338,275 results match your criteria controlled trials


High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials.

Mult Scler Relat Disord 2021 Jul 21;55:103159. Epub 2021 Jul 21.

Division of Neurology, Department of Medicine, St. Michael\220s Hospital, University of Toronto, ON M5B 1W8, Canada. Electronic address:

Background: Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of adenosine triphosphate (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials.

Methods: We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials. Read More

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The choice of biologics in patients with severe chronic rhinosinusitis with nasal polyps.

J Allergy Clin Immunol Pract 2021 Jul 28. Epub 2021 Jul 28.

Tayside Rhinology Mega-clinic, & Scottish Centre for Respiratory Research, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, Scotland, UK.

Patients with severe CRSwNP represent an unmet clinical need in terms of recurrent disease despite current medical and surgical therapy. Targeting type 2 inflammatory cytokines (IL4/5/13) appears to be a promising therapeutic approach for such patients akin to what has already been seen in severe asthma. An indirect comparison from Phase 3 placebo controlled trials have shown relative improvements in the co-primary end point of nasal polyp score ranging from a 15% reduction (-0. Read More

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A randomized crossover trial of HEPA air filtration to reduce cardiovascular risk for near highway residents: Methods and approach.

Contemp Clin Trials 2021 Jul 28:106520. Epub 2021 Jul 28.

Department of Public Health and Community Medicine, Tufts University, Boston, MA 02111, United States of America.

Background: Near highway residents are exposed to elevated levels of traffic-related air pollution (TRAP), including ultrafine particles, which are associated with adverse health effects. The efficacy of using in-home air filtration units that reduce exposure and potentially yield health benefits has not been tested in a randomized controlled trial.

Methods: We will conduct a randomized double-blind crossover trial of portable air filtration units for 200 adults 30 years and older who live in near-highway homes in Somerville, MA, USA. Read More

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Accelerated theta burst stimulation for the treatment of depression: A randomised controlled trial.

Brain Stimul 2021 Jul 28. Epub 2021 Jul 28.

Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Department of Psychiatry, Monash University, Camberwell, Victoria, Australia.

Introduction: Theta burst pattern repetitive transcranial magnetic stimulation (TBS) is increasingly applied to treat depression. TBS's brevity is well-suited to application in accelerated schedules. Sizeable trials of accelerated TBS are lacking; and optimal TBS parameters such as stimulation intensity are not established. Read More

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Efficacy of chemoprophylaxis and immunoprophylaxis in leprosy prevention: a systematic review and network meta-analysis of randomized controlled trials.

Clin Microbiol Infect 2021 Jul 28. Epub 2021 Jul 28.

Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam; Institute of Tropical Medicine (NEKKEN), School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8523, Japan. Electronic address:

Background: Vaccination and single-dose rifampin are the main proven effective intervention types for preventing leprosy among contacts of Mycobacterium leprae endemic areas. Currently, no high-quality evidence is available regarding the best prophylactic intervention.

Objectives: Our primary study aim is to detect the most effective prophylactic intervention for the prevention of leprosy. Read More

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Use of prophylactic mesh during initial stoma creation to prevent parastomal herniation: a systematic review and meta-analysis of randomised controlled trials.

Colorectal Dis 2021 Jul 31. Epub 2021 Jul 31.

Royal Devon & Exeter Hospital, Royal Devon & Exeter NHS Foundation Trust, Exeter, UK.

Background: Parastomal hernia (PSH) is a common complication following stoma creation. Previous reviews found mesh reinforcement during initial stoma creation beneficial in reducing PSH incidence. Since then, several multicentre randomised controlled trials (RCTs) produced widely ranging results rendering previous findings debatable. Read More

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Curcumin for the Treatment of Prostate Diseases: A Systematic Review of Controlled Clinical Trials.

Adv Exp Med Biol 2021 ;1291:345-362

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Prostate cancer is one of the significant causes of morbidity and mortality worldwide. Benign prostatic hyperplasia is another condition of the prostate which, like prostate cancer, is more common among ageing men and is linked to inflammation. In this study, a systematic review was undertaken to estimate the effect of turmeric or curcumin supplementation on prostate diseases. Read More

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January 2021

The Use of Curcumin for the Treatment of Renal Disorders: A Systematic Review of Randomized Controlled Trials.

Adv Exp Med Biol 2021 ;1291:327-343

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Chronic kidney disease (CKD) is one of the significant causes of morbidity and mortality worldwide, which could develop and progress to end-stage renal disease. Increased inflammation and reduced antioxidant capacity commonly occur in CKD and hemodialysis patients. Curcumin is a natural bioactive compound with antioxidant and anti-inflammatory properties. Read More

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January 2021

A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.

Adv Exp Med Biol 2021 ;1291:295-326

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Gastrointestinal (GI) diseases are highly prevalent worldwide, with considerable morbidity and mortality. Curcumin has been used for many years as a plant-derived product for the management of various conditions such as abdominal pain and poor digestion. This systematic review was undertaken with the aim of investigating the effect of curcumin or turmeric supplementation on GI diseases. Read More

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January 2021

A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis.

Adv Exp Med Biol 2021 ;1291:265-282

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Osteoarthritis is characterized by degeneration of joint structure over time, resulting in limitation of joint mobility. There is growing evidence that curcumin has anti-inflammatory properties and could be a potential therapeutic option for chronic inflammatory diseases. Hence, curcumin could potentially have a positive impact on osteoarthritis symptoms. Read More

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January 2021

Does Curcumin Have an Anticaries Effect? A Systematic Review of In Vitro Studies.

Adv Exp Med Biol 2021 ;1291:213-227

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Dental caries is one of the most important oral health problems and a common infectious microbial disease. Streptococcus mutans (S. mutans) has been regarded as the primary etiologic factor in the formation of dental caries. Read More

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January 2021

The Effect of Curcumin in Improving Lipid Profile in Patients with Cardiovascular Risk Factors: A Systematic Review of Clinical Trials.

Adv Exp Med Biol 2021 ;1291:165-177

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Cardiovascular disease (CVD) is a major cause of death worldwide. Lipid abnormalities are one of the major risk factors for CVD. Curcumin is a natural polyphenol with lipid-lowering properties. Read More

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January 2021

The Effect of Curcumin Supplemsentation on Anthropometric Indices in Overweight and Obese Individuals: A Systematic Review of Randomized Controlled Trials.

Adv Exp Med Biol 2021 ;1291:121-137

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Curcumin is an active molecule present in turmeric and is the main therapeutic compound. There is growing evidence that curcumin could affect various anthropometric indices. We performed a systematic review to evaluate the efficacy of curcumin supplementation on anthropometric indices in obese and overweight individuals. Read More

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January 2021

Impact of Daridorexant, a Dual Orexin Receptor Antagonist, on Cardiac Repolarization Following Bedtime Dosing: Results from a Thorough QT Study Using Concentration-QT Analysis.

Clin Drug Investig 2021 Jul 31. Epub 2021 Jul 31.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland.

Background And Objective: Daridorexant is a new dual orexin receptor antagonist currently in late-stage clinical development for the treatment of insomnia. This randomized, double-blind, placebo-controlled, four-period crossover study investigated the effect of daridorexant at a therapeutic and supratherapeutic dose on QT interval duration.

Methods: Thirty-six healthy subjects received single oral doses of daridorexant (50 mg; 200 mg), moxifloxacin (400 mg; open label), and placebo. Read More

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Efficacy and safety of remdesivir in hospitalised COVID-19 patients: a systematic review and meta-analysis.

Infection 2021 Jul 31. Epub 2021 Jul 31.

School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia.

Purpose: This review was aimed to synthesise the best available evidence on the effectiveness and safety of remdesivir in the treatment of moderate to severe COVID-19.

Method: Randomised controlled trials (RCTs) and observational studies reporting the effectiveness and safety of remdesivir were searched via databases and other sources from December 2019 to December 2020. Two independent reviewers performed literature screening, data extraction and assessment of risk bias. Read More

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Statins and cognitive decline in the Cardiovascular Health Study: A comparison of different analytical approaches.

J Gerontol A Biol Sci Med Sci 2021 Jul 31. Epub 2021 Jul 31.

Department of Epidemiology and Population Health, Stanford University, Stanford, CA.

Background: Despite their well-established benefits for the prevention of cardiovascular disease, robust evidence on the effects of statins on cognition is largely inconclusive. We apply various study designs and analytical approaches to mimic randomized controlled trial (RCT) effects from observational data.

Methods: We used observational data from 5,580 participants enrolled in the Cardiovascular Health Study from 1989/90 to 1999/2000. Read More

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Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.

Pediatr Blood Cancer 2021 Jul 31:e29237. Epub 2021 Jul 31.

University Hospital Southampton NHS Foundation Trust, Southampton, UK.

There is increasing recognition that contralateral metachronous tumor may occur following treatment of unilateral mature ovarian teratoma. We aimed to define this risk to guide appropriate surveillance strategies. We undertook a systematic review of three large medical databases (Ovid Medline, Embase, and Cochrane Controlled Trials Register) to April 2020 using a defined search strategy. Read More

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FALL PREVENTION EDUCATION TO REDUCE FALL RISK AMONG COMMUNITY-DWELLING OLDER PERSONS: A SYSTEMATIC REVIEW.

J Nurs Manag 2021 Jul 31. Epub 2021 Jul 31.

Department of Sport Studies, Faculty of Educational Studies, Universiti Putra, Malaysia, Serdang, Selangor.

Objectives: This review aims to identify types of the existing fall prevention education and their effectiveness in promoting fall risk awareness, knowledge and preventive fall behaviour change among community-dwelling older people.

Background: Fall prevention education is a cost-effective and helpful tool for reducing fall occurrences.

Evaluation: This is a systematic review study using electronic searches via EBSCOHost® platform, ScienceDirect, Scopus and Google Scholar in March 2021. Read More

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The effects of resistance training on children with burns: a meta-analysis.

Pediatr Surg Int 2021 Jul 30. Epub 2021 Jul 30.

Department of Orthopedics, The Children's Hospital of Chongqing Medical University, 136 Zhongshan Second Road, Yuzhong District, Chongqing, 400014, China.

Aim: The aim of this study was to evaluate effectiveness and safety of resistance training (RT). Data were retrieved from Medline, EMBASE, PubMed, CINAHL and Cochrane Central Register of Controlled Trials (Central) databases from inception to April 2020. Quantitative studies on RT for muscle strength, lean body mass, cardiopulmonary function, metabolism, quality of life, and pain in burned children were included in this study. Read More

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Differential Impact of Home Nurse Contact After Discharge by Financial Strain, Primary Care Access, and Medical Complexity.

Hosp Pediatr 2021 Jul 30. Epub 2021 Jul 30.

James M. Anderson Center for Health System Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: The Hospital to Home Outcomes (H2O) trials examined the effectiveness of postdischarge nurse support on reuse after pediatric discharge. Unexpectedly, children randomly assigned to a nurse visit had higher rates of reuse than those in the control group. Participants in randomized control trials are heterogeneous. Read More

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Gabapentin in Infants: Critical Evaluation of a Novel Sedative/Analgesic Medication.

Neonatal Netw 2021 Jul;40(4):267-272

Chronic pain and agitation can complicate the clinical course of critically ill infants. Randomized controlled trials of analgesia and sedation in neonatal intensive care have focused on relatively short durations of exposure. To date, clinicians have few options to treat chronic visceral pain and hyperalgesia. Read More

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Missing data in randomised controlled trials of rheumatoid arthritis drug therapy are substantial and handled inappropriately.

RMD Open 2021 Jul;7(2)

Divison of Rheumatology, Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA

Objectives: To analyse the amount, reporting and handling of missing data, approach to intention-to-treat (ITT) principle application and sensitivity analysis utilisation in randomised clinical trials (RCTs) of rheumatoid arthritis (RA). To assess the trend in such reporting 10 years apart (2006 and 2016).

Methods: Parallel group drug therapy RA RCTs with a clinical primary endpoint. Read More

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Early Postoperative Basal Insulin Therapy versus Standard of Care for the Prevention of Diabetes Mellitus after Kidney Transplantation: A Multicenter Randomized Trial.

J Am Soc Nephrol 2021 Aug;32(8):2083-2098

Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

Background: Post-transplantation diabetes mellitus (PTDM) might be preventable.

Methods: This open-label, multicenter randomized trial compared 133 kidney transplant recipients given intermediate-acting insulin isophane for postoperative afternoon glucose ≥140 mg/dl with 130 patients given short-acting insulin for fasting glucose ≥200 mg/dl (control). The primary end point was PTDM (antidiabetic treatment or oral glucose tolerance test-derived 2 hour glucose ≥200 mg/dl) at month 12 post-transplant. Read More

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Prevention of Post-Transplantation Diabetes: Small Steps, Big Opportunities.

Authors:
Adnan Sharif

J Am Soc Nephrol 2021 Aug;32(8):1833-1834

Department of Nephrology and Transplantation, Queen Elizabeth Hospital, Birmingham, United Kingdom,

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Once daily 300 mg aspirin with compression versus compression alone in patients with chronic venous leg ulcers (ASPiVLU): A randomised, double-blinded, multicentre, placebo-controlled, clinical trial.

J Tissue Viability 2021 Jul 25. Epub 2021 Jul 25.

Monash Public Health and Preventive Medicine, 553 St Kilda Road, Melbourne, VIC, 3800, Australia. Electronic address:

Aim: Venous leg ulcers are lower limb skin ulcers characterised by a cycle of healing and recurrence due to underlying chronic venous insufficiency. While compression improves healing outcomes, many ulcers do not heal. As a daily 300 mg oral dose of aspirin in conjunction with compression may improve healing outcomes, we investigated the effect of adjuvant aspirin on venous leg ulcer healing in participants already receiving compression. Read More

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In vivo study of the efficacy of bupivacaine-eluting novel soy protein wound dressings in a rat burn model.

Burns 2021 Jul 17. Epub 2021 Jul 17.

Department of Plastic and Reconstructive Surgery, Kaplan Medical Center, Rehovot, Israel.

Dealing with wound related pain is an integral part of treatment. Systemic administration of analgesic and anesthetic agents is a common solution for providing pain relief to patients but comes at a risk of severe side effects as well as addiction. To overcome these issues, research efforts were madeto provide a platform for local controlled release of pain killers. Read More

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Are implant-supported removable partial dentures a suitable treatment for partially edentulous patients? A systematic review and meta-analysis.

J Prosthet Dent 2021 Jul 27. Epub 2021 Jul 27.

Full Professor, Departament of Dental Materials and Prosthodontics, São Paulo State Univeristy (UNESP), Araçatuba Dental School, Araçatuba, São Paulo, Brazil.

Statement Of Problem: A consensus on the clinical performance of implant-supported removable partial dentures (ISRPDs) is lacking.

Purpose: The purpose of this systematic review and meta-analysis was to evaluate the clinical performance of ISRPDs in terms of the implant survival rates, marginal bone loss, and patient-reported outcome measures (PROMs).

Material And Methods: Four electronic databases (MEDLINE/PubMed, EMBASE, Web of Science, and Cochrane Library) were independently searched by 2 reviewers for articles published up to December 2020. Read More

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The effect of timing of enteral nutrition support on feeding outcomes and dysphagia in patients with head and neck cancer undergoing radiotherapy or chemoradiotherapy: A systematic review.

Clin Nutr ESPEN 2021 Aug 3;44:96-104. Epub 2021 Jun 3.

School of Human Movement and Nutrition Sciences, University of Queensland, Queensland, Australia. Electronic address:

Background & Aims: Patients with head and neck cancer (HNC) often require enteral nutrition (EN). This systematic review reports the effect of EN timing in patients with HNC undergoing curative-intent and definitive or adjuvant radiotherapy or chemoradiotherapy on tube feeding duration, tube-related complications and dysphagia.

Methods: Randomised controlled trials (RCTs) published between January 2015-April 2020 were obtained from Medline, CINAHL and Embase. Read More

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The effect of inositol supplementation on blood pressure: A systematic review and meta-analysis of randomized-controlled trials.

Clin Nutr ESPEN 2021 Aug 25;44:78-84. Epub 2021 Jun 25.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background & Aims: Potential effects of inositol supplementation on blood pressure (BP) have been examined in several interventional studies. Nevertheless, findings in this context are controversial. Therefore, the current systematic review and meta-analysis aimed to comprehensively assess the impact of inositol supplementation on BP. Read More

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