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Materiovigilance In Health Centers: The Role Of Notifiers To Ensure Safer Use Of Medical Devices.

Ann Pharm Fr 2021 Sep 24. Epub 2021 Sep 24.

Team of Formulation and Quality Control of Health Products, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, National Institute of Oncology, Ibn Sina University Hospital Center, 10170 Rabat, Morocco.

Background: The implementation of efficient health and vigilance strategy is one of the essential aspects of the health policy of public and private health establishments, in order to reduce the risk of incidents due to medical devices.

Aim: The objective of this study is to demonstrate the importance of user notification and to recognize the role of nursing staff in the materiovigilance process.

Methods: This is a retrospective study of materiovigilance cases notified for three years (2016, 2017, and 2018) at the National Institute of Oncology. Read More

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September 2021

A Compliant Model of the Ventricular Apex to Study Suction in Ventricular Assist Devices.

ASAIO J 2021 Feb 4. Epub 2021 Feb 4.

From the Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium Institute of Clinical Physiology, National Research Council, Pisa, Italy Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria Ludwig-Boltzmann-Cluster for Cardiovascular Research, Vienna, Austria School of Engineering and Built Environment, Griffith University, Southport, QLD, Australia Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia ReinVAD GmbH, Aachen, Germany Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.

Ventricular suction is a frequent adverse event in patients with a ventricular assist device (VAD). This study presents a suction module (SM) embedded in a hybrid (hydraulic-computational) cardiovascular simulator suitable for the testing of VADs and related suction events. The SM consists of a compliant latex tube reproducing a simplified ventricular apex. Read More

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February 2021

[Anti-interleukin-1 agents: a new class of drugs for recurrent pericarditis. A practical guide for cardiologists].

G Ital Cardiol (Rome) 2021 Oct;22(10):833-843

Università di Milano, Dipartimento di Scienze Cliniche e Biomediche "Sacco", Ospedale Fatebenefratelli, Milano.

Anti-interleukin (IL)-1 agents have been developed for the treatment of autoinflammatory diseases characterized by overproduction of IL-1. Idiopathic recurrent pericarditis with inflammatory phenotype (fever, leukocytosis, and elevation of C-reactive protein) has similar features and responds well to this treatment. At present, in Italy, prescription of anakinra is possible for idiopathic recurrent pericarditis with corticosteroid dependence and colchicine resistance. Read More

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October 2021

Efficacy of Apneic Oxygenation During Pediatric Endotracheal Intubation.

Mark A Dancy

Pediatr Emerg Care 2021 Sep 20. Epub 2021 Sep 20.

From the University of Mississippi Medical Center, School of Nursing, Madison, MS.

Objective: Because of the abundance of complications associated with peri-intubation hypoxia, maintaining adequate oxygen saturation during endotracheal intubation (ETI) is of great concern. In addition to standard preoxygenation techniques, apneic oxygenation (AO), the continuous flow of passive oxygenation, is a potential tool that can be used to eliminate hypoxia during ETI. Although scarcely studied in the pediatric population, AO has proven effective in reducing the incidence of hypoxia in adult patients with minimal side effects. Read More

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September 2021

Effects of Esketamine on Acute and Chronic Pain After Thoracoscopy Pulmonary Surgery Under General Anesthesia: A Multicenter-Prospective, Randomized, Double-Blind, and Controlled Trial.

Front Med (Lausanne) 2021 8;8:693594. Epub 2021 Sep 8.

Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Post-operative pain management for patients undergoing thoracoscopy surgery is challenging for clinicians which increase both health and economic burden. The non-selective NMDA receptor antagonist esketamine possesses an analgesic effect twice that of ketamine. The application of esketamine might be beneficial in alleviating acute and chronic pain after thoracic surgery. Read More

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September 2021

Qualitative and Quantitative Analyses of Donor Site Morbidity Following a Graft of the Acellular Dermal Matrix Versus Primary Fascial Repair After ALT Flap Harvesting.

Plast Surg (Oakv) 2021 Aug 18;29(3):153-159. Epub 2020 Jun 18.

Department of Plastic and Reconstructive Surgery, College of Medicine, Chungnam National University, Daejeon, South Korea.

Background: The anterolateral thigh (ALT) flap is one of the most useful flaps in reconstruction because of its reliability, large skin flap territory, and versatility. The relatively small number of side effects is a common reason for preferring this flap. Primary repair is usually performed at the donor site closure; however, this requires substantial tension and causes many donor site morbidities, including pain. Read More

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Comparison of canine retraction by conventional and corticotomy-facilitated methods: A split mouth clinical study.

J Orthod Sci 2021 9;10. Epub 2021 Jul 9.

Department of Periodontics, I.T.S. Center for Dental Studies and Research, Muradnagar, Ghaziabad, Uttar Pradesh, India.

Objective: The purpose of this split-mouth single-centered, parallel-group, randomized clinical trial was to evaluate the efficiency of corticotomy-facilitated orthodontics in rapid canine retraction.

Methods: The sample consisted of 10 patients (15-25 years old) requiring extraction of the maxillary first premolars with subsequent canine retraction. The patients' right sides were randomly assigned to either the corticotomy (experimental) or control groups. Read More

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The role of diffusion tensor imaging in idiopathic sensorineural hearing loss: is it significant?

Pol J Radiol 2021 9;86:e474-e480. Epub 2021 Aug 9.

Department of Diagnostic Radiology, Mansoura University, Egypt.

Purpose: To assess the role of diffusion tensor imaging metrics in the evaluation of the microstructural integrity of the central auditory tract in patients with idiopathic sensorineural hearing loss (SNHL), and to compare these patients with healthy controls.

Material And Methods: This prospective study, which was conducted upon 30 subjects (21 males, 9 females; age range from 16 to 65 years, mean age 45years) with SNHL proven by audiometric tests. Ten age- and sex-matched healthy volunteers were included as a control group. Read More

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The impact of the COVID-19 pandemic on cancer care in the public health subsector, province of Santa Fe, Argentina.

Ecancermedicalscience 2021 26;15:1270. Epub 2021 Jul 26.

Cancer Control Agency, Ministry of Health, Bv. Pellegrini 3551, Zip Code 3000, Santa Fe, Argentina.

Introduction: The severe acute respiratory syndrome coronavirus 2 pandemic coronavirus disease (COVID-19) and the measures taken to lessen its impact have had side effects affecting timely care of other diseases. The aim of this paper is to quantify the impact of the pandemic on the cancer care line in the province of Santa Fe, Argentina.

Method: It is an observational cross-sectional study comparing the impact on selected variables of the pre-pandemic and intra-pandemic periods. Read More

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Transdermal buprenorphine for pain management in children.

Drugs Context 2021 14;10. Epub 2021 Sep 14.

Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Pain is one of the main symptoms reported by sick children, particularly by those suffering from cancer. Opioids are very useful in controlling this symptom but they are burdened with significant side effects that limit their use in children. Buprenorphine is a strong opioid that, due to its particular pharmacological characteristics, ensures excellent pain relief with fewer side effects than other opioids. Read More

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September 2021

Molecular Genetics, Clinical Characteristics, and Treatment Outcomes of K-Channel Neonatal Diabetes Mellitus in Vietnam National Children's Hospital.

Front Endocrinol (Lausanne) 2021 9;12:727083. Epub 2021 Sep 9.

Department of Endocrinology, Metabolism and Genetics, Vietnam National Children's Hospital, Hanoi, Vietnam.

Background: Neonatal diabetes mellitus (NDM) is defined as insulin-requiring persistent hyperglycemia occurring within the first 6 months of life, which can result from mutations in at least 25 different genes. Activating heterozygous mutations in genes encoding either of the subunits of the ATP-sensitive K channel (K channel; or ) of the pancreatic beta cell are the most common cause of permanent NDM and the second most common cause of transient NDM. Patients with NDM caused by K channel mutations are sensitive to sulfonylurea (SU) treatment; therefore, their clinical management can be improved by replacing insulin with oral agents. Read More

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September 2021

Quantifying the Changes of Mechanical and Electrical Properties of Paralyzed Muscle in Survivors With Cervical Spinal Cord Injury.

Front Neurol 2021 8;12:720901. Epub 2021 Sep 8.

Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China.

Survivors with spinal cord injury (SCI) have neuromuscular deficits such as muscle atrophy that lead to functional impairments. This study utilized myotonometry and electrical impedance myography (EIM) to quantitatively evaluate the changes in muscle mechanical properties and compositions after SCI. This study adopted a cross-sectional design. Read More

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September 2021

Multi-Target and Multi-Session Transcranial Direct Current Stimulation in Patients With Prolonged Disorders of Consciousness: A Controlled Study.

Front Neurosci 2021 8;15:641951. Epub 2021 Sep 8.

Department of Rehabilitation, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

To investigate the effect of multi-session transcranial direct current stimulation (tDCS) over the prefrontal area, left dorsolateral prefrontal cortex (DLPFC), and bilateral fronto-temporo-parietal cortices (FTPCs) in patients with prolonged disorders of consciousness (DOC) and to examine the altered cortical interconnections using non-linear electroencephalography (EEG). In this open-label controlled study, conventional treatments were implemented in both the control and tDCS groups, together with 80 tDCS sessions only in the tDCS group. The order of tDCS targets was as follows: prefrontal area, left FTPC, right FTPC, and left DLPFC. Read More

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September 2021

Effects of Sant. F against gamma radiation-induced testicular injuries in Swiss albino mice.

Ayu 2020 Jan-Mar;41(1):45-51. Epub 2021 Jul 30.

Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, Rajasthan, India.

Background: Radiation therapy is considered as an important tool in cancer treatment. Despite its impressive role in treating cancer, severe side effects in organs have been reported. To address these therapeutic side effects, several combination methods have been identified to minimize adverse effects caused by radiation therapy. Read More

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Evaluation of sodium lauryl sulfate for the development of cow-side mastitis screening test.

Vet World 2021 Aug 31;14(8):2290-2295. Epub 2021 Aug 31.

Population Medicine and AMR Laboratory, Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh.

Background And Aim: Subclinical mastitis (SCM) is an economically important disease for dairy cattle worldwide; therefore, regular screening is imperative to detect SCM at an early stage so as to control it. The study was conducted to compare the test characteristics of sodium lauryl sulfate (SLS) as a test reagent to detect SCM in dairy cows.

Materials And Methods: First, 106 milk samples of dairy cows were subjected to available indirect screening tests (white side test [WST], surf field mastitis test, Leucocytest, and Immucell) considering somatic cell count (SCC) as gold standard test. Read More

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Wound healing potential of human umbilical cord mesenchymal stem cell conditioned medium: An and study in diabetes-induced rats.

Vet World 2021 Aug 17;14(8):2109-2117. Epub 2021 Aug 17.

Department of Dermatovenereology, Faculty of Medicine, Tarumanagara University, 11440, Jakarta, Indonesia.

Background And Aim: Human umbilical cord mesenchymal stem cells (hUC-MSCs) and its conditioned medium (CM) promote wound healing. This study investigated the wound healing potential of hUC-MSC CM and using diabetic animal models.

Materials And Methods: The CM from hUC-MSC CM prepared under hypoxic conditions (hypoxic hUC-MSC) was evaluated for stimulating rat fibroblast growth, collagen production (), and wound healing in animal models (). Read More

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Oral Progestins in Hormonal Contraception: Importance and Future Perspectives of a New Progestin Only-Pill Containing 4 mg Drospirenone.

Geburtshilfe Frauenheilkd 2021 Sep 14;81(9):1021-1030. Epub 2021 Jun 14.

Medical Director Exeltis Europe, Ismaning, Germany.

Hormonal contraceptives are an effective and safe method for preventing pregnancy. Progestins used in contraception are either components of combined hormonal contraceptives (tablets, patches or vaginal rings) or are used as a single active ingredient in progestin mono-preparations (the progestin-only pill (POP), implants, intrauterine systems or depot preparations). Progestins are highly effective in long-term contraception when used properly, and have a very good safety profile with very few contraindications. Read More

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September 2021

Direct intraoperative versus percutaneous computed tomographyguided celiac plexus neurolysis in non-resectable pancreatic cancer: A randomized, controlled, non-inferiority study.

Rev Esp Anestesiol Reanim 2021 Sep 23. Epub 2021 Sep 23.

Department of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Egipto.

Background: Celiac plexus neurolysis (CPN) has been used to control pancreatic cancer (PC) pain, up to our knowledge, there is no study compared intraoperative CPN and computed tomography (CT)-guided techniques.

Objectives: To compare the effects of intraoperative and CT-guided CPN in unresectable PC on pain intensity and analgesic requirements.

Methods: A total of 90 patients were enrolled in this prospective, randomized, open label, controlled, non-inferiority study, 20 patients were excluded or lost to follow up. Read More

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September 2021

Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews.

Cochrane Database Syst Rev 2021 Sep 26;9:CD013092. Epub 2021 Sep 26.

Global Health Nursing, Graduate School of Nursing Science, St. Luke's International University , Tokyo, Japan.

Background: Anaemia is a prevalent health problem worldwide. Some types are preventable or controllable with iron supplementation (pills or drops), fortification (sprinkles or powders containing iron added to food) or improvements to dietary diversity and quality (e.g. Read More

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September 2021

Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction: a randomized, double-blind clinical trial.

Med Oral Patol Oral Cir Bucal 2021 Sep 25. Epub 2021 Sep 25.

Avenida dos Portugueses, s/n, Cidade Universitária Dom Delgado CEP 65085-580, São Luís, MA, Brazil

Background: To evaluate the efficacy of intra-alveolar administration of dexamethasone 4 mg in the control of edema, trismus, and pain resulting from the extraction of impacted lower third molars and the drug permeability through the oral mucosa by in silico prediction.

Material And Methods: The randomized, double-blind, split-mouth clinical trial included patients who had both impacted lower third molars in equivalent positions. Hemiarches were divided into control side when dexamethasone was administered orally and experimental side when dexamethasone was administered using the intra-alveolar route. Read More

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September 2021

Cannabidiol (CBD) and cognition in epilepsy.

Epilepsy Behav 2021 Sep 23;124:108316. Epub 2021 Sep 23.

Department of Neurology and the UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA; Departments of Neurobiology and Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Anecdotal reports of the benefits of cannabis and its components in the treatment of epilepsy have been reported for millennia. However, only recently randomized controlled trial data in support of cannabidiol (CBD) became available resulting in its FDA approval for the treatment of seizures and epilepsy. One of the most common and debilitating comorbidities of epilepsy is cognitive impairment. Read More

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September 2021

Adaptive current harmonics suppression strategy for grid-tie inverters.

ISA Trans 2021 Sep 2. Epub 2021 Sep 2.

School of Automation Science and Engineering, South China University of Technology, Guangzhou, 510640, China. Electronic address:

Since the observed angle of a phase-locked loop (PLL) is relatively accurate even under distorted grid conditions, the mathematical model of the voltage errors caused by the switching modulation and the dead-time effect are derived as a function of the grid voltage angle in this paper. Based on the model analysis, an adaptive compensation algorithm is proposed to suppress the grid-side current harmonics in three-phase converters. The proposed algorithm fits the unmeasurable voltage errors by a truncated Fourier series expansion, and then takes it as an equivalent disturbance in the current control loop to achieve harmonic compensation. Read More

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September 2021

The PRolaCT studies - a study protocol for a combined randomised clinical trial and observational cohort study design in prolactinoma.

Trials 2021 Sep 25;22(1):653. Epub 2021 Sep 25.

Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.

Background: First-line treatment for prolactinomas is a medical treatment with dopamine agonists (DAs), which effectively control hyperprolactinaemia in most patients, although post-withdrawal remission rates are approximately 34%. Therefore, many patients require prolonged DA treatment, while side effects negatively impact health-related quality of life (HRQoL). Endoscopic transsphenoidal resection is reserved for patients with severe side effects, or with DA-resistant prolactinoma. Read More

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September 2021

The effect of an eye mask on midazolam requirement for sedation during spinal anesthesia: a randomized controlled trial.

BMC Anesthesiol 2021 Sep 25;21(1):232. Epub 2021 Sep 25.

Department of Anesthesiology and Pain Medicine, Jeonbuk National University Medical School and Hospital, 20, Geonji-ro, Deokjin-gu, Jeonju, 54907, South Korea.

Background: Midazolam is frequently used for sedation during spinal anesthesia. However, external environmental factors, such as bright surgical lights, may hamper patient relaxation, which may lead to an increase in the dose of midazolam required and the likelihood of adverse drug effects. We investigated whether using an eye mask to block the external environment could reduce midazolam requirements during spinal anesthesia. Read More

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September 2021

A Vascular Intervention Assist Device Using Bi-Motional Roller Cartridge Structure and Clinical Evaluation.

Biosensors (Basel) 2021 Sep 10;11(9). Epub 2021 Sep 10.

Department of Biomedical Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Conventional vascular intervention procedures present issues including X-ray exposure during operation, and an experience-dependent success rate and clinical outcome. This paper presents a novel robotic system using modularized bi-motional roller cartridge assemblies for robotic vascular interventions, specifically percutaneous coronary interventions (PCIs). The patient-side robot manipulates instruments such as the guiding catheter, guidewire, balloon/stent catheter, and diagnostic sensor catheter via commands from the user interface device, which is controlled by the physician. Read More

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September 2021

Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system.

J Control Release 2021 Sep 22;339:75-90. Epub 2021 Sep 22.

Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

The multidisciplinary field of photodynamic therapy (PDT) is a combination of photochemistry and photophysics sciences, which has shown tremendous potential for cancer therapy application. PDT employs a photosensitizing agent (PS) and light to form cytotoxic reactive oxygen species and subsequently oxidize light-exposed tissue. Despite numerous advantages of PDT and enormous progress in this field, common PSs are still far from ideal treatment because of their poor permeability, non-specific phototoxicity, side effects, hydrophobicity, weak bioavailability, and tendency to self-aggregation. Read More

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September 2021

The effects of maximal radial bowing on forearm rotation in pediatric diaphyseal forearm fractures.

Musculoskelet Surg 2021 Sep 24. Epub 2021 Sep 24.

Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok, 10700, Thailand.

Purpose: To evaluate the effects of radial bowing on forearm rotation in forearm fractures compared with healthy children.

Methods: A retrospective study was conducted on children aged 1-16 years old. Group 1 was children with history of diaphyseal forearm fractures, and group 2 was healthy children. Read More

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September 2021

Resection of Clival Chordoma Through the Anterior Clivectomy: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Clival chordomas are rare malignant behaving tumors that grow, locally invade, metastasize, and seed, and they have a high recurrence rate.1,2 The longest disease control is achieved by radical resection followed by high doses of radiation therapy, commonly proton beam.3  To achieve radical tumor removal, multiple surgical procedures through different approaches might be required. Read More

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September 2021

3D Real IR MR Findings in Acoustic Neuromas: Altered Perilymph Metabolism.

Ear Nose Throat J 2021 Sep 24:1455613211047124. Epub 2021 Sep 24.

ENT Institute and Otorhinolaryngology Department, 159395Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.

Objectives: This study aimed to investigate the perilymph metabolism by analyzing the 3D real IR MR findings in acoustic neuroma (AN) after intravenous administration of gadolinium (Gd).

Methods: Eleven patients (6 men and 5 women) diagnosed with AN were included, and 3D real IR MRI was performed 4 hours after intravenous Gd injection. The signal intensity and details of inner ear, tumor, and internal auditory canal (IAC) by MRI were analyzed. Read More

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September 2021