364,045 results match your criteria controlled trials

Diagnostic accuracy of urinary antigen tests for pneumococcal pneumonia among patients with acute respiratory failure suspected pneumonia: a systematic review and meta-analysis.

BMJ Open 2022 Aug 11;12(8):e057216. Epub 2022 Aug 11.

Department of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.

Background/objectives: Urinary antigen tests have been used for the rapid identification of infection in patients with pneumonia, thereby leading to earlier targeted therapy than when using conventional diagnostic culture methods. This study aimed to update the knowledge on the diagnostic accuracy of urinary antigen tests for among patients with acute respiratory failure suspected of pneumonia based on a systematic review and meta-analysis.

Methods: A systematic search was performed using MEDLINE and the Cochrane Central Register of Controlled Trials for studies published up to 3 June 2020. Read More

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Workplace interventions for cardiovascular diseases: protocol of a systematic review and meta-analysis.

BMJ Open 2022 Aug 11;12(8):e061586. Epub 2022 Aug 11.

Department of Epidemiology and Public Health, University College London Research, London, UK.

Introduction: Cardiovascular diseases (CVDs) are the number one cause of death globally, impacting on public and private sectors. Current traditional interventions to prevent CVDs are mainly provided in healthcare centres and even when they are effective, they are not enough to reduce the rising prevalence; therefore, additional strategies are needed. Evidence suggests that health interventions in the workplace supply numerous benefits improving cardiovascular risk factor profiles in individuals. Read More

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Recommendations for Systemic Lupus Erythematosus: Balancing Evidence and Eminence to Facilitate the Medical Care of a Complex Disease.

George Bertsias

Rheum Dis Clin North Am 2022 Aug 5;48(3):617-636. Epub 2022 Jul 5.

Rheumatology and Clinical Immunology, University of Crete Medical School, Heraklion 71008, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas (FORTH), Heraklion, Greece. Electronic address:

Since the first systemic lupus erythematosus (SLE) guidelines published by the American College of Rheumatology in 1999, accumulating data from observational and randomized-controlled studies, including the advent of biological agents, have stimulated the production of recommendations by various committees and task forces. Still, several areas relating to the diagnosis, treatment, and monitoring of SLE remain uncertain due to limited or inconclusive evidence, therefore emphasizing the role of expert consensus in reaching balanced and informative statements. This review outlines the most recent SLE recommendations highlighting key differences and important challenges that will also need to be considered in future updates. Read More

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Use of sequentially inoculation of Saccharomyces cerevisiae and Hanseniaspora uvarum strains isolated from honey by-products to improve and stabilize the quality of mead produced in Sicily.

Food Microbiol 2022 Oct 27;107:104064. Epub 2022 May 27.

Department of Agricultural, Food and Forest Science, University of Palermo, Viale Delle Scienze Bldg. 5, Ent. C, 90128, Palermo, Italy.

Mead is a beverage produced by alcoholic fermentation of honey-must. The starter yeasts that are commonly used for the alcoholic fermentation of honey-must are oenological Saccharomyces cerevisiae strains. The objective of the present work was, for the first time, to apply yeasts of honey by-products origin to evaluate the influences the taste-olfactory attributes of mead. Read More

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October 2022

Transversus abdominis plane block for laparoscopic colorectal surgery: A meta-analysis of randomised controlled trials.

Int J Surg 2022 Aug 8:106825. Epub 2022 Aug 8.

Evidence-based Medicine Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Research Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan; Institute of Health Policy & Management, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address:

Background: The effectiveness of transversus abdominis plane block (TAP) on pain management after laparoscopic colorectal surgery (CRS) remains unclear since the only relevant meta-analysis on this topic did not separate laparoscopic CRS from open CRS. The aim of the study was to compare the analgesic efficacy and safety of TAP with non-TAP in patients undergoing laparoscopic CRS.

Methods: Four databases were searched for randomized controlled trials (RCTs) on this topic using relevant keywords. Read More

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Effects of Virtual Reality Combined Cognitive and Physical Interventions on Cognitive Function in Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-analysis.

Ageing Res Rev 2022 Aug 8:101708. Epub 2022 Aug 8.

School of Nursing, Jilin University, Changchun 130021, China. Electronic address:

Objective: Combined cognitive and physical interventions based on virtual reality may help delay the progression of MCI to dementia or prevent dementia. However, their efficacy is less well studied compared to pharmaceutical treatments. The purpose of this review was to evaluate the effects of cognitive and physical interventions based on virtual reality on cognitive function (global cognition, memory or executive function/attention) of older adults with mild cognitive impairment. Read More

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The effect of continuation and maintenance electroconvulsive therapy on cognition: A systematic review of the literature and meta-analysis.

J Affect Disord 2022 Aug 8. Epub 2022 Aug 8.

Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada. Electronic address:

Background: Electroconvulsive therapy (ECT) is an effective treatment for depression, mania, and refractory schizophrenia. Its tolerability profile is established for acute treatment, but less is known regarding the effects of longer treatment courses, particularly on cognitive performance.

Objectives: To assess the effect of the long-term ECT on cognition. Read More

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Quality of Life in Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-Analysis.

Eur J Vasc Endovasc Surg 2022 Aug 8. Epub 2022 Aug 8.

Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom.

Objectives: To assess comparative effectiveness and temporal changes in quality of life (QOL) outcomes after revascularisation, major lower extremity amputation (MLEA), and conservative management (CM) in chronic limb-threatening ischemia (CLTI).

Data Sources: MEDLINE, EMBASE, PsycINFO, CINAHL, and WOS databases.

Review Methods: A systematic review and meta-analysis was performed on QOL measured by any QOL instrument in adult CLTI patients after open surgery (OS), endovascular intervention (EVI), MLEA, or CM. Read More

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Effects of testosterone therapy in adult males with hypogonadism and T2DM: A meta-analysis and systematic review.

Diabetes Metab Syndr 2022 Aug 1;16(8):102588. Epub 2022 Aug 1.

Medicine, Services Institute of Medical Sciences, Lahore, Lahore, Pakistan. Electronic address:

Background And Aims: Testosterone supplementation therapy (TST) is a longstanding treatment for hypogonadal men with type 2 diabetes mellitus (T2DM), even though the benefits of TST are variable among trials. This meta-analysis was done to determine the specific role of TST in hypogonadal men with T2DM.

Methods: PubMed, Embase, and Google Scholar were queried to discover eligible randomized controlled trials (RCTs) and observational studies. Read More

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A randomised, pragmatic clinical trial of ACUpuncture plus standard care versus standard care alone FOr Chemotherapy Induced peripheral Neuropathy (ACUFOCIN).

Eur J Oncol Nurs 2022 Jul 11;60:102171. Epub 2022 Jul 11.

School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK; Outreach Research & Innovation Group, Adamson House, Ground Floor, Towers Business Park, Wilmslow Road, Didsbury, M20 2YY, UK. Electronic address:

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose limiting toxicity posing a major clinical challenge for managing patients receiving specific chemotherapy regimens (e.g., Taxanes). Read More

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Forgiveness Is the Attribute of the Strong: Nonadherence and Regimen-Shortening in Drug-Sensitive TB.

Am J Respir Crit Care Med 2022 Aug 11. Epub 2022 Aug 11.

London School of Hygiene and Tropical Medicine, London, United Kingdom of Great Britain and Northern Ireland.

Rationale: 'Forgiveness' charts the ability of a drug or regimen to withstand non-adherence without negative clinical consequences.

Objectives: We aimed to determine the influence of regimen length, regimen drugs and dosing, and when during treatment non-adherence occurs on the forgiveness of anti-tuberculosis regimens.

Methods: Using data from three randomised controlled trials comparing experimental four-month regimens for drug-sensitive tuberculosis with the standard six-month regimen, we used generalised linear models to examine how the risk of a negative composite outcome changed as dose-taking decreased. Read More

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Psychological therapies for temporomandibular disorders (TMDs).

Cochrane Database Syst Rev 2022 Aug 11;8:CD013515. Epub 2022 Aug 11.

Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, New York, USA.

Background: Temporomandibular disorders (TMDs) are a group of musculoskeletal disorders affecting the jaw. They are frequently associated with pain that can be difficult to manage and may become persistent (chronic). Psychological therapies aim to support people with TMDs to manage their pain, leading to reduced pain, disability and distress. Read More

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Efficacy and treatment-related adverse events of multi-targeted tyrosine kinase inhibitors in advanced non-small-cell lung cancer: a meta-analysis of randomized controlled trials.

Int J Clin Pharm 2022 Aug 11. Epub 2022 Aug 11.

Department of Respiratory, The First Hospital Affiliated to Army Medical University, Chongqing, China.

Background: Multitargeted tyrosine kinase inhibitors (TKIs) are used to treat advanced non-small cell lung cancer (NSCLC). Their efficacy and safety have been studied in randomized controlled trials.

Aim: This meta-analysis aimed to summarize the most up-to-date evidence regarding the efficacy and adverse events of TKIs in NSCLC treatment. Read More

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Improving Children's Behavior in Seven Sessions: A Randomized Controlled Trial of Parent-Child Care (PC-CARE) for Children Aged 2-10 Years.

Child Psychiatry Hum Dev 2022 Aug 11. Epub 2022 Aug 11.

University of California, Davis Children's Hospital, 3671 Business Dr., Ste 110, 95820, Sacramento, CA, USA.

Parent-Child Care (PC-CARE) is a brief intervention for children with externalizing behaviors designed to address issues with their access to and retention in treatment. A growing evidence base of open trials and comparison studies support PC-CARE's benefits, but no randomized controlled trials (RCTs) of its effectiveness exist. The current study presents the first RCT of PC-CARE, a 7-session dyadic parenting intervention (trial number removed for blind review). Read More

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Efficacy of Er:YAG laser for the peri-implantitis treatment and microbiological changes: a randomized controlled trial.

Lasers Med Sci 2022 Aug 11. Epub 2022 Aug 11.

Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.

The aims of this study were to identify the microbiological changes in the periodontal pockets following an Er:YAG laser (ERL) irradiation and mechanical debridement to compare the effectiveness of ERL irradiation to mechanical debridement for peri-implantitis treatment through randomized controlled trials. Twenty-three patients with peri-implantitis lesions were treated in either a test group, ERL set at energy level of 100 mJ/pulse, frequency of 10 Hz, pulse duration was 100 µs, and irradiated by three passages, or a control group, with mechanical debridement using an ultrasonic scaler. An examiner measured the following clinical parameters at different stages (a baseline and at 3- and 6-month post-treatment): probing depth (PD), bleeding on probing (BOP), marginal bone loss (MBL), and anaerobic bacteria counts. Read More

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[Multiple sclerosis: interventions to halt disease : Which patients can be considered for autologous stem cell transplantation].

Nervenarzt 2022 Aug 11. Epub 2022 Aug 11.

Klinik für Neurologie, Universitätsklinikum Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland.

Background: Autologous hematopoietic stem cell transplantation (aHSCT) for treatment of multiple sclerosis (MS) is gaining increasing prominence in the therapeutic landscape. This review article focuses on describing the evidence and European guidelines for aHSCT so that neurologists in Germany can consider this treatment option for appropriate MS patients. In this context, it must be taken into consideration that in every case a cost transfer must be individually applied for. Read More

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A Review of Laser Therapies for the Treatment of Scarring and Vascular Anomalies.

Adv Wound Care (New Rochelle) 2022 Aug 11. Epub 2022 Aug 11.

Department of Surgery, Center for Organogenesis Research and Trauma, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Laser use has become part of the gold standard of treatment as an effective adjuvant in multimodal therapy for pathologic scarring caused by burns, trauma, acne, and surgery, as well as vascular anomalies. Understanding indications and applications for laser therapy is essential for physicians to improve patient outcomes. Since the 1980s, the medical use of lasers has continuously evolved with improvements in technology. Read More

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Mechanisms for blood pressure reduction following isometric exercise training: a systematic review and meta-analysis.

J Hypertens 2022 Aug 9. Epub 2022 Aug 9.

School of Psychology and Life Sciences, Canterbury Christ Church University, Kent, UK.

Objective: Isometric exercise training (IET) is established as an effective antihypertensive intervention. Despite this, the physiological mechanisms driving blood pressure (BP) reductions following IET are not well understood. Therefore, we aimed to perform the first meta-analysis of the mechanistic changes measured following IET. Read More

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Differences in Efficacy between Short- and Long-Course Antibiotic Agents for Joint Prosthesis Infection: A Systematic Review and Meta-Analysis.

Surg Infect (Larchmt) 2022 Aug 10. Epub 2022 Aug 10.

The People's Hospital of Baoan Shenzhen.

To evaluate systematically the failure rate of short versus long courses of antibiotic agents for prosthetic joint infections (PJIs). PubMed, Embase, and Cochrane Library databases were searched for controlled studies of short- and long-course antibiotic agents for joint prosthesis infections, all from the time of database creation to April 2022. Literature search, quality evaluation, and data extraction were performed independently by two researchers, and the primary outcome was the rate of surgical failure after antibiotic treatment. Read More

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Effects of probiotic supplementation on performance of resistance and aerobic exercises: a systematic review.

Nutr Rev 2022 Aug 11. Epub 2022 Aug 11.

School of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.

Context: Strenuous exercise may lead to negative acute physiological effects that can impair athletic performance. Some recent studies suggest that probiotic supplementation can curtail these effects by reducing the permeability of the intestinal barrier, yet results are inconsistent.

Objective: The aim of this systematic review is to assess the effects of probiotic supplementation on athletic performance. Read More

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Evidence Based Update on Psychosocial Treatments for Eating Disorders in Children and Adolescents.

J Clin Child Adolesc Psychol 2022 Aug 11:1-12. Epub 2022 Aug 11.

Department of Psychiatry and Behavioral Science, Stanford University School of Medicine.

Eating disorders (EDs) are life-threatening psychiatric illnesses that occur in adolescents. Unfortunately, limited randomized controlled trials exist to address EDs in this vulnerable population. The current review updates a prior review from 2015. Read More

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The role of ex-situ perfusion for thoracic organs.

Curr Opin Organ Transplant 2022 Aug 4. Epub 2022 Aug 4.

Department of Cardiothoracic Surgery, Deutsches Herzzentrum Berlin, Germany.

Purpose Of Review: Ex-situ machine perfusion for both heart (HTx) and lung transplantation (LuTx) reduces ischemia-reperfusion injury (IRI), allows for greater flexibility in geographical donor management, continuous monitoring, organ assessment for extended evaluation, and potential reconditioning of marginal organs. In this review, we will delineate the impact of machine perfusion, characterize novel opportunities, and outline potential challenges lying ahead to improve further implementation.

Recent Findings: Due to the success of several randomized controlled trials (RCT), comparing cold storage to machine perfusion in HTx and LuTx, implementation and innovation continues. Read More

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Efficacy and safety of chemotherapy regimens for first-line treatment of advanced esophageal squamous cell carcinoma in asia: a systematic review.

Expert Rev Anticancer Ther 2022 Aug 11. Epub 2022 Aug 11.

MSD China, Shanghai, China.

Introduction: There is currently no consensus on the optimal chemotherapy regimen in the palliative first-line setting for East Asian patients with advanced esophageal squamous cell carcinoma (ESCC).

Areas Covered: We conducted a systematic review using a literature search of PubMed, Embase, and the Cochrane Library without date restrictions, and abstracts from major oncology congresses. Studies meeting the following criteria were included: East Asian patients ≥18 years old with pathologically proven metastatic or locally advanced unresectable ESCC; first-line chemotherapy; reporting of overall survival, progression-free survival, duration of response, overall response rate, and/or safety; randomized controlled trials, non-randomized controlled trials, and prospective or retrospective comparative studies. Read More

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Minimal invasiveness in soft tissue augmentation at dental implants: A systematic review and meta-analysis of patient-reported outcome measures.

Periodontol 2000 2022 Aug 11. Epub 2022 Aug 11.

Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich, Zürich, Switzerland.

The aim of this study was to compare patient-reported outcome measures (PROMs) of soft tissue substitutes versus autogenous grafts for soft tissue augmentation procedures at implant sites. Comprehensive and systematic literature searches were performed until December 2021. A focused question was formulated based on the Population, Intervention, Comparison and Outcome criteria (PICO): In patients with dental implants undergoing soft tissue augmentation (P), do soft tissue substitutes (I) compared to autogenous soft tissue graft (SCTG [subepithelial connective tissue graft]) (C) limit the post-operative morbidity and other patient reported-outcomes measures (O). Read More

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Extended chemothromboprophylaxis use in colorectal cancer surgery: a literature review.

ANZ J Surg 2022 Jul 10;92(7-8):1644-1650. Epub 2022 Jan 10.

Department of General Surgery, Royal Perth Hospital, Perth, Western Australia, Australia.

Venous thromboembolism (VTE) is a potentially fatal condition associated with chronic morbidity. Patients undergoing colorectal cancer surgery have an especially high rate of VTE postoperatively. This risk continues to be elevated for up to 3 months after discharge, hence arises the question of extended thromboprophylaxis (ETP). Read More

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Efficacy and safety of manuka honey for dry eye.

Clin Exp Optom 2022 Aug 11:1-11. Epub 2022 Aug 11.

Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Dry eye has become an increasingly prevalent public health issue for which there is currently no cure. Manuka honey possesses anti-inflammatory and antioxidant properties that can be used to treat dry eye. The present study aimed to systematically review evidence supporting the treatment of dry eye with manuka honey and quantify this evidence via meta-analysis. Read More

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A literature review of coping strategies and health-related quality of life among patients with heart failure.

Eur J Cardiovasc Nurs 2022 Aug 11. Epub 2022 Aug 11.

College of Nursing, Michigan State University, 1355 Bogue Street East Lansing, MI 48824, USA.

Aims: To identify and provide clarity on factors that influence coping and the type of coping strategies used by patients with heart failure (HF) to improve health-related quality of life (HRQoL).

Methods And Results: The Arksey and O'Malley template framed this scoping review guided by the stress and coping model. Five databases were explored: PubMed, Web of Science, Cochrane, CINAHL, and PsycINFO. Read More

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Respiratory syncytial virus is the most common causatives of viral bronchiolitis in young children: An updated Review.

Curr Pediatr Rev 2022 Aug 10. Epub 2022 Aug 10.

Department of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Hong Kong.

Background: Viral bronchiolitis is a common condition and a leading cause of hospitalization in young children.

Objective: This article provides readers with an update on the evaluation, diagnosis, and treatment of viral bronchiolitis, primarily due to RSV Methods: A PubMed search was conducted in December 2021 in Clinical Queries using the key terms "acute bronchiolitis" OR "respiratory syncytial virus infection". The search included clinical trials, randomized controlled trials, case control studies, cohort studies, meta-analyses, observational studies, clinical guidelines, case reports, case series, and reviews. Read More

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Continuous positive airway pressure in managing acute respiratory distress in children in district hospitals: evidence for scale-up.

Ghana Med J 2021 Sep;55(3):221-225

Department of Paediatrics, Division of Critical Care Medicine, Columbia University Medical Center/New York-Presbyterian Morgan Stanley Children's Hospital, 3959 Broadway, New York, NY 10032, United States of America.

In children, acute respiratory distress (ARD) is a clinical presentation requiring emergency management, including mechanical ventilation. Mechanical ventilators are lacking in sub-Saharan Africa. Continuous Positive Airway Pressure (CPAP) is an alternative form of non-invasive respiratory support that has been used in high-income countries for over four decades. Read More

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September 2021

Efficacy and safety of dupilumab in the treatment of moderate-to-severe atopic dermatitis: a meta-analysis of randomized controlled trials.

Postepy Dermatol Alergol 2022 Jun 14;39(3):601-610. Epub 2022 Jul 14.

Department of Dermatovenereology, Tianjin Medical University General Hospital/Tianjin Institute of Sexually Transmitted Disease, Tianjin, China.

Introduction: Patients with atopic dermatitis (AD) have high disease burden negatively affecting quality of life.

Aim: To assess the efficacy and safety of dupilumab in patients with moderate-to-severe AD.

Material And Methods: A systematic literature search was performed using the main-stream databases of PubMed, Web of Science, and Embase. Read More

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