83,458 results match your criteria cord injury


Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.

J Pineal Res 2021 Sep 25:e12769. Epub 2021 Sep 25.

Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Spinal cord injury (SCI) is a devastating trauma that leads to irreversible motor and sensory dysfunction and is, so far, without effective treatment. Recently, however, nano-sized extracellular vesicles derived from preconditioned mesenchymal stem cells (MSCs) have shown great promise in treating various diseases, including SCI. In this study, we investigated whether extracellular vesicles (MEVs) derived from MSCs pretreated with melatonin (MT), which is well-recognized to be useful in treating diseases, including Alzheimer's disease, nonsmall cell lung cancer, acute ischemia-reperfusion liver injury, chronic kidney disease and SCI, are better able to promote functional recovery in mice after SCI than extracellular vesicles derived from MSCs without preconditioning (EVs). Read More

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September 2021

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review.

Curr Neuropharmacol 2021 Sep 23. Epub 2021 Sep 23.

Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.

Chronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. Read More

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September 2021

Broad opioid antagonism amplifies disruption of locomotor function following therapy-like hindlimb stretching in spinal cord injured rats.

Spinal Cord 2021 Sep 24. Epub 2021 Sep 24.

Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY, USA.

Study Design: Preclinical pilot study.

Objectives: To test the hypothesis that spinal opioidergic circuitry contributes to muscle stretch-induced locomotor deficits.

Setting: Kentucky Spinal Cord Injury Research Center, Louisville, KY, USA. Read More

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September 2021

Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions.

Prog Brain Res 2021 13;265:385-406. Epub 2021 Aug 13.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Nanoparticles affect blood-brain barrier (BBB) and brain edema formation resulting in sensory-motor dysfunction. Exposure of Mn nanoparticles from industrial sources in humans could target basal ganglia resulting in Parkinson's disease. In present investigation, Mn exposure on brain pathology in a rat model was examined. Read More

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Who is at risk of loneliness? A cross-sectional recursive partitioning approach in a population-based cohort of persons with spinal cord injury.

Arch Phys Med Rehabil 2021 Sep 21. Epub 2021 Sep 21.

Swiss Paraplegic Research, Nottwil, Switzerland; Department of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.

Objective: To develop a more thorough understanding of the risk factors for loneliness in persons with a physical impairment, using a population-based sample of persons with SCI, based on regression modelling and a recursive partitioning approach.

Design: Cross-sectional, observational cohort.

Setting: Community, Switzerland. Read More

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September 2021

Application of Extradural Nerve Root Transfer in the Restoration of Lower Limb Function in Spinal Cord Injury: Hypothesis and a Cadaver Feasibility Study.

Spine (Phila Pa 1976) 2021 Oct;46(20):1363-1369

Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Study Design: Two fresh-frozen and six formalin-fixed cadavers were included in the study.

Objective: To ascertain whether transferring T9 or T11 ventral root (VR) to L2 VR and T10 or T12 VR to L3 VR in restoring lower limb function after spinal cord injury is anatomically feasible.

Summary Of Background Data: Lower limb paralysis impairs the quality of the life and places burden on the whole society. Read More

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October 2021

Delayed postoperative cervical spinal cord ischemic lesion after a thoracolumbar fusion for syndromic scoliosis: a case report and systematic review of the literature.

Childs Nerv Syst 2021 Sep 24. Epub 2021 Sep 24.

Spine Surgery Unit III-Scoliosis, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.

Introduction: We report a case and a literature review of delayed postoperative cervical spinal cord injury after thoraco-lumbar spine surgery.

Case Report: A 13-year-old Prader-Willi Syndrome female was treated by a T3-L5 posterior spine fusion for progressive scoliosis. Intraoperative neuromonitoring and immediate postoperative neurological examination were normal. Read More

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September 2021

Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury.

Neural Regen Res 2022 May;17(5):1080-1087

College of Pharmacy, Shaanxi University of Chinese Medicine; Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Life Sciences, Shaanxi Normal University; Translational Medicine Center, Hong Hui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system diseases. However, the mechanism behind the neuroprotective effects remains unclear. In this study, rat models of spinal cord injury were established using a modified Allen's impact method and then treated with intraperitoneal injection of Baicalin. Read More

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M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury.

Neural Regen Res 2022 May;17(5):1072-1079

Department of Orthopedics, The Second Hospital of Anhui Medical University, Hefei, Anhui Province, China.

After spinal cord injury (SCI), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon regeneration. Meanwhile, microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. However, the effect of microglia polarization on astrocytes is unclear. Read More

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Effect of vocal respiratory training on respiratory function and respiratory neural plasticity in patients with cervical spinal cord injury: a randomized controlled trial.

Neural Regen Res 2022 May;17(5):1065-1071

School of Rehabilitation Medicine, Capital Medical University; China Rehabilitation Science Institute; Beijing Key Laboratory of Neural Injury and Rehabilitation; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.

In previous studies, researchers have used singing to treat respiratory function in patients with spinal cord injury. However, few studies have examined the way in which vocal training affects respiratory neural plasticity in patients with spinal cord injury. Vocal respiratory training (VRT) is a type of vocal muscle-related treatment that is often a component of music therapy (MT) and focuses on strengthening respiratory muscles and improving lung function. Read More

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Growth associated protein 43 and neurofilament immunolabeling in the transected lumbar spinal cord of lizard indicates limited axonal regeneration.

Authors:
Lorenzo Alibardi

Neural Regen Res 2022 May;17(5):1034-1041

Comparative Histolab Padova and Department of Biology, University of Bologna, Bologna, Italy.

Previous cytological studies on the transected lumbar spinal cord of lizards have shown the presence of differentiating glial cells, few neurons and axons in the bridge region between the proximal and distal stumps of the spinal cord in some cases. A limited number of axons (20-50) can cross the bridge and re-connect the caudal stump of the spinal cord with small neurons located in the rostral stump of the spinal cord. This axonal regeneration appears to be related to the recovery of hind-limb movements after initial paralysis. Read More

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Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury.

Neural Regen Res 2022 May;17(5):963-971

Department of Orthopedics; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin; Department of Orthopedics, Qilu Hospital; Shandong University Center for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.

Recent studies in patients with spinal cord injuries (SCIs) have confirmed the diagnostic potential of biofluid-based biomarkers, as a topic of increasing interest in relation to SCI diagnosis and treatment. This paper reviews the research progress and application prospects of recently identified SCI-related biomarkers. Many structural proteins, such as glial fibrillary acidic protein, S100-β, ubiquitin carboxy-terminal hydrolase-L1, neurofilament light, and tau protein were correlated with the diagnosis, American Spinal Injury Association Impairment Scale, and prognosis of SCI to different degrees. Read More

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Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury.

Neural Regen Res 2022 May;17(5):959-962

Institute of Clinical Neuroimmunology, Ludwig-Maximilians Universität München; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

Serotonin is a monoamine neurotransmitter synthetized in various populations of brainstem neurons. In the spinal cord, descending serotonergic projections regulate postural muscle tone, locomotion and rhythm and coordination of movements via the Central Pattern Generator. Following a spinal cord injury, serotonergic projections to the lumbar spinal cord, where the Central Pattern Generators are located, are interrupted resulting in devastating locomotor impairments and changes in the expression and activation of serotonin and its spinal receptors. Read More

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Time-to-enrollment in clinical trials investigating neurological recovery in chronic spinal cord injury: observations from a systematic review and ClinicalTrials.gov database.

Neural Regen Res 2022 May;17(5):953-958

Mayo Clinic Neuro-Informatics Laboratory; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Currently, large numbers of clinical trials are performed to investigate different forms of experimental therapy for patients suffering from chronic spinal cord injury (SCI). However, for the enrollment process, there are different views on how the time period between injury and interventions should be determined. Herein, we sought to evaluate the impact of time-to-enrollment in chronic SCI clinical trials. Read More

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Postoperative clinicoradiological outcome of pott's spine.

Ann Afr Med 2021 Jul-Sep;20(3):164-168

Department of Orthopaedics, DMIMS, Wardha, Maharashtra, India.

Introduction: Tuberculosis (TB) is one of the main diseases impacting humanity. Fifty percent of all the cases of skeletal TB belong to spinal TB (STB), and it is also the most common form of TB. In India, patients usually present late after the onset of neurological symptoms, for which surgical management is essential for recovery. Read More

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September 2021

[Effect of moxibustion on the expression of microglia and brain-derived neurotrophic factor protein in the spinal cord of rats with myofascial pain syndrome].

Zhen Ci Yan Jiu 2021 Sep;46(9):769-74

School of Acupuncture and Moxibustion, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.

Objective: To observe the effect of moxibustion at myofascial trigger points on microglia activation and the expression of brain-derived neurotrophic factor (BDNF) in the spinal cord of rats with myofascial pain syndrome (MPS), so as to explore the central mechanism of the analgesic effect of moxibustion.

Methods: Twenty-four male SD rats were randomly divi-ded into control, model and moxibustion groups (=8 in each group). The MPS model was established by strinking on fascia musculares and eccentric exercise. Read More

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September 2021

[Spinal cord Toll like receptor 4 and its co-stimulatory molecule heat shock protein 90 may parti-cipate in electroacupuncture analgesia in rats with chronic neuropathic pain].

Zhen Ci Yan Jiu 2021 Sep;46(9):735-41

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700.

Objective: To observe the effect of electroacupuncture (EA) on the expression of Toll like receptor 4(TLR4)and heat shock protein 90(HSP90) in the spinal cord of rats with chronic constriction injury (CCI) of sciatic nerve, so as to explore the mechanism of spinal cord TLR4 and HSP90 in alleviating chronic neuropathic pain by EA.

Methods: Male Wistar rats were randomized into control, model, EA, HSP90 inhibitor (inhibitor) and EA+ inhibitor groups (=10 in each group). The neuropathic pain model was established by ligature of the right sciatic nerve to induce CCI. Read More

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September 2021

[Effect of electroacupuncture on urodynamics of neurogenic bladder and PACAP/cAMP/PKA signaling pathway in detrusor tissue of rats after suprasacral spinal cord injury].

Zhen Ci Yan Jiu 2021 Sep;46(9):728-34

College of Acupuncture and Massage, Hunan University of Chinese Medicine, Changsha 410208, China.

Objective: To observe the effect of electroacupuncture (EA) on urodynamics of neurogenic bladder and pituitary adenylate cyclase activating peptide(PACAP)/cyclic adenosine monophosphate (cAMP)/protein kinase A(PKA) signaling pathway in detrusor tissue of rats after suprasacral spinal cord injury (SCI), so as to explore its possible mechanism in improving detrusor hyperreflexia bladder function after shock stage of suprasacral SCI.

Methods: Female SD rats were randomly divided into control, sham operation, model and EA groups, with 12 rats in each group. T10 spinal cord transection (SCT) was performed by surgery. Read More

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September 2021

Developmental programming and lineage branching of early human telencephalon.

EMBO J 2021 Sep 24:e107277. Epub 2021 Sep 24.

Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

The dorsal and ventral human telencephalons contain different neuronal subtypes, including glutamatergic, GABAergic, and cholinergic neurons, and how these neurons are generated during early development is not well understood. Using scRNA-seq and stringent validations, we reveal here a developmental roadmap for human telencephalic neurons. Both dorsal and ventral telencephalic radial glial cells (RGs) differentiate into neurons via dividing intermediate progenitor cells (IPCs_div) and early postmitotic neuroblasts (eNBs). Read More

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September 2021

Structure and conceptualization of acceptance: A split-sample exploratory and confirmatory Factor analysis approach to Investigate the multidimensionality of acceptance of spinal cord injury.

J Rehabil Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Psychology, University of Southern Denmar, Odense, Denmark. E-mail:

Objective: To determine the multidimensionality of acceptance of spinal cord injury (SCI).

Participants: Adults with SCI who were admitted to an SCI centre between 1991 and 2020.

Methods: All eligible participants (n=686) were invited to complete a survey via REDCap. Read More

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September 2021

An instrument for assessing quality of life in persons with neurogenic lower urinary tract dysfunction: validation of the German short-form Qualiveen questionnaire.

Spinal Cord 2021 Sep 23. Epub 2021 Sep 23.

Neuro-Urology, Swiss Paraplegic Centre, Nottwil, Switzerland.

Study Design: Prospective validation study.

Objectives: To validate and evaluate the measurement properties of the German Qualiveen short-form (SF) questionnaire in individuals with chronic neurogenic lower urinary tract dysfunction (NLUTD) resulting from spinal cord injury (SCI).

Setting: Tertiary neuro-urologic referral center in Switzerland. Read More

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September 2021

Resilience and mental health in individuals with spinal cord injury during the COVID-19 pandemic.

Spinal Cord 2021 Sep 23. Epub 2021 Sep 23.

Department of Rehabilitation Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.

Study Design: Cross-sectional, observational study.

Objectives: To understand how resilience, access to personal care attendants (PCAs) and medical supplies, and concerns about medical rationing, finances, and social isolation are related to overall and mental health in individuals with spinal cord injury (SCI) in the context of the COVID-19 pandemic.

Setting: Community dwelling adults (N = 187) with SCI. Read More

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September 2021

Lower Limb Revascularisation for Paraplegic Patients.

Eur J Vasc Endovasc Surg 2021 Sep 20. Epub 2021 Sep 20.

Department of Vascular Surgery, Ambroise Paré University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Boulogne-Billancourt, France; Faculté de Médecine Paris-Ile de France-Ouest, UFR des sciences de la santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Montigny-le-Bretonneux, France.

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September 2021

Thermo-sensitive electroactive hydrogel combined with electrical stimulation for repair of spinal cord injury.

J Nanobiotechnology 2021 Sep 23;19(1):286. Epub 2021 Sep 23.

Department of Spine Surgery, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130021, People's Republic of China.

The strategy of using a combination of scaffold-based physical and biochemical cues to repair spinal cord injury (SCI) has shown promising results. However, integrating conductivity and neurotrophins into a scaffold that recreates the electrophysiologic and nutritional microenvironment of the spinal cord (SC) remains challenging. In this study we investigated the therapeutic potential of a soft thermo-sensitive polymer electroactive hydrogel (TPEH) loaded with nerve growth factor (NGF) combined with functional electrical stimulation (ES) for the treatment of SCI. Read More

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September 2021

Case report of restless anal syndrome as restless legs syndrome variant after COVID-19.

BMC Infect Dis 2021 Sep 23;21(1):993. Epub 2021 Sep 23.

Tokyo Medical University Hospital, Tokyo, Japan.

Background: Coronavirus disease 2019 (COVID-19) has a broad spectrum from respiratory and nasopharyngeal symptoms, cerebrovascular diseases, impaired consciousness, and skeletal muscle injury. Emerging evidence has indicated the neural spread of this novel coronavirus. Restless legs syndrome (RLS) is a common neurological, sensorimotor disorder, but highly under diagnosis disorder. Read More

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September 2021

Geniposide exerts protective effects on spinal cord injury in rats by inhibiting the IKKs/NF-κB signaling pathway.

Int Immunopharmacol 2021 Sep 20;100:108158. Epub 2021 Sep 20.

Department of Medicine, Quzhou College of Technology, Quzhou, 324000, Zhejiang, China.

Background: Spinal cord injury (SCI) is a traumatic condition of the central nervous system , which can cause nerve injury and affect nerve regeneration, thus leading to severe dysfunction of motor and sensory pathways, and unfortunately these effects are irreversible. Inflammatory response constitutes one of the important mechanisms of spinal cord secondary injury. Geniposide (Gen) is reported to possess anti-inflammation and neuronal repair capacities. Read More

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September 2021

Effect of combination therapy with neural stem cell transplantation and teramethylpyrazine in rats following acute spinal cord injury.

Neuroreport 2021 Sep 21. Epub 2021 Sep 21.

Department of Orthopaedics, The General Hospital of Northern Theater Command, Shenyang The Second Clinical College of Graduate School, Dalian Medical University, Dalian, Liaoning, China.

Objectives: This study was to explore the effects of teramethylpyrazine (TMP) administered in conjunction with neural stem cell transplantation on motor function, pathological lesions and the Janus kinase (JAK)2/signal transducer and activator of transcription 3 signal transduction pathway in rats following acute spinal cord injury (SCI).

Methods: Female Sprague-Dawley rats were randomly divided into sham, model, neural stem cells (NSCs) and NSCs+TMP groups. Motor function was evaluated using the Basso, Beattie, Bresnahan scale. Read More

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September 2021

Regenerative potential of Stem cell-derived extracellular vesicles in spinal cord injury (SCI).

Curr Stem Cell Res Ther 2021 Sep 23. Epub 2021 Sep 23.

Centre for Stem Cell Research, a unit of inStem Bengaluru, CMC Rehab Campus Bagayam, Christian Medical College Vellore, Tamil Nadu 632002, India.

Spinal cord injury is a devastating condition that is critically challenging and progressive, needing immediate medical attention due to its complex pathophysiology and affecting the social status and economic burden. Stem cell therapy has been the emerging therapeutic trend to treat various diseases for decades. Mesenchymal stem cells pose more advantages over other stem cells in immune-modulation, immune evasiveness, self-renewal, multipotency, etc. Read More

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September 2021

Transcranial Direct Current Stimulation for the Management of Neuropathic Pain: A Narrative Review.

Pain Physician 2021 Sep;24(6):E771-E781

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Korea.

Background: Neuropathic pain (NP) is common and often resistant to conventional analgesics. Among different types of noninvasive brain stimulation techniques, transcranial direct current stimulation (tDCS) has been widely used to mitigate pain in patients with NP.

Objective: The aim of this study was to review the effects of tDCS on the management of various types of NP. Read More

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September 2021