64,867 results match your criteria controlled release


Efficient recovery of phosphorus and sulfur from Anaerobic Membrane Bioreactor (AnMBR) permeate using chemical addition of iron and evaluation of its nutrient availability for plant uptake.

Sci Total Environ 2021 Apr 1;783:146850. Epub 2021 Apr 1.

Department of Civil Engineering, Kansas State University, 2118 Fiedler Hall, 1701C Platt St., Manhattan, KS 66506, USA.

Anaerobic membrane bioreactors (AnMBRs) represent an emerging environmental biotechnology platform with the potential to simultaneously recover water, energy, and nutrients from concentrated wastewaters. The removal and beneficial capture of nutrients from AnMBR permeate has yet to be fully explored, therefore this study sought to foster iron phosphate recovery through a tertiary coagulation process, as well as characterize the recovered nutrient product (RNP) and assess its net phosphorus release, diffusion, and availability for plant uptake. One of the primary goals of this study was to optimize the dose of the coagulant, ferric chloride, and coagulant aid, aluminum chlorohydrate (ACH), for continuous application to the coagulation-flocculation-sedimentation (CFS) unit of an AnMBR pilot plant treating municipal wastewater, through controlled bench-scale jar tests. Read More

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Fabrication of polydopamine-based NIR-light responsive imprinted nanofibrous membrane for effective lysozyme extraction and controlled release from chicken egg white.

Food Chem 2021 Apr 1;357:129613. Epub 2021 Apr 1.

Department of Biological and Agricultural Engineering, University of California, Davis, CA 95616, USA. Electronic address:

The development of highly efficient performance matrix for protein adsorption and scalable throughput adsorbent is highly desired, especially in pharmaceuticals and food industries. In this work, we present a simple methodology to prepare a nanofibrous membrane based surface molecular imprinted matrix (MIP) for selective separation of lysozyme. The MIP was developed by coating carboxylated poly (vinyl alcohol-co-ethylene) nanofibrous mat (EVOH-CCA NFM) with a near infrared (NIR)-light responsive polydopamine (PDA) layer. Read More

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Comparison of two intravaginal progesterone-releasing devices in shortened-timed artificial insemination protocols in beef cattle.

Theriogenology 2021 Apr 1;168:75-82. Epub 2021 Apr 1.

Department of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada. Electronic address:

Commercially available intravaginal progesterone (P4) devices differ in shape, surface area and P4 load, which may affect the resulting pregnancy per AI (P/AI) following timed-AI (TAI). The objective of this study was to compare two intravaginal P4 devices on estrus rate, follicular dynamics and P/AI in beef cattle subjected to shortened-TAI protocols. In Expt. Read More

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Controlled Release of MSC-Derived Small Extracellular Vesicles by an Injectable Diels-Alder Crosslinked Hyaluronic Acid/PEG Hydrogel for Osteoarthritis Improvement.

Acta Biomater 2021 Apr 13. Epub 2021 Apr 13.

Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, 600# Yishan Road, Shanghai 200233, China.

Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) show great therapeutic potential for osteoarthritis (OA). However, their low bioavailability through intraarticular injection inhibits the process of clinical application. In the present study, an injectable Diels-Alder crosslinked hyaluronic acid/PEG (DAHP) hydrogel was developed as an intraarticular delivery platform for MSC-sEVs. Read More

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Biodegradable Electrospun Nanofibers: A New Approach For Rhinosinusitis Treatment.

Eur J Pharm Sci 2021 Apr 13:105852. Epub 2021 Apr 13.

Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG. 31270-901, Brazil. Electronic address:

Biodegradable polymeric nanofibers containing mometasone furoate can be a new approach to drug delivery to treat chronic rhinosinusitis, providing controlled steroid delivery to the sinonasal mucosa. This study aimed to develop biodegradable polymeric nanofibers and explore the safety of these fibers in an in vivo rabbit model. The nanofibers' development has been optimized using the Response Surface Methodology (RSM) obtained with Design of Experiments (DoE) with the best conditions related to the polymer concentration and proportion of solvents used in the electrospinning process. Read More

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Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.

Int J Pharm 2021 Apr 13:120606. Epub 2021 Apr 13.

Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy. Electronic address:

18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment. Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams. Polymeric bioadhesive microparticles (MP), loaded with Gly, were developed to be introduced in the wound bed and swell, once in contact with the exudate, to form a hydrogel in situ able to close the wound. Read More

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Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT.

Health Technol Assess 2021 Apr;25(25):1-166

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.

Background: Adrenaline has been used as a treatment for cardiac arrest for many years, despite uncertainty about its effects on long-term outcomes and concerns that it may cause worse neurological outcomes.

Objectives: The objectives were to evaluate the effects of adrenaline on survival and neurological outcomes, and to assess the cost-effectiveness of adrenaline use.

Design: This was a pragmatic, randomised, allocation-concealed, placebo-controlled, parallel-group superiority trial and economic evaluation. Read More

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Smart Layer-by-Layer Polymeric Microreactors: pH-Triggered Drug Release and Attenuation of Cellular Oxidative Stress as Prospective Combination Therapy.

ACS Appl Mater Interfaces 2021 Apr 16. Epub 2021 Apr 16.

Department of Mining-Metallurgy Engineering and Materials Science, POLYMAT, Faculty of Engineering in Bilbao, University of the Basque Country (UPV/EHU), Plaza Torres Quevedo 1, 48013 Bilbao, Spain.

Polymer capsules fabricated the layer-by-layer (LbL) approach have emerged as promising biomedical systems for the release of a wide variety of therapeutic agents, owing to their tunable and controllable structure and the possibility to include several functionalities in the polymeric membrane during the fabrication process. However, the limitation of the capsules with a single functionality to overcome the challenges involved in the treatment of complex pathologies denotes the need to develop multifunctional capsules capable of targeting several mediators and/or mechanisms. Oxidative stress is caused by the accumulation of reactive oxygen species [, hydrogen peroxide (HO), hydroxyl radicals (OH), and superoxide anion radicals (O)] in the cellular microenvironment and is a key modulator in the pathology of a broad range of inflammatory diseases. Read More

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Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted Chemistry.

ACS Pharmacol Transl Sci 2021 Apr 16;4(2):824-833. Epub 2021 Feb 16.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

The development of highly selective and fast biocompatible reactions for ligation and cleavage has paved the way for new diagnostic and therapeutic applications of pretargeted chemistry. The concept of bioorthogonal pretargeting has attracted considerable interest, in particular for the targeted delivery of radionuclides and drugs. In nuclear medicine, pretargeting can provide increased target-to-background ratios at early time-points compared to traditional approaches. Read More

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Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review.

ACS Pharmacol Transl Sci 2021 Apr 3;4(2):589-612. Epub 2021 Mar 3.

Department of Chemical Engineering, American University of Sharjah, Sharjah, United Arab Emirates.

The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and bioavailability. Nanocarriers are nanosized particles designed for the selectivity of anticancer drugs and gene transport to tumors. Read More

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CD45ROCD8 T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ERβ/miR-765/PLP2/Notch axis.

Theranostics 2021 11;11(11):5330-5345. Epub 2021 Mar 11.

Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, People's Republic of China.

Estrogen-dependent cancers (e.g., breast, endometrial, and ovarian cancers) are among the leading causes of morbidity and mortality in women worldwide. Read More

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Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions.

Drug Des Devel Ther 2021 9;15:1495-1507. Epub 2021 Apr 9.

Pharmaceutical Innovation and Development (PIDG) Group, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.

Background: Drug-eluting gastrointestinal (GI) stents are emerging as promising platforms for the treatment of GI cancers and provide the combined advantages of mechanical support to prevent lumen occlusion and as a reservoir for localized drug delivery to tumors. Therefore, in this work we present a detailed quality assurance study of 5-fluorouracil (5FU) drug-eluting stents (DESs) as potential candidates for the treatment of obstructive GI cancers.

Methods: The 5FU DESs were fabricated via a simple two-step sequential dip-coating process of commercial GI self-expanding nitinol stents with a 5FU-loaded polyurethane basecoat and a drug-free protective poly(ethylene-co-vinyl acetate) topcoat. Read More

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Effect of various dialysis modalities on intradialytic hemodynamics, tissue injury and patient discomfort in chronic dialysis patients: design of a randomized cross-over study (HOLLANT).

BMC Nephrol 2021 Apr 15;22(1):131. Epub 2021 Apr 15.

Department of Nephrology and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, VU University of Amsterdam, Amsterdam, The Netherlands.

Background: From a recent meta-analysis it appeared that online post-dilution hemodiafiltration (HDF), especially with a high convection volume (HV-HDF), is associated with superior overall and cardiovascular survival, if compared to standard hemodialysis (HD). The mechanism(s) behind this effect, however, is (are) still unclear. In this respect, a lower incidence of intradialytic hypotension (IDH), and hence less tissue injury, may play a role. Read More

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Formulation and Characterization of Febuxostat loaded Nanostructured Lipid Carriers (NLCs) - Gel for Topical Treatment of Gout.

Recent Pat Nanotechnol 2021 Apr 14. Epub 2021 Apr 14.

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan. India.

Background: The aim of present study was to formulate and characterize Nano Structured lipid carriers (NLCs) of Febuxostat (FB) incorporated in gel for the treatment of Gout. FB is a Xanthine Oxidase (XO) inhibitor drug used for chronic Gout and hyperuricemia. FB is BCS class II drug so water solubility is very poor and due to its poor solubility and wettability, it leads to poor dissolution. Read More

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[A Motivational-Volitional Program for Women after Breast Cancer Increases Physical Activity 12 Months Post Rehabilitation - Results of a Prospective Controlled Trial].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):110-123. Epub 2021 Apr 15.

Pädagogische Hochschule Freiburg.

Purpose: To assess the effectiveness of a motivational-volitional program for women after breast cancer (MoVo-BnB) who engage less than 60 minutes per week in physical activity.

Methods: This is a non-randomised, prospective bi-centered controlled trial in 2 in-patient medical rehabilitation centers. Data are assessed at 4 measurement points: at admission, discharge, 6 and 12 months post discharge. Read More

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Effect of citalopram on hippocampal volume in first-episode schizophrenia: Structural MRI results from the DECIFER trial.

Psychiatry Res Neuroimaging 2021 Apr 7;312:111286. Epub 2021 Apr 7.

Department of Psychiatry, NYU Langone Health, 1 Park Avenue, New York, NY 10016, United States of America; Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States of America. Electronic address:

Hippocampal volume loss is prominent in first episode schizophrenia (FES) and has been associated with poor clinical outcomes and with BDNF genotype; antidepressants are believed to reverse hippocampal volume loss via release of BDNF. In a 12-month, placebo-controlled add-on trial of the antidepressant, citalopram, during the maintenance phase of FES, negative symptoms were improved with citalopram. We now report results of structural brain imaging at baseline and 6 months in 63 FES patients (34 in citalopram group) from the trial to assess whether protection against hippocampal volume loss contributed to improved negative symptoms with citalopram. Read More

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Multifunctional Ultrasmall AgNP Hydrogel Accelerates Healing of S. aureus Infected Wounds.

Acta Biomater 2021 Apr 12. Epub 2021 Apr 12.

Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia; UniSA Clinical & Health Sciences, University of South Australia, Adelaide, SA 5000, Australia. Electronic address:

The increasing emergence of antibiotic resistance coupled with the limited effectiveness of current treatments highlights the need for the development of new treatment modalities. Silver nanoparticles (AgNPs) are a promising alternative with broad-spectrum antibacterial activity. However, the clinical translation of AgNPs have been hampered primarily due to the delivery of unsafe levels of silver ions (Ag) resulting in cellular toxicity and their susceptibility to aggregation resulting in loss of efficacy. Read More

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Development of polyoxyethylene (2) oleyl ether-gliadin nanoparticles: characterization and in vitro cytotoxicity.

Eur J Pharm Sci 2021 Apr 12:105849. Epub 2021 Apr 12.

Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S Venuta", I-88100, Catanzaro, Italy. Electronic address:

Natural polymers have been widely investigated as materials for the delivery of active compounds as a consequence of their biocompatibility, low-cost and the opportunity they furnish to obtain micro- and nanostructures. In this investigation, commercial wheat gliadin was used as raw material with the aim of obtaining a vegetal protein-based nanoformulation to be used for various applications. The influence of non-ionic and anionic surfactants on the physico-chemical properties of gliadin nanoparticles was evaluated in order to propose a suitable candidate able to stabilize the colloidal structure. Read More

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fvVaginal drug delivery approaches for localized management of cervical cancer.

Adv Drug Deliv Rev 2021 Apr 12. Epub 2021 Apr 12.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, P. R. China. Electronic address:

Cervical cancer or cervical intraepithelial neoplasia (CIN) remain a major public health problem among women globally. Traditional methods such as surgery are often associated with possible complications which may impact future pregnancies and childbirth especially for young female patients. Vagina with a high contact surface is a suitable route for the local and systemic delivery of drugs but its abundant mucus in continuous exchange presents a barrier for the popularization of conventional vaginal formulations including suppositories, gel, patch, creams and so on. Read More

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Microfluidic synthesis of chitosan-coated magnetic alginate microparticles for controlled and sustained drug delivery.

Int J Biol Macromol 2021 Apr 15;182:639-647. Epub 2021 Apr 15.

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China. Electronic address:

The present work aimed to assemble a simple, portable and economical L-junction microfluidic device to realize the adjustment and tunability of homogeneous round-shaped particles synthesis. In this study, we synthesize two kind of microparticles, including magnetic alginate microparticles (MAM) and chitosan-coated magnetic alginate (CMAM) used for controlling the drug release under a mild condition. Comparing to the traditional method, the MAM synthesized via this microfluidic approach has uniform size distribution, adjustable diameter as well as tunable magnetism. Read More

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Development of active packaging films based on chitosan and nano-encapsulated luteolin.

Int J Biol Macromol 2021 Apr 14;182:545-553. Epub 2021 Apr 14.

College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, PR China. Electronic address:

Luteolin is a flavone with potent antioxidant and antimicrobial activities. In this study, luteolin was encapsulated in oil-in-water nanoemulsions that were emulsified by glycerol monooleate and Tween 20. Results showed 68 mg luteolin-loaded nanoemulsions had the highest stability (zeta potential of -39. Read More

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Strategies to Control or Mimic Growth Factor Activity for Bone, Cartilage, and Osteochondral Tissue Engineering.

Bioconjug Chem 2021 Apr 15. Epub 2021 Apr 15.

Department of Materials Science and Engineering, Lehigh University, Bethlehem, Pennsylvania 18015, United States.

Growth factors play a critical role in tissue repair and regeneration. However, their clinical success is limited by their low stability, short half-life, and rapid diffusion from the delivery site. Supraphysiological growth factor concentrations are often required to demonstrate efficacy but can lead to adverse reactions, such as inflammatory complications and increased cancer risk. Read More

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A Light-Triggered pH-Responsive Metal-Organic Framework for Smart Delivery of Fungicide to Control Sclerotinia Diseases of Oilseed Rape.

ACS Nano 2021 Apr 15. Epub 2021 Apr 15.

Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, P.R. China.

Using a simple one-pot method, we developed a prochloraz (Pro) and pH-jump reagent-loaded zeolitic imidazolate framework-8 (PD@ZIF-8) composite for the smart control of Sclerotinia disease. The pH-jump reagent can induce the acidic degradation of ZIF-8 using UV light to realize the controlled release of Pro. Thus, the physical properties of PD@ZIF-8, such as its release, formulation stability, and adhesion, were investigated in detail. Read More

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Facile, Smart, and Degradable Metal-Organic Framework Nanopesticides Gated with Fe-Tannic Acid Networks in Response to Seven Biological and Environmental Stimuli.

ACS Appl Mater Interfaces 2021 Apr 15. Epub 2021 Apr 15.

Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key Laboratory of Coordination Chemistry, and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People's Republic of China.

Nanopesticides were selected as one of the top 10 emerging technologies in chemistry that will change our world in 2019. Facile, smart, and degradable metal-organic framework MIL-101(Fe) nanopesticides gated with Fe-tannic acid (TA) networks are created using a universal strategy. The capping of the Fe-TA network gatekeepers is instinctively oriented by the coordinatively unsaturated Fe sites on the surfaces of the MIL-101(Fe) nanocarriers; thus, their combination is perfectly matched. Read More

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3D Printed Bioceramic Scaffolds as a Universal Therapeutic Platform for Synergistic Therapy of Osteosarcoma.

ACS Appl Mater Interfaces 2021 Apr 15. Epub 2021 Apr 15.

Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.

The postoperative tumor recurrence and chemotherapy resistance in clinical osteosarcoma treatment have raised an imperative need to develop local implants for selectively killing residual tumor cells and simultaneously provide a scaffold for effectively filling the tumor resection-induced bone defects. Herein, a multifunctional platform is developed through successively coating TiN microparticles and doxorubicin (DOX) on the surface of tricalcium phosphate (TCP) scaffolds to achieve synergetic effects of photothermal therapy and chemotherapy for osteosarcoma. The content of TiN and DOX in the scaffolds can be flexibly adjusted by immersing the scaffolds into the solution containing different concentrations of TiN and DOX. Read More

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Randomized Controlled Trial Comparing the Short-term Outcomes of Enhanced Recovery After Surgery and Conventional Care in Laparoscopic Distal Gastrectomy (GISSG1901).

Ann Surg 2021 Apr 7. Epub 2021 Apr 7.

Affiliated Hospital of Qingdao University, Department of Gastrointestinal Surgery, China Shandong Provincial Hospital, Department of Gastrointestinal Surgery, China Qilu Hospital of Shandong University, Department of Gastrointestinal Surgery, China Yantai Yuhuangding Hospital, Department of Gastrointestinal Surgery, China Weihai Central Hospital, Department of Gastrointestinal Surgery, China Jining People's Hospital, Department of Gastrointestinal Surgery, China Dongying People's Hospital, Department of Gastrointestinal Surgery, China Qianfoshan Hospital of Shandong Province, Department of Gastrointestinal Surgery, China Second Hospital of Shandong University, Department of Gastrointestinal Surgery, China Qingdao Municipal Hospital, Department of Gastrointestinal Surgery, China Rizhao People's Hospital, Department of Gastrointestinal Surgery, China Weifang People's Hospital, Department of Oncological Surgery, China Weihai Municipal Hospital, Department of Gastrointestinal Surgery, China Section of Surgical Pathophysiology 7621, Rigshospitalet Copenhagen University, Denmark.

Objective: This study aimed to compare the effects of ERAS and conventional programs on short-term outcomes after laparoscopic distal gastrectomy (LDG).

Summary Background Data: Currently, the enhanced recovery after surgery (ERAS) program is broadly applied in surgical areas. Although several benefits of LDG with the ERAS program have been covered, high-level evidence is still limited, specifically in advanced gastric cancer (AGC). Read More

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PTH/PTHrP in controlled release hydrogel enhances orthodontic tooth movement by regulating periodontal bone remodaling.

J Periodontal Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Objective: This study aimed to evaluate the effects of local application of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP) on osteogenesis and osteoclastogenesis during orthodontic tooth movement (OTM).

Background: Periodontal bone remodeling is the crucial biological process in the OTM that involves both bone resorption and formation, with the former more important as the initiator. PTH or PTHrP both play dual roles in bone remodeling regulation, and the balance may shift to the bone resorption side when they are given continuously, suggesting them as potential candidate medicine for OTM acceleration. Read More

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Encapsulation, release and insecticidal activity of (L.) seed oil.

Heliyon 2021 Mar 24;7(3):e06557. Epub 2021 Mar 24.

Department of Agricultural Chemicals, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, 741 252, Nadia, West Bengal, India.

(L.) seed oil is effective for its insecticidal and larvicidal activities. However, its low aqueous solubility, high photosensitivity, and high volatility restrict its application for the control of agricultural pests. Read More

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Nanostructured Dense Collagen-Polyester Composite Hydrogels as Amphiphilic Platforms for Drug Delivery.

Adv Sci (Weinh) 2021 Apr 18;8(7):2004213. Epub 2021 Feb 18.

Sorbonne Université CNRS, UMR 7574, Laboratoire de Chimie de la Matière Condensée de Paris Paris F-75005 France.

Associating collagen with biodegradable hydrophobic polyesters constitutes a promising method for the design of medicated biomaterials. Current collagen-polyester composite hydrogels consisting of pre-formed polymeric particles encapsulated within a low concentrated collagen hydrogel suffer from poor physical properties and low drug loading. Herein, an amphiphilic composite platform associating dense collagen hydrogels and up to 50 wt% polyesters with different hydrophobicity and chain length is developed. Read More

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Comparing Minor Hand Procedures Performed with or without the Use of a Tourniquet: A Randomized Controlled Trial.

Plast Reconstr Surg Glob Open 2021 Apr 8;9(4):e3513. Epub 2021 Apr 8.

Division of Plastic and Reconstructive Surgery, Université de Montréal, Montréal, Québec, Canada.

Background: Carpal tunnel syndrome and trigger finger are two of the most common conditions treated by the hand surgeon. During these procedures, a tourniquet is often used to minimize bleeding and improve visualization of the operative field. However, it may be associated with pain and discomfort. Read More

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