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Proline isomerization of histone H3 regulates lysine methylation and gene expression.

Cell 2006 Sep;126(5):905-16

Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK.

The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 proline P30 and P38 in vitro. We show that P38 is necessary for methylation of K36 and that isomerization by Fpr4 inhibits the ability of Set2 to methylate H3 K36 in vitro. Read More

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September 2006
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