4,316 results match your criteria controls n=11

Hematocrit-Related Alterations of Circulating microRNA-21 Levels in Heart Failure Patients with Reduced Ejection Fraction: A Preliminary Study.

Genet Test Mol Biomarkers 2021 Apr;25(4):302-306

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovakia.

Circulating microRNA-21 (miR-21) has been utilized as a diagnostic tool in the assessment of heart failure (HF). Blood constitution may be altered when HF occurs and miR-21 may affect hematopoiesis. Sample hemolysis may influence the determination of circulating miRNAs, challenging the diagnostic use of miRNAs. Read More

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The effects of free weights and iso-inertial resistance during semi-squatting exercise on amateur soccer players' physical performance indicators: a randomized controlled study.

J Sports Med Phys Fitness 2021 Apr 19. Epub 2021 Apr 19.

Laboratory of Evaluation of Human Biological Performance, Department of Physical Education and Sport Science, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: The aim was to compare the effects of two lower extremity strengthening programs using iso-inertial resistance or free weights on amateur soccer players' physical performance indicators.

Methods: Thirty-five amateur soccer players (average age 22.6±5. Read More

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The prevalence of screened trichotillomania in medical students of Saint-Joseph University.

Encephale 2021 Apr 13. Epub 2021 Apr 13.

Psychiatry department, Hôtel-Dieu de France, Faculty of Medicine, Université Saint-Joseph de Beyrouth, BP, 166830 Beirut, Lebanon.

Objectives: Our study aims to determine the prevalence of trichotillomania among medical students. Furthermore, we aim to determine the perception of trichotillomania in this population.

Methods: Our study is a cross-sectional study that aims to determine the prevalence and the perception of trichotillomania among medical students in, compared to a control population. Read More

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Time-dependent association between selective serotonin reuptake inhibitors and hospitalization due to hyponatremia.

J Psychopharmacol 2021 Apr 16:2698811211001082. Epub 2021 Apr 16.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

Background: Selective serotonin reuptake inhibitors (SSRIs) have a wide and increasing use for the treatment of depression and anxiety. Previous studies have indicated an increased risk of hyponatremia during the first months of treatment. We aimed to investigate the detailed time-course of SSRI-associated hyponatremia with a high temporal resolution, using registry data encompassing the total Swedish population. Read More

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Pre-stimulus low-alpha frontal networks are associated with pareidolias in Parkinson's disease.

Brain Connect 2021 Apr 15. Epub 2021 Apr 15.

Osaka University, 13013, Suita, Osaka prefecture, Japan;

Pareidolias are visual phenomena wherein ambiguous, abstract forms or shapes appear meaningful due to incorrect perception. In Parkinson's disease (PD), patients susceptible to visual hallucinations experience visuo-perceptual deficits in the form of pareidolias. While pareidolias necessitate top-down modulation of visual processing, the cortical dynamics of internally generated perceptual priors on these visual misperceptions is unknown. Read More

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Cardiac Afferent Signaling Partially Underlies Premature Ventricular Contraction-Induced Cardiomyopathy.

Heart Rhythm 2021 Apr 9. Epub 2021 Apr 9.

UCLA Cardiac Arrhythmia Center, UCLA Neurocardiology Research Program of Excellence, University of California, Los Angeles CA. Electronic address:

Background: The mechanisms underlying premature ventricular contraction (PVC)-induced cardiomyopathy remain unknown. Transient receptor potential vanilloid 1 (TRPV1) afferent fibers are implicated in the reflex processing of cardiac stress.

Objective: We aimed to determine whether cardiac TRPV1 afferent signaling promote PVC-induced cardiomyopathy. Read More

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Is there an athlete's artery? A comparison of brachial and femoral artery structure and function in male strength, power and endurance athletes.

J Sci Med Sport 2021 Feb 26. Epub 2021 Feb 26.

School of Human Sciences, University of Western Australia, Australia.

Objectives: Exercise places physiological demands upon the cardiovascular system, subsequently leading to adaptations in structure and function. Different exercise modalities (endurance, strength and power) lead to distinct hemodynamic demands and, possibly, different patterns of adaptation. Our aim was to assess and compare brachial and femoral artery function and structure in elite level athletes engaged in endurance, strength and power sports. Read More

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February 2021

Myeloproliferative neoplasms and clonal hematopoiesis in patients with giant cell arteritis: a case-control and exploratory study.

Rheumatology (Oxford) 2021 Apr 9. Epub 2021 Apr 9.

Department of Internal Medicine, Cochin Hospital, National Referral Center for Rare Systemic Autoimmune Diseases, Paris University, Paris, France.

Objectives: Giant cell arteritis (GCA) is a large vessel vasculitis for which triggering factors remain unknown. Clonal hematopoiesis (CH) was associated with atherosclerosis through the induction of inflammation in myeloid cells, and data suggest that CH expansion and inflammation may support each other to induce a proinflammatory loop. Our objective was to describe the impact of JAK2p. Read More

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The Adult Phenylketonuria (PKU) Gut Microbiome.

Microorganisms 2021 Mar 4;9(3). Epub 2021 Mar 4.

Department of Microbiology, Immunology, and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism primarily treated through a phenylalanine-restrictive diet that is frequently supplemented with an amino acid formula to maintain proper nutrition. Little is known of the effects of these dietary interventions on the gut microbiome of PKU patients, particularly in adults. In this study, we sequenced the V4 region of the 16S rRNA gene from stool samples collected from adults with PKU ( = 11) and non-PKU controls ( = 21). Read More

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HERV-K Gag RNA and Protein Levels Are Elevated in Malignant Regions of the Prostate in Males with Prostate Cancer.

Viruses 2021 Mar 10;13(3). Epub 2021 Mar 10.

Life Sciences Discipline, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia.

Heightened expression of human endogenous retrovirus (HERV) sequences has been associated with a range of malignancies, including prostate cancer, suggesting that they may serve as useful diagnostic or prognostic cancer biomarkers. We analysed the expression of HERV-K (Gag and Env/Np9 regions), HERV-E 4.1 (Pol and Env regions), HERV-H (Pol) and HERV-W (Gag) sequences in prostate cancer cells lines and normal prostate epithelial cells using qRT-PCR. Read More

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Steatitis in Cold-Stunned Kemp's Ridley Sea Turtles ().

Animals (Basel) 2021 Mar 21;11(3). Epub 2021 Mar 21.

Department of Comparative, Diagnostic, and Population Medicine, University of Florida College of Veterinary Medicine, Gainesville, FL 32608, USA.

The pathogenesis of steatitis that infrequently occurs in cold-stunned Kemp's ridley sea turtles (KRT; ) has been undetermined. The objectives of this study were to investigate the clinical ( = 23) and histologic findings ( = 11) in cold-stunned KRT, and to compare plasma concentrations of α-tocopherol (vitamin E), thiobarbituric acid reactive substances (TBARS), and the TBARS to vitamin E (T/E) ratio (an assessment of oxidative stress) between cold-stunned KRT with clinically and/or histologically confirmed steatitis ( = 10) and free-ranging KRT ( = 9). None of the cold-stunned turtles had clinically detectable steatitis at admission, and the median number of days to diagnosis of steatitis was 71 (range 33-469). Read More

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Air distribution within the lungs after total liquid ventilation in a neonatal ovine model.

Respir Physiol Neurobiol 2021 Mar 30;290:103666. Epub 2021 Mar 30.

Department of Pharmacology-Physiology, Université de Sherbrooke, 3001, 12(e)Avenue Nord, Sherbrooke, QC, J1H 5H3, Canada; Department of Pediatrics, Université de Sherbrooke. 3001, 12(e)Avenue Nord, Sherbrooke, QC, J1H 5H3, Canada. Electronic address:

Objective: To gain insight into the total and regional lung aeration dynamics at the transition from total liquid ventilation (TLV) to conventional mechanical ventilation (GV).

Methods: Neonatal lambs received either TLV for 4 h followed by GV (n = 15) or GV only (n = 11, controls). Monitoring was performed in the prone position with both videofluoroscopy and electrical impedance tomography (EIT) for the first 10 min of the transition. Read More

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Can plasma antioxidants prevent DNA damage in oxidative stress condition induced by growth hormone deficiency? A pilot study.

PLoS One 2021 1;16(4):e0248971. Epub 2021 Apr 1.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress, is related to augmented cardiovascular, metabolic and oncological risk. A case-control observational study has been performed to evaluate DNA oxidative damage analysing the production of thymidine-glycol in lymphocytes and its correlation with plasma antioxidant levels, evaluated as Total Antioxidant Capacity (TAC). GHD was diagnosed using GHRH 50μg iv+arginine 0,5 g/Kg test, with peak GH response <9 μg/L when BMI was <30 kg/m2 or <4 μg/L when BMI was >30 kg/m2. Read More

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Macrophage migration inhibitory factor predicts an unfavorable outcome after TACE for hepatic malignancies.

Clin Transl Sci 2021 Mar 30. Epub 2021 Mar 30.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.

Transarterial chemoembolization (TACE) is a therapeutic option for patients with intermediate-stage hepatocellular carcinoma (HCC) or metastatic liver cancers. Identifying those patients who particularly benefit from TACE remains challenging. Macrophage migration inhibitory factor (MIF) represents is an inflammatory protein described in liver cancer patients, but no data on its prognostic relevance in TACE patients exist. Read More

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Gross Motor Skills and Gait Performance in Two- and Three-year-old Children With Developmental Delay Participating in Hippotherapy.

J Equine Vet Sci 2021 Apr 30;99:103359. Epub 2020 Dec 30.

Department of Pediatrics, Texas Tech University Health Sciences Center, Lubbock, TX.

This study examined the effects of 15 sessions of hippotherapy (HPOT) on gross motor skills in children (aged 2-3 years) with gross motor developmental delay (DD) (n = 11) in comparison with age-based controls without DD (n = 6). Gross motor skills in both groups were assessed with the Battelle Developmental Inventory 2nd Edition, and gait parameters were measured using a computerized gait analysis system prestudy and poststudy. The DD group took part in 15 sessions of HPOT, and the control (CON) group did not participate in any equine activities. Read More

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Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study.

Front Neurol 2021 10;12:636668. Epub 2021 Mar 10.

Department of Pathology, Harvard School of Medicine, Boston Children's Hospital, Boston, MA, United States.

Pre-natal exposures to nicotine and alcohol are known risk factors for sudden infant death syndrome (SIDS), the leading cause of post-neonatal infant mortality. Here, we present data on nicotinic receptor binding, as determined by I-epibatidine receptor autoradiography, in the brainstems of infants dying of SIDS and of other known causes of death collected from the Safe Passage Study, a prospective, multicenter study with clinical sites in Cape Town, South Africa and 5 United States sites, including 2 American Indian Reservations. We examined 15 pons and medulla regions related to cardiovascular control and arousal in infants dying of SIDS ( = 12) and infants dying from known causes ( = 20, 10 pre-discharge from time of birth, 10 post-discharge). Read More

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Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis.

J Hepatol 2021 Mar 24. Epub 2021 Mar 24.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246 Germany; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg 20246 Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg 20246 Germany. Electronic address:

Background And Aims: Little is known on the composition of intrahepatic immune cells and their contribution to the pathogenesis of primary sclerosing cholangitis (PSC). We here aimed to create an atlas of intrahepatic T cells and thereby in detail characterize T cells in human inflamed liver.

Methods: Different single-cell RNA sequencing methods were combined with in silico analyses on intrahepatic and peripheral T cells from patients with PSC (n=11) and healthy donors (HD, n=4). Read More

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Carvedilol and Exercise Combination Therapy Improves Systolic but not Diastolic Function and Reduces Plasma Osteopontin in Col4a3-/- Mice.

Am J Physiol Heart Circ Physiol 2021 Mar 26. Epub 2021 Mar 26.

Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA; Peggy and Harold Katz Family Drug Discovery Center, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States.

There are currently no FDA-approved treatments for heart failure with preserved ejection fraction (HFpEF). Here we compared the effects of exercise with and without α/β-adrenergic blockade with carvedilol in Col4a3 Alport mice, a model of the Phenogroup 3 subclass of HFpEF with underlying renal dysfunction. Alport mice were assigned to the following groups: no treatment control (n=29), carvedilol (n=11), voluntary exercise (n=9), combination carvedilol and exercise (n=8). Read More

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Contemporary outcomes of the Foker process and evolution of treatment algorithms for long-gap Esophageal Atresia.

J Pediatr Surg 2021 Feb 26. Epub 2021 Feb 26.

Boston Children's Hospital, Department of General Surgery; Johns Hopkins All Children's Hospital, Department of Surgery.

Background: Esophageal growth using the Foker process (FP) for long-gap esophageal atresia (LGEA) has evolved over time.

Methods: Contemporary LGEA patients treated from 2014-2020 were compared to historical controls (2005 to <2014).

Results: 102 contemporary LGEA patients (type A 50%, B 18%, C 32%; 36% prior anastomotic attempt; 20 with esophagostomy) underwent either primary repair (n=23), jejunal interposition (JI; n = 14), or Foker process (FP; n = 65; 49 primary [p], 16 rescue [r]). Read More

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February 2021

Effect of non-invasive brain stimulation on behavior and serum brain-derived neurotrophic factor and insulin-like growth factor-1 levels in autistic patients.

Drug Dev Res 2021 Mar 18. Epub 2021 Mar 18.

Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Aberrant neural connectivity and intra-cortical inhibitory dysfunction are key features of autism. Non-invasive brain stimulation (NIBS) protocols have been proposed that modulate this aberrant plasticity. However, additional investigations are needed to evaluate the impact of this intervention on biological biomarkers of the disease. Read More

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Prehabilitation with wearables versus standard of care before major abdominal cancer surgery: a randomised controlled pilot study (trial registration: NCT04047524).

Surg Endosc 2021 Mar 15. Epub 2021 Mar 15.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Background: Prehabilitation aims to improve post-operative outcomes by enhancing pre-operative fitness but is labour-intensive. This pilot study aimed to assess the efficacy of a tri-modal prehabilitation programme delivered by smartwatches for improving functional fitness prior to major abdominal cancer surgery.

Methods: A single-centre, randomised controlled pilot study, in which 22 patients were randomised to: (a) a prehabilitation group (n = 11), comprising of home-based exercise, nutritional, and dietary advice delivered using a wrist-worn smartwatch connected to a smartphone application; or (b) a control group (n = 11) receiving usual care, with patients given a smartwatch as a placebo. Read More

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Effectiveness of psychosocial interventions for reducing parental substance misuse.

Cochrane Database Syst Rev 2021 03 16;3:CD012823. Epub 2021 Mar 16.

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Background: Parental substance use is a substantial public health and safeguarding concern. There have been a number of trials of interventions relating to substance-using parents that have sought to address this risk factor, with potential outcomes for parent and child.

Objectives: To assess the effectiveness of psychosocial interventions in reducing parental substance use (alcohol and/or illicit drugs, excluding tobacco). Read More

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Non-contrast myocardial T1 global and regional reference values at 3 Tesla cardiac magnetic resonance in aortic stenosis.

Arch Cardiovasc Dis 2021 Mar 11. Epub 2021 Mar 11.

Monaco cardiothoracic centre, 11 bis, avenue d'Ostende, 98000 MC, Monaco. Electronic address:

Background: T1 mapping using cardiac magnetic resonance (CMR) was recently proposed as a promising non-contrast imaging technique for the assessment of diffuse myocardial fibrosis (MF) in aortic stenosis (AS).

Aims: To provide reference values for native T1 mapping at 3 Tesla magnetic field strength in subjects with moderate or severe AS and in control subjects; to identify factors associated with the presence of diffuse MF in severe AS; to assess the regional distribution of diffuse MF; and to compare the level of diffuse MF in the different types of AS, stratified by flow and gradient patterns.

Methods: Retrospective study based on 160 consecutive patients with moderate (n=11) to severe (n=149) AS and 47 control subjects referred for CMR. Read More

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Circulating extracellular vesicles induce monocyte dysfunction and are associated with sepsis and high mortality in cirrhosis.

Liver Int 2021 Mar 13. Epub 2021 Mar 13.

Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Sepsis is common in cirrhosis and is often a result of immune dysregulation. Specific stimuli and pathways of inter-cellular communications between immune cells in cirrhosis and sepsis are incompletely understood. Immune cell-derived extracellular vesicles (EV) were studied to understand mechanisms of sepsis in cirrhosis. Read More

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Olfactory dysfunction in patients with cluster headache.

Eur Arch Otorhinolaryngol 2021 Mar 13. Epub 2021 Mar 13.

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: Cluster headache (CH) is a primary headache characterized by strictly unilateral, short-lasting severe headache attacks accompanied by at least one ipsilateral autonomic symptom. Our study aimed to determine whether CH patients had olfactory dysfunction and to correlate it with clinical characteristics.

Materials And Methods: Twenty patients and 57 healthy volunteers were included in the study. Read More

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Redistribution of brain glucose metabolism in people with HIV after antiretroviral therapy initiation.

AIDS 2021 Mar 11. Epub 2021 Mar 11.

Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA Laboratory of Immunoregulation, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Section of Infections of the Nervous System, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA.

Objective: We evaluated brain glucose metabolism in people living with HIV (PLWH) with [18F]-Fluoro-Deoxyglucose (FDG) PET/CT before and after antiretroviral therapy (ART) initiation.Design: We conducted a longitudinal study where ART-naïve late-presenting untreated PLWH with CD4 counts < 100 cells/uL were prospectively assessed for FDG uptake at baseline and at 4-8 weeks (n=22) and 19-26 months (n = 11) following ART initiation.

Methods: Relative uptake in the subcortical regions (caudate, putamen and thalamus) and cortical regions (frontal, parietal, temporal, and occipital cortices) were compared across time and correlated with biomarkers of disease activity and inflammation, in addition to being compared to a group of uninfected individuals (n = 10). Read More

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Downregulated IRF8 in Monocytes and Macrophages of Patients with Systemic Sclerosis May Aggravate the Fibrotic Phenotype.

J Invest Dermatol 2021 Mar 9. Epub 2021 Mar 9.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Monocytes and macrophages may be involved in the pathogenesis of systemic sclerosis (SSc); however, the etiology and regulation of monocyte and macrophage function in SSc remain unknown. IRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage phenotypes in SSc fibrosis. In this study, we measured IRF8 levels in circulating monocytes of 26 patients with SSc (diffuse cutaneous SSc, n = 11; limited cutaneous SSc, n = 15) and 14 healthy controls. Read More

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Bone quality analysis of jaw bones in individuals with type 2 diabetes mellitus-post mortem anatomical and microstructural evaluation.

Clin Oral Investig 2021 Mar 11. Epub 2021 Mar 11.

Laboratory for Anthropology and Skeletal Biology, Institute for Anatomy, School of Medicine, University of Belgrade, Dr Subotica starijeg 4, Belgrade, 11000, Serbia.

Objectives: With the higher risk of dental implant failure with type 2 diabetes mellitus (T2DM), there is a need to characterize the jaw bones in those individuals. The aim of this post mortem study was to compare jaw bone quality of individuals with T2DM to healthy controls.

Material And Methods: Bone cores from the edentulous lower first molar region and the region of mandibular angle were collected from male individuals with T2DM (n = 10, 70. Read More

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Plasma checkpoint protein levels and galectin-9 in juvenile systemic lupus erythematosus.

Lupus 2021 May 10;30(6):998-1004. Epub 2021 Mar 10.

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.

SLE is a disease of the adaptive immune system where T lymphocyte dysfunction has an important role as well. We assessed the plasma levels of checkpoint receptors expressed on T cells, along with Galectin-9 to reflect type-1 IFN activity and IL-2Rα in childhood SLE patients. Forty-nine children with SLE and15 healthy controls were included. Read More

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Body Composition, Energy Availability, Training, and Menstrual Status in Female Runners.

Int J Sports Physiol Perform 2021 Mar 9:1-6. Epub 2021 Mar 9.

Purpose: To determine body composition, energy availability, training load, and menstrual status in young elite endurance running athletes (ATH) over 1 year, and in a secondary analysis, to investigate how these factors differ between nonrunning controls (CON), and amenorrheic (AME) and eumenorrheic (EUM) ATH. Correlations to injury, illness, and performance were also examined.

Methods: Altogether 13 ATH and 8 CON completed the Low Energy Availability in Females Questionnaire. Read More

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