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Effects of dicopper oxide and copper sulfate on growth performance and gut microbiota in broilers.

Poult Sci 2021 Apr 27;100(8):101224. Epub 2021 Apr 27.

Animal Nutrition and Welfare Service (SNiBA), Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

An experiment was conducted to determine the effects of two sources of copper (Cu) from copper sulfate (CuSO) and dicopper oxide (CuO, CoRouge) at three levels of inclusion (15, 75, and 150 mg/kg) on growth performance and gut microbiota of broilers. A total of 840 one-d-old male chickens (Ross 308) were weighed and randomly allocated to seven dietary treatments: negative control (NC, a basal diet without Cu addition), and the NC supplemented with 15, 75, or 150 mg Cu/kg from CuSO or CuO (12 replicate pens/treatment, 10 chicks per pen). Broilers were challenged by reusing an old litter with high concentrations in Clostridium perfringens to promote necrotic enteritis. Read More

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Age-dependence of hypervirulent fowl adenovirus type 4 pathogenicity in specific-pathogen-free chickens.

Poult Sci 2021 May 8;100(8):101238. Epub 2021 May 8.

College of Veterinary Medicine, Yangzhou University, Yangzhou, China; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China. Electronic address:

Hypervirulent fowl adenovirus serotype 4 (hvFAdV-4) has emerged as a major pathogen of hepatitis-hydropericardium syndrome (HHS) with increased mortality in chickens, resulting in economic losses to the Chinese poultry industry since June 2015. Here, we isolated a hypervirulent FAdV-4 (hvFAdV-4) strain (designated GD616) from 25-day-old meat-type chickens with severe HHS in Guangdong Province China in June 2017. The whole genome of the strain GD616 shares high homology with those in the recently-reported hvFAdV-4 isolates in China, with natural deletions of ORF19 and ORF27. Read More

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Perspective taking reduces intergroup bias in visual representations of faces.

Cognition 2021 Jun 19;214:104808. Epub 2021 Jun 19.

University of California, Davis, CA, USA. Electronic address:

Intergroup biases shape most aspects of person construal, including lower-level visual representations of group members' faces. Specifically, ingroup members' faces tend to be represented more positively than outgroup members' faces. Here, we used a reverse-correlation paradigm to test whether engaging in perspective taking (i. Read More

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Pharmaceuticals and alkylphenols in transplanted Pacific oysters (Crassostrea gigas): Spatial variation and growth effects.

Mar Pollut Bull 2021 Jun 19;170:112584. Epub 2021 Jun 19.

Portland State University, Department of Environmental Science and Management, Science Research and Teaching Center, Rm. 218, 1719 SW 10th Ave, Portland, OR, 97201, USA. Electronic address:

Pharmaceuticals and personal care products in wastewater discharge can be stressors to estuarine species. We transplanted juvenile Pacific oysters at varying distances within sites near wastewater treatment plant outfalls or oyster aquaculture control sites to assess small scale spatial variation in contaminant uptake and oyster condition. Oysters were transplanted to sites in Coos and Netarts Bays, Oregon and Grays Harbor, Washington, then collected after 9 and 12 months. Read More

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Dengue disease dynamics are modulated by the combined influences of precipitation and landscape: A machine learning approach.

Sci Total Environ 2021 Jun 10;792:148406. Epub 2021 Jun 10.

Center for Marine Environmental Studies (CMES), Ehime University, Matsuyama 790-8577, Japan; Graduate School of Science and Engineering, Ehime University, Matsuyama 790-8577, Japan; Biology Department, De La Salle University, Taft Ave, Manila 1004, Philippines; Biological Control Research Unit, Center for Natural Science and Environmental Research, De La Salle University, Taft Ave, Manila, Philippines. Electronic address:

Background: Dengue is an endemic vector-borne disease influenced by environmental factors such as landscape and climate. Previous studies separately assessed the effects of landscape and climate factors on mosquito occurrence and dengue incidence. However, both factors concurrently coexist in time and space and can interact, affecting mosquito development and dengue disease transmission. Read More

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Steroid hormones in the aquatic environment.

Sci Total Environ 2021 Jun 16;792:148306. Epub 2021 Jun 16.

Division of Environmental Science, Department of Life Sciences, Brunel University London, Uxbridge, Middlesex UB8 3PH, United Kingdom. Electronic address:

Steroid hormones are extremely important natural hormones in all vertebrates. They control a wide range of physiological processes, including osmoregulation, sexual maturity, reproduction and stress responses. In addition, many synthetic steroid hormones are in widespread and general use, both as human and veterinary pharmaceuticals. Read More

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Spatial and temporal variations of Cu and Cd mobility and their controlling factors in pore water of contaminated paddy soil under acid mine drainage: A laboratory column study.

Sci Total Environ 2021 Jun 17;792:148523. Epub 2021 Jun 17.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, South China University of Technology, Guangzhou 510006, PR China; Guangdong Provincial Key Lab of Solid Wastes Pollution Control and Recycling, South China University of Technology, Guangzhou 510006, PR China.

Acid mine drainage (AMD) poses a potential threat to human health worldwide, due to its high content of inorganic contaminants including heavy metals. Nevertheless, AMD is commonly used for irrigation of paddy soils. To determine the extent to which AMD affects contaminant levels in such practices, the effect of continuous AMD flooding on pH, redox potential Eh and the migration of Cu and Cd in contaminated paddy soil was studied in column experiments. Read More

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Face masks, public policies and slowing the spread of COVID-19: Evidence from Canada.

J Health Econ 2021 Jun 3;78:102475. Epub 2021 Jun 3.

Department of Economics, Simon Fraser University, Canada.

We estimate the impact of indoor face mask mandates and other non-pharmaceutical interventions (NPI) on COVID-19 case growth in Canada. Mask mandate introduction was staggered from mid-June to mid-August 2020 in the 34 public health regions in Ontario, Canada's largest province by population. Using this variation, we find that mask mandates are associated with a 22 percent weekly reduction in new COVID-19 cases, relative to the trend in absence of mandate. Read More

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Experiences of place attachment and mental wellbeing in the context of urban regeneration.

Health Place 2021 Jun 19;70:102604. Epub 2021 Jun 19.

University of Salford School of Health & Society, Mary Seacole Building, Frederick Road Campus, Broad St, Frederick Road Campus, Salford, M6 6PU, UK.

Urban regeneration is an important policy focus across the European Union, with initiatives seeking to address inequalities in public health. Although theoretically such initiatives should produce benefits for mental wellbeing, this lacks strong supporting evidence. The current research addressed a prior overreliance on quantitative methods and underappreciation of the psychological significance of place, through the adoption of qualitative interviews with residents, as part of an independent review of a £650m regeneration project. Read More

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Baoyuan decoction (BYD) attenuates cardiac hypertrophy through ANKRD1-ERK/GATA4 pathway in heart failure after acute myocardial infarction.

Phytomedicine 2021 Jun 1;89:153617. Epub 2021 Jun 1.

Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address:

Background: The pathological cardiac functions of ankyrin repeat domain 1 (ANKRD1) in left ventricle can directly aggravate cardiac hypertrophy (CH) and fibrosis through the activation of extracellular signal-regulated kinase (ERK)/ transcription factor GATA binding protein 4 (GATA4) pathway, and subsequently contribute to heart failure (HF). Baoyuan Decoction (BYD), which is a famous classic Chinese medicinal formulation, has shown impressive cardioprotective effects clinically and experimentally. However, the knowledge is still limited in its underlying mechanisms against HF. Read More

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Generating an iPSC line (with isogenic control) from the PBMCs of an ACTA1 (p.Gly148Asp) nemaline myopathy patient.

Stem Cell Res 2021 Jun 17;54:102429. Epub 2021 Jun 17.

Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Pediatrics, The University of Melbourne, Victoria, Australia. Electronic address:

To produce an in vitro model of nemaline myopathy, we reprogrammed the peripheral blood mononuclear cells (PBMCs) of a patient with a heterozygous p.Gly148Asp mutation in exon 3 of the ACTA1 gene to iPSCs. Using CRISPR/Cas9 gene editing we corrected the mutation to generate an isogenic control line. Read More

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Preschoolers are capable of fine-grained implicit cognitive control: Evidence from development of the context-specific proportion congruency effect.

J Exp Child Psychol 2021 Jun 19;210:105211. Epub 2021 Jun 19.

Laboratoire de Psychologie Cognitive (UMR 7290), Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université, 13331 Marseille, France.

Whereas much of the developmental literature has focused on the difficulties of young children in regulating their behavior, an increasing base of evidence suggests that children may be capable of surprisingly flexible engagement of cognitive control when based on implicit experience with the situation. One of the most fine-grained examples of implicit cognitive control in adults is the context-specific proportion congruency (CSPC) effect-the finding that interference in a conflict task is reduced for stimuli that are presented in a context (e.g. Read More

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The effects of reflexology on anxiety, depression and quality of life in patients with gynecological cancers with reference to Watson's theory of human caring.

Complement Ther Clin Pract 2021 Jun 17;44:101428. Epub 2021 Jun 17.

Department of Obstetrics and Gynecology Nursing, Faculty of Health Sciences, Pamukkale University, Kınıklı Campus, Denizli, Turkey. Electronic address:

Objectives: This study aimed to examine the effects of reflexology based on Watson's theory of human caring on anxiety, depression, and quality of life in gynecological cancer patients.

Material And Methods: The study was a prospective, single-blind, randomized controlled trial with a pretest-posttest and a control group. The clinical trial was conducted at a university hospital in the Aegean region between October 2016 and June 2018. Read More

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Sleep and self-control: A systematic review and meta-analysis.

Sleep Med Rev 2021 Jun 5;59:101514. Epub 2021 Jun 5.

Foster School of Business, University of Washington, USA.

Controlling impulses and overcoming temptations (i.e., self-control) are key aspects of living a productive life. Read More

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A Nation-wide Review of Elective Surgery and COVID-Surge Capacity.

J Surg Res 2021 Jun 19;267:211-216. Epub 2021 Jun 19.

Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Surgery Service, Veterans Affairs Medical Centre, Baltimore, Maryland. Electronic address:

Background: The COVID-19 pandemic has resulted in over 225,000 excess deaths in the United States. A moratorium on elective surgery was placed early in the pandemic to reduce risk to patients and staff and preserve critical care resources. This report evaluates the impact of the elective surgical moratorium on case volumes and intensive care unit (ICU) bed utilization. Read More

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Deep learning radiomics-based prediction of distant metastasis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy: A multicentre study.

EBioMedicine 2021 Jun 19;69:103442. Epub 2021 Jun 19.

Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, Beihang University, Beijing 100191, China; Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology, Beijing 100191, China. Electronic address:

Background: Accurate predictions of distant metastasis (DM) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) are helpful in developing appropriate treatment plans. This study aimed to perform DM prediction through deep learning radiomics.

Methods: We retrospectively sampled 235 patients receiving nCRT with the minimum 36 months' postoperative follow-up from three hospitals. Read More

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A γ-glutamylcysteine ligase AcGCL alleviates cadmium-inhibited fructooligosaccharides metabolism by modulating glutathione level in Allium cepa L.

J Hazard Mater 2021 Jun 8;419:126255. Epub 2021 Jun 8.

Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China), Ministry of Agriculture and Rural Affairs, College of Horticulture, South China Agricultural University, Guangzhou 510642, China; Lingnan Guangdong Laboratory of Modern Agriculture, Guangzhou 510642, China; Guangdong Vegetable Engineering and Technology Research Center, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Fructooligosaccharides (FOS) are important carbohydrates in plants. Cadmium (Cd) toxicity limits growth and development in several plant species. Whether FOS metabolism is affected by Cd and the molecular mechanisms of tolerance of the effects of Cd toxicity in plants remain enigmatic. Read More

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The "STARS - CT-MADE" Study: Advanced Rehearsal and Intraoperative Navigation for Skull Base Tumors.

World Neurosurg 2021 Jun 19. Epub 2021 Jun 19.

Department of Neurosurgery, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy; Besta NeuroSim Center, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy; EANS Training Committee; Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, MD, USA.

Background: Skull base meningiomas represent a challenge for neurosurgeons and the procedures are typically performed by experienced neurosurgeons, thus limiting resident training. A new simulation and rehearsal device can be used as an aid for senior surgeons during these operations and serve as a training tool for junior surgeons.

Methods: 40 patients harboring an anterior/middle fossa meningioma were recruited. Read More

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Engineered Neural Circuits for Modeling Brain Physiology and Neuropathology.

Acta Biomater 2021 Jun 19. Epub 2021 Jun 19.

Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea. Electronic address:

The neural circuits of the central nervous system are the regulatory pathways for feeling, motion control, learning, and memory, and their dysfunction is closely related to various neurodegenerative diseases. Despite the growing demand for the unraveling of the physiology and functional connectivity of the neural circuits, their fundamental investigation is hampered because of the inability to access the components of neural circuits and the complex microenvironment. As an alternative approach, in vitro human neural circuits show principles of in vivo human neuronal circuit function They allow access to the cellular compartment and permit real-time monitoring of neural circuits. Read More

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Comparative study of placental T2* and intravoxel incoherent motion in the prediction of fetal growth restriction.

Placenta 2021 Jun 17;111:47-53. Epub 2021 Jun 17.

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Introduction: Both transverse relaxation time (T2*) and intravoxel incoherent motion (IVIM) on magnetic resonance imaging (MRI) are promising for discriminating fetal growth restriction (FGR). We aimed to compare the utility of these two parameters and their combination in the same cohort.

Methods: Twenty-seven FGR and 24 control pregnancies after 28 weeks of gestation in which both T2* and IVIM scans were performed on a 3. Read More

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Severe Maternal Morbidity and Mortality During Delivery Hospitalization of Class I, II, III, and Super Obese Women.

Am J Obstet Gynecol MFM 2021 Jun 19:100420. Epub 2021 Jun 19.

Yale School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut.

Background: Previous studies show that obesity predisposes patients to higher risks of adverse pregnancy outcomes. Data on the relationship between increasing degrees of obesity and risks of severe maternal morbidity (SMM), including mortality, are limited.

Objective: We examined the association of increasing classes of obesity, especially super obesity, with the risk of SMM and mortality at the time of delivery hospitalization. Read More

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Cancer-elicited inflammation attenuates response and outcome in tyrosine kinase inhibitor naive patients with advanced NSCLC.

Pharmacol Res 2021 Jun 19:105734. Epub 2021 Jun 19.

Biological Resource Center, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China; Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China. Electronic address:

Objective: Cancer elicited inflammation is the main environmental cause leading to carcinogenesis and metastasis of non-small cell lung cancer (NSCLC). Roles of the inflammatory biomarker in predicting the clinical efficacy of tyrosine kinase inhibitor (TKI) and prognosis of naive patients with advanced NSCLC need to be determined, and the best inflammatory predicted biomarker remains unknown.

Methods: A total of 178 eligible advanced NSCLC patients (124 and 54 cases within discovery and validation cohorts, respectively) who received first-line EGFR-TKI between July of 2014 and October of 2020 were enrolled in the present study. Read More

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Optical control of adenosine A receptor function in psoriasis.

Pharmacol Res 2021 Jun 19:105731. Epub 2021 Jun 19.

Pharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Spain. Electronic address:

Psoriasis is a chronic and relapsing inflammatory skin disease lacking a cure that affects approximately 2% of the population. Defective keratinocyte proliferation and differentiation, and aberrant immune responses are major factors in its pathogenesis. Available treatments for moderate to severe psoriasis are directed to immune system causing systemic immunosuppression over time, and thus concomitant serious side effects (i. Read More

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Immunogenicity and safety of a live attenuated varicella vaccine in children 1-12 years of age: A randomized, blinded, controlled, non-inferiority phase 3 clinical trial.

Contemp Clin Trials 2021 Jun 19:106489. Epub 2021 Jun 19.

Institute of Expanded Programme on Immunization, Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, Guizhou Province, People's Republic of China. Electronic address:

Objectives: To evaluate the immunogenicity and safety of a live attenuated varicella vaccine produced using a cell factory process.

Methods: In this randomized, blinded, controlled, non-inferiority phase 3 clinical trial conducted in Guizhou, healthy children aged 1-12 years were randomly assigned in a 2: 1 ratio to receive one dose of experimental or control vaccine. Physical examination and first blood collection were performed preimmunization on day 0. Read More

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Hot water extract of Pleurotus pulmonarius stalk waste enhances innate immune response and immune-related gene expression in red hybrid tilapia Oreochromis sp. following challenge with pathogen-associated molecular patterns.

Fish Shellfish Immunol 2021 Jun 19. Epub 2021 Jun 19.

Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia; Department of Biology, Faculty of Science, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

In aquaculture, commercial fish such as red hybrid tilapia are usually raised at high density to boost the production within a short period of time. This overcrowded environment, however, may cause stress to the cultured fish and increase susceptibility to infectious diseases. Antibiotics and chemotherapeutics are used by fish farmers to overcome these challenges, but this may increase the production cost. Read More

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Subpatent Plasmodium with mutant pfmdr1, pfcrt and pvmdr1 alleles from endemic provinces in Mindanao, The Philippines: implications for local malaria elimination.

Int J Infect Dis 2021 Jun 19. Epub 2021 Jun 19.

Dept of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; PHE Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine, London, UK. Electronic address:

Objectives: This study identifies and characterises circulating Plasmodium species in three provinces of Mindanao approaching malaria elimination.

Methods: RDT, microscopic examination and PCR were used to detect malaria parasites. PCR-positive isolates were genotyped for polymorphisms in loci of interest. Read More

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Countries with similar Covid-19 vaccination rates yet divergent outcomes: are all vaccines created equal?

Int J Infect Dis 2021 Jun 19. Epub 2021 Jun 19.

Child Health Department, Infectious Diseases Unit, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. PO Box. 35, Alkoudh.123. Electronic address:

The world is currently engaged in a race of vaccination vs. infection in an effort to control the Covid-19 pandemic. Some countries have already achieved high vaccination rates, offering a glimpse into the so-called "post-vaccination" world. Read More

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The relationship between height of vertical jumps, functionality and fall episodes in patients with chronic obstructive pulmonary disease: A case-control study.

Exp Gerontol 2021 Jun 19:111457. Epub 2021 Jun 19.

Exercise Research Laboratory, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address:

This study aimed to compare the height of jumps and functional parameters in patients with chronic obstructive pulmonary disease (COPD) to those in healthy people, in addition to assessing the relationship among variables in patients with COPD. Twenty patients with COPD (forced expiratory volume [FEV1] % of predicted: 39.98 ± 11. Read More

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Automated Segmentation of Choroidal Layers from 3-Dimensional Macular Optical Coherence Tomography Scans.

J Neurosci Methods 2021 Jun 19:109267. Epub 2021 Jun 19.

Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States; Institute for Vision Research, University of Iowa, Iowa City, Iowa, United States. Electronic address:

Background: Changes in choroidal thickness are associated with various ocular diseases, and the choroid can be imaged using spectral-domain optical coherence tomography (SD-OCT) and enhanced depth imaging OCT (EDI-OCT).

New Method: Eighty macular SD-OCT volumes from 80 patients were obtained using the Zeiss Cirrus machine. Eleven additional control subjects had two Cirrus scans done in one visit along with enhanced depth imaging (EDI-OCT) using the Heidelberg Spectralis machine. Read More

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Growth Rates of Infants Randomized to CPAP or Intubation After Extremely Preterm Birth.

J Pediatr 2021 Jun 19. Epub 2021 Jun 19.

National Institute of Child Health and Human Development, Bethesda, MD and Department of Global and Community Health, George Mason University, Fairfax, VA.

Objective: To evaluate the effects of early treatment with CPAP on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants.

Study Design: EPT infants (24-0/7 to 27-6/7 weeks of gestation) enrolled in the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) were included. EPT infants who died before 36 weeks' postmenstrual age (PMA) were excluded. Read More

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