Radiology 2021 Mar 9:203568. Epub 2021 Mar 9.
From the Departments of Radiology (P.L., G.L., Z.L., H.L.) and Neurosurgery (J.H.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 324, Baltimore, MD 21287; Department of Radiology (M.C.P., B.G.W.), Advanced Imaging Research Center (M.C.P., B.P.T.), and Department of Neurologic Surgery (B.G.W.), UT Southwestern Medical Center, Dallas, Tex; and Center for Vital Longevity, University of Texas at Dallas, Dallas, Tex (M.R., D.C.P.).
Background Cerebrovascular reserve, the potential capacity of brain tissue to receive more blood flow when needed, is a desirable marker in evaluating ischemic risk. However, current measurement methods require acetazolamide injection or hypercapnia challenge, prompting a clinical need for resting-state (RS) blood oxygen level-dependent (BOLD) functional MRI data to measure cerebrovascular reactivity (CVR). Purpose To optimize and evaluate an RS CVR MRI technique and demonstrate its relationship to neurosurgical treatment. Read More