J Pharmacol Exp Ther 2021 Sep 16;378(3):244-250. Epub 2021 Jun 16.
Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps Universität, Marburg, Germany (H.B.); and Departament of Parasitology, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, Mexico City, Mexico (G.M.)
Neuroinflammation (NI) is an important physiologic process which promotes the tissue repair and homeostatic maintenance in the central nervous system after different types of insults. However, when it is exacerbated and sustained in time, NI plays a critical role in the pathogenesis of different neurologic diseases. The high systemic doses required for brain-specific targeting lead to severe undesirable effects. Read More