114,596 results match your criteria control include

Experiences of people with opioid use disorder during the COVID-19 pandemic: A qualitative study.

PLoS One 2021 29;16(7):e0255396. Epub 2021 Jul 29.

Department of Emergency Medicine, St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

Aim: To capture pandemic experiences of people with opioid use disorder (OUD) to better inform the programs that serve them.

Design: We designed, conducted, and analyzed semi-structured qualitative interviews using grounded theory. We conducted interviews until theme saturation was reached and we iteratively developed a codebook of emerging themes. Read More

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Effects of screen-based retinal light stimulation measured with a novel contrast sensitivity test.

PLoS One 2021 29;16(7):e0254877. Epub 2021 Jul 29.

Institute for Ophthalmic Research, Eberhard Karls University Tübingen, Tübingen, Germany.

Myopia is increasing worldwide hence it exists a pressing demand to find effective myopia control strategies. Previous studies have shown that light, spectral composition, spatial frequencies, and contrasts play a critical role in refractive development. The effects of light on multiple retinal processes include growth regulation, but also visual performance and perception. Read More

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Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults.

PLoS Med 2021 Jul 29;18(7):e1003716. Epub 2021 Jul 29.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.

Background: Over 3.5 billion individuals worldwide are exposed to household air pollution from solid fuel use. There is limited evidence from cohort studies on associations of solid fuel use with risks of major eye diseases, which cause substantial disease and economic burden globally. Read More

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Awareness regarding and vaccines acceptability of human papillomavirus among parents of middle school students in Zunyi, Southwest China.

Hum Vaccin Immunother 2021 Jul 29:1-6. Epub 2021 Jul 29.

School of Public Health, Zunyi Medical University, Zunyi, China.

The objective of this study was to investigate the parent cognition of information regarding the human papillomavirus (HPV) and their willingness toward HPV vaccination of their middle-school-aged children in Zunyi, Guizhou Province, China.The results provide a basis for improving the awareness concerning HPV-related information as a key vaccination strategy for implementing the HPV vaccine in the local context. Methods include the random cluster sampling method and questionnaires to survey parents. Read More

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Cardiac structural and functional abnormalities in primary hyperparathyroidism.

J Endocrinol Invest 2021 Jul 29. Epub 2021 Jul 29.

Department of Medicine, Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India.

Purpose: Studies on cardiac structural and functional abnormalities in primary hyperparathyroidism (PHPT) have yielded conflicting and inconsistent results. In this prospective case-control study, we sought to compare cardiac structure and function in symptomatic PHPT patients and controls.

Methods: One hundred consecutive symptomatic PHPT patients and 113 matched controls underwent echocardiographic evaluation by the same operator. Read More

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Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic.

JAMA Netw Open 2021 Jul 1;4(7):e2118433. Epub 2021 Jul 1.

SWOG Cancer Research Network Group Chair's Office, Portland, Oregon.

Importance: During the initial outbreak of the COVID-19 pandemic, cancer clinical trial participation decreased precipitously. Given the continued pandemic-especially the severe wave of new cases and deaths in winter 2020 to 2021-a vital question is whether trial enrollments have remained low or even worsened.

Objective: To examine the experience of cancer clinical trial enrollment 1 year after the COVID-19 outbreak. Read More

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Evaluation and Management of Posterior Wall Acetabulum Fractures.

J Am Acad Orthop Surg 2021 Jul 23. Epub 2021 Jul 23.

From the Department of Orthopaedic Surgery (Perdue, Toney), Christiana Hospital, Newark, DE (Tainter) Virginia Commonwealth University, Richmond, VA, and the Department of Orthopaedic Surgery (Lee), University of California, Los Angeles, Los Angeles, CA.

Posterior wall acetabulum fractures typically result from high-energy mechanisms and can be associated with various orthopaedic and nonorthopaedic injuries. They range from isolated simple patterns to multifragmentary with or without marginal impaction. Determination of hip stability, which can depend on fragment location, size, and displacement, directs management. Read More

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Chlorella vulgaris phycoremediation at low Cu contents: Proteomic profiling of microalgal metabolism related to fatty acids and CO fixation.

Chemosphere 2021 Jun 29;284:131272. Epub 2021 Jun 29.

Dempster MS Lab, Chemical Engineering Department of Polytechnic School of University of São Paulo (USP), R. Do Lago, 250, Butantã, São Paulo, SP, 05338-110, Brazil.

The aim of this work was to correlate metabolic changes with copper ions (Cu) bioremediation by microalgae C. vulgaris 097 CCMA-UFSCar at low Cu content. The metabolic effects include proteome changes related to fatty acid biosynthesis (value-added product) and carbon fixation (climate change mitigation). Read More

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Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme.

Biomed Pharmacother 2021 Jul 19;141:111928. Epub 2021 Jul 19.

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address:

Glioblastoma multiforme is one of the most deadly malignant tumors, with more than 10,000 cases recorded annually in the United States. Various clinical analyses and studies show that certain chronic diseases, including cancer, interact between cell-reactive radicals rise and pathogenesis. Reactive oxygen and nitrogenous sources include endogenous (physiological processes), and exogenous sources contain reactive oxygen and nitrogen (xenobiotic interaction). Read More

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The Pyrazinacenes.

Acc Chem Res 2021 Jul 29. Epub 2021 Jul 29.

Functional Chromophores Group, International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.

ConspectusPyrazinacenes are a class of nitrogen-containing heteroacene molecules composed of linearly fused pyrazine units, which might also include dihydropyrazine groups leading to different reduced states of the compounds. While they are structurally similar to hydrocarbon acenes (e.g. Read More

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Pancreatic Cancer Related Pain: Review of Pathophysiology and Intrathecal Drug Delivery Systems for Pain Management.

Gabriel Carvajal

Pain Physician 2021 Aug;24(5):E583-E594

Centro Nacional de Control del Dolor y Cuidados Paliativos Interventional Pain Management Unit, San José, Costa Rica.

Background: Pancreatic cancer (PC) is one of the most lethal cancers and is the eleventh most common cancer worldwide. This disease is characterized by an often-fatal evolution and a high burden of symptoms, particularly pain. Several studies have demonstrated that pancreatic cancer patients have a high prevalence of pain, with up to 82% of patients reporting pain, often requiring systemic strong opioids as mainstay treatment. Read More

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Quadratus Lumborum Block is an Effective Postoperative Analgesic Technique in Pediatric Patients Undergoing Lower Abdominal Surgery: A Meta-Analysis.

Pain Physician 2021 Aug;24(5):E555-E563

Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou First People's Hospital Qianjiang New City Campus, The Affiliated Women's Hospital of Hangzhou Normal University), Hangzhou, China.

Background: Quadratus lumborum (QL) block has shown promising analgesic efficacy in the adult population in previous meta-analyses. However, the response of the pediatric group to pain stimulation is stronger than that in the adult population, and the management of pediatric pain is constrained by limited available analgesia agents. All data analyzed during this study are collected from published articles. Read More

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Registered report: A pilot investigation of acute exercise response among girls and young women with and without eating disorders.

Int J Eat Disord 2021 Jul 29. Epub 2021 Jul 29.

Department of Psychiatry and Behavioral Sciences, University of California - San Francisco, San Francisco, California, USA.

Objective: Driven exercise (DEx) is a serious and common feature of eating disorders (EDs), but current understanding of factors that give rise to and maintain DEx is limited. DEx may be reinforced through its effects on the threat reduction and reward systems. The current protocol is designed to evaluate acute psychobiological response to exercise among female participants (age 16-22) with and without EDs. Read More

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Self-affirmation inductions to reduce defensive processing of threatening health risk information.

Psychol Health 2021 Jul 29:1-22. Epub 2021 Jul 29.

Office of the Associate Director, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Objective: Self-affirmation reduces defensiveness toward threatening health messages. In this study, we compared several possible self-affirmation inductions in order to identify the most effective strategy.

Design: Women at increased risk for breast cancer (i. Read More

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Exploring the Perceived Impact of the COVID-19 Pandemic Social Distancing Measures on Athlete Wellbeing: A Qualitative Study Utilising Photo-Elicitation.

Front Psychol 2021 12;12:624023. Epub 2021 Jul 12.

Department of Psychology, Teesside University, Middlesbrough, United Kingdom.

Countries all over the globe have implemented mandatory social distancing measures in an attempt to suppress and control the spread of the Coronavirus disease (COVID-19). This enforced period of isolation, disruption to normal training routines and competition cancellation, could be having an adverse effect on the mental health and wellbeing of athletes. This study sought to explore the perceived impact of the COVID-19 social distancing measures on athlete wellbeing. Read More

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The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled Trial.

Front Aging Neurosci 2021 12;13:680341. Epub 2021 Jul 12.

Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan.

The Japan-Multi-domain Intervention Trial for Prevention of Dementia in Older Adults with Diabetes (J-MIND-Diabetes) is an 18-month, multi-centered, open-labeled, randomized controlled trial designed to identify whether multi-domain intervention targeting modifiable risk factors for dementia could prevent the progression of cognitive decline among older adults with type 2 diabetes mellitus (T2DM). This manuscript describes the study protocol for the J-MIND-Diabetes trial. Subjects of this trial will comprise a total of 300 T2DM outpatients aged 70-85 years with mild cognitive impairment. Read More

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A Case-Control Study on Behavioral Addictions and Neurocognition: Description of the BANCO and BANCO2 Protocols.

Neuropsychiatr Dis Treat 2021 20;17:2369-2386. Epub 2021 Jul 20.

CHU Nantes, Addictology and Psychiatry Department, Nantes, France.

Introduction: Only two behavioral addictions (BAs) are currently recognized in international classifications (gambling disorder: GbD; gaming disorder: GmD), while some of them await further investigation (food addiction: FA; sexual addiction: SA). Neurocognitive functioning is considered a risk factor for BAs. Research is quite abundant for GbD and highlights specific deficits in several cognitive functions. Read More

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A process-based approach to understanding and managing triggered seismicity.

Nature 2021 Jul 28;595(7869):684-689. Epub 2021 Jul 28.

Department of Earth and Planetary Sciences, Harvard University, Cambridge, MA, USA.

There is growing concern about seismicity triggered by human activities, whereby small increases in stress bring tectonically loaded faults to failure. Examples of such activities include mining, impoundment of water, stimulation of geothermal fields, extraction of hydrocarbons and water, and the injection of water, CO and methane into subsurface reservoirs. In the absence of sufficient information to understand and control the processes that trigger earthquakes, authorities have set up empirical regulatory monitoring-based frameworks with varying degrees of success. Read More

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Antitumor potential of Hedyotis diffusa Willd: A systematic review of bioactive constituents and underlying molecular mechanisms.

Biomed Pharmacother 2020 Oct 12;130:110735. Epub 2020 Sep 12.

Department of Pharmacy, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250013, China. Electronic address:

Cancer is a major cause of death in the world. Chemotherapy can extend the life of cancer patients to some extent, but the quality of life is reduced. Therefore, the quest for more efficient and less toxic medication strategies is still at the forefront of current research. Read More

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October 2020

Relation of therapies for ankylosing spondylitis and psoriatic arthritis to risk of myocardial infarction: a nested case control study.

BMC Rheumatol 2021 Jul 29;5(1):36. Epub 2021 Jul 29.

Section of Rheumatology, Boston University School of Medicine, 650 Albany Street, X-200, Boston, MA, 02118, USA.

Background: Risk of myocardial infarction (MI) is elevated in ankylosing spondylitis and psoriatic arthritis (AS/PsA) compared to the general population. We evaluated the risk of MI related to the use of tumor necrosis factor inhibitor (TNFi) and other therapies in AS/PsA.

Methods: We conducted a nested case-control study using 1994-2018 data from OptumLabs® Data Warehouse, which includes de-identified medical and pharmacy claims, laboratory results, and enrollment records for commercial and Medicare Advantage enrollees. Read More

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The efficacy of Tuina with herbal ointment for patients with post-stroke depression: study protocol for a randomized controlled trial.

Trials 2021 Jul 28;22(1):504. Epub 2021 Jul 28.

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Hongkou District, Shanghai, 200437, China.

Background: Post-stroke depression (PSD) is a common complication after stroke which hinders functional recovery and return to social participation of stroke patients. Efficacy of conventional drug therapies for patients with PSD is still uncertain. Therefore, many patients prefer to use complementary and alternative therapies for PSD. Read More

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Preoperative stereotactic radiosurgery for brain metastases: the STEP study protocol for a multicentre, prospective, phase-II trial.

BMC Cancer 2021 Jul 28;21(1):864. Epub 2021 Jul 28.

INSERM U1240 IMoST, University of Clermont Auvergne, Clermont-Ferrand, France.

Background: Surgery is an important therapeutic option for brain metastases. Currently, postoperative stereotactic radiosurgery (SRT) leads to 6-month and 1-year local control estimated at 70 and 62% respectively. However, there is an increased risk of radio-necrosis and leptomeningeal relapse. Read More

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Triggering biological processes: methods and applications of photocaged peptides and proteins.

Chem Soc Rev 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry, Rice University, Houston, TX 77005, USA.

There has been a significant push in recent years to deploy fundamental knowledge and methods of photochemistry toward biological ends. Photoreactive groups have enabled chemists to activate biological function using the concept of photocaging. By granting spatiotemporal control over protein activation, these photocaging methods are fundamental in understanding biological processes. Read More

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Stable fly activity is associated with dairy management practices and seasonal weather conditions.

PLoS One 2021 28;16(7):e0253946. Epub 2021 Jul 28.

Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California Davis, Tulare, California, United States of America.

Stable flies (Stomoxys calcitrans) are blood-sucking insects commonly associated with cattle production systems worldwide and are known to cause severe irritation to cattle due to painful bites. Cattle react to biting stable flies with an aggregating behavior known as bunching. Bunching behavior reduces grazing or feed consumption and thus reduces cattle productivity and welfare. Read More

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Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.

PLoS Negl Trop Dis 2021 Jul 28;15(7):e0008824. Epub 2021 Jul 28.

Department of Health Policy Planning and Management, University of Health and Allied Sciences, Ho, Ghana.

Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which endemicity status is currently unknown. Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa. Read More

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Impact of assessment and intervention by a health and social care professional team in the emergency department on the quality, safety, and clinical effectiveness of care for older adults: A randomised controlled trial.

PLoS Med 2021 Jul 28;18(7):e1003711. Epub 2021 Jul 28.

School of Allied Health, Faculty of Education and Health Sciences, Health Research Institute, Ageing Research Centre, University of Limerick, Castletroy, Ireland.

Background: Older adults frequently attend the emergency department (ED) and experience high rates of adverse events following ED presentation. This randomised controlled trial evaluated the impact of early assessment and intervention by a dedicated team of health and social care professionals (HSCPs) in the ED on the quality, safety, and clinical effectiveness of care of older adults in the ED.

Methods And Findings: This single-site randomised controlled trial included a sample of 353 patients aged ≥65 years (mean age = 79. Read More

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Influence of Angiotensin Converting Enzyme I/D Polymorphism on Hemodynamic and Antioxidant Response to Long-Term Intradialytic Resistance Training in Patients With Chronic Kidney Disease: A Randomized Controlled Trial.

J Strength Cond Res 2021 Jul 26. Epub 2021 Jul 26.

Graduate Program of Physical Education, Catholic University of Brasilia, Brazil; Graduate Program of Physical Education, Federal University of Maranhão, Maranhão, Brazil; Department of Biophysics and Physiology, Nucleus of Study in Physiology Applied to Performance and Health (NEFADS), Federal University of Piaui (UFPI), Teresina, Brazil; Department of Nephrology, Federal University of São Paulo, São Paulo, Brazil; Seção de Educação Física, Colégio Militar de Brasília (CMB), Brasília, Brazil and Faculty of Medicine, Federal University of Tocantins, Tocantins, Brazil.

Abstract: Corrêa, HdL, Deus, LA, Neves, RVP, Reis, AL, de Freitas, GS, de Araújo, TB, da Silva Barbosa, JM, Prestes, J, Simões, HG, Amorim, CE, dos Santos, MAP, Haro, A, de Melo, GF, Gadelha, AB, Neto, LS, and Rosa, TdS. Influence of angiotensin converting enzyme I/D polymorphism on hemodynamic and antioxidant response to long-term intradialytic resistance training in patients with chronic kidney disease: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2021-The aim of the study was to verify the influence of Angiotensin-converting enzyme (ACE) I/D genotype on blood pressure, muscle mass, and redox balance response to long-term resistance training (RT) in end-stage renal disease patients. Read More

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First Report of Lotus Seedpod Withering Caused by Fusarium proliferatum on Nelumbo nucifera Plants in China.

Plant Dis 2021 Jul 28. Epub 2021 Jul 28.

Jiangxi Agricultural University, 91595, College of Agronomy, Zhimin Road, Nanchang, China, 330045;

Nelumbo nucifera (Nymphaeaceae family) is a well-known plant in China and with the increasing value of this crop, the planting area of lotus is expanding. In May 2019, an unknown withering lotus seedpod was obtained in Guangchang County of Jiangxi Province (26.79°N, 116. Read More

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An environmental measurement for a dynamic and endogenous global environmental Kuznets curve in the global context.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

Instituto de Administración, Facultad de Ciencias Económicas y Administrativas, Universidad Austral de Chile, Los Laureles N° 35 Interior, Campus Isla Teja, Valdivia, Chile.

Planetary boundaries (PB) is a novel conceptual framework that assesses the state of processes fundamental to the stability of the Earth system. Studies argue a non-linear relationship between economy and environmental degradation, known as the environmental Kuznets curve (EKC). We postulate this inverted-U association between PB and economic output in a worldwide sample. Read More

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Efficacy and Safety of Text Messages Targeting Adherence to Cardiovascular Medications in Secondary Prevention: TXT2HEART Colombia Randomized Controlled Trial.

JMIR Mhealth Uhealth 2021 Jul 28;9(7):e25548. Epub 2021 Jul 28.

Centre for Global Chronic Conditions, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide, with a prevalence of approximately 100 million patients. There is evidence that antiplatelet agents and antihypertensive medications could reduce the risk of new vascular events in this population; however, treatment adherence is very low. An SMS text messaging intervention was recently developed based on behavior change techniques to increase adherence to pharmacological treatment among patients with a history of ASCVD. Read More

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