111 results match your criteria coordinates roc

Breaks in peristaltic integrity predict abnormal esophageal bolus clearance better than contraction vigor or residual pressure at the esophagogastric junction.

Neurogastroenterol Motil 2021 Mar 27:e14141. Epub 2021 Mar 27.

Division of Gastroenterology, Washington University School of Medicine, St Louis, MO, USA.

Background: High-resolution impedance manometry (HRIM) evaluates esophageal peristalsis and bolus transit. We used esophageal impedance integral (EII), the ratio between bolus presence before and after an expected peristaltic wave, to evaluate predictors of bolus transit.

Methods: From HRIM studies performed on 61 healthy volunteers (median age 27 years, 48%F), standard metrics were extracted from each of 10 supine water swallows: distal contractile integral (DCI, mmHg cm s), integrated relaxation pressure (IRP, mmHg), and breaks in peristaltic integrity (cm, using 20 mmHg isobaric contour). Read More

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Application of the electronic nose in predicting preeclampsia in high-risk pregnancies. Pilot study.

Arch Med Res 2021 Feb 14. Epub 2021 Feb 14.

Centro de Investigación Aplicada en Ambiente y Salud, CIACYT, Facultad de Medicina, Universidad Autónoma de San Luis Potosí. Avenida Sierra Leona No. 550, CP 78210, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, México; Labinnova Center of Investigation in Breath for early detection diseases, Guadalajara, Mexico. Electronic address:

Background: Preeclampsia is a syndrome that affects 2-8 % of pregnancies worldwide and is the leading cause of maternal death. Therefore, early detection is crucial to identify women who require clinical monitoring during pregnancy and to evaluate new preventive therapies before clinical symptoms occur.

Methods: The chemical fingerprints of the urine from three study groups pregnant with Preeclampsia, Healthy Pregnant (HP) and pregnant at High Risk of Preeclampsia (HRP) were evaluated using an electronic nose and the data obtained were subjected to principal component analysis (PCA), Canonical Analysis of Principal Coordinates (CAP), Partial Least Squares - Discriminant Analysis (PLS-DA) and ROC curves to determine the diagnostic power of the test. Read More

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February 2021

Infection biomarkers in assisting the judgement of blood stream infection and patient prognosis: a retrospective study incorporating principal components analysis.

Ann Transl Med 2020 Dec;8(23):1581

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: This study aimed to evaluate whether inexpensive and quickly available infection biomarkers including procalcitonin (PCT), C-reactive protein (CRP), white blood cell (WBC) count, and percentage of neutrophils (N%) are helpful in assisting the judgement of blood culture results and patient prognosis.

Methods: This retrospective study included patients who were admitted to the intensive care unit (ICU) of Changzheng Hospital from July 2015 to June 2017 and had at least one episode of blood culture with matched infection biomarkers (PCT, CRP, WBC, and N%). Primary infection biomarkers were transformed into newly derived components using the principal component analysis (PCA) method. Read More

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December 2020

Pediatric Acute Lymphoblastic Leukemia Patients Exhibit Distinctive Alterations in the Gut Microbiota.

Front Cell Infect Microbiol 2020 16;10:558799. Epub 2020 Oct 16.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Division of Pediatric Blood Diseases Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Previous studies have shown that gut microbiota can affect human immune system in many ways. Our aim was to investigate quantitative differences in fecal bacterial compositions of childhood acute lymphoblastic leukemia (ALL) patients compared to those of healthy children, so as to identify individual bacterial species that are related to the etiology of ALL. We recruited 81 subjects, including 58 patients with ALL and 23 healthy controls. Read More

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October 2020

A Novel Method for Quantifying Intestinal Inflammatory Burden in Inflammatory Bowel Disease Using Register Data.

Clin Epidemiol 2020 9;12:1059-1072. Epub 2020 Oct 9.

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Background: The Swedish Quality Register for Inflammatory Bowel Disease (SWIBREG) contains clinical data for the study of inflammatory bowel disease (IBD). The Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) cohort was recently established for the study of gastrointestinal histopathology. We aimed to develop and validate a histology score from ESPRESSO using clinical information from SWIBREG, and secondarily, to evaluate the association of the score on IBD-related hospitalization. Read More

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October 2020

Dynamic-shared Pharmacophore Approach as Tool to Design New Allosteric PRC2 Inhibitors, Targeting EED Binding Pocket.

Mol Inform 2021 02 16;40(2):e2000148. Epub 2020 Sep 16.

Fondazione Ri.MED, Via Bandiera 11, 90133, Palermo, Italy.

The Polycomb Repressive complex 2 (PRC2) maintains a repressive chromatin state and silences many genes, acting as methylase on histone tails. This enzyme was found overexpressed in many types of cancer. In this work, we have set up a Computer-Aided Drug Design approach based on the allosteric modulation of PRC2. Read More

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February 2021

Comparison of Geographic Information System and Subjective Assessments of Momentary Food Environments as Predictors of Food Intake: An Ecological Momentary Assessment Study.

JMIR Mhealth Uhealth 2020 07 22;8(7):e15948. Epub 2020 Jul 22.

College of Health and Medicine, University of Tasmania, Hobart, Australia.

Background: It has been observed that eating is influenced by the presence and availability of food. Being aware of the presence of food in the environment may enable mobile health (mHealth) apps to use geofencing techniques to determine the most appropriate time to proactively deliver interventions. To date, however, studies on eating typically rely on self-reports of environmental contexts, which may not be accurate or feasible for issuing mHealth interventions. Read More

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Combining multi-scale feature fusion with multi-attribute grading, a CNN model for benign and malignant classification of pulmonary nodules.

J Digit Imaging 2020 08;33(4):869-878

College of Information and Computer, Taiyuan University of Technology, Jinzhong, China.

Lung cancer has the highest mortality rate of all cancers, and early detection can improve survival rates. In the recent years, low-dose CT has been widely used to detect lung cancer. However, the diagnosis is limited by the subjective experience of doctors. Read More

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Correlation of cancer antigen 15-3 (CA15-3) serum level and bony metastases in breast cancer patients.

Med J Islam Repub Iran 2019 19;33:142. Epub 2019 Dec 19.

Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.

Cancer antigen 15-3 (CA15-3) is a common tumor marker and the serum level of this tumor marker is evaluated during the treatment period (periodically) in breast cancer patients. Assuming that the elevated serum levels of this tumor marker can be a potential risk, this study was conducted to determine the association between CA15-3 and bone metastasis and CA15-3 and metastasis spreading rate in breast cancer patients. In this study, 70 women with the mean of age 51. Read More

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December 2019

Improved multi-parametric prediction of tissue outcome in acute ischemic stroke patients using spatial features.

PLoS One 2020 24;15(1):e0228113. Epub 2020 Jan 24.

Department of Radiology and Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.

Introduction: In recent years, numerous methods have been proposed to predict tissue outcome in acute stroke patients using machine learning methods incorporating multiparametric imaging data. Most methods include diffusion and perfusion parameters as image-based parameters but do not include any spatial information although these parameters are spatially dependent, e.g. Read More

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Reflection on modern methods: Revisiting the area under the ROC Curve.

Int J Epidemiol 2020 08;49(4):1397-1403

Department of Clinical Genetics, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, The Netherlands.

The area under the receiver operating characteristic (ROC) curve (AUC) is commonly used for assessing the discriminative ability of prediction models even though the measure is criticized for being clinically irrelevant and lacking an intuitive interpretation. Every tutorial explains how the coordinates of the ROC curve are obtained from the risk distributions of diseased and non-diseased individuals, but it has not become common sense that therewith the ROC plot is just another way of presenting these risk distributions. We show how the ROC curve is an alternative way to present risk distributions of diseased and non-diseased individuals and how the shape of the ROC curve informs about the overlap of the risk distributions. Read More

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School bus accommodation-relaxing skiascopy.

Clin Ophthalmol 2019 8;13:1841-1851. Epub 2019 Oct 8.

Alaska Blind Child Discovery, Alaska Children's Eye & Strabismus, Anchorage, AK, USA.

Objective: Accurate estimation of hyperopia and astigmatism is challenging in delayed children. Conventional skiascopy holds rows of increasing power ± lenses vertically in front of one eye. The school bus accommodation-relaxing skiascopy (SBA-RS) design holds child-friendly, lenses +1 to +10D horizontally so that a higher power fogs the nontested eye-relaxing accommodation without cycloplegia. Read More

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October 2019

Utilization of the Caprini score in conjunction with thrombodynamic testing reduces the number of unpredicted postoperative venous thromboembolism events in patients with colorectal cancer.

J Vasc Surg Venous Lymphat Disord 2020 01 5;8(1):31-41. Epub 2019 Sep 5.

Department of General Surgery and Radiology, Pirogov Russian National Research Medical University, Moscow, Russian Federation.

Background: The thrombodynamic test (TD) is a novel global test of hemostasis that allows to study the spatial-temporal characteristics of a clot formation in real time under conditions close to natural ones and demonstrates high sensitivity to detect the state of hypercoagulation. The main paraments of the test are the velocity of clot growth, clot's size, and clot density. The objective of this study was to compare the classic Caprini 2005 score and its modified version in association with the results of TD. Read More

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January 2020

White-light emission of single carbon dots prepared by hydrothermal carbonization of poly(diallyldimethylammonium chloride): Applications to fabrication of white-light-emitting films.

J Colloid Interface Sci 2019 Nov 14;556:120-127. Epub 2019 Aug 14.

Department of Chemistry, National Sun Yat-sen University, No. 70, Lienhai Rd., Kaohsiung 80424, Taiwan, ROC; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100, Shiquan 1st Rd., Kaohsiung, 80708, Taiwan, ROC. Electronic address:

Different-sized carbon dots (CDs) with full-color emissions have immerse potentials as a novel class of light source in the field of light-emitting diodes (LED). However, few studies have been devoted to the development of the one-step process for preparing white-light-emitting CDs (WLECDs). Herein, we present a facile and one-pot synthesis of the WLECDs through microwave-assisted hydrothermal carbonization of poly(diallyldimethylammonium chloride) (PDDA). Read More

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November 2019

Ultrafast gas chromatography coupled to electronic nose to identify volatile biomarkers in exhaled breath from chronic obstructive pulmonary disease patients: A pilot study.

Biomed Chromatogr 2019 Dec 9;33(12):e4684. Epub 2019 Sep 9.

Centro de Investigación Aplicada en Ambiente y Salud, CIACYT, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., Mexico.

An analytical method to identify volatile organic compounds (VOCs) in the exhaled breath from patients with a diagnosis of chronic obstructive pulmonary disease (COPD) using a ultrafast gas chromatography system equipped with an electronic nose detector (FGC eNose) has been developed. A prospective study was performed in 23 COPD patients and 33 healthy volunteers; exhalation breathing tests were performed with Tedlar bags. Each sample was analyzed by FCG eNose and the identification of VOCs was based on the Kovats index. Read More

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December 2019

Measurement of Internal Jugular Vein and Common Carotid Artery Diameter Ratio by Ultrasound to Estimate Central Venous Pressure.

Cureus 2018 Mar 5;10(3):e2277. Epub 2018 Mar 5.

Department of Internal Medicine, Shifa International Hospital, Islamabad, PAK.

Objective The objective of this study is to find a correlation between internal jugular vein (IJV) and common carotid artery (CCA) diameter ratio and central venous pressure (CVP) measurement and find a cut-off value for the IJV/CCA ratio to predict low CVP i.e. < 10 cm H0, for estimating the volume status in critically ill patients. Read More

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Low Range of Shoulders Horizontal Abduction Predisposes for Shoulder Pain in Competitive Young Swimmers.

Front Psychol 2019 6;10:478. Epub 2019 Mar 6.

Department of Orthopaedic Surgery, Pediatrics, Obstetrics and Gynecology, Faculty of Medicine, Hospital Universitario Virgen de la Arrixaca, University of Murcia, Murcia, Spain.

The prevalence of shoulder pain (SP) among competitive swimmers is high, and may profoundly restrict their ability to compete. This prospective cohort study investigated the association between 3 blocks of performance factors (anthropometric characteristics, sport experience and training regimen) and the presence of SP. The aims of the present study were: (a): to determine the profile of shoulder flexibility in young swimmers, (b) to analyze whether a restricted range of movement (ROM) could be a predictor of subsequent SP in young swimmers. Read More

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Impact of tricuspid annular size reduction on right ventricular function, geometry and strain.

Eur J Cardiothorac Surg 2019 Jan 29. Epub 2019 Jan 29.

Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, MI, USA.

Objectives: Restrictive tricuspid annuloplasty is a clinically accepted approach to treat functional tricuspid regurgitation. We set out to investigate the effect of varying degrees of tricuspid annular reduction on the right ventricular (RV) function, geometry and strain.

Methods: Eight, healthy sheep (45 ± 4 kg) had 6 sonomicrometry crystals implanted around the tricuspid annulus and 20 onto the epicardium of the right ventricle defining 3 free wall regions: basal, mid and lower. Read More

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January 2019

Role of Actinobacteria and Coriobacteriia in the antidepressant effects of ketamine in an inflammation model of depression.

Pharmacol Biochem Behav 2019 01 5;176:93-100. Epub 2018 Dec 5.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Ketamine, an N-methyl-d-aspartic acid receptor (NMDAR) antagonist, elicits rapid-acting and sustained antidepressant effects in treatment-resistant depressed patients. Accumulating evidence suggests that gut microbiota via the gut-brain axis play a role in the pathogenesis of depression, thereby contributing to the antidepressant actions of certain compounds. Here we investigated the role of gut microbiota in the antidepressant effects of ketamine in lipopolysaccharide (LPS)-induced inflammation model of depression. Read More

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January 2019

Display colour scale effects on diagnostic performance and reader agreement in cardiac CT and prostate apparent diffusion coefficient assessment.

Clin Radiol 2019 01 15;74(1):79.e1-79.e9. Epub 2018 Oct 15.

Division of Imaging, Diagnostics and Software Reliability, OSEL/CDRH/FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993-0002, USA.

Aim: To investigate the effect of colour scale choice on diagnostic performance in the interpretation of medical images.

Materials And Methods: Twelve clinicians interpreted 210 myocardial computed tomography (CT) perfusion (CTP) examinations, and nine clinicians interpreted 165 magnetic resonance imaging (MRI) apparent diffusion coefficient (ADC) prostate images. In three separate sessions, each participant read the same image set using greyscale, hot-iron, and rainbow scales, respectively. Read More

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January 2019

The risk of graft loss 5 years after kidney transplantation is increased if cold ischemia time exceeds 14 hours.

Clin Transplant 2018 09 31;32(9):e13377. Epub 2018 Aug 31.

Transplant Institute, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Background: The state of the evidence is unclear regarding the impact of cold ischemia time (CIT) on the outcome of kidney transplantation. The aim of this study was to investigate the effect of CIT on the short- and long-term function of kidneys transplanted at the Sahlgrenska University Hospital in 2007-2009 from donors after brain death (DBDs).

Methods: This study was designed as a retrospective analysis of data from local and national transplantation registers. Read More

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September 2018

Prognostic value of Ki-67 according to age in patients with triple-negative breast cancer.

Clin Transl Oncol 2018 Nov 18;20(11):1448-1454. Epub 2018 Apr 18.

Oncology Department, Hospital Fundación Jiménez Díaz, Madrid, Spain.

Purpose: The prognostic value of Ki-67 in triple-negative breast cancer (TNBC) is yet unclear because the cut-off points employed differ widely and its predictive effect may vary according to age. The purpose of this study was to analyze the role of Ki-67 among patients with TNBC, and determine the optimal Ki-67 cut-off point to demonstrate its prognostic relevance associated with patient age and treatment strategy.

Methods/patients: 201 consecutive patients treated for primary TNBC from 1999 to 2014 were analyzed. Read More

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November 2018

Development of a Risk Tool to Support Discussions of Care for Older Adults Admitted to the ICU With Pneumonia.

Am J Hosp Palliat Care 2018 Sep 18;35(9):1201-1206. Epub 2018 Mar 18.

4 Excellus Health Plan, Buffalo, NY, USA.

Background: Early, data-driven discussion surrounding palliative care can improve care delivery and patient experience.

Objective: To develop a 30-day mortality prediction tool for older patients in intensive care unit (ICU) with pneumonia that will initiate palliative care earlier in hospital course.

Design: Retrospective Electronic Health Record (EHR) review. Read More

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September 2018

Assessment of image co-registration accuracy for frameless gamma knife surgery.

PLoS One 2018 2;13(3):e0193809. Epub 2018 Mar 2.

Department of Nuclear Engineering, Hanyang University College of Engineering, Seoul, Korea.

Image co-registration is used in frameless gamma knife radiosurgery (GKSRS) to assign a stereotactic coordinate system and verify patient setup before irradiation. The accuracy of co-registration with cone beam computed tomography (CBCT) images of a Gamma Knife IconTM (GK Icon) was assessed, and the effects of the region of co-registration (ROC) were studied. CBCT-to-CBCT co-registration is used for patient setup verification, and its accuracy was examined by co-registering CBCT images taken at various configurations with a reference CBCT series. Read More

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An electroglottographical analysis-based discriminant function model differentiating multiple sclerosis patients from healthy controls.

Neurol Sci 2018 May 15;39(5):847-850. Epub 2018 Feb 15.

Health Sciences Department, Speech Therapy, European University Cyprus, 6 Diogenous Street, Engomi, P.O. Box: 22006, 1516, Nicosia, Cyprus.

Dysarthrophonia is a predominant symptom in many neurological diseases, affecting the quality of life of the patients. In this study, we produced a discriminant function equation that can differentiate MS patients from healthy controls, using electroglottographic variables not analyzed in a previous study. We applied stepwise linear discriminant function analysis in order to produce a function and score derived from electroglottographic variables extracted from a previous study. Read More

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A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA 'grey zone'.

World J Urol 2018 Mar 16;36(3):341-348. Epub 2017 Dec 16.

Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge, UK.

Purpose: To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the 'grey zone' (PSA < 10 ng/ml). The test quantifies a previously described 3.4 kb mitochondrial DNA (mtDNA) deletion. Read More

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Structural insights into RNA unwinding and degradation by RNase R.

Nucleic Acids Res 2017 Nov;45(20):12015-12024

Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 11529, ROC.

RNase R is a conserved exoribonuclease in the RNase II family that primarily participates in RNA decay in all kingdoms of life. RNase R degrades duplex RNA with a 3' overhang, suggesting that it has RNA unwinding activity in addition to its 3'-to-5' exoribonuclease activity. However, how RNase R coordinates RNA binding with unwinding to degrade RNA remains elusive. Read More

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November 2017

Potential Pitfalls of a Fiducial Marker-matching Technique in Carbon-ion Radiotherapy for Lung Cancer.

Anticancer Res 2017 10;37(10):5673-5680

Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan.

Background/aim: To analyze the accuracy of patient positioning and dose distribution quality using a fiducial marker-matching technique in carbon-ion radiotherapy (C-ion RT) for stage I lung cancer.

Patients And Methods: Thirteen patients with 26 fiducial markers and 104 radiation fields were examined. Change in the fiducial marker position coordinates from the gross tumor volume center (Δm), and change in the water-equivalent path length of the chest wall (ΔWEL) were measured in each radiation field. Read More

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October 2017

Comparison of platelet-lymphocyte ratio and CA 19-9 in differentiating benign from malignant head masses in patients with chronic pancreatitis.

Indian J Gastroenterol 2017 Jul 16;36(4):263-267. Epub 2017 Sep 16.

Department of Surgical Gastroenterology, Government Medical College, Trivandrum, 695 011, India.

Introduction: Pancreatic head ductal adenocarcinoma (PDAC) and inflammatory head masses (IHM) related to chronic pancreatitis are often difficult to differentiate. PDAC produces significant inflammatory response with resultant lymphopenia and thrombocytosis. The prognostic role of platelet-lymphocyte ratio (PLR) as a tumor marker has been defined. Read More

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Anti--benzoquinone antibody level as a prospective biomarker to identify smokers at risk for COPD.

Int J Chron Obstruct Pulmon Dis 2017 21;12:1847-1856. Epub 2017 Jun 21.

Department of Biotechnology and Dr B C Guha Centre for Genetic Engineering and Biotechnology, University College of Science and Technology, University of Calcutta.

Background And Objective: Identification of smokers having predisposition to COPD is important for early intervention to reduce the huge global burden of the disease. Using a guinea pig model, we have shown that -benzoquinone (-BQ) derived from cigarette smoke (CS) in the lung is a causative factor for CS-induced emphysema. -BQ is also derived from CS in smokers and it elicits the production of anti--BQ antibody in humans. Read More

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