43,764 results match your criteria controlled vocabulary


Development of the International Classification of Diseases Ontology (ICDO) and its application for COVID-19 diagnostic data analysis.

BMC Bioinformatics 2021 Oct 18;22(Suppl 6):508. Epub 2021 Oct 18.

University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Background: The 10th and 9th revisions of the International Statistical Classification of Diseases and Related Health Problems (ICD10 and ICD9) have been adopted worldwide as a well-recognized norm to share codes for diseases, signs and symptoms, abnormal findings, etc. The international Consortium for Clinical Characterization of COVID-19 by EHR (4CE) website stores diagnosis COVID-19 disease data using ICD10 and ICD9 codes. However, the ICD systems are difficult to decode due to their many shortcomings, which can be addressed using ontology. Read More

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October 2021

Why do early mathematics skills predict later mathematics and reading achievement? The role of executive function.

J Exp Child Psychol 2021 Oct 13;214:105306. Epub 2021 Oct 13.

Norwegian Centre for Learning Environment and Behavioural Research in Education, University of Stavanger, 4036 Stavanger, Norway.

A robust association between young children's early mathematical proficiency and later academic achievement is well established. Less is known about the mechanisms through which early mathematics skills may contribute to later mathematics and especially reading achievement. Using a parallel multiple mediator model, the current study investigated whether executive function (integration of working memory, inhibition, and cognitive flexibility) can explain the relations between early mathematics skills and elementary school mathematics and reading achievement. Read More

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October 2021

Effectiveness and Safety of Dabigatran Compared to Vitamin K Antagonists in Non-Asian Patients with Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Clin Drug Investig 2021 Oct 13. Epub 2021 Oct 13.

Grup de Recerca d'Epidemiologia Clínica i Serveis Sanitaris, Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain.

Background And Objective: Real-life data about the use of dabigatran in patients with non-valvular atrial fibrillation are warranted. The objective of this systematic review and meta-analysis was to assess the effectiveness and safety of dabigatran, globally and stratified by dose (110/150 mg twice daily), vs vitamin K antagonists in non-Asian patients with non-valvular atrial fibrillation from "real-world" studies.

Methods: A systematic review was performed according to Cochrane methodological standards. Read More

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October 2021

O-JMeSH: creating a bilingual English-Japanese controlled vocabulary of MeSH UIDs through machine translation and mutual information.

Genomics Inform 2021 Sep 30;19(3):e26. Epub 2021 Sep 30.

Graduate School of Integrative Science and Engineering, Tokyo City University, Tokyo 158-8557, Japan.

Previous approaches to create a controlled vocabulary for Japanese have resorted to existing bilingual dictionary and transformation rules to allow such mappings. However, given the possible new terms introduced due to coronavirus disease 2019 (COVID-19) and the emphasis on respiratory and infection-related terms, coverage might not be guaranteed. We propose creating a Japanese bilingual controlled vocabulary based on MeSH terms assigned to COVID-19 related publications in this work. Read More

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September 2021

Visualizing diversity: the Oregon Health & Science University Educational Use Photo Diversity Repository.

J Med Libr Assoc 2021 Jul;109(3):472-477

Associate Professor, OHSU School of Nursing, Oregon Health & Science University, Portland, OR.

Background: Health science education needs images that represent both the diversity of patients served and the diversity of its students and clinicians. To begin to address this need, a nurse educator and librarian collaborated to launch the Oregon Health & Science University (OHSU) Educational Use Photo Diversity Repository. This online resource provides educators of health professional students with access to photos of pathophysiological conditions in skin of various colors so their students can increase their awareness of issues related to health and diversity and prepare themselves for more effective clinical work with their future patients. Read More

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Performance of conceptual framework elements for the retrieval of qualitative health literature: a case study.

J Med Libr Assoc 2021 Jul;109(3):388-394

University of Southern Denmark, Denmark.

Objective: A growing volume of studies address methods for performing systematic reviews of qualitative studies. One such methodological aspect is the conceptual framework used to structure the review question and plan the search strategy for locating relevant studies. The purpose of this case study was to evaluate the retrieval potential of each element of conceptual frameworks in qualitative systematic reviews in the health sciences. Read More

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Hsp90-associated DNA replication checkpoint protein and proteasome-subunit components are involved in the age-related macular degeneration.

Chin Med J (Engl) 2021 Sep 20;134(19):2322-2332. Epub 2021 Sep 20.

Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China.

Background: Age-related macular degeneration (AMD) is the leading cause of vision loss worldwide. However, the mechanisms involved in the development and progression of AMD are poorly delineated. We aimed to explore the critical genes involved in the progression of AMD. Read More

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September 2021

The politics of scaling.

Soc Stud Sci 2021 Oct 8:3063127211048945. Epub 2021 Oct 8.

University College London, London, UK.

A fixation on 'scaling up' has captured current innovation discourses and, with it, political and economic life at large. Perhaps most visible in the rise of platform technologies, big data and concerns about a new era of monopolies, scalability thinking has also permeated public policy in the search for solutions to 'grand societal challenges', 'mission-oriented innovation' or transformations through experimental 'living labs'. In this paper, we explore this scalability zeitgeist as a key ordering logic of current initiatives in innovation and public policy. Read More

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October 2021

Evaluating the effect of an in-service training workshop on ICD-10 coding instructions of pregnancy, childbirth and the puerperium for clinical coders.

J Med Life 2021 Jul-Aug;14(4):565-569

Department of Health Information Technology and Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The quality of the data coded based on the 10 revision of the International Classification of Diseases (ICD-10) can be improved by providing continuous education and promoting the clinical coders' knowledge and skills. Due to the significance of maternal health in promoting the health of society, the present study evaluated the effects of an in-service training workshop on ICD-10 coding instructions of pregnancy, childbirth, and the puerperium for clinical coders. This applied evaluation study was conducted to evaluate the effects of a coding instructions training course focusing on the 15 chapter of the ICD-10. Read More

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October 2021

Teaching Medical Students How to Teach: A Scoping Review.

Teach Learn Med 2021 Oct 7:1-13. Epub 2021 Oct 7.

Center for Health Professions Education, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Phenomenon: Teaching medical students how to teach is a growing and essential focus of medical education, which has given rise to student teaching programs. Educating medical students on how to teach can improve their own learning and lay the foundation for a professional identity rooted in teaching. Still, medical student-as-teacher (MSAT) programs face numerous obstacles including time constraints, prioritizing curriculum, and determining effective evaluation techniques. Read More

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October 2021

Shifting parental beliefs about child development to foster parental investments and improve school readiness outcomes.

Nat Commun 2021 10 1;12(1):5765. Epub 2021 Oct 1.

Department of Surgery, University of Chicago Medicine, 5841 S. Maryland Avenue, Chicago, IL, 60637, USA.

Socioeconomic gaps in child development open up early, with associated disparities in parental investments in children. Understanding the drivers of these disparities is key to designing effective policies. We first show that parental beliefs about the impact of early parental investments differ across socioeconomic status (SES), with parents of higher SES being more likely to believe that parental investments impact child development. Read More

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October 2021

Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation.

Dis Markers 2021 22;2021:4129993. Epub 2021 Sep 22.

The First Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Hyperinflammation is related to the development of COVID-19. Resveratrol is considered an anti-inflammatory and antiviral agent. Herein, we used a network pharmacological approach and bioinformatic gene analysis to explore the pharmacological mechanism of Resveratrol in COVID-19 therapy. Read More

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October 2021

Predicting metabolic pathway membership with deep neural networks by integrating sequential and ontology information.

BMC Genomics 2021 Sep 27;22(Suppl 4):691. Epub 2021 Sep 27.

University of Delaware, Computer and Information Sciences, 101 Smith Hall, Newark, 19716, DE, US.

Background: Inference of protein's membership in metabolic pathways has become an important task in functional annotation of protein. The membership information can provide valuable context to the basic functional annotation and also aid reconstruction of incomplete pathways. Previous works have shown success of inference by using various similarity measures of gene ontology. Read More

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September 2021

Identification of Sperm Antigens for Immune Contraceptive Purposes.

Int J Mol Sci 2021 Sep 15;22(18). Epub 2021 Sep 15.

UMR GReD Institute (Génétique Reproduction & Développement) CNRS 6293, INSERM U1103, Equipe «Mécanismes de L'infertilité Mâle Post-Testiculaire», Université Clermont Auvergne, 63000 Clermont-Ferrand, France.

The cyclical proliferation of the wild fossorial rodent () is critical in mid-mountain ecosystems of several European countries. Our goal is to develop an immunocontraceptive vaccine to control their fertility, as a sustainable alternative to chemical poisons currently used. Indeed, these chemicals cause the death of predators and animals sharing their ecosystem, and current laws progressively limit their use, making the development of a targeted vaccination strategy an interesting and efficient alternative. Read More

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September 2021

Serum-Derived Neuronal Exosomal miRNAs as Biomarkers of Acute Severe Stress.

Int J Mol Sci 2021 Sep 15;22(18). Epub 2021 Sep 15.

Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu 41944, Korea.

Stress is the physical and psychological tension felt by an individual while adapting to difficult situations. Stress is known to alter the expression of stress hormones and cause neuroinflammation in the brain. In this study, miRNAs in serum-derived neuronal exosomes (nEVs) were analyzed to determine whether differentially expressed miRNAs could be used as biomarkers of acute stress. Read More

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September 2021

Deep Sequencing Discovery and Profiling of Known and Novel miRNAs Produced in Response to DNA Damage in Rice.

Int J Mol Sci 2021 Sep 15;22(18). Epub 2021 Sep 15.

Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Jiangsu Key Laboratory of Crop Genetics and Physiology/Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Agricultural College of Yangzhou University, Yangzhou 225009, China.

Under extreme environmental conditions such as ultraviolet and ionizing radiation, plants may suffer DNA damage. If these damages are not repaired accurately and rapidly, they may lead to chromosomal abnormalities or even cell death. Therefore, organisms have evolved various DNA repair mechanisms to cope with DNA damage which include gene transcription and post-translational regulation. Read More

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September 2021

Concurrent Associations between Expressive Language Ability and Independence in Adolescents and Adults with Fragile X Syndrome.

Brain Sci 2021 Sep 8;11(9). Epub 2021 Sep 8.

MIND Institute & Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95817, USA.

Background: Few individuals with fragile X syndrome (FXS) successfully meet adult normative expectations in education, employment, peer relations, and habitation, although there is within-syndrome variability in this regard. The primary goal of this study was to determine whether expressive language skills contribute to the capacity for independent functioning in adulthood even after controlling for nonverbal cognitive ability.

Methods: Participants were 18- to 23-year-olds with FXS. Read More

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September 2021

Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse.

Cells 2021 09 9;10(9). Epub 2021 Sep 9.

Institute of Neurobiology, Ulm University, 89081 Ulm, Germany.

The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of transcripts associated with the beige adipogenesis program. This was an unexpected finding, as thermogenic BAT was believed to be the only site of nonshivering thermogenesis in the young mouse. Read More

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September 2021

Affective Disorders in Complex Disabilities: Strategies Empowerment for Improving the Lifestyle of the Disabled Person.

Psychiatr Danub 2021 Sep;33(Suppl 9):80-83

Serafico Institute, Viale Guglielmo Marconi, 6, 06081, Assisi, Italy,

The concept of physical and intellectual disability has experienced a series of changes and evolutions over time with regard to approach, classification and rehabilitation-therapeutic programs, since it contemplates a heterogeneous clinical phenomenology in terms of severity, complexity, pervasiveness and severity of the diagnosis. The significant repercussions on the quality of life mean that a comprehensive approach is required with attention to the physical, social, emotional, sensory and cognitive profile, and that there is a need for the adoption of classification systems and assessment tools that are different and in some ways pioneering, so as to guarantee the surpassing of the concept of disability as a "mere defect" physical and/or impairment and/or loss of psychological, physiological or anatomical function (Holden & Gitlesen 2003, Linden 2017, WHO 2001). It is exactly in contemplation of a bio-psycho-social model, that the International Classification of Functioning, Disability and Health (ICF) arises, which possesses a neutral position with respect to etiology and a complementarity with the ICD-10 classification (WHO 2001), since it allows the functional diagnosis (i. Read More

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September 2021

Does Post-Traumatic Spectrum Comorbidity Influence Symptom Severity in Bipolar Disorders? A Cross-Sectional Study in a Real-World Setting.

Psychiatr Danub 2021 Sep;33(Suppl 9):41-46

Department of Psychiatry, University of Perugia, Piazzale Lucio Severi, 1, 06132, S. Andrea delle Fratte, Perugia, Italy.

Background: The present cross-sectional study investigates the relationship between post-traumatic spectrum comorbidity and the severity of symptoms in subjects diagnosed with Bipolar Disorders (BD).

Subjects And Methods: In- and outpatients diagnosed with BD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) were consecutively recruited. Sociodemographic and clinical data were collected. Read More

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September 2021

The DSM-5 introduction of the Social (Pragmatic) Communication Disorder as a new mental disorder: a philosophical review.

Hist Philos Life Sci 2021 Sep 24;43(4):108. Epub 2021 Sep 24.

Department of Classics, Philosophy and History (DAFIST), Philosophy Section, University of Genoa, Via Balbi 4, 16126, Genoa, Italy.

The latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) included the Social (Pragmatic) Communication Disorder (SPCD) as a new mental disorder characterized by deficits in pragmatic abilities. Although the introduction of SPCD in the psychiatry nosography depended on a variety of reasons-including bridging a nosological gap in the macro-category of Communication Disorders-in the last few years researchers have identified major issues in such revision. For instance, the symptomatology of SPCD is notably close to that of (some forms of) Autism Spectrum Disorder (ASD). Read More

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September 2021

Deep GONet: self-explainable deep neural network based on Gene Ontology for phenotype prediction from gene expression data.

BMC Bioinformatics 2021 Sep 22;22(Suppl 10):455. Epub 2021 Sep 22.

IBISC, Univ Evry, Université Paris-Saclay, 91020, Évry-Courcouronnes, France.

Background: With the rapid advancement of genomic sequencing techniques, massive production of gene expression data is becoming possible, which prompts the development of precision medicine. Deep learning is a promising approach for phenotype prediction (clinical diagnosis, prognosis, and drug response) based on gene expression profile. Existing deep learning models are usually considered as black-boxes that provide accurate predictions but are not interpretable. Read More

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September 2021

Incident Major Depressive Disorder Predicted by Three Measures of Insulin Resistance: A Dutch Cohort Study.

Am J Psychiatry 2021 10 23;178(10):914-920. Epub 2021 Sep 23.

Department of Epidemiology and Population Health (Watson, Simard, Henderson), Department of Psychiatry and Behavioral Sciences (Watson, Nutkiewicz, Rasgon), and Department of Neurology and Neurological Sciences (Henderson), Stanford School of Medicine, Stanford, Calif.; Department of Psychiatry and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam (Lamers, Penninx); and Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York (Nasca).

Objective: Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the disorder. An important first step in this process is identifying risk factors for the incidence of major depression. Read More

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October 2021

Leveraging the Cell Ontology to classify unseen cell types.

Nat Commun 2021 09 21;12(1):5556. Epub 2021 Sep 21.

Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.

Single cell technologies are rapidly generating large amounts of data that enables us to understand biological systems at single-cell resolution. However, joint analysis of datasets generated by independent labs remains challenging due to a lack of consistent terminology to describe cell types. Here, we present OnClass, an algorithm and accompanying software for automatically classifying cells into cell types that are part of the controlled vocabulary that forms the Cell Ontology. Read More

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September 2021

Providing ART-DECOR ValueSets via FHIR Terminology Servers - A Technical Report.

Stud Health Technol Inform 2021 Sep;283:127-135

Institute of Medical Informatics, University of Lübeck, Lübeck, Germany.

To ensure semantic interoperability within healthcare systems, using common, curated terminological systems to identify relevant concepts is of fundamental importance. The HL7 FHIR standard specifies means of modelling terminological systems and appropriate ways of accessing and querying these artefacts within a terminology server. Hence, initiatives towards healthcare interoperability like IHE specify not only software interfaces, but also common codes in the form of value sets and code systems. Read More

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September 2021

Hub Genes and Key Pathways of Intervertebral Disc Degeneration: Bioinformatics Analysis and Validation.

Biomed Res Int 2021 10;2021:5340449. Epub 2021 Sep 10.

College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan 430061, China.

Objective: To identify significant pathways and genes in intervertebral disc degeneration (IDD) based on bioinformatics analysis.

Design: The GEO database was used to download the GSE124272 dataset. Differentially expressed genes (DEGs) were analyzed using Limma package in R language. Read More

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September 2021

Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma.

Nat Commun 2021 09 20;12(1):5531. Epub 2021 Sep 20.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial radiation therapy. We performed DNA methylation profiling, RNA-seq, and DNA sequencing on 32 RIG tumors and an in vitro drug screen in two RIG cell lines. We report that based on DNA methylation, RIGs cluster primarily with the pediatric receptor tyrosine kinase I high-grade glioma subtype. Read More

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September 2021

Multidimensional Analyses of Tumor Immune Microenvironment Reveal the Possible Rationality of Immunotherapy and Identify High Immunotherapy Response Subtypes for Renal Papillary Cell Carcinoma.

Front Immunol 2021 31;12:657951. Epub 2021 Aug 31.

Department of Urology, The First Hospital of China Medical University, Shenyang, China.

Kidney renal papillary cell carcinoma (KIRP), the second most common subtype of renal cell carcinoma, still lacks effective treatment regimens for individualized immunotherapy because of the heterogeneity of its elusive immune microenvironment. Therefore, we aimed to comprehensively evaluate the immune microenvironment of KIRP by using the computational biology strategy to analyze the expression profile data of 289 KIRP patients obtained from The Cancer Genome Atlas database. Based on multidimensional, multi-omics bioinformatics analysis, we found that the tumor of patients with KIRP exhibited "hot" tumor characteristics but the CD8+ T cells in the tumor tissues did not limit tumor progression. Read More

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October 2021

The biogeographic differentiation of algal microbiomes in the upper ocean from pole to pole.

Nat Commun 2021 09 16;12(1):5483. Epub 2021 Sep 16.

U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Eukaryotic phytoplankton are responsible for at least 20% of annual global carbon fixation. Their diversity and activity are shaped by interactions with prokaryotes as part of complex microbiomes. Although differences in their local species diversity have been estimated, we still have a limited understanding of environmental conditions responsible for compositional differences between local species communities on a large scale from pole to pole. Read More

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September 2021