AIDS 2021 Mar 11. Epub 2021 Mar 11.
Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA Laboratory of Immunoregulation, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Section of Infections of the Nervous System, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA.
Objective: We evaluated brain glucose metabolism in people living with HIV (PLWH) with [18F]-Fluoro-Deoxyglucose (FDG) PET/CT before and after antiretroviral therapy (ART) initiation.Design: We conducted a longitudinal study where ART-naïve late-presenting untreated PLWH with CD4 counts < 100 cells/uL were prospectively assessed for FDG uptake at baseline and at 4-8 weeks (n=22) and 19-26 months (n = 11) following ART initiation.
Methods: Relative uptake in the subcortical regions (caudate, putamen and thalamus) and cortical regions (frontal, parietal, temporal, and occipital cortices) were compared across time and correlated with biomarkers of disease activity and inflammation, in addition to being compared to a group of uninfected individuals (n = 10). Read More