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Favorable Survival After Screening for Young-Onset Colorectal Cancer: Benefits of Screening in Young Adults.

Dis Colon Rectum 2021 Nov 24. Epub 2021 Nov 24.

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Background: The increasing incidence and mortality of young-onset colorectal cancer has drawn increasing attention. However, screening for young adults is controversial, given the limited evidence regarding its effectiveness.

Objective: We aimed to clarify the characteristics of young-onset colorectal cancer and to compare long-term outcomes of screening-detected colorectal cancer and non-screening-detected colorectal cancer. Read More

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November 2021

Sentinel lymph node biopsy at robotic-assisted hysterectomy for atypical hyperplasia and endometrial cancer.

J Robot Surg 2021 Dec 2. Epub 2021 Dec 2.

Gynaecology Oncology Department, Liverpool Hospital, Sydney, NSW, Australia.

Lymph node (LN) evaluation in endometrial cancer is controversial. Sentinel lymph node biopsy (SLNB) allows for an accurate nodal assessment while minimising the risks of a full pelvic lymph node dissection (PLND). The aims of this study are to examine the characteristics and peri-operative outcomes of women with atypical hyperplasia (AH) or endometrial cancer undergoing robotic-assisted hysterectomy (RAH) ± SLNB or PLND; to examine the utilisation, feasibility and role of SLNB and compare their peri-operative outcomes. Read More

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December 2021

Anatomical nonanatomical liver resection for solitary hepatocellular carcinoma: A systematic review and meta-analysis.

World J Gastrointest Oncol 2021 Nov;13(11):1833-1846

Department of Liver Surgery, Liver Transplantation Division, Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: The long-term survival of patients with solitary hepatocellular carcinoma (HCC) following anatomical resection (AR) non-anatomical resection (NAR) is still controversial. It is necessary to investigate which approach is better for patients with solitary HCC.

Aim: To compare perioperative and long-term survival outcomes of AR and NAR for solitary HCC. Read More

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November 2021

Intertrochanteric fractures treated by diaphyseal support arthroplasty with hook plate vs cerclage wires only: A retrospective cohort study.

Ann Med Surg (Lond) 2021 Dec 17;72:103075. Epub 2021 Nov 17.

Department of Orthopedic Surgery and Traumatology, Saint Georges University Medical Center, Balamand University, P.O.Box 166378, Achrafieh, Beirut, 1100 2807, Lebanon.

Background: The treatment of unstable fractures of the intertrochanteric region of the hip in the elderly is controversial. Conventionally, internal fixation with intramedullary nail or a dynamic hip screw is the treatment of choice in intertrochanteric fractures. Nowadays, some authors encouraged the use hip arthroplasty for management of these fractures with good outcome. Read More

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December 2021

Survival outcomes of management in metastatic gastric adenocarcinoma patients.

Sci Rep 2021 Nov 30;11(1):23142. Epub 2021 Nov 30.

National Institute of Cancer Research, National Health Research Institutes, No 367, Sheng-Li Road, Tainan, 70456, Taiwan.

Chemotherapy is generally considered as the main treatment for metastatic gastric adenocarcinoma. The role of gastrectomy for metastatic gastric cancer without obvious symptoms is controversial. The objective of this study is to investigate survival outcomes of treatment modalities using a real-world data setting. Read More

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November 2021

Trends in remote health care consumption in Sweden: A comparison before and during the first wave of the Covid-19 pandemic.

JMIR Hum Factors 2021 Nov 28. Epub 2021 Nov 28.

Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Malmö, SE.

Background: Remote assessment of respiratory tract infections (RTIs) has been a controversial topic during the fast development of private telemedicine providers in Swedish primary health care. The possibility to unburden the traditional care has been put against a questionable quality of care as well as risks of increased utilization and costs. The covid-19 pandemic has contributed to a changed management of patient care to decrease viral spread, with an expected shift in contact types from in-person to remote ones. Read More

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November 2021

Comparison of effectiveness and safety between endoscopic and surgical resection for 2-5 cm gastric stromal tumors.

Surg Endosc 2021 Nov 29. Epub 2021 Nov 29.

Department of Gastroenterology, Sichuan University, West China Hospital, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Background: As endoscopic resection remains controversial, this study aims to compare the effectiveness and safety between endoscopic and surgical resection for 2-5 cm gastric stromal tumors (GSTs).

Methods: Patients with 2-5 cm GST resected at West China Hospital from March 2008 to April 2019 were enrolled. Propensity score matching (PSM) (1:1) was performed to achieve baseline data consistency. Read More

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November 2021

Endovascular Therapy Versus Anticoagulation for Treatment of Cerebral Venous Sinus Thrombosis: A Meta-analysis.

Neurologist 2021 Nov 26. Epub 2021 Nov 26.

Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou Department of Neurosurgery, The Affiliated Jiangyin Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu Province, China Department of Neurosurgery, Baylor Scott and White Medical Center, Texas A&M University College of Medicine, Temple, TX.

Background: Cerebral venous sinus thrombosis (CVST) is a rare cause of stroke that mainly affects the young. Anticoagulation (AC) with heparin is the mainstay of treatment for CVST. Although highly anticipated, endovascular therapy (ET) including local thrombolysis and mechanical thrombectomy has been controversial. Read More

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November 2021

Comparative Study of Laparoscopic Versus Open Liver Resection in Gallbladder Cancer.

J Laparoendosc Adv Surg Tech A 2021 Nov 25. Epub 2021 Nov 25.

Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, Republic of Korea.

In recent decades, laparoscopic liver resection (LLR) has been gradually adopted at high-volume centers, particularly for hepatocellular carcinoma and liver metastasis. However, LLR in patients with gallbladder cancer (GBC) is a controversial issue, and there are few studies of LLR for GBC. Our aim was to compare the outcomes of patients who underwent laparoscopic or open liver resection for GBC. Read More

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November 2021

Multiple microRNA signature panel as promising potential for diagnosis and prognosis of head and neck cancer.

Mol Biol Rep 2021 Nov 27. Epub 2021 Nov 27.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

MicroRNAs are small non-coding RNA that regulate gene expressions of human body. To date, numerous studies have reported that microRNAs possess great diagnostic and prognostic power in head and neck cancer and had governed a lot of attention. The factor for the successfulness of miRNAs in these aspects is due to cancer being fundamentally tied to genetic changes, which are regulated by these miRNAs. Read More

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November 2021

Stable Low-Grade Degenerative Spondylolisthesis Does Not Compromise Clinical Outcome of Minimally Invasive Tubular Decompression in Patients with Spinal Stenosis.

Medicina (Kaunas) 2021 Nov 19;57(11). Epub 2021 Nov 19.

The Department of Neurosurgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv 6423906, Israel.

In recent literature, the routine addition of arthrodesis to decompression for lumbar spinal stenosis (LSS) with concomitant stable low-grade degenerative spondylolisthesis remains controversial. The purpose of this study is to compare the clinical outcome, complication and re-operation rates following minimally invasive (MIS) tubular decompression without arthrodesis in patients suffering from LSS with or without concomitant stable low-grade degenerative spondylolisthesis. This study is a retrospective review of prospectively collected data. Read More

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November 2021

Saccular aneurysms in the post-Barrow Ruptured Aneurysm Trial era.

J Neurosurg 2021 Nov 26:1-8. Epub 2021 Nov 26.

Objective: The Barrow Ruptured Aneurysm Trial (BRAT) was a single-center trial that compared endovascular coiling to microsurgical clipping in patients treated for aneurysmal subarachnoid hemorrhage (aSAH). However, because patients in the BRAT were treated more than 15 years ago, and because there have been advances since then-particularly in endovascular techniques-the relevance of the BRAT today remains controversial. Some hypothesize that these technical advances may reduce retreatment rates for endovascular intervention. Read More

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November 2021

Different Cutoff Values for Increased Nuchal Translucency in First-Trimester Screening to Predict Fetal Chromosomal Abnormalities.

Int J Gen Med 2021 18;14:8437-8443. Epub 2021 Nov 18.

Fujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

Introduction: Increased nuchal translucency (NT) is closely related to an increased risk of chromosomal abnormalities. However, the criterion of increased NT for invasive prenatal diagnosis remains controversial, as the cutoff values are inconsistent among countries. This study was conducted to compare the various cutoff values of increased NT and calculate the incidence of chromosomal abnormalities to determine the predictive ability of these cutoff values in conventional chromosome analysis. Read More

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November 2021

Excision Margin and Survival in Patients with High-Risk, Primary Cutaneous Melanoma: A Retrospective Study Based on Surveillance Epidemiology and End Result (SEER) Database.

Authors:
Meng-Nan Xu Qiu Rao

Dermatology 2021 Nov 24:1-8. Epub 2021 Nov 24.

Department of Pathology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Objectives: The optimal excision margin of primary cutaneous melanoma greater than 2 mm in thickness is still a controversial topic. The aim of the present study was to compare the long-term survival between narrow and wide excision margins in the surgical excision of patients with high-risk primary melanoma.

Methods: We chose the patients with primary melanoma of the skin thicker than 2 mm in The Surveillance, Epidemiology, and End Results database. Read More

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November 2021

Comparing the effectiveness of blended learning and traditional learning in an orthopedics course.

Ann Med Surg (Lond) 2021 Dec 18;72:103037. Epub 2021 Nov 18.

Department of Orthopedics, Faculty of Medicine, Prince of Songkla University, 15 Karnjanavanich Road, Hat Yai, Songkhla, 90110, Thailand.

Introduction: The ongoing COVID-19 pandemic is forcing medical schools to replace substantial parts of the traditional lecture method with online formats to maintain social distancing guidelines and reduce face-to-face contact in the classroom. To our knowledge, there have to date been few studies comparing the effectiveness of traditional teaching with blended teaching based on the students' final grades which the efficacy of online learning is still controversial, and this study aimed to compare the efficacy of blended teaching with conventional teaching in an orthopedics course.

Methods: This study was a retrospective cohort study based on data collected from fifth-year medical students between April 2019 and March 2021. Read More

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December 2021

The Effects of Smoking on Clinical and Structural Outcomes After Rotator Cuff Repair: A Systematic Review and Meta-Analysis.

J Shoulder Elbow Surg 2021 Nov 20. Epub 2021 Nov 20.

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Several factors have been reported to adversely affect clinical and structural outcomes after rotator cuff repair (RCR). However, the effects of smoking on rotator cuff healing and clinical outcomes remain controversial. The purpose of this study was to compare the clinical and structural outcomes after RCR between smokers and nonsmokers. Read More

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November 2021

Efficacy and safety of short-term dual antiplatelet therapy in East Asians: a systematic review and a meta-analysis of randomized clinical trials.

J Cardiovasc Pharmacol 2021 Nov 22. Epub 2021 Nov 22.

The First Clinical Medical College of Lanzhou University, Lanzhou, China Department of Cardiology, The First Hospital of Lanzhou University.

Abstract: The optimal duration of dual antiplatelet therapy (DAPT) for patients implanted with new-generation drug-eluting stents (DES) in East Asians is currently still controversial. The purpose of this meta-analysis was to investigate the efficacy and safety of short-term DAPT in patients with those. In this study, randomized controlled trials from PubMed, EMBASE, and Cochrane Library were searched to compare the efficacy and safety of short-term DAPT (6- month or less) with long-term DAPT (12- month or more) in patients implanted with new-generation DES in East Asian from inception to September 2020. Read More

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November 2021

Survival after secondary liver resection in metastatic colorectal cancer: Comparing data of three prospective randomized European trials (LICC, CELIM, FIRE-3).

Int J Cancer 2021 Nov 22. Epub 2021 Nov 22.

Johannes Gutenberg-University Mainz, Mainz, Germany.

Metastatic colorectal cancer (mCRC) patients with liver-limited disease (LLD) have a chance of long-term survival and potential cure after hepatic metastasectomy. However, the appropriate postoperative treatment strategy is still controversial. The CELIM and FIRE-3 studies demonstrated that secondary hepatic resection significantly improved overall survival. Read More

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November 2021

Minimally invasive and full sternotomy in aortic valve replacement: a comparative early operative outcomes.

Pan Afr Med J 2021 30;40:68. Epub 2021 Sep 30.

Cardiovascular Surgery Department, Mohammed VI University Hospital, Marrakech, Morocco.

Introduction: aortic valve replacement is usually performed through a median full sternotomy (MFS) in our department. Minimally invasive aortic valve replacement (MIAVR) has been recently adopted as a new approach. According to the literature, the superiority of MIAVR is controversial. Read More

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November 2021

The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea.

BMC Pulm Med 2021 Nov 21;21(1):378. Epub 2021 Nov 21.

Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Clinical Research Center for Cardiovascular Diseases, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 BeiLiShi Road, Xicheng District, Beijing, 100037, China.

Objective: Obstructive sleep apnoea (OSA) is one cause of pulmonary hypertension (PH) and can also emerge along with PH. The clinical diagnosis and treatment of OSA in patients with PH are still controversial. The purpose of this clinical observation study was to observe and summarize the incidence and clinical characteristics of OSA in patients with PH and to explore possible predictors of PH combined with OSA. Read More

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November 2021

Efficacy of erector spinae plane block on postoperative pain in patients undergoing lumbar spine surgery.

Eur Spine J 2021 Nov 20. Epub 2021 Nov 20.

Department of Neurosurgery, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Turkey.

Background: Major lumbar spine surgery causes severe pain in the postoperative period. There are few studies regarding the effect of erector spinae plane block (ESPB) effect on lumbar surgery and its effect is still controversial. Therefore, the study aimed to investigate the effect of ultrasound-guided low thoracic ESPB on opioid consumption and postoperative pain score. Read More

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November 2021

Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials.

Crit Rev Oncol Hematol 2021 Nov 18;168:103530. Epub 2021 Nov 18.

Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining 810000, China. Electronic address:

Background: One of the front treatment regimens used for metastatic triple-negative breast cancer (mTNBC) is treatment with programmed death-1 (PD-1) or programmed death ligand-1 (PD-L1) blockade combine with chemotherapy. However, the results of such studies have been controversial.

Methods: A systematic searched of PubMed, Embase, Cochrane Library, and the proceedings of the last 5 years of several meetings until February 18, 2021. Read More

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November 2021

Cost-Effectiveness of long-term tolvaptan administration for chronic heart failure treatment in Japan.

J Cardiol 2021 Nov 16. Epub 2021 Nov 16.

Department of Cardiology, Pulmonology, Nephrology and Hypertension, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.

Background: Tolvaptan (TLV) is effective for acute heart failure (HF) with congestion, but its long-term administration in patients with chronic HF (CHF) remains controversial. Moreover, the cost-effectiveness of TLV for CHF treatment has not yet been investigated. Thus, we sought to validate the cost-effectiveness of TLV for CHF treatment in Japan. Read More

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November 2021

Pathological investigations and correlation research of microfibrillar-associated protein 4 and tropoelastin in oral submucous fibrosis.

BMC Oral Health 2021 11 19;21(1):588. Epub 2021 Nov 19.

Department of Oral Medicine, Xiangya Stomalogical Hospital, Central South University, Changsha, China.

Background: Oral submucous fibrosis (OSF), distinguished by abnormal collagen deposition, is a potentially malignant disorder with 4.2% (95% CI 2.7-5. Read More

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November 2021

Laparoscopic versus open resection for rectal cancer: An individual patient data meta analysis of randomized controlled trials.

Eur J Surg Oncol 2021 Nov 11. Epub 2021 Nov 11.

Yong Loo Lin School of Medicine, National University Singapore, Singapore; Division of Colorectal Surgery, Department of Surgery, National University Hospital, Singapore. Electronic address:

Background And Aims: The role of laparoscopic rectal cancer resection remains controversial. Thus, we aimed to conduct a one-stage meta-analysis with reconstructed patient-level data using randomized trial data to compare long-term oncologic efficacy of laparoscopic and open surgical resection for rectal cancer.

Methods: Medline, EMBASE and Scopus were searched for articles comparing laparoscopic with open surgery for rectal cancer. Read More

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November 2021

Comparison of Outcomes of Catheter Ablation in Asymptomatic Versus Symptomatic Preexcitation to Guidelines and Beyond.

Am J Cardiol 2021 12;161:51-55

The Fundación Jiménez Díaz- Quirónsalud, Madrid, Spain.

Management of asymptomatic subjects with preexcitation remains controversial. Our objective was to analyze the reasons an electrophysiological study (EPS) was performed in an asymptomatic population referred for the procedure, and compare the results of catheter ablation between asymptomatic and symptomatic patients. Patients ≥18 years of age with preexcitation referred for an EPS and ablation were grouped as either symptomatic or asymptomatic. Read More

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December 2021

Analysis of sentinel lymph node biopsy and non-sentinel lymph node metastasis in invasive ductal and invasive lobular breast cancer: a nationwide cross-sectional study (CSBrS-001).

Ann Transl Med 2021 Oct;9(20):1588

Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background: Information regarding the implementation of sentinel lymph node biopsy (SLNB) in invasive lobular carcinoma (ILC) is scarce, and whether ILC patients with 1-2 positive sentinel lymph nodes (SLNs) can be omitted from axillary lymph node dissection (ALND) remains controversial. This study aimed to compare involvement of SLNs and non-SLNs between patients with invasive ductal carcinoma (IDC) and ILC.

Methods: We retrospectively collected the clinical and pathological data of invasive breast cancer patients from 37 medical centers in China from January 2018 to December 2018. Read More

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October 2021

Antibiotics in the Treatment of Periodontitis: A Systematic Review of the Literature.

Int J Dent 2021 8;2021:6846074. Epub 2021 Nov 8.

University of Monastir, Dental Medecine Faculty of Monastir, Periodontal Departement, Oral Health and Oral Rehabilitation Research Laboratory, LR12ES11, Monastir 5019, Tunisia.

Introduction: Systemic antibiotics present one of the alternative adjunctive therapies in nonsurgical periodontal treatment (NSPT). Different protocols have been proposed, but their indication and effectiveness are still controversial. The aim of this study is to assess the effectiveness of the addition of antibiotics after nonsurgical debridement during initial therapy and compare different antimicrobial prescription protocols. Read More

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November 2021

Differential uptake of three clinically relevant allergens by human plasmacytoid dendritic cells.

Clin Mol Allergy 2021 Nov 17;19(1):23. Epub 2021 Nov 17.

Department of Pediatrics, University Medical Center Ulm, Eythstr. 24, 89075, Ulm, Germany.

Background: Human plasmacytoid dendritic cells (pDC) have a dual role as interferon-producing and antigen-presenting cells. Their relevance for allergic diseases is controversial. and the impact of pDC on allergic immune responses is poorly understood. Read More

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November 2021

Clinical evaluation of single and repeated sessions of photobiomodulation with two different therapeutic wavelengths for reducing postoperative sequelae after impacted mandibular third molar surgery: a randomized, double-blind clinical study.

J Appl Oral Sci 2021 15;29:e20210383. Epub 2021 Nov 15.

Yuzuncu Yil University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Van, Turkey.

Objective: The effects of the number of photobiomodulation (PBM) sessions on the postoperative inflammatory process remain controversial. The current literature comparing single and repeated PBM sessions is limited. This study aimed to compare the effects of single and repeated PBM sessions, applied at two different therapeutic wavelengths within the infrared spectrum, on postoperative inflammatory response after impacted third molar tooth extraction. Read More

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November 2021