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Ammonia nitrogen exposure caused structural damages to gill mitochondria of clam Ruditapes philippinarum.

Ecotoxicol Environ Saf 2021 Jul 23;222:112528. Epub 2021 Jul 23.

Ocean School, Yantai University, Yantai 264005, PR China.

Ammonia nitrogen has been one of the key pollution indicators along the Chinese coastline for quite a few years. Our previous studies have proved that ammonia nitrogen is harmful for Ruditapes philippinarum clam in several aspects. Environmental concentrations of ammonia nitrogen were found to significantly decrease ATP contents and disturb ATP metabolism, in addition to reducing the potential across the mitochondrial membrane in clam gill tissues. Read More

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Dual electrochemical genosensor for early diagnosis of prostate cancer through lncRNAs detection.

Biosens Bioelectron 2021 Jul 21;192:113520. Epub 2021 Jul 21.

Departamento de Química Física y Analítica. Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma, 33011, Oviedo, Spain. Electronic address:

The prostate specific antigen (PSA) test is the gold standard for the screening of prostate cancer (PCa), despite its limited clinical specificity. Long noncoding RNAs are released from the tumor tissue to the urine and show great potential for improving specificity in PCa diagnosis. This work reports on a sandwich-type hybridization assay to detect both the urinary biomarker prostate cancer antigen 3 (PCA3) and an endogenous control, the PSA mRNA. Read More

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Bioassay-guided study of the anti-inflammatory effect of Anoectochilus burmannicus ethanolic extract in RAW 264.7 cells.

J Ethnopharmacol 2021 Jul 23:114452. Epub 2021 Jul 23.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Muang Chiang Mai, Chiang Mai, 50200, Thailand. Electronic address:

Ethnopharmacological Relevance: Anoectochilus species is a small terrestrial orchid found in tropical and subtropical rain forest. These orchids are traditionally used extensively in China, Taiwan, and Vietnam due to their medicinal properties and therapeutic benefits. They are employed for treatment in different systems, such as stomach disorders, chest pain, arthritis, tumor, piles, boils, menstrual disorders, and inflammation. Read More

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Sedentary Behavior in United States Adults: Fall 2019.

Med Sci Sports Exerc 2021 Jul 23. Epub 2021 Jul 23.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO Risk Factor Assessment Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control, Atlanta, GA Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Department of Geography, University of Hong Kong, Hong Kong, China Department of Kinesiology, California Polytechnic State University, San Luis Obispo, CA Health Behaviors Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD.

Purpose: Higher levels of sedentary behavior are associated with early mortality, but the distribution of sedentary time by classes of behavior and demographic groups is poorly described in United States (US) adults. To quantify the amount and sources of sedentary time in US adults we conducted a nationwide survey using a novel validated self-administerd previous-day recall method and compare these values with a commonly used sitting time question.

Methods: Participants from the AmeriSpeak panel aged 20 to 75 years (N = 2,640) completed up to two Activities Completed over Time in 24 Hours (ACT24) previous day recalls. Read More

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Risk factors for gastric cancer: a large-scale, population-based case-control study.

Chin Med J (Engl) 2021 Jul 22. Epub 2021 Jul 22.

Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implement, Beijing 100021, China Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Background: Early detection of gastric cancer (GC) has been the topic of major efforts in China. This study aimed to explore the risk factors associated with GC and to provide evidence for the selection of a high-risk population of GC.

Methods: Based on the cancer screening cohort of the National Cancer Screening Program in Urban China, GC patients diagnosed by endoscopy and pathological examinations constituted the case group, and controls were 1:3 matched by sex and age (±5 years) individually. Read More

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At Preeclampsia Diagnosis, Total Cell-Free DNA Concentration is Elevated and Correlates With Disease Severity.

J Am Heart Assoc 2021 Jul 26:e021477. Epub 2021 Jul 26.

Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Washington Seattle WA.

Background Placental derived cell-free DNA (cfDNA), widely utilized for prenatal screening, may serve as a biomarker for preeclampsia. To determine whether cfDNA parameters are altered in preeclampsia, we conducted a case-control study using prospectively collected maternal plasma (n=20 preeclampsia, n=22 normal) using our in-house validated prenatal screening assay. Methods and Results Isolated cfDNA was quantified, sequenced using Illumina NextSeq 500, and the placental-derived fraction was determined. Read More

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High-throughput detection of eukaryotic parasites and arboviruses in mosquitoes.

Biol Open 2021 Jul 19;10(7). Epub 2021 Jul 19.

Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Vector-borne pathogens cause many human infectious diseases and are responsible for high mortality and morbidity throughout the world. They can also cause livestock epidemics with dramatic social and economic consequences. Due to its high costs, vector-borne disease surveillance is often limited to current threats, and the investigation of emerging pathogens typically occurs after the reports of clinical cases. Read More

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The effects of vitamin D-fortified foods on circulating 25(OH)D concentrations in adults: A systematic review and meta-analysis.

Br J Nutr 2021 Jul 26:1-47. Epub 2021 Jul 26.

Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, ;

Improvement of vitamin D status of the general population has been a challenge for policymakers. We conducted a meta-analysis to evaluate whether vitamin D-fortified products can be a suitable solution for tackling vitamin D deficiency (VDD). Our secondary objective was to determine the effect of some variables including age, latitude and body mass index (BMI) on efficacy of this strategy. Read More

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The substantial burden of non-communicable diseases and HIV-comorbidity amongst adults: Screening results from an integrated HIV testing services clinic for adults in Soweto, South Africa.

EClinicalMedicine 2021 Aug 14;38:101015. Epub 2021 Jul 14.

Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Chris Hani Baragwanath Academic Hospital, Johannesburg 1864, South Africa.

Background: South Africa is disproportionately impacted by non-communicable diseases (NCDs) and HIV/AIDS. We investigated the prevalence of known/unknown NCD risk factors, HIV, and NCD risk factor-HIV comorbidity; and treatment status on known diseases to determine the prevalence of controlled/uncontrolled disease.

Methods: This cross-sectional study (June 2018-March 2019) within an integrated testing centre in Soweto, South Africa, screened adults (aged ≥18 years) for body mass index (BMI), hypertension (HT), rapid glucose and cholesterol, and HIV. Read More

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Reproductive and Lifestyle Characteristics of Kenyan Women Presenting With Precancerous Cervical Lesions: A Hospital-Based Case-Control Study.

East Afr Health Res J 2019 29;3(2):115-124. Epub 2019 Nov 29.

Department of Microbiology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya.

Background: Cervical cancer is a leading cause of cancer in women, accounting for 68% of cancer-related deaths among women in developing countries. Several reproductive, lifestyle and demographic risk factors are associated with increased risk for cervical cancer. This study examined the association of risk factors with precancerous cervical lesion grade in women attending Nakuru County Referral Hospital. Read More

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November 2019

Dataset on the use of MGIDI index in screening drought-tolerant wild wheat accessions at the early growth stage.

Data Brief 2021 Jun 26;36:107096. Epub 2021 Apr 26.

Botany Unit, Finnish Museum of Natural History, University of Helsinki, P.O. Box 7, Helsinki FI-00014, Finland.

The dataset herein indicated the novelty of the article entitled "Dataset on the use of MGIDI in screening drought-tolerant wild wheat accessions at the early growth stage". Data were gathered during 2018-2019 on a set of wild wheat germplasm under two control and water deficit stress conditions. One hundred and forty-six accessions belonging to , and were assessed under optimal glasshouse conditions to screen the drought-tolerant samples at the early growth stage. Read More

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Depression and Coping Styles of College Students in China During COVID-19 Pandemic: A Systemic Review and Meta-Analysis.

Front Public Health 2021 7;9:613321. Epub 2021 Jul 7.

Department of Mathematics and Computer Science, Changsha University, Changsha, China.

The rapid spread and uncertain outcome of the 2019 novel coronavirus disease (COVID-19) around the world have caused worry, fear, and stress among the general population. Nevertheless, the prevalence of depression among college students in China during lockdown, following the COVID-19 pandemic, and their coping strategies have not been quantitatively assessed. We aimed to evaluate the prevalence of depression among college students in China during the lockdown due to the COVID-19 pandemic and assess their coping strategies. Read More

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Persian Validation and Cultural Adaptation of the Body Dysmorphic Disorder Questionnaire-Aesthetic Surgery for Iranian Rhinoplasty Patients.

World J Plast Surg 2021 May;10(2):55-60

ENT and Head & Neck Research Center, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran, Iran.

Background: Body dysmorphic disorder (BDD) is one of the obsessive-compulsive disorders (OCD) which is very common in populations. However, the diagnosis rate is lower than the reality. BDD may lead to loneliness, jobless, avoidance of daily life and public activities. Read More

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Anaemia Associated with Trypanosomes Infections in Cattle of West Gojjam Zone, Northwest Ethiopia.

Vet Med Int 2021 29;2021:5531537. Epub 2021 Jun 29.

National Institute for the Control and Eradication of Tsetse Fly and Trypanosomosis, Akaki Kaliti Sub-City P.O. Box 19917, Addis Ababa, Ethiopia.

Background: African animal trypanosomosis is a major veterinary problem over a large area of the tsetse belt region of Africa. Anaemia is a cardinal sign of trypanosome infections. The mechanism of anaemia due to trypanosomosis is complex and multifactorial in origin. Read More

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Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task.

Neural Plast 2021 1;2021:8825091. Epub 2021 Jul 1.

Department of Clinical Neurosciences, Psychiatry, Pediatrics and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

Background: Tic disorders may reflect impaired inhibitory control. This has been evaluated using different behavioural tasks, yielding mixed results. Our objective was to test inhibitory control in children with tics through simultaneous presentation of multiple, mobile stimuli. Read More

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Untargeted Metabolomic Profiling of Liver in a Chronic Intermittent Hypoxia Mouse Model.

Front Physiol 2021 8;12:701035. Epub 2021 Jul 8.

Department of Laboratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.

Obstructive sleep apnea (OSA) has been demonstrated to be associated with liver injury. Nevertheless, the mechanisms linking the two disorders remain largely unexplored to date. Based on UHPLC/Q-TOF MS platform, the present study aimed to study the hepatic metabolomic profiling in a chronic intermittent hypoxia (CIH) mouse model to identify altered metabolites and related metabolic pathways. Read More

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Serum Golgi protein 73 as a sensitive biomarker for early detection of hepatocellular carcinoma among Egyptian patients with hepatitis C virus-related cirrhosis.

Med J Armed Forces India 2021 Jul 22;77(3):331-336. Epub 2021 Feb 22.

Internal Medicine Department, Mansoura University, El-Gomhouria Street, El-Mansoura, 35516, Egypt.

Background: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy. Early detection of HCC is always a challenging task for physicians. Serum Golgi protein 73 (GP73) is considered a potential tumor marker for the detection of HCC. Read More

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[The characteristic analysis of benign paroxysmal vertigo and vestibular migraine in children with anxiety and depression].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 May;35(5):416-419

National Center for Children's Health,Department of Otorhinolaryngology Head and Neck Surgery,Beijing Children' s Hospital,Capital Medical University,Beijing,100045,China.

Benign paroxysmal vertigo (BPV) and vestibular migraine (VM) are the most common causes of recurrent vertigo in children. The objective of this article is Tto investigate the clinical characteristic of anxiety and depression in children with BPV and VM. Fifty-six patients diagnosed as BPV and VM with vertigo were collected. Read More

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The role of thyroid hormones in carotid arterial wall remodeling in women.

Rom J Intern Med 2021 Jul 23. Epub 2021 Jul 23.

Croatian Academy of Sciences and Arts, Trg Nikole Subica Zrinskog 11, 10000Zagreb, Croatia.

Introduction: Thyroid hormones affect the cardiovascular system, but the precise mechanisms of their effects on the development of atherosclerosis are not entirely clear. The relationship between subclinical hypothyroidism, dyslipidemia and carotid atherosclerosis has been widely investigated, but the findings were controversial. The aim of the present study was to determine whether female subjects with subclinical hypothyroidism (SHypo) have increased carotid intima-media thickness (IMT) compared with euthyroid subjects, as well as to examine the association of SHypo, carotid atherosclerosis and dyslipidemia. Read More

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Exploring qualities of ethnically diverse parents related to the healthy home environment of toddlers.

Appetite 2021 Jul 21;167:105608. Epub 2021 Jul 21.

Department of Health and Human Performance, University of Houston, USA. Electronic address:

Parents serve as role models and household policy makers for their children's home social environment. Also, parents may influence the home physical environment through the provision of resources to support their children's dietary, activity, and sleep behaviors. Understanding the parental characteristics related to children's home environment may allow for tailoring obesity interventions to families' needs. Read More

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Effects of home-based walking on cancer-related fatigue in patients with breast cancer: a meta-analysis of randomized controlled trials.

Arch Phys Med Rehabil 2021 Jul 21. Epub 2021 Jul 21.

The First Affiliated Hospital of Soochow University, Suzhou 215006, People's Republic of China; School of Nursing, Medical College of Soochow University, Suzhou 215006, People's Republic of China. Electronic address:

Objective: This study was designed to critically evaluate the effect of home-based walking on cancer-related fatigue (CRF) in patients with breast cancer receiving anti-cancer treatment.

Data Sources: Eight databases were systematically searched from inception to March 2021 for randomized controlled trials (RCTs) without language restrictions.

Study Selection: Two reviewers scanned the titles and abstracts, and then read the full texts of potentially eligible trials to screen the literature. Read More

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Vikela Ekhaya: a novel, community-based, tuberculosis contact management program in a high burden setting.

Clin Infect Dis 2021 Jul 24. Epub 2021 Jul 24.

The Global Tuberculosis Program, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.

Background: The prevention of tuberculosis (TB) in child contacts of TB cases and people living with HIV is a public health priority, but global access to TB preventive therapy (TPT) remains low. In 2019, we implemented Vikela Ekhaya, a novel community-based TB contact management program in Eswatini designed to reduce barriers to accessing TPT.

Methods: Vikela Ekhaya offered differentiated TB and HIV testing for household contacts of TB cases, by utilizing mobile contact management teams to screen contacts, assess their TPT eligibility, and initiate and monitor TPT adherence in participants' homes. Read More

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Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity.

Genes Dev 2021 Jul 22. Epub 2021 Jul 22.

Laboratory of Chronobiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin,10117 Berlin, Germany.

In all organisms with circadian clocks, post-translational modifications of clock proteins control the dynamics of circadian rhythms, with phosphorylation playing a dominant role. All major clock proteins are highly phosphorylated, and many kinases have been described to be responsible. In contrast, it is largely unclear whether and to what extent their counterparts, the phosphatases, play an equally crucial role. Read More

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The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping.

Genes Dev 2021 Jul 22. Epub 2021 Jul 22.

Department of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA.

Knowledge of how Mediator and TFIID cross-talk contributes to promoter-enhancer (P-E) communication is important for elucidating the mechanism of enhancer function. We conducted an shRNA knockdown screen in murine embryonic stem cells to identify the functional overlap between Mediator and TFIID subunits on gene expression. Auxin-inducible degrons were constructed for TAF12 and MED4, the subunits eliciting the greatest overlap. Read More

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Proinflammatory and Hepatic Features Related to Morbidity and Fatal Outcomes in COVID-19 Patients.

J Clin Med 2021 Jul 15;10(14). Epub 2021 Jul 15.

Precision Nutrition and Cardiometabolic Health, IMDEA Food Institute, CEI UAM+CSIC, 28049 Madrid, Spain.

Objective: to screen putative associations between liver markers and proinflammatory-related features concerning infectious morbidity and fatal outcomes in COVID-19 patients.

Methods: a total of 2094 COVID-19 positive patients from the COVID-DATA-SAFE-LIFES cohort (HM hospitals consortium) were classified according to median values of hepatic, inflammatory, and clinical indicators. Logistic regression models were fitted and ROC cures were generated to explain disease severity and mortality. Read More

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Dysregulated Tear Film Proteins in Macular Edema Due to the Neovascular Age-Related Macular Degeneration Are Involved in the Regulation of Protein Clearance, Inflammation, and Neovascularization.

J Clin Med 2021 Jul 10;10(14). Epub 2021 Jul 10.

Department of Vitreoretinal Surgery, Medical University of Lublin, 20-079 Lublin, Poland.

Macular edema and its further complications due to the leakage from the choroidal neovascularization in course of the age-related macular degeneration (AMD) is a leading cause of blindness among elderly individuals in developed countries. Changes in tear film proteomic composition have been reported to occur in various ophthalmic and systemic diseases. There is an evidence that the acute form of neovascular AMD may be reflected in the tear film composition. Read More

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Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.

Cancers (Basel) 2021 Jul 19;13(14). Epub 2021 Jul 19.

Department of Molecular Pathology, Osaka City University Graduate School of Medicine, Abeno-ku, 1-4-3 Asahi-machi, Osaka 545-8585, Japan.

In the present study, the role of a novel protein involved in neurite development and endoplasmic reticulum (ER) stress, canopy homolog 2 (CNPY2), was investigated in mouse and human hepatocarcinogenesis. Firstly, a sensitive quantitative and qualitative detection of protein expression using QSTAR Elite LC-Ms/Ms was performed for the analysis of lysates of microdissected hepatocellular altered foci (AF), adenomas (HCAs), carcinomas (HCCs) and peri-tumoral livers from C57Bl/6J mice treated with diethylnitrosamine (DEN) and then maintained for 27 or 38 weeks on basal diet. Significant overexpression of 18. Read More

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Identification of autophagy-associated miRNA signature for the cervical squamous cell cancer and high-grade cervical intraepithelial lesions.

Reprod Biol 2021 Jul 20;21(3):100536. Epub 2021 Jul 20.

Department of Obstetrics and Gynecology, University of Gaziantep, Gaziantep, Turkey.

Cervical cancer markedly threatens women's health worldwide and currently ranks fourth leading cause of cancer mortality in women according to recent global cancer statistics. Recent advances have proven that not only tumor suppressor and oncogenes but also non-coding RNAs including micro RNAs (miRNAs) have significant impact in the development and progression of cervical cancers. Previous studies have identified many cancer-specific miRNAs for the early detection of cervical cancers. Read More

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Potent in vitro synergistic antibacterial activity of natural amphiphilic Sapindoside A and B against Cutibacterium acnes with destructive effect on bacterial membrane.

Biochim Biophys Acta Biomembr 2021 Jul 20;1863(11):183699. Epub 2021 Jul 20.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, No. 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, China. Electronic address:

Sapindus saponins are obtained from the outer bark of Sapindus mukorossi Gaertn. (S. mukorossi), and they have become an interesting subject in the search for new anti-acne agents without resistance. Read More

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Perception of breast cancer risk factors: Dysregulation of TGF-β/miRNA axis in Pakistani females.

PLoS One 2021 23;16(7):e0255243. Epub 2021 Jul 23.

Laboratory of Applied and Functional Genomics, National Center of Excellence in Molecular Biology, University of the Punjab Lahore, Lahore, Pakistan.

Breast cancer poses a serious health risk for women throughout the world. Among the Asian population, Pakistani women have the highest risk of developing breast cancer. One out of nine women is diagnosed with breast cancer in Pakistan. Read More

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