179 results match your criteria cord milking


Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns.

Am J Perinatol 2022 Jan 13. Epub 2022 Jan 13.

Biochemistry, Gaziantep University, Gaziantep, Turkey.

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. Read More

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January 2022

Effects of delayed versus immediate umbilical cord clamping in reducing death or major disability at 2 years corrected age among very preterm infants (APTS): a multicentre, randomised clinical trial.

Lancet Child Adolesc Health 2021 Dec 8. Epub 2021 Dec 8.

NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.

Background: Very preterm infants are at increased risk of adverse outcomes in early childhood. We assessed whether delayed clamping of the umbilical cord reduces mortality or major disability at 2 years in the APTS Childhood Follow Up Study.

Methods: In this long-term follow-up analysis of the multicentre, randomised APTS trial in 25 centres in seven countries, infants (<30 weeks gestation) were randomly assigned before birth (1:1) to have clinicians aim to delay clamping for 60 s or more or clamp within 10 s of birth, both without cord milking. Read More

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December 2021

Management of Placental Transfusion to Neonates After Delivery.

Obstet Gynecol 2022 01;139(1):121-137

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; and the Department of Pediatrics, UC Davis Children's Hospital, UC Davis Health, Sacramento, California.

This review summarizes high-quality evidence supporting delayed umbilical cord clamping to promote placental transfusion to preterm and term neonates. In preterm neonates, delayed cord clamping may decrease mortality and the need for blood transfusions. Although robust data are lacking to guide cord management strategies in many clinical scenarios, emerging literature is reviewed on numerous topics including delivery mode, twin gestations, maternal comorbidities (eg, gestational diabetes, red blood cell alloimmunization, human immunodeficiency virus [HIV] infection, and severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infection) and neonatal complications (eg, fetal growth restriction, congenital heart disease, and the depressed neonate). Read More

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January 2022

The Association Between Placental Residual Blood Volume and Two Placental Transfusion Methods After Delivery at Term.

Front Pediatr 2021 8;9:768075. Epub 2021 Nov 8.

Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei, Taiwan.

Despite reports of the beneficial effects, such as increasing hemoglobin level and iron store in the neonatal period, of delayed cord clamping, or umbilical cord milking after delivery in healthy term-born infants, the duration of delayed clamping or rounds of milking in most previous reports were determined arbitrarily and varied widely across different studies. We prospectively recruited 80 women with normal singleton pregnancies at 38-40 weeks' gestation. Participants were classified according to the mode of delivery and randomly assigned to either collecting blood from the placenta by umbilical cord drainage (CD) or cord milking (CM), with the placenta left in the uterus. Read More

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November 2021

A 20-cm cut umbilical cord milking may not benefit the preterm infants < 30 week's gestation: A randomized clinical trial.

J Formos Med Assoc 2021 Sep 27. Epub 2021 Sep 27.

Division of Neonatology, Department of Pediatrics, MacKay Children's Hospital, Taipei City, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan. Electronic address:

Background/purpose: To evaluate whether a shorter length (20 cm) of C-UCM has potential benefits, compared to immediate cord clamping (ICC), in very preterm babies.

Methods: Inborn preterm infants less than 30 weeks of gestational age (GA) were randomly assigned to the 20-cm C-UMC and ICC groups. The primary outcome was the need for packed red blood cell (pRBC) transfusion before the 21st day of life. Read More

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September 2021

Behaviors and Attitudes of Obstetricians in Turkey Related to Cord Clamping, Cord Milking, and Skin-To-Skin Contact.

Cureus 2021 Jul 7;13(7):e16227. Epub 2021 Jul 7.

Obstetrics and Gynecology, Yozgat Bozok University, Yozgat, TUR.

Objective This study was planned to evaluate obstetricians' practices of umbilical cord clamping, milking, and skin-to-skin contact applications and to determine the related variables. Material and methods A total of 522 obstetricians participated in the study. Participants were reached via the internet and a 15-item questionnaire was applied about umbilical cord clamping, cord milking, and skin-to-skin contact. Read More

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Placental Transfusion, Timing of Plastic Wrap or Bag Placement, and Preterm Neonates.

Am J Perinatol 2021 Jul 12. Epub 2021 Jul 12.

Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.

Objective:  Compare delivery room practices and outcomes of infants born at less than 32 weeks' gestation or less than 1,500 g who have plastic wrap/bag placement simultaneously during placental transfusion to those receiving plastic wrap/bag placement sequentially following placental transfusion.

Study Design:  Retrospective analysis of data from a multisite quality improvement initiative to refine stabilization procedures pertaining to placental transfusion and thermoregulation using a plastic wrap/bag. Delivery room practices and outcome data in 590 total cases receiving placental transfusion were controlled for propensity score matching and hospital of birth. Read More

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Delayed cord clamping: Time for physiologic implementation.

Authors:
A Surak Y Elsayed

J Neonatal Perinatal Med 2021 Jun 29. Epub 2021 Jun 29.

Division of Neonatology, Health Sciences Centre, Winnipeg, MB, Canada.

Delayed cord clamping has been shown to be beneficial in both preterm and term babies. Practice guidelines have not been consistent between centers and the practice of delayed cord clamping has not been standardized. The concept of physiologic-based cord clamping emerged into practice as well. Read More

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Milking of Umbilical Cord vs Delayed Cord Clamping: Authors' Reply.

Indian Pediatr 2021 06;58(6):593

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

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Milking of Umbilical Cord vs Delayed Cord Clamping.

Indian Pediatr 2021 06;58(6):593

Department of Neonatology, Rainbow Children's Hospital, Bengaluru 560037, Karnataka.

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Considering an Update on Umbilical Cord Milking for the New Guidelines for Neonatal Resuscitation.

JAMA Pediatr 2021 09;175(9):894-895

Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy.

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September 2021

[Effect of delayed cord clamping and umbilical cord milking on cerebral hemodynamics in preterm infants: a randomized double-blind controlled trial].

Authors:
Ling Lin Hao Peng

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):332-337

Department of Pediatrics, Suining Central Hospital, Suining, Sichuan 629000, China.

Objective: To compare the effect of delayed cord clamping (DCC) versus umbilical cord milking (UCM) on cerebral blood flow in preterm infants.

Methods: This was a single-center, prospective, double-blind, randomized controlled trial. A total of 46 preterm infants, with a gestational age of 30-33 weeks, who were born in Suining Central Hospital from November 2, 2018 to November 15, 2019 were enrolled and randomly divided into DCC group and UCM group, with 23 infants in each group. Read More

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Effects of Placental Transfusion on Late Preterm Infants Admitted to a Mother Baby Unit.

Am J Perinatol 2021 Mar 15. Epub 2021 Mar 15.

Division of Neonatology, Baylor University Medical Center, Pediatrix Medical Group of Dallas, Dallas, Texas.

Objective:  Well-appearing late preterm infants admitted to a mother baby unit may benefit from either delayed cord clamping (DCC) or umbilical cord milking (UCM). However, there are concerns of adverse effects of increased blood volume such as polycythemia and hyperbilirubinemia. The purpose of this study is to examine the short-term effects of placental transfusion on late preterm infants born between 35 and 36 weeks of gestation. Read More

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Association of Umbilical Cord Management Strategies With Outcomes of Preterm Infants: A Systematic Review and Network Meta-analysis.

JAMA Pediatr 2021 04 5;175(4):e210102. Epub 2021 Apr 5.

Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.

Importance: It is unclear which umbilical cord management strategy is the best for preventing mortality and morbidities in preterm infants.

Objective: To systematically review and conduct a network meta-analysis comparing 4 umbilical cord management strategies for preterm infants: immediate umbilical cord clamping (ICC), delayed umbilical cord clamping (DCC), umbilical cord milking (UCM), and UCM and DCC.

Data Sources: PubMed, Embase, CINAHL, and Cochrane CENTRAL databases were searched from inception until September 11, 2020. Read More

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A 3-armed multicenter randomized controlled trial: Placental Transfusion in Very Preterm Infants (PT-VPI).

Contemp Clin Trials 2021 04 2;103:106337. Epub 2021 Mar 2.

Neonatal Department, Chengdu Women's and Children's Central Hospital, School of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, PR China. Electronic address:

Preterm infants constitute an important proportion of neonatal deaths and various complications, and very preterm infants (VPI) are more likely to develop severe complications, such as intraventricular hemorrhage (IVH), anemia, and sepsis. It has been confirmed that placental transfusion can supplement blood volume in infants and reduce preterm-associated complications, which is further conducive to the development of the nervous system and a better long-term prognosis. Based on these advantages, placental transfusion has been widely used in VPI. Read More

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Umbilical Cord Management at Term and Late Preterm Birth: A Meta-analysis.

Pediatrics 2021 03;147(3)

Department of Pediatrics, The Robert Larner College of Medicine, The University of Vermont, Burlington, Vermont.

Context: The International Liaison Committee on Resuscitation prioritized scientific review of umbilical cord management at term and late preterm birth.

Objective: To assess effects of umbilical cord management strategies (clamping timing and cord milking) in infants ≥34 weeks' gestational age.

Data Sources: Cochrane Central Register of Controlled Trials, Medline, PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, and trial registries searched July 2019. Read More

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Umbilical Cord Management for Newborns <34 Weeks' Gestation: A Meta-analysis.

Pediatrics 2021 03;147(3)

Department of Pediatrics, The Robert Larner College of Medicine, The University of Vermont, Burlington, Vermont; and.

Context: The International Liaison Committee on Resuscitation prioritized scientific review of umbilical cord management strategies at preterm birth.

Objective: To determine the effects of umbilical cord management strategies (including timing of cord clamping and cord milking) in preterm infants <34 weeks' gestation.

Data Sources: Cochrane Central Register of Controlled Trials, Medline, PubMed, Embase, CINAHL, and trial registries were searched through July 2019 for randomized controlled trials assessing timing of cord clamping and/or cord milking. Read More

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Umbilical cord milking versus delayed cord clamping in term and late-preterm infants: a systematic review and meta-analysis.

J Matern Fetal Neonatal Med 2021 Feb 10:1-11. Epub 2021 Feb 10.

Surya Hospitals, Mumbai, India.

Objective: To conduct a systematic review and meta-analysis to compare the efficacy and safety of umbilical cord milking (UCM) versus delayed cord clamping (DCC) in term and late-preterm infants.

Methods: MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Clinical trial registries, and Gray literature were searched for randomized controlled trials (RCTs) comparing UCM with DCC in term and late-preterm infants for both short-term and long-term outcomes. Intact and cut UCM were compared separately with DCC using subgroup analysis. Read More

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February 2021

Interventions to minimize blood loss in very preterm infants-A systematic review and meta-analysis.

PLoS One 2021 8;16(2):e0246353. Epub 2021 Feb 8.

Department of Pediatrics, Lund University, Lund, Sweden.

Blood loss in the first days of life has been associated with increased morbidity and mortality in very preterm infants. In this systematic review we included randomized controlled trials comparing the effects of interventions to preserve blood volume in the infant from birth, reduce the need for sampling, or limit the blood sampled. Mortality and major neurodevelopmental disabilities were the primary outcomes. Read More

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Effect of umbilical cord milking versus delayed cord clamping on preterm neonates in Kenya: A randomized controlled trial.

PLoS One 2021 26;16(1):e0246109. Epub 2021 Jan 26.

Department of Obstetrics and Gynecology, College of Health Sciences, University of Nairobi, Nairobi, Kenya.

Background: Delayed cord clamping (DCC) is a placental to new-born transfusion strategy recommended by obstetric and gynaecological societies. Though not widely adopted, umbilical cord milking (UCM) may achieve faster transfusion when DCC cannot be performed such as when a neonate requires resuscitation.

Methods: Pragmatic, two-arm, randomized clinical trial in which consenting women in spontaneous labour or provider-initiated delivery at 28 to less than 37 weeks at Kenyatta National Hospital in Nairobi, Kenya, were enrolled. Read More

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Umbilical Cord Management in Late Preterm and Term Infants: A Randomized Controlled Trial.

Am J Perinatol 2021 01 20. Epub 2021 Jan 20.

Department of Obstetrics and Gynecology, Adana Acibadem Hospital, Adana, Turkey.

Objective: The study aimed to compare the effects of three different methods of umbilical cord management on hematological parameters in term and late-preterm infants.

Study Design: A randomized controlled trial comparing intact-umbilical cord milking (I-UCM) with cut-umbilical cord milking (C-UCM) and immediate cord clamping (ICC) in neonates born >35 weeks' gestation.

Results: A total of 587 infants were evaluated. Read More

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January 2021

Umbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants.

J Pediatr 2021 05 5;232:87-94.e4. Epub 2021 Jan 5.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Leonard Davis Institute of Health Economics, The University of Pennsylvania, Philadelphia, PA. Electronic address:

Objective: To compare in-hospital outcomes after umbilical cord milking vs delayed cord clamping among infants <29 weeks of gestation.

Study Design: Multicenter retrospective study of infants born <29 weeks of gestation from 2016 to 2018 without congenital anomalies who received active treatment at delivery and were exposed to umbilical cord milking or delayed cord clamping. The primary outcome was mortality or severe (grade III or IV) intraventricular hemorrhage (IVH) by 36 weeks of postmenstrual age (PMA). Read More

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Neonatal Outcomes at Extreme Prematurity by Gestational Age Versus Birth Weight in a Contemporary Cohort.

Am J Perinatol 2021 07 6;38(9):880-888. Epub 2021 Jan 6.

Department of Pediatrics, Division of Neonatology, Neonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California.

Objective: The aim of the study is to describe the rates of neonatal death and severe neonatal morbidity in a contemporary cohort, as well as to evaluate the predictive value of birth gestational age (GA) and birth weight, independently and combined, for neonatal mortality and morbidity in the same contemporary cohort.

Study Design: We performed a secondary analysis of an international, multicenter randomized controlled trial of delayed umbilical cord clamping versus umbilical cord milking in preterm infants born at 23 to 31 weeks of gestation. The current analysis was restricted to infants delivered <28 weeks. Read More

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The risk of hyperbilirubinemia in term neonates after placental transfusion - a randomized-blinded controlled trial.

Ginekol Pol 2020;91(10):613-619

Department of Neonatology and Intensive Care Unit, Faculty of Medicine, Medical University of Warsaw, Poland.

Objective: We aimed to demonstrate non-inferiority of delayed cord clamping (DCC) and cord milking (CM) in comparison to early cord clamping (ECC) in the incidence of hyperbilirubinemia requiring phototherapy.

Material And Methods: 467 of maternal-foetal dyads were screened for eligibility. 389 term infants, of breastfeeding, non-smoking mothers were randomized to receive ECC ( < 40 s), DCC (1-2 min) or CM (4 times towards the neonate). Read More

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Perinatal Outcomes of Subjects Enrolled in a Multicenter Trial with a Waiver of Antenatal Consent.

Am J Perinatol 2020 Nov 3. Epub 2020 Nov 3.

Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah.

Objective:  This study aimed to determine whether outcomes differed between infants enrolled in the PREMOD2 trial and those otherwise eligible but not enrolled, and whether the use of waiver effected these differences.

Study Design:  The multicenter PREMOD2 (PREmature infants receiving Milking Or Delayed cord clamping) trial was approved for waiver of antenatal consent by six of the nine sites institutional review boards, while three sites exclusively used antenatal consent. Every randomized subject delivered at a site with a waiver of consent was approached for postnatal consent to allow for data collection. Read More

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November 2020

Guidelines on Deferred Cord Clamping and Cord Milking: A Systematic Review.

Pediatrics 2020 11;146(5)

Departments of Obstetrics and Gynecology,

Context: Deferred cord clamping (DCC) saves lives. It reduces extremely preterm infants' mortality by 30%, yet a minority of eligible infants receive it. This may in part be due to lack of awareness or confidence in evidence, or conflicting or vague guidelines. Read More

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November 2020

Variations in umbilical cord clamping practices in the United States: a national survey of neonatologists.

J Matern Fetal Neonatal Med 2020 Oct 20:1-7. Epub 2020 Oct 20.

Division of Neonatology, Research institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.

Objective: Since the first publication of the American College of Obstetricians and Gynecologists committee opinion in 2012, and following the update in 2017, multiple institutions in the United States (US) adopted the practice of delayed cord clamping (DCC) and/or umbilical cord milking (UCM) in preterm and term infants. However, there have been variations reported in practices with regard to method of placental transfusion, timing of cord clamping and gestational age thresholds. Furthermore, the optimal cord clamping practice in situations of depressed infants needing resuscitation or in higher-risk delivery situations, such as placental abruption, intrauterine growth restriction, multiple gestation, chorioamnionitis, maternal human immunodeficiency virus syndrome/hepatitis or maternal general anesthesia is often debated. Read More

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October 2020

Effect of Umbilical Cord Milking vs Delayed Cord Clamping on Venous Hematocrit at 48 Hours in Late Preterm and Term Neonates: A Randomized Controlled Trial.

Indian Pediatr 2020 Dec 16;57(12):1119-1123. Epub 2020 Sep 16.

Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Objective: To compare the effect of intact umbilical cord milking (MUC) and delayed cord clamping (DCC) on venous hematocrit at 48 (±6) hours in late preterm and term neonates (350/7- 426/7 wk).

Study Design: Randomized trial.

Setting And Participants: All late preterm and term neonates (350/7 - 426/7 wk) neonates born in the labor room and maternity operation theatre of tertiary care unit were included. Read More

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December 2020

Umbilical cord milking versus delayed cord clamping in term infants: a systematic review and meta-analysis.

J Perinatol 2021 07 24;41(7):1549-1557. Epub 2020 Sep 24.

Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan.

Objective: Delayed cord clamping (DCC) is recommended for healthy term infants. However, the effectiveness of umbilical cord milking (UCM) in term infants remains unknown. The study aimed to compare the effects of UCM versus DCC on term infants. Read More

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Umbilical cord management strategies at cesarean section.

J Obstet Gynaecol Res 2020 Sep 22. Epub 2020 Sep 22.

Department of Obstetrics and Pediatrics, Azienda Socio Sanitaria Territoriale Vimercate, Vittorio Emanuele III Hospital, Carate Brianza, University of Milano-Bicocca, Monza, Italy.

Aim: To evaluate the effect of different strategies to improve placental transfusion in cesarean section (CS).

Methods: Retrospective analysis of all singleton term pregnancies that underwent CS over 6 months. Delayed umbilical cord clamping (dUCC) was defined as one done at least 60 s after birth. Read More

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September 2020