass level, uncontrolled fission reaction occurred. A procedure was carried out according to the JCO manual, although not an officially approved manual. Read More

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September 2021

Dynamic alignment changes during level walking in patients with dropped head syndrome: analyses using a three-dimensional motion analysis system.

Sci Rep 2021 Sep 14;11(1):18254. Epub 2021 Sep 14.

Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare, 852 Hatakeda, Narita City, Chiba, 286-8520, Japan.

In patients with dropped head syndrome (DHS), cervical malalignment is one of the risk factors for impaired horizontal gaze and restrictions to ambulation. The characteristics of gait in patients with DHS have not been clarified biomechanically from the viewpoint of dynamic alignment and lower limb kinematics. This study aimed to clarify kinematic and kinetic differences during level walking in patients with DHS compared to the healthy elderly. Read More

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September 2021

The Distinct Immune Nature of the Fetal Inflammatory Response Syndrome Type I and Type II.

Immunohorizons 2021 Sep 14;5(9):735-751. Epub 2021 Sep 14.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI;

Fetal inflammatory response syndrome (FIRS) is strongly associated with neonatal morbidity and mortality and can be classified as type I or type II. Clinically, FIRS type I and type II are considered as distinct syndromes, yet the molecular underpinnings of these fetal inflammatory responses are not well understood because of their low prevalence and the difficulty of postdelivery diagnosis. In this study, we performed RNA sequencing of human cord blood samples from preterm neonates diagnosed with FIRS type I or FIRS type II. Read More

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September 2021

Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report.

J Neuroimmunol 2021 Aug 28;360:577704. Epub 2021 Aug 28.

Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. Read More

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Intraoperative Neuromonitoring for Tethered Cord Surgery in Infants: Challenges and Outcome.

Pediatr Neurosurg 2021 Aug 30:1-10. Epub 2021 Aug 30.

Department of Anaesthesia, Amrita Institute of Medical Sciences and Research Centre, Kochi, India.

Objective: The aim of this study was to evaluate the efficacy and safety of intraoperative neuromonitoring (IONM) in surgery for tethered cord in infants.

Materials And Methods: The study included 87 infants who underwent surgery for closed spinal dysraphism under IONM. Their preoperative neurological and urological statuses were compared with postoperative status clinically. Read More

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A Patient with Kabuki Syndrome Mutation Presenting with Very Severe Aplastic Anemia.

Acta Haematol 2021 Sep 3:1-8. Epub 2021 Sep 3.

Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.

Kabuki syndrome (KS) is a rare congenital disorder commonly complicated by humoral immunodeficiency. Patients with KS present with mutation in the histone-lysine N-methyltransferase 2D (KMT2D) gene. Although various KMT2D mutations are often identified in lymphoma and leukemia, those encountered in aplastic anemia (AA) are limited. Read More

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September 2021

Chronic refractory angina pectoris treated by bilateral stereotactic radiosurgical stellate ganglion ablation: first-in-man case report.

Eur Heart J Case Rep 2021 Aug 31;5(8):ytab184. Epub 2021 Aug 31.

Department of Cardiology, Nemocnice Agel Trinec-Podlesi, Konska 453, Trinec 739 61, Czechia.

Background: Refractory angina pectoris (AP) significantly impairs quality of life in patients with chronic coronary syndrome. Several minimally invasive methods (coronary sinus reducer, cell therapy, laser or shockwave revascularization, and spinal cord stimulation) or non-invasive methods (external counterpulzation) have been studied. However, their routine clinical use has not been widely implemented. Read More

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24-Month Effectiveness of Periduoscopic Adhesiolysis in Reducing the Use of Spinal Cord Stimulation in Patient With Chronic Lumbar Pain: A Possible Therapeutic Regimen?

Cureus 2021 Aug 30;13(8):e17563. Epub 2021 Aug 30.

II Service Anesthesia, Critical Care and Pain Medicine, Azienda Ospedaliera Universitaria Parma, Parma, ITA.

Objectives Epiduroscopy is a minimally invasive procedure that is used in pain therapy to treat lumbar and root pain that is resistant to medical and infiltrative therapies. The indications for periduroscopy are partly shared with those of spinal cord stimulation (SCS): failed back surgery syndrome (FBSS) and stenosis of the vertebral canal in particular. The costs and risks of periduroscopy are considerably lower than those of SCS. Read More

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Dural splitting reconstruction in retethering after lipomeningocele repair: Technical note.

Surg Neurol Int 2021 24;12:422. Epub 2021 Aug 24.

Department of Neurosurgery, Highly Specialized Hospital of National Importance "Garibaldi," Catania, Sicily, Italy.

Background: Tethered spinal cord syndrome (TCS) can occur after the surgical repair of lipomeningoceles (LMCs). In these cases, the tethering results from postoperative adhesions between the spinal cord and the overlying repaired dura. A watertight dural closure using the residual dura and/or the surrounding tissues does not always provide enough space for the spinal cord and risks retethering. Read More

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