J Chromatogr A 2021 Feb 8;1638:461892. Epub 2021 Jan 8.
Department of Chemistry, The University of Kansas, Lawrence, KS 66045; Center of Biomodular Multiscale Systems for Precision Medicine; Sunflower Genomics, Inc. Lawrence, KS 66047; Department of Mechanical Engineering, The University of Kansas, Lawrence, KS 66045; Bioengineering Program, The University of Kansas, Lawrence, KS 66045; KU Cancer Center, University of Kansas Medical Center, Kansas City, KS 66160. Electronic address:
With advances in the design and fabrication of nanofluidic devices during the last decade, there have been a few reports on nucleic acid analysis using nanoscale electrophoresis. The attractive nature of nanofluidics is the unique phenomena associated with this length scale that are not observed using microchip electrophoresis. Many of these effects are surface-related and include electrostatics, surface roughness, van der Waals interactions, hydrogen bonding, and the electric double layer. Read More