J Hypertens 2021 Jul 13. Epub 2021 Jul 13.
University Hospital Erlangen, Department of Nephrology and Hypertension, Erlangen Department of Internal Medicine, Universitätsklinikum des Saarlandes, Saarland, University, Homburg/Saar, Germany University of Milano-Bicocca, Milan, Italy Université de Paris, INSERM, AP-HP, Hypertension Department and DMU CARTE, Hôpital Européen Georges-Pompidou Paris, France Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Saarland University (Kardiologie, Angiologie und Internistische Intensivmedizin), Homburg/Saar, Germany National and Kapodistrian University of Athens, 1st Cardiology Clinic, Hippocratio Hospital, Athens, Greece Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University of Medicine, Tochigi, Japan Department of Internal Medicine, Maastricht University Medical Center & Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands Barts NIHR Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London, UK Department of Nephrology and Hypertension, Paracelsus Medical University, Nürnberg, Germany Department of Cardiovascular Medicine, Princess Grace Hospital, Monaco and Research Unit Toulouse University, Centre National de la Recherche Scientifique UMR 5288, Toulouse, France Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, and Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium Interventional Cardiology Department, Heart Center, Policlinico di Monza, Monza, Italy and ESH Excellence Center, Istituto Clinico Verano Brianza, Verano Brianza, Italy Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, Medical Research Foundation, Faculty of Medicine, Dentistry & Health Sciences, The University of Western Australia, Perth Australia and Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth, Western Australia, Australia Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany National and Kapodistrian University of Athens, 1st Cardiology Clinic, Hippocratio Hospital, Athens, Greece.
This ESH Position Paper 2021 with updated proposed recommendations was deemed necessary after the publication of a set of new pivotal sham-controlled randomized clinical trials (RCTs), which provided important information about the efficacy and safety of endovascular device-based renal denervation (RDN) for hypertension treatment. RDN is effective in reducing or interrupting the sympathetic signals to the kidneys and decreasing whole body sympathetic activity. Five independent, fully completed, sham-controlled RCTs provide conclusive evidence that RDN lowers ambulatory and office blood pressure (BP) to a significantly greater extent than sham treatment. Read More