5,992 results match your criteria copd china


Genetic evidence for the causal association between programmed death-ligand 1 and lung cancer.

J Cancer Res Clin Oncol 2021 Jul 29. Epub 2021 Jul 29.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, People's Republic of China.

PD-1/PD-L1 might have a causal role in operating lung cancer risk. However, such an association has not been investigated in the general population. We assessed whether PD-L1 has an independent effect on lung cancer risk using two-sample Mendelian randomization (MR) based on a proteomic genome-wide association study (3301 health participants) of European ancestry and the International Lung cancer Consortium (11,348 cases and 15,861 controls). Read More

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Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1.

Clin Transl Med 2021 Jul;11(7):e479

National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Xi Road, Guangzhou, Guangdong, 510000, China.

Chronic obstructive pulmonary disease is a complex condition with multiple etiologies, including inflammation. We identified a novel long noncoding RNA (lncRNA), interleukin 6 antisense RNA 1 (IL6-AS1), which is upregulated in this disease and is associated with airway inflammation. We found that IL6-AS1 promotes the expression of inflammatory factors, especially interleukin (IL) 6. Read More

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Rationale and design of REGULATE: an observational study protocol for relationship between plasma metabolome and the efficacy of systemic glucocorticoid in acute exacerbation of chronic obstructive pulmonary disease.

BMC Pulm Med 2021 Jul 28;21(1):250. Epub 2021 Jul 28.

Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly increases the mortality of patients with COPD. Guidelines have recommended systemic glucocorticoid as a regular treatment. Recently, evidence has shown that systemic glucocorticoid cannot be a benefit to all of the patients with AECOPD. Read More

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Baicalin ameliorates cigarette smoke-induced airway inflammation in rats by modulating HDAC2/NF-κB/PAI-1 signalling.

Pulm Pharmacol Ther 2021 Jul 24:102061. Epub 2021 Jul 24.

Huashan Hospital, Fudan University, Shanghai, China; Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China. Electronic address:

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease distinguished by airway remodelling and progressive inflammation. PAI-1 is an important regulator of fibrosis. Recent studies have shown that PAI-1 seems to be involved in COPD progression. Read More

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Effect of Community-Acquired Pneumonia on Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

COPD 2021 Jul 26:1-8. Epub 2021 Jul 26.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.

Community-acquired pneumonia (CAP) is a major contributor to hospitalization for acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The clinical manifestations of AECOPD with and without CAP are confusing. The difference in the survival or readmission rate of AECOPD with or without CAP remains controversial. Read More

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[Comparison of different evaluation systems for assessing disease severity and treatment efficacy in patients with chronic obstructive pulmonary disease].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1119-1124

Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.

Objective: To compare the practicability and clinical value of different evaluation systems for assessing disease severity and treatment efficacy in patients with chronic obstructive pulmonary disease (COPD).

Methods: We retrospectively analyzed the clinical data of 28 patients with acute exacerbation of COPD admitted to our hospital between November, 2020 and January, 2021. All the patients were assessed with percentage of predicted forced expiratory volume in 1 second (FEV1% pred), COPD assessment test (CAT), modified British Medical Research Council (mMRC), baseline dyspnea index (BDI), clinical COPD questionnaire (CCQ), St. Read More

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White Blood Cell Counts to High-Density Lipoprotein Cholesterol Ratio, as a Novel Predictor of Long-Term Adverse Outcomes in Patients After Percutaneous Coronary Intervention: A Retrospective Cohort Study.

Front Cardiovasc Med 2021 8;8:616896. Epub 2021 Jul 8.

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

White blood cell (WBC) counts and high-density lipoprotein cholesterol (HDL-C) are widely available in clinical practice. However, the predictive value for cardiovascular disease (CVD) is uncertain. In the present study, we firstly assessed the prognostic value of WBC to HDL-C ratio (WHR) in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI). Read More

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Effects of azithromycin on treating chronic obstructive pulmonary disease with acute exacerbation of chronic bronchitis in the stable phase.

Am J Transl Res 2021 15;13(6):7370-7375. Epub 2021 Jun 15.

Department of Respiratory Medicine, The First People's Hospital of Fuyang Hangzhou Hangzhou 311400, Zhejiang 311400, China.

Objective: To explore the effects of azithromycinon in treatment of chronic obstructive pulmonary disease (COPD) in patients with acute exacerbation (AE) of chronic bronchitis (CB) in the stable phase.

Methods: Totally, 60 COPD patients with AE of CB were divided into control group (CG, 30 cases) and experimental group (EG, 30 cases) using the random number residue method. The CG was administered 250 mg salmeterol-fluticasone powder inhalation twice a day combined with 18 µg tiotropium bromide inhalation once a day. Read More

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Effect of cardiopulmonary rehabilitation nursing on exercise endurance and quality of life of stable COPD patients.

Am J Transl Res 2021 15;13(6):7356-7362. Epub 2021 Jun 15.

Department II of Respiratory and Critical Care Medicine, Cangzhou Central Hospital Cangzhou, China.

Objective: To investigate the effect of cardiopulmonary rehabilitation nursing on exercise endurance and quality of life (QOL) of patients with stable chronic obstructive pulmonary disease (COPD).

Methods: This randomized trial was conducted on 84 subjects with stable COPD recruited in our hospital from March 2018 to December 2019 and they were divied into the observation group (n=42) and the control group (n=42) based on nursing methods. The control group adopted conventional nursing, and the observation group received cardiopulmonary rehabilitation nursing in addition to conventional method. Read More

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Risk factors for carbapenem-resistant infection and associated clinical outcomes.

Am J Transl Res 2021 15;13(6):7276-7281. Epub 2021 Jun 15.

Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu, China.

Objective: To evaluate the risk factors and clinical outcomes of carbapenem-resistant () (CRKP) infection.

Materials And Methods: A case-control study was performed from January 2017 to September 2017. The risk factors and clinical outcomes of CRKP cases (n = 91) were compared with those of the controls infected with carbapenem-susceptible (CSKP) (n = 91). Read More

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Efficacy and prognosis of continuous renal replacement therapy at different times in the treatment of patients with sepsis-induced acute kidney injury.

Am J Transl Res 2021 15;13(6):7124-7131. Epub 2021 Jun 15.

Blood Purification Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) Haikou, Hainan Province, China.

Objective: To investigate the efficacy and prognosis of CRRT at different times in the treatment of sepsis-induced acute kidney injury (SAKI).

Methods: A total of 156 patients with SAKI were grouped into two groups in accordance with a random number table, with 78 patients in each group. Patients in the observation group (OG) were treated with early CRRT, and in the control group (CG), patients were treated with delayed CRRT. Read More

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Clinical efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease.

Am J Transl Res 2021 15;13(6):7029-7034. Epub 2021 Jun 15.

Department of Respiratory and Critical Care Medicine, The 3rd Affiliated Hospital of Chengdu Medical College Chengdu 611700, Sichuang Province, China.

Background: To investigate the efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods: 248 patients with AECOPD were assigned into two groups, 124 patients in the control group were only given terbutaline treatment, while 124 patients in the experimental group were treated with glucocorticoid and terbutaline. The effect on lung function and blood gas indexes were compared between the two groups. Read More

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Effect of terbutaline plus doxofylline on chronic obstructive pulmonary disease.

Am J Transl Res 2021 15;13(6):6959-6965. Epub 2021 Jun 15.

Department of Geriatrics, Sichuan Provincial People's Hospital Chengdu, Sichuan Province, China.

Objectives: This study focused on patients with chronic obstructive pulmonary disease (COPD) and aimed at investigating the effect of terbutaline plus doxofylline on their pulmonary function and quality of life.

Methods: Ninety COPD patients were divided by using a random number table into a control group (administration of doxofylline) and experimental group (administration of terbutaline combined with doxofylline), with 45 patients in each group. The therapeutic efficacy, pre- and post-treatment pulmonary function and the quality of life were compared between the control and experimental groups. Read More

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Application of traditional Chinese and Western medicine combined with chronic disease management in pulmonary rehabilitation and evaluation of efficacy.

Am J Transl Res 2021 15;13(6):6372-6381. Epub 2021 Jun 15.

Department of Pain, Shanghai Quyang Hospital Hongkou, Shanghai 200092, China.

Objective: This study evaluated the efficacy of traditional Chinese and western medicine combined with chronic disease management on rehabilitation of chronic obstructive pulmonary disease (COPD) patients.

Methods: A total of 199 COPD patients in Shanghai Construction Group (SCG) Hospital were recruited as research objects. The control group (CG) consisted of 100 patients treated with conventional western chronic disease management, and the research group (RG) consisted of 99 patients treated with chronic disease management with combined traditional Chinese and western medicine. Read More

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Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease?

Front Pharmacol 2021 2;12:695957. Epub 2021 Jul 2.

The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital; State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that causes high rates of disability and mortality worldwide because of severe progressive and irreversible symptoms. During the period of COPD initiation and progression, the immune system triggers the activation of various immune cells, including Regulatory T cells (Tregs), dendritic cells (DCs) and Th17 cells, and also the release of many different cytokines and chemokines, such as IL-17A and TGF-β. In recent years, studies have focused on the role of IL-17A in chronic inflammation process, which was found to play a highly critical role in facilitating COPD. Read More

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Population-based retrospective cohort study on risk of age-related macular degeneration in people with chronic obstructive pulmonary disease.

Sci Rep 2021 Jul 23;11(1):15079. Epub 2021 Jul 23.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung, 404, Taiwan.

Chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD) are both common diseases of the elderly people. COPD induced systemic inflammation and hypoxia may have an impact on the development of AMD. This study investigated the possible association between COPD and subsequent risk of AMD. Read More

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Single-inhaler triple vs single-inhaler dual therapy in patients with chronic obstructive pulmonary disease: a meta-analysis of randomized control trials.

Respir Res 2021 Jul 23;22(1):209. Epub 2021 Jul 23.

Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Background: In some RCTs comparing triple therapy with dual therapy in COPD, there might be a bias resulting from the use of multiple inhaler devices. This meta-analysis included only RCTs that compared ICS/LABA/LAMA vs. LABA/LAMA or ICS/LABA using a single device. Read More

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[Effect of high-flow nasal cannula oxygen on patients with chronic obstructive pulmonary disease and mild hypercapnia: a retrospective cohort study based on the Medical Information Mart for Intensive Care-IV database].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):686-691

Department of Medical ICU, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China. Corresponding author: Du Bin, Email:

Objective: To observe the effect of high-flow nasal cannula oxygen therapy (HFNC) in patients with chronic obstructive pulmonary disease (COPD) and mild hypercapnia, and to evaluate the early predictive ability of physiological parameters in these patients.

Methods: A retrospective cohort study was conducted based on Medical Information Mart for Intensive Care-IV (MIMIC-IV) updated in September 2020 and the data of adult patients with COPD and mild hypercapnia [45 mmHg (1 mmHg = 0.133 kPa) < arterial partial pressure of carbon dioxide (PaCO) ≤ 60 mmHg] from 2008 to 2019 were collected. Read More

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Video-assisted thoracoscopic surgery for primary lung cancer resections in patients with moderate to severe chronic obstructive pulmonary diseases.

Transl Lung Cancer Res 2021 Jun;10(6):2603-2613

Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

Background: Lung cancer patients with chronic obstructive pulmonary disease (COPD) are considered a high-risk population to receive radical surgical treatment due to the high incidence of cardiopulmonary complications. The aim of this study was to evaluate the clinical factors associated with postoperative complications in primary lung cancer patients with moderate to extremely severe grades of COPD.

Methods: From December 2015 to June 2020, 138 patients with moderate to extremely severe COPD who underwent video-assisted thoracoscopic surgery (VATS) lung cancer resection (lobectomy or sublobar resection) were retrospectively reviewed. Read More

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Randomized phase III study comparing the first-line chemotherapy regimens in patients with driver mutation-negative advanced non-small cell lung cancer and poor performance status complicated with chronic obstructive pulmonary disease.

Transl Lung Cancer Res 2021 Jun;10(6):2573-2587

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Patients with non-small cell lung cancer (NSCLC) complicated with chronic obstructive pulmonary disease (COPD) with poor performance status (PS) are common in clinical practice with few related studies. Present studies have found that weekly low-dose docetaxel or gemcitabine combined with platinum is suitable for elderly or poor PS patients with advanced NSCLC.

Methods: Untreated advanced driver mutation-negative NSCLC patients with COPD and PS ≥2 were enrolled in this double-blind randomized trial. Read More

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Circ-RBMS1 Knockdown Alleviates CSE-Induced Apoptosis, Inflammation and Oxidative Stress via Up-Regulating FBXO11 Through miR-197-3p in 16HBE Cells.

Int J Chron Obstruct Pulmon Dis 2021 16;16:2105-2118. Epub 2021 Jul 16.

Department of Cardiovascular Medicine, Chinese People's Liberation Army Joint Service Support Unit 920 Hospital, Kunming City, Yunnan Province, People's Republic of China.

Background: Emerging evidence has reported that circular RNAs (circRNAs) are aberrantly expressed and act as significant regulators in pathological processes of chronic obstructive pulmonary disease (COPD). Here, the purpose of this article was to evaluate and clarify the biological functions and mechanism of circRNA single stranded interacting protein 1 (circ-RBMS1) in cigarette smoke (CS)-induced COPD.

Methods: Human bronchial epithelial cells 16HBE treated with or without cigarette smoke extract (CSE) were used in the experimental group in vitro. Read More

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Does Chronic Obstructive Pulmonary Disease Affect Workers' Health?

Authors:
Li-Peng Yao Ran Tao

Front Public Health 2021 5;9:711629. Epub 2021 Jul 5.

Qingdao Municipal Center for Disease Control and Preventation, Qingdao, China.

During recent decades, the elevation of workers' health has become the utmost point of concern since it is considered among the primary indicators of economies. The economies, especially the emerging ones, are primarily focusing on every indicator to uplift their businesses. Along with the other aspects, it is also required to assess the impact of Chronic Obstructive Pulmonary Disease (COPD) on workers' health conditions in small- and medium-scale enterprises (SMEs). Read More

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Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP.

J Inflamm Res 2021 15;14:3335-3348. Epub 2021 Jul 15.

Department of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, People's Republic of China.

Background: Chronic obstructive pulmonary disease (COPD) often coexists with multiple comorbidities which may have a significant impact on acute exacerbations of patients. At present, what kind of comorbidities affects acute exacerbations and how comorbidities lead to poor prognosis are still controversial. The purpose of our study is to determine the impact of comorbidities on COPD exacerbation and establish an acute exacerbation risk assessment system related to comorbidities. Read More

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The Reliability and Validity of the Brief ICF Core Set in Patients with Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2021 15;16:2077-2087. Epub 2021 Jul 15.

School of Nursing, Tianjin Medical University, Tianjin, People's Republic of China.

Purpose: To analyze the reliability and validity of the Brief international classification of functioning, disability and health (ICF) core set for chronic obstructive pulmonary disease (COPD).

Patients And Methods: A cross-sectional study was conducted in four tertiary hospitals in Tianjin, China. A total of 100 patients with COPD were selected to evaluate functioning and disability involving body functions, body structures, activities and participation as well as environmental factors of the Brief ICF core set for COPD. Read More

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Hyperpolarized Helium MRI Measured Apparent Diffusion Coefficient and its Correlations with Pulmonary Functions Tests in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis.

Clin Respir J 2021 Jul 19. Epub 2021 Jul 19.

Department of Stomatology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.

Background: This study evaluates role of hyperpolarized helium ( He) MRI measured apparent diffusion coefficient (ADC) in examining pulmonary function of chronic obstructive pulmonary disease (COPD) patients.

Methods: After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to estimate mean difference in ADC between COPD patients and healthy individuals, and to seek correlations between lung ADC and pulmonary function. Read More

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Reversal of emphysema by restoration of pulmonary endothelial cells.

J Exp Med 2021 Aug 21;218(8). Epub 2021 Jul 21.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY.

Chronic obstructive pulmonary disease (COPD) is marked by airway inflammation and airspace enlargement (emphysema) leading to airflow obstruction and eventual respiratory failure. Microvasculature dysfunction is associated with COPD/emphysema. However, it is not known if abnormal endothelium drives COPD/emphysema pathology and/or if correcting endothelial dysfunction has therapeutic potential. Read More

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Blood eosinophil count-guided corticosteroid therapy and as a prognostic biomarker of exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Ther Adv Chronic Dis 2021 7;12:20406223211028768. Epub 2021 Jul 7.

Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.

Background: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and dyspnea, as well as an increase in the number of leukocytes in the airways, lungs, and pulmonary vessels. A 'One size fits all' approach to COPD patients with different clinical features may be considered outdated. The following are the two major objectives of this meta-analysis: the first is to determine if blood eosinophil counts (BEC) can serve as a prognostic biomarker of COPD outcomes, and the second is to determine which level of BEC is effective for inhaled corticosteroid (ICS) treatment. Read More

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Effects of Atmospheric Fine Particulate Matter and Its Carrier Microbes on Pulmonary Microecology in Patients with COPD.

Int J Chron Obstruct Pulmon Dis 2021 12;16:2049-2063. Epub 2021 Jul 12.

State Key Laboratory of Respiratory Disease, National Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangdong Sheng, People's Republic of China.

Objective: The aim of this paper was to analyse the influence of atmospheric fine particulate matter (AFPM) and atmospheric microorganisms on the pulmonary microecology of chronic obstructive pulmonary disease (COPD) patients in northeast China.

Methods: Collected bronchoalveolar lavage fluid (BALF) of COPD patients in the high-risk period (group A) and low-risk period (group B) of AFPM inhalation and samples of AFPM in the same time range (group C) were collected. DNA sample sequencing, the bacterial abundance, and diversity bioinformatics of BALFs were performed by methods of Illumina MiSeq™ platform and Mothur and Uclust. Read More

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Performance of COPD population screener questionnaire in COPD screening: a validation study and meta-analysis.

Ann Med 2021 12;53(1):1198-1206

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.

This study aimed to validate the chronic obstructive pulmonary disease (COPD) Population Screener (COPD-PS) questionnaire as a screening tool in a cohort of Chinese subjects who underwent a health examination, and to summarise its overall performance through a meta-analysis. We enrolled 997 subjects aged ≥40 years who underwent a health examination, both lung function and COPD-PS data were collected. The screening performance of COPD-PS was evaluated with a receiver operating characteristic (ROC) curve analysis, using the area under the curve (AUC) to assess the screening accuracy. Read More

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December 2021

Hydrogen regulates the M1/M2 polarization of alveolar macrophages in a rat model of chronic obstructive pulmonary disease.

Exp Lung Res 2021 Jul 20:1-10. Epub 2021 Jul 20.

College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, China.

Objective: Chronic obstructive pulmonary disease (COPD) is a respiratory disease with high morbidity and mortality worldwide, so far there is no ideal treatment method. Previous studies have shown that hydrogen (H) is involved in the treatment of COPD as an antioxidant. In this study, the effect of H on M1/M2 polarization of alveolar macrophages in COPD rats was observed, and its anti-inflammatory mechanism was further elucidated. Read More

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