47,791 results match your criteria controlled hypertension


A Low-Sodium DASH Dietary Pattern Affects Serum Markers of Inflammation and Mineral Metabolism in Adults with Elevated Blood Pressure.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.

Background: The blood pressure-lowering effects of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and reduced sodium intake are well established. The effects on other biomarkers related to vascular health are of interest and might assist in explaining the effects of the DASH diet and sodium reduction.

Objectives: We hypothesized that a low-sodium DASH diet improves (lowers) biomarkers of inflammation [C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR)] and mineral metabolism [phosphorus and fibroblast growth factor-23 (FGF23)]. Read More

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Favorable Pregnancy Outcomes in Women With Well-Controlled Pulmonary Arterial Hypertension.

Front Med (Lausanne) 2021 5;8:689764. Epub 2021 Jul 5.

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Since pregnancy in women with pulmonary arterial hypertension (PAH) is associated with a high risk of morbidity and mortality, it is recommended that pregnancy should be avoided in PAH. However, some women with mild PAH may consider this recommendation as unsuitable. Unfortunately knowledge on pregnancy outcomes and best management of PAH during pregnancy is limited. Read More

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Clinical characteristics, imaging phenotypes and events free survival in Takayasu arteritis patients with hypertension.

Arthritis Res Ther 2021 Jul 21;23(1):196. Epub 2021 Jul 21.

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Background: Hypertension occurred in 30-80% of Takayasu arteritis (TAK) patients around the world and the occurrence of hypertension might worsen the disease prognosis. This study aimed to investigate the clinical characteristics and imaging phenotypes, as well as their associations with events free survival (EFS) in Chinese TAK patients with hypertension.

Methods: This current research was based on a prospectively ongoing observational cohort-the East China Takayasu Arteritis (ECTA) cohort, centered in Zhongshan Hospital, Fudan University. Read More

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The efficacy of cognitive behavioral therapy-based interventions on patients with hypertension: A systematic review and meta-analysis.

Prev Med Rep 2021 Sep 6;23:101477. Epub 2021 Jul 6.

School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

Recently, the benefits of cognitive behavioral therapy (CBT)-based interventions for patients with hypertension have been recognized, but there has been no systematic review that has comprehensively analyzed the efficacy of CBT on health outcomes in this population. We aimed to explore the therapeutic effect of CBT-based interventions on hypertension patients through a meta-analysis. Relevant randomized controlled trials (RCTs) were obtained by searching electronic databases. Read More

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September 2021

Randomized controlled study of the impact of a participatory patient care plan among primary care patients with common chronic diseases: a one-year follow-up study.

BMC Health Serv Res 2021 Jul 20;21(1):715. Epub 2021 Jul 20.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

Backround: Chronic diseases and multimorbidity are common in the ageing population and affect the health related quality of life. Health care resources are limited and the continuity of care has to be assured. Therefore it is essential to find demonstrable tools for best treatment practices for patients with chronic diseases. Read More

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Breastfeeding in the First Days of Life Is Associated With Lower Blood Pressure at 3 Years of Age.

J Am Heart Assoc 2021 Jul 21:e019067. Epub 2021 Jul 21.

Department of Pediatrics and Child Health University of Manitoba Winnipeg Canada.

Background Breastfeeding in infancy is associated with lower cardiovascular disease risk in adulthood; however, the amount of breastfeeding required to achieve this benefit is unknown. Methods and Results In the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study, we analyzed 2382 children with complete data on early life feeding and blood pressure. Infant feeding was documented from hospital records in the first few days of life and reported by mothers throughout infancy. Read More

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Effect of Lisinopril and Verapamil on Angiopoietin 2 and Endostatin in Hypertensive Diabetic Patients with Nephropathy: A Randomized Trial.

Horm Metab Res 2021 Jul 19;53(7):470-477. Epub 2021 Jul 19.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Angiogenesis is a multistep process implicated in the pathophysiology and progression of diabetic nephropathy (DN). Angiotensin-converting enzyme inhibitors (ACEI) and calcium channel blockers (CCB) have an important role in DN. We performed a randomized-controlled trial of lisinopril alone (an ACEI) or in combination with verapamil (a CCB) as a therapy for DN in type 2 diabetes mellitus (T2DM) patients with hypertension (HTN) and urinary albumin creatinine ratio (UACR) (30-300 mg/g) also to evaluate their effect on UACR, the angiogenic proteins: Angiopoietin 2 (Ang-2) and Endostatin (EST). Read More

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sternoclavicular joint osteomyelitis in an otherwise healthy 55-year-old man.

BMJ Case Rep 2021 Jul 19;14(7). Epub 2021 Jul 19.

Family Medicine, Henry Ford Hospital, Detroit, Michigan, USA.

Sternoclavicular joint osteomyelitis is extremely rare, with only 225 reported cases in the last 45 years. We present an unusual case in an otherwise healthy 55-year-old man with a history of well-controlled type 2 diabetes mellitus and hypertension. He presented to the emergency department after a week of left knee pain that worsened to full-body joint pain with left sternoclavicular swelling. Read More

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Perioperative control of paroxysmal hypertension using esmolol with alpha-blockade in a child with a germline mutated paraganglioma.

Endocrinol Diabetes Metab Case Rep 2021 Jul 19;2021(20-0101). Epub 2021 Jul 19.

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi Arabia.

Summary: The use of antihypertensive medications in patients with pheochromocytomas and paragangliomas (PCC/PG) is usually a challenge. We report a case of familial paraganglioma that was successfully treated by esmolol and other antihypertensive medications without associated perioperative complications. Our patient was an 11-year-old girl who presented with classic symptoms and signs of PCC/PG and a CT scan of the abdomen that showed a right-sided paravertebral mass. Read More

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Quality of life in patients with pulmonary embolism treated with edoxaban versus warfarin.

Res Pract Thromb Haemost 2021 Jul 14;5(5):e12566. Epub 2021 Jul 14.

Daiichi Sankyo Pharma Development Basking Ridge NJ USA.

Background: Long-term sequelae of acute pulmonary embolism (PE) include decreased quality of life (QoL). Evidence suggests that adequacy of initial anticoagulant treatment in the acute phase of venous thrombosis has a key impact on late postthrombotic complications. We hypothesize that patients with acute PE treated with edoxaban for acute PE experience have improved QoL compared to those treated with warfarin. Read More

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Baseline characteristics of participants in the LANDMARC trial: A 3-year, -india, prospective, longitudinal study to assess management and real-world outcomes of diabetes mellitus.

Endocrinol Diabetes Metab 2021 Jul 8;4(3):e00231. Epub 2021 Feb 8.

Center for Diabetes & Endocrine Care Srinagar India.

Introduction: Longitudinal data on progression, complications, and management of type 2 diabetes mellitus (T2DM) across India are scarce. LANDMARC (CTRI/2017/05/008452), the first -India, longitudinal, prospective, observational study, aims to understand the management and real-world outcomes of T2DM over 3 years.

Methods: Adults (≥25 to ≤60 years old at T2DM diagnosis; diabetes duration ≥2 years at enrollment; controlled/uncontrolled on ≥2 anti-diabetic agents) were enrolled. Read More

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Effectiveness and Safety of Adding Bevacizumab to Platinum-Based Chemotherapy as First-Line Treatment for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis.

Front Med (Lausanne) 2021 30;8:616380. Epub 2021 Jun 30.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Previous studies have evaluated the efficacy (OS, overall survival; PFS, progression-free survival; ORR, objective response rate) and adverse events of bevacizumab combined with platinum-based chemotherapy in first-line treatment of advanced non-small-cell lung cancer (NSCLC) compared with chemotherapy alone. However, the results were inconsistent. We conducted a comprehensive search of PubMed, EMBASE, and Cochrane Library for potentially eligible articles. Read More

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Blood pressure normalizing effect of Talahridaya marma therapy: A case report.

J Ayurveda Integr Med 2021 Jul 15. Epub 2021 Jul 15.

Department of Rachana Sharir, Faculty of Ayurveda, IMS, B.H.U, India. Electronic address:

Ancient Ayurvedic literature described 107 vital regions of the body and considered them as a seat of prana (life force) and collectively termed them as marma. The applied aspect of this concept, marma chikitsa or marma therapy, is gaining popularity as it is being practiced by many clinicians in which these marma are stimulated in different ways to treat different diseases. Hypertension is one of the major disorders affecting majority of the world population. Read More

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Randomized, Placebo-Controlled Trial of the Angiotensin Receptor Antagonist Losartan for Posttraumatic Stress Disorder.

Biol Psychiatry 2021 May 21. Epub 2021 May 21.

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; McLean Hospital, Belmont, Massachusetts. Electronic address:

Background: Evidence-based pharmacological treatments for posttraumatic stress disorder (PTSD) are few and of limited efficacy. Previous work suggests that angiotensin type 1 receptor inhibition facilitates fear inhibition and extinction, important for recovery from PTSD. This study tests the efficacy of the angiotensin type 1 receptor antagonist losartan, an antihypertensive drug, repurposed for the treatment of PTSD. Read More

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North American Practice-Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension.

Clin Gastroenterol Hepatol 2021 Jul 15. Epub 2021 Jul 15.

Department of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Complications of portal hypertension, including ascites, gastrointestinal bleeding, hepatic hydrothorax, and hepatic encephalopathy are associated with significant morbidity and mortality. Despite few high quality randomized controlled trials to guide therapeutic decisions, transjugular intrahepatic portosystemic shunt (TIPS) creation has emerged as a crucial therapeutic option to treat complications of portal hypertension. In North America, the decision to perform TIPS involves gastroenterologists, hepatologists, and interventional radiologists, but TIPS creation is performed by interventional radiologists. Read More

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Occurrence of hypertension during third-line anlotinib is associated with progression-free survival in patients with squamous cell lung cancer (SCC): A post hoc analysis of the ALTER0303 trial.

Thorac Cancer 2021 Jul 17. Epub 2021 Jul 17.

Department of Oncology, Linyi Cancer Hospital, Linyi, China.

Background: There is a lack of targeted therapeutic options for squamous cell lung cancer (SCC). Accelerated hypertension is an issue with many targeted therapies for lung cancer. This study aimed to analyze the efficacy of anlotinib, based on progression-free survival (PFS) and overall survival (OS) in patients with SCC, stratified by hypertension and Eastern Cooperative Oncology Group (ECOG) score. Read More

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The short- and long-term effects of dietary patterns on cardiometabolic health in adults aged 65 years or older: a systematic review.

Nutr Rev 2021 Jul 17. Epub 2021 Jul 17.

R. Luong, R. Ribeiro, J. Cunningham, S. Chen, and V. Hirani are with the School of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, New South Wales, Australia.

Context: Cardiometabolic diseases are leading causes of death and morbidity. Aging increases the risk of disease development. Diet has protective and causal effects on cardiometabolic health. Read More

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Course and outcomes of pregnancy in women treated for acromegaly: Discerning a contemporary cohort.

Growth Horm IGF Res 2021 Jul 8;60-61:101417. Epub 2021 Jul 8.

Department of Obstetrics and Gynecology, PGIMER, Chandigarh, India. Electronic address:

Objective: To analyze pregnancy course and outcomes in women treated for acromegaly and compare outcomes based on disease activity at the time of conception.

Design: Retrospective study.

Patients: Women with acromegaly diagnosed prior to or during pregnancy from 2010 to 2019, representing cases (14 pregnancies in 12 cases), were later stratified based on active (n = 5) or controlled disease (n = 9) at time of conception. Read More

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Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.

PLoS One 2021 16;16(7):e0254699. Epub 2021 Jul 16.

Department of First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.

Background: Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Read More

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Renal Denervation for Patients With Atrial Fibrillation.

Curr Cardiol Rep 2021 Jul 16;23(9):126. Epub 2021 Jul 16.

Clinical Cardiovascular Research Center, University of Rochester School of Medicine and Dentistry, 85 Woodland Road, Short Hills, NJ, 07078, USA.

Purpose Of Review: During the last decade, several case series and small reports have indicated that pulmonary vein isolation (PVI) in combination with renal denervation (RDN) may increase the rate of atrial fibrillation (AF) freedom in patients with hypertension. We aimed to provide a contemporary systematic overview on the techniques, and the efficacy/safety of RDN on AF recurrence, and the current landscape of ongoing investigation.

Recent Findings: The recent Evaluate Renal Denervation in Addition to Catheter Ablation to Eliminate Atrial Fibrillation (ERADICATE-AF) trial has demonstrated convincingly that among patients with paroxysmal AF and poorly controlled (but not "resistant") hypertension, RDN added to catheter ablation, compared with catheter ablation alone, significantly increased the likelihood of freedom from AF at 12 months. Read More

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The effects of the dietary approaches to stop hypertension (DASH) diet on oxidative stress and clinical indices of migraine patients: a randomized controlled trial.

Nutr Neurosci 2021 Jul 16:1-10. Epub 2021 Jul 16.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Aims: The relationship between the Dietary Approaches to Stop Hypertension (DASH) diet and oxidative stress (OS) in patients diagnosed with migraine is unknown and remains to be examined. Hence, we conducted a parallel-group, randomized controlled trial to investigate this issue.

Methods: Of the 102 women who met all the inclusion criteria, 51 individuals were randomized to the DASH diet group and 51 to the usual dietary advice group to receive allocated intervention for three months. Read More

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The pharmacodynamic effect of terlipressin versus high-dose octreotide in reducing hepatic venous pressure gradient: a randomized controlled trial.

Ann Transl Med 2021 May;9(9):793

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Vasoactive drugs can reduce portal venous pressure and control variceal bleeding. However, few studies have explored the hemodynamic effects of terlipressin and high-dose octreotide in such patients. Our purpose was to evaluate the hemodynamic changes and safety of using terlipressin and high-dose octreotide in patients with decompensated liver cirrhosis. Read More

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Ropinirole-Associated Orthostatic Hypotension as Cause of a Prescribing Cascade in an Elderly Man.

Cureus 2021 Jun 7;13(6):e15506. Epub 2021 Jun 7.

Department of Internal Medicine, Saint Francis Hospital, Trinity Health of New England (NE), Hartford, USA.

Ropinirole is an overall well-tolerated antiparkinsonian medication that is also used to treat restless leg syndrome (RLS). The incidence of side effects is low, with orthostatic hypotension (OH) only anecdotally reported. Additionally, it is known that the elderly population is very susceptible to adverse drug effects and the prevalence of prescribing cascades that these can trigger is unknown. Read More

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The effect of vitamin D supplementation on flow-mediated dilatation, oxidized LDL and intracellular adhesion molecule 1 on type 2 diabetic patients with hypertension: A randomized, placebo-controlled, double-blind trial.

Diabetes Metab Syndr 2021 Jul 5;15(4):102200. Epub 2021 Jul 5.

Department of Biostatistics, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran.

Aims: Current study aimed to evaluate the effect of vitamin D supplementation on flow-mediated dilatation (FMD), oxidized LDL (oxLDL) and intracellular adhesion molecule 1 (ICAM1) in type 2 diabetic patients with hypertension.

Methods: In a double-blinded, placebo-controlled trial, 44 patients were randomly divided into vitamin D group (2000 IU/d, n = 23) and placebo group (control, n = 21) for 12 weeks. Vascular function with FMD, Serum 25-OH vitamin D, oxLDL and ICAM1 were assessed at the baseline and after the intervention. Read More

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The association between cardiovascular risk factors and major cardiovascular diseases decreases with increasing frailty levels in geriatric outpatients.

Exp Gerontol 2021 Jul 12;153:111475. Epub 2021 Jul 12.

Department of Psychiatry, University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands.

Background: Frailty marks a process of increasing dysregulation of physiological systems which increases the risk of adverse health outcomes. This study examines the hypothesis that the association between multiple cardiovascular risk factors (CVRF) and cardiovascular diseases (CVD) becomes stronger with increasing frailty severity.

Methods: Cross-sectional analysis of 339 older adults (55. Read More

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Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot.

Int J Cardiol 2021 Jul 12. Epub 2021 Jul 12.

Division of Cardiology, UPMC Children's Hospital of Pittsburgh and Department of Pediatrics, 4401 Penn Ave, Pittsburgh, PA 15224, USA; Pediatric Institute for Heart Regeneration and Therapeutics (I-HRT), UPMC Children's Hospital of Pittsburgh and Department of Pediatrics, 4401 Penn Ave, Pittsburgh, PA 15224, USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address:

Background: Patients with Tetralogy of Fallot with pulmonary stenosis (ToF/PS), the most common form of cyanotic congenital heart disease (CHD), develop adverse right ventricular (RV) remodeling, leading to late heart failure and arrhythmia. We recently demonstrated that overactive β-adrenergic receptor signaling inhibits cardiomyocyte division in ToF/PS infants, providing a conceptual basis for the hypothesis that treatment with the β-adrenergic receptor blocker, propranolol, early in life would increase cardiomyocyte division. No data are available in ToF/PS infants on the efficacy of propranolol as a possible novel therapeutic option to increase cardiomyocyte division and potentially reduce adverse RV remodeling. Read More

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Effects of Renin-Angiotensin-Aldosterone Inhibitors on Early Outcomes of Hypertensive COVID-19 Patients: A Randomized Triple-Blind Clinical Trial.

Am J Hypertens 2021 Jul 15. Epub 2021 Jul 15.

Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Prehospital and Hospital Emergency Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: The role of angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) has been addressed in some studies related to the current coronavirus disease-2019 (COVID-19) pandemic with possible higher severity and mortality in patients with hypertension. A triple-blind randomized controlled trial was designed to evaluate the effects of these medications on the COVID-19 progression.

Methods: Patients were enrolled in this trial between April and September 2020. Read More

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Cardiovascular Risk Prediction, Glycemic Control, and Determinants in Diabetic and Hypertensive Patients in Massawa Hospital, Eritrea: Cross-Sectional Study on 600 Subjects.

Diabetes Metab Syndr Obes 2021 5;14:3035-3046. Epub 2021 Jul 5.

Medical Department, Massawa Hospital, Northern Red Sea Zone, Ministry of Health, Massawa, Eritrea.

Background: Hypertension and diabetes are key determinants of cardiovascular risks. The objective of this study was to calculate 10-year incidence of cardiovascular risk, determine cardiovascular risk factors, and evaluate how diabetes and hypertension are controlled in patients in Massawa Hospital, Eritrea.

Methods: This was a hospital-based cross-sectional study using census sampling. Read More

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Isolated Adrenocorticotropic Hormone Deficiency Associated with Severe Hyperkalemia During Pembrolizumab Therapy in a Patient with Ureteral Cancer and an Ileal Conduit: A Case Report and Literature Review.

Am J Case Rep 2021 Jul 15;22:e931639. Epub 2021 Jul 15.

Department of Urology, Uonuma Kikan Hospital, Minamiuonuma, Niigata, Japan.

BACKGROUND Immune checkpoint inhibitors (ICIs) are anticancer medications that enhance the antitumor immune response. The clinical benefit afforded by ICIs, however, can be accompanied by immune-related adverse events (IRAEs). One of the common endocrine IRAEs is hypophysitis, which often causes hypopituitarism with secondary adrenal insufficiency (AI). Read More

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European Society of Hypertension position paper on renal denervation 2021.

J Hypertens 2021 Jul 13. Epub 2021 Jul 13.

University Hospital Erlangen, Department of Nephrology and Hypertension, Erlangen Department of Internal Medicine, Universitätsklinikum des Saarlandes, Saarland, University, Homburg/Saar, Germany University of Milano-Bicocca, Milan, Italy Université de Paris, INSERM, AP-HP, Hypertension Department and DMU CARTE, Hôpital Européen Georges-Pompidou Paris, France Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Saarland University (Kardiologie, Angiologie und Internistische Intensivmedizin), Homburg/Saar, Germany National and Kapodistrian University of Athens, 1st Cardiology Clinic, Hippocratio Hospital, Athens, Greece Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University of Medicine, Tochigi, Japan Department of Internal Medicine, Maastricht University Medical Center & Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands Barts NIHR Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London, UK Department of Nephrology and Hypertension, Paracelsus Medical University, Nürnberg, Germany Department of Cardiovascular Medicine, Princess Grace Hospital, Monaco and Research Unit Toulouse University, Centre National de la Recherche Scientifique UMR 5288, Toulouse, France Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, and Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium Interventional Cardiology Department, Heart Center, Policlinico di Monza, Monza, Italy and ESH Excellence Center, Istituto Clinico Verano Brianza, Verano Brianza, Italy Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, Medical Research Foundation, Faculty of Medicine, Dentistry & Health Sciences, The University of Western Australia, Perth Australia and Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth, Western Australia, Australia Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany National and Kapodistrian University of Athens, 1st Cardiology Clinic, Hippocratio Hospital, Athens, Greece.

This ESH Position Paper 2021 with updated proposed recommendations was deemed necessary after the publication of a set of new pivotal sham-controlled randomized clinical trials (RCTs), which provided important information about the efficacy and safety of endovascular device-based renal denervation (RDN) for hypertension treatment. RDN is effective in reducing or interrupting the sympathetic signals to the kidneys and decreasing whole body sympathetic activity. Five independent, fully completed, sham-controlled RCTs provide conclusive evidence that RDN lowers ambulatory and office blood pressure (BP) to a significantly greater extent than sham treatment. Read More

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