Mult Scler Relat Disord 2021 Jul 21;55:103159. Epub 2021 Jul 21.
Division of Neurology, Department of Medicine, St. Michael\220s Hospital, University of Toronto, ON M5B 1W8, Canada. Electronic address:
Background: Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of adenosine triphosphate (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials.
Methods: We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials. Read More