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Remodeling of extracellular matrix in the urinary bladder of paraplegic rats results in increased compliance and delayed fiber recruitment 16 weeks after spinal cord injury.

Acta Biomater 2022 Jan 12. Epub 2022 Jan 12.

Michigan State University, Department of Mechanical Engineering, 428 S. Shaw Lane, Rm 2555, East Lansing, MI 48824. Electronic address:

The ability of the urinary bladder to maintain low intravesical pressures while storing urine is key in ensuring proper organ function and highlights the key role that tissue mechanics plays in the lower urinary tract. Loss of supraspinal neuronal connections to the bladder after spinal cord injury can lead to remodeling of the structure of the bladder wall, which may alter its mechanical characteristics. In this study, we investigate if the morphology and mechanical properties of the bladder extracellular matrix are altered in rats 16 weeks after spinal cord injury as compared to animals who underwent sham surgery. Read More

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January 2022

Megakaryocyte-stromal cell interactions: effect on megakaryocyte proliferation, proplatelet production, and survival.

Exp Hematol 2022 Jan 12. Epub 2022 Jan 12.

Institute of Medical Research A Lanari, University of Buenos Aires, Buenos Aires, Argentina; Department of Experimental Hematology, Institute of Medical Research (IDIM), National Scientific and Technical Research Council (CONICET), University of Buenos Aires, Buenos Aires, Argentina. Electronic address:

Bone marrow stromal cells provide a proper environment for the development of hematologic lineages. The incorporation of different stromal cells to in vitro culture systems would be an attractive model to study megakaryopoiesis and thrombopoiesis. Our objective was to evaluate the participation of different types of stromal cells on in vitro megakaryopoiesis, thrombopoiesis and megakaryocyte (MK) survival. Read More

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January 2022

Kearns-Sayre syndrome: expanding spectrum of a "novel" mitochondrial leukomyeloencephalopathy.

Neurol Sci 2022 Jan 14. Epub 2022 Jan 14.

Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Kearns-Sayre syndrome (KSS) is a rare mitochondrial disease associated to a widespread cerebral leukodystrophy. MRI shows a typical centripetal pattern where U-fibers are mainly affected with a relative spare of periventricular white matter. Recently, different patterns of spinal cord involvement have been described in KSS. Read More

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January 2022

The biology of ependymomas and emerging novel therapies.

Nat Rev Cancer 2022 Jan 14. Epub 2022 Jan 14.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Ependymomas are rare central nervous system tumours that can arise in the brain's supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey published the first comprehensive study of ependymomas. Since then, and especially over the past 10 years, our understanding of ependymomas has grown exponentially. Read More

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January 2022

Cervical myelopathy in a patient with Klippel-Feil syndrome treated with a patient-specific custom cervical spine locking plate.

Spinal Cord Ser Cases 2022 Jan 14;8(1). Epub 2022 Jan 14.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.

Introduction: Klippel-Feil Syndrome is the congenital fusion of at least two cervical vertebrae. Often asymptomatic, though in rare cases it may lead to severe cervical spine deformity and neurologic injury.

Case Presentation: We report a case of a 48-year-old woman with a history of Klippel-Feil Syndrome and congenital scoliosis who developed progressive cervical myelopathy. Read More

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January 2022

The role of Even-skipped in Drosophila larval somatosensory circuit assembly.

eNeuro 2022 Jan 10. Epub 2022 Jan 10.

Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago IL, 60637

Proper somatosensory circuit assembly is critical for processing somatosensory stimuli and for responding accordingly. In comparison to other sensory circuits (e.g. Read More

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January 2022

Adherence to long-term medical follow-up: a qualitative, experience-focused study of people with spinal cord injury.

Ann Phys Rehabil Med 2022 Jan 12:101629. Epub 2022 Jan 12.

Neurological PMR department, University Hospital, 85, rue Saint-Jacques, 44093, Nantes cedex, France; National Institute for Health and Medical research (INSERM), 101, rue de Tolbiac, 75654, cedex 13, France.

Background: Scientific evidence indicates the presence of secondary conditions (such as pressure ulcers) after spinal cord injury (SCI). Treatment methods focusing on the management of paraplegia and tetraplegia include systematic preventive follow-up. These advances have significantly improved the functional and vital prognosis of people with SCI, but some people may not have access to these specialized organizations or may not adhere closely to this medicalized vision. Read More

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January 2022

KEPI Plays a Negative Role in the Repression that Accompanies Translational Inhibition Guided by the uORF Element of Human chop Transcript during Stress Response.

Gene 2022 Jan 11:146160. Epub 2022 Jan 11.

Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan; Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan; Department of Life Science, Fu-Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Translation of the downstream coding sequence of some mRNAs may be repressed by the upstream open reading frame (uORF) at their 5'-end. The mechanism underlying this uORF-mediated translational inhibition (uORF-MTI) is not fully understood in vivo. Recently, it was found that zebrafish Endouc or its human orthologue ENDOU (Endouc/ENDOU) plays a positive role in repressing the uORF-MTI of human chop (uORF-MTI) during stress by blocking its activity However, the repression of uORF-MTI assisted by an as-yet unidentified negative effector remains to be elucidated. Read More

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January 2022

Neurotrophin-3 and neurotrophin-4: The unsung heroes that lies behind the meninges.

Neuropeptides 2022 Jan 7;92:102226. Epub 2022 Jan 7.

Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia. Electronic address:

Neurotrophin is a growth factor that regulates the development and repair of the nervous system. From all factors, two pioneer groups, the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), have been widely explored for their role in disease pathogenesis and potential use as therapeutic agents. Nonetheless, neurotrophin-3 (NT3) and neurotrophin-4 (NT4) also have promising potential, albeit less popular than their counterparts. Read More

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January 2022

Isolation of Transcriptomic-Quality Total RNA from Mouse Spinal Cords.

Curr Protoc 2022 Jan;2(1):e338

Department of Comparative Biomedical Sciences, Mississippi State University, Mississippi State, Mississippi.

Assessing cells, proteins, and total RNA in the spinal cord is vital for advancing our understanding of neuroinflammation and neurodegenerative diseases. For instance, immune cells infiltrate the spinal cord in the experimental autoimmune encephalomyelitis (EAE) model, commonly used to study multiple sclerosis. Thus, it is valuable to assess total RNA to determine the neuronal and inflammatory profiles in the spinal cord. Read More

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January 2022

Prognostic Factors Independently Associated With Improved Progression-Free Survival After Surgical Resection in Patients With Spinal Cord Astrocytomas: An Institutional Case Series.

Oper Neurosurg (Hagerstown) 2022 Jan 14. Epub 2022 Jan 14.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Spinal astrocytomas are rare tumors in which the extent of resection and adjuvant therapy remain controversial. A number of new molecular markers are used, but their utility in spinal cord tumors remains unclear.

Objective: To determine prognostic indicators of progression-free survival (PFS) in patients with spinal astrocytomas. Read More

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January 2022

Medical Device-Related Pressure Injury in an Intensive Care Unit: A Cross-Sectional Study.

Wound Manag Prev 2021 Nov;67(11):26-32

Federal University of São João del Rei, Campus Centro Oeste, Divinópolis, Minas Gerais State, Brazil.

Background: Medical devices can cause pressure injuries.

Purpose: This study was conducted to determine the prevalence of and factors associated with medical device-related pressure injury (MDRPI) in an intensive care unit (ICU).

Methods: A cross-sectional study was performed among adult patients (at least 18 years of age) admitted to an ICU in a referral hospital in Brazil between December 2019 and February 2020. Read More

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November 2021

Late-infantile GM1 gangliosidosis: A case report.

Medicine (Baltimore) 2022 Jan;101(1):e28435

Departments of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Rationale: Monosialotetrahexosylganglioside (GM1) gangliosidosis is a rare lysosomal storage disorder caused by the deficiency of ß-galactosidase. Because clinical symptoms of GM1 gangliosidosis overlap with other neurodevelopmental disorders, the diagnosis of this disease is not easy, specifically in late infantile GM1 gangliosidosis. This report described a case of late-infantile GM1 gangliosidosis mistaken for juvenile idiopathic arthritis. Read More

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January 2022

Monitoring Spinal Cord Tissue Oxygen in Patients With Acute, Severe Traumatic Spinal Cord Injuries.

Crit Care Med 2022 Jan 6. Epub 2022 Jan 6.

Academic Neurosurgery Unit, St. George's, University of London, London, United Kingdom.

Objectives: To determine the feasibility of monitoring tissue oxygen tension from the injury site (psctO2) in patients with acute, severe traumatic spinal cord injuries.

Design: We inserted at the injury site a pressure probe, a microdialysis catheter, and an oxygen electrode to monitor for up to a week intraspinal pressure (ISP), spinal cord perfusion pressure (SCPP), tissue glucose, lactate/pyruvate ratio (LPR), and psctO2. We analyzed 2,213 hours of such data. Read More

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January 2022

ThoraxNet: a 3D U-Net based two-stage framework for OAR segmentation on thoracic CT images.

Phys Eng Sci Med 2022 Jan 14. Epub 2022 Jan 14.

MVR Cancer Centre & Research Institute, Calicut, India.

An important phase of radiation treatment planning is the accurate contouring of the organs at risk (OAR), which is necessary for the dose distribution calculation. The manual contouring approach currently used in clinical practice is tedious, time-consuming, and prone to inter and intra-observer variation. Therefore, a deep learning-based auto contouring tool can solve these issues by accurately delineating OARs on the computed tomography (CT) images. Read More

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January 2022

Functional MRI evidence for primary motor cortex plasticity contributes to the disease's severity and prognosis of cervical spondylotic myelopathy patients.

Eur Radiol 2022 Jan 14. Epub 2022 Jan 14.

Department of Orthopedics Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.

Objective: To investigate the brain mechanism of non-correspondence between diseases severity and compression degree of the spinal cord in cervical spondylotic myelopathy (CSM) patients and to test the utility of brain imaging biomarkers for predicting prognosis of CSM.

Methods: We calculated voxel-wise zALFF from 54 CSM patients and 50 healthy controls using resting-state fMRI data. In analysis 1, we identified the brain regions exhibited significant differences of zALFF between CSM patients and healthy controls. Read More

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January 2022

Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain.

Pain 2022 Feb;163(2):e368-e381

Department of Pharmacology, College of Medicine, the University of Arizona, Tucson, AZ, United States. Dr. Yu is now with the Institute of Chinese Medicine Clinical Basics, Institute of Chinese Medicine on Rheumatology, College of Basic Medical Science, Zhejiang Chinese Medical University, Binjiang District, Hangzhou, Peoples Republic of China.

Abstract: Mechanistic studies principally focusing on primary afferent nociceptive neurons uncovered the upregulation of collapsin response mediator protein 2 (CRMP2)-a dual trafficking regulator of N-type voltage-gated calcium (Cav2.2) as well as Nav1.7 voltage-gated sodium channels-as a potential determinant of neuropathic pain. Read More

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February 2022

Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function.

FEBS J 2022 Jan 13. Epub 2022 Jan 13.

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.

Mesenchyme homeobox protein 2 (MEOX2) is a transcription factor involved in mesoderm differentiation, including development of bones, muscles, vasculature and dermatomes. We have previously identified dysregulation of MEOX2 in fibroblasts from Congenital Insensitivity to Pain (CIP) patients, and confirmed that btn, the Drosophila homologue of MEOX2, plays a role in nocifensive responses to noxious heat stimuli. To determine the importance of MEOX2 in the mammalian peripheral nervous system, we used a Meox2 heterozygous (Meox2 ) mouse model to characterize its function in the sensory nervous system, and more specifically, in nociception. Read More

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January 2022

Biliary atresia combined Wilson disease identified by whole exome sequencing in Vietnamese patient with severe liver failure.

Medicine (Baltimore) 2022 Jan;101(2):e28547

Institute of Genome Research, Vietnam Academy of Science and Technology, 18 - Hoang Quoc Viet Str., Caugiay, Hanoi, Vietnam.

Rationale: Hepatobiliary diseases such as biliary atresia (BA), Wilson disease, and progressive familial intrahepatic cholestasis are common causes of morbidity and mortality in young children. Affected patients progress rapidly to end-stage cirrhosis and require liver transplantation or die. Mutations in many genes have been identified to play an important role in the pathogenesis of hepatobiliary diseases. Read More

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January 2022

Restoring hand functions in people with tetraplegia through multi-contact, fascicular and auto-pilot stimulation: a proof-of-concept demonstration.

J Neurotrauma 2022 Jan 14. Epub 2022 Jan 14.

INRIA, University of Montpellier, Montpellier, France;

Two multi-contact epineural electrodes were placed around radial and median nerves of 2 subjects with high tetraplegia C4, AIS A, group 0 of the International Classification for Surgery of the Hand in Tetraplegia. The purpose was to study the safety and capability of these electrodes to generate synergistic motor activation and functional movements and to test control interfaces that allow subjects to trigger pre-programmed stimulation sequences. The device consists of a pair of neural cuff electrodes and percutaneous cables with two extracorporeal connection cables inserted during a surgical procedure and maintained for 28 days. Read More

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January 2022

Relationship between donor-specific HPA-15 antibodies and poor graft function in HPA-15 mismatched cord blood transplantation.

Int J Hematol 2022 Jan 13. Epub 2022 Jan 13.

Department of Hematology, Rinku General Medical Center, 2-3 Ourai-Kita, Rinku, Izumisano, Osaka, 598-8577, Japan.

Poor graft function (PGF) is a fatal complication following hematopoietic stem cell transplantation and is influenced by multiple factors, such as donor-specific anti-HLA antibodies, a poor infused CD34 cell count, and the donor source. Alloantibodies against human platelet antigen 15 (HPA-15) recognize platelet membrane glycoprotein CD109, which is expressed not only on platelets, but also on megakaryocytes and specific hematopoietic stem cells. HPA-15 antibodies are known to induce platelet transfusion refractoriness and neonatal alloimmune thrombocytopenia, but their effects on graft function following hematopoietic stem cell transplantation remain unknown. Read More

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January 2022

Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression.

Cell Biol Toxicol 2022 Jan 14. Epub 2022 Jan 14.

Spine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai, 200032, China.

Cervical spondylotic myelopathy (CSM) is a clinically symptomatic entity arising from the spinal cord compression by degenerative diseases. Although endoplasmic reticulum (ER) stress has been commonly observed in several neurodegenerative diseases, the relationship between ER stress and CSM remains unknown. Shikonin is known to protect PC12 by inhibiting apoptosis in vitro. Read More

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January 2022

Low donor chimerism may be sufficient to prevent demyelination in adrenoleukodystrophy.

JIMD Rep 2022 Jan 17;63(1):19-24. Epub 2021 Nov 17.

Department of Pediatrics Jichi Medical University Tochigi Japan.

Adrenoleukodystrophy (ALD) is a peroxisomal disorder characterized by white matter degeneration caused by adenosine triphosphate-binding cassette subfamily D member 1 () gene mutations, which lead to an accumulation of very-long-chain fatty acids (VLCFA). Hematopoietic stem cell transplantation (HSCT) is the most effective treatment; however, the ratio of donor-to-recipient cells required to prevent the progression of demyelination is unclear. The proband was diagnosed with the childhood cerebral form of ALD at 5 years of age based on the clinical phenotype, elevated plasma VLCFA levels, and pathogenic mutation c. Read More

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January 2022

Rosiglitazone Ameliorates Spinal Cord Injury Inhibiting Mitophagy and Inflammation of Neural Stem Cells.

Oxid Med Cell Longev 2022 4;2022:5583512. Epub 2022 Jan 4.

Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

Background: Neurodegenerative diseases, such as Alzheimer's disease, and traumatic brain and spinal cord injury (SCI) are prevalent in clinical practice. Inhibition of hyperactive inflammation and proliferation of endogenous neural stem cells (NSCs) is a promising treatment strategy for SCI. Our previous studies demonstrated the beneficial effects of rosiglitazone (Rosi) on SCI, but its roles in inflammation inhibition and proliferation of NSCs are unknown. Read More

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January 2022

Role of NETosis in Central Nervous System Injury.

Oxid Med Cell Longev 2022 4;2022:3235524. Epub 2022 Jan 4.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Central nervous system (CNS) injury is divided into brain injury and spinal cord injury and remains the most common cause of morbidity and mortality worldwide. Previous reviews have defined numerous inflammatory cells involved in this process. In the human body, neutrophils comprise the largest numbers of myeloid leukocytes. Read More

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January 2022

Chiari type III malformation: Case report and review of literature.

Radiol Case Rep 2022 Mar 22;17(3):628-630. Epub 2021 Dec 22.

Department of Pediatric Radiology, Abderrahim Harouchi Children's Hospital, CHU Ibn Rochd, Casablanca, Morocco.

Chiari III (CM III) is the rarest of the Chiari malformations, characterized by high cervical or occipital encephalocele and osseous defects, associated with herniation of the posterior cerebral fossa contents through the foramen magnum. We report the case of a female newborn, with a cervico-occipital mass, hypotonia and sharp osteotendinous reflexes in the lower limbs. An MRI was performed showing a low occipital encephalocele with caudal displacement of cerebellar tonsils. Read More

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Ductus venosus reversed flow in omphalocele: Could it be a prognostic factor for long-term neurological impairment?

J Med Life 2021 Sep-Oct;14(5):726-730

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Omphalocele (exomphalos) represents one of the most frequent congenital abdominal wall defects. It presents as a defect of inconstant size and is located on the midline, at the base of the umbilical cord, the skin, fascia, and abdominal muscles being absent at this level. Omphaloceles are classified as liver-containing or non-liver-containing, the latter containing primarily bowel loops. Read More

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Early prenatal diagnosis of an atypical phenotype of sacral spina bifida.

J Med Life 2021 Sep-Oct;14(5):716-721

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Neural tube defects (NTDs) occur during embryogenesis, specifically during the fifth or sixth week of gestation, and are described as aberrant neural tube closing. The defect may alter the normal development of the vertebrae, spinal cord, cranium, or brain. The present study describes the case of a 41-year-old pregnant woman with fetal sacral meningocele, no associated pathologies, no family history of neural tube defects, a pregnancy under folate supplementation with the aim of highlighting the importance of ultrasound in diagnosing neural tube defects. Read More

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Rapid and effective treatment of traumatic spinal cord injury using stem cell derived exosomes.

Asian J Pharm Sci 2021 Nov 29;16(6):806-815. Epub 2021 Oct 29.

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Traumatic spinal cord injury is a fatal acute event without effective clinical therapies. Following the trauma, immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair, where stem cell-based therapies could be eclipsed by the deficiency of cells due to the hostile microenvironment as well as the transport and preservation processes. Effective emergency strategies are required to be convenient, biocompatible, and stable. Read More

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November 2021

Modulation of Ryanodine Receptors Activity Alters the Course of Experimental Autoimmune Encephalomyelitis in Mice.

Front Physiol 2021 17;12:770820. Epub 2021 Dec 17.

Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, United States.

Ryanodine receptors (RyRs), the intracellular Ca release channels, are expressed in T lymphocytes and other types of immune cells. Modulation of RyRs has been shown to affect T cell functions and immune responses . The effects of modulation of RyRs on the development of autoimmune diseases have not been investigated. Read More

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December 2021