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Diagnostic Accuracy of High-Resolution 3D T2-SPACE in Detecting Cerebral Venous Sinus Thrombosis.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the University Institute of Diagnostic and Interventional Neuroradiology (A.H., C.K., K.P., M.E.).

Background And Purpose: Assessment of cerebral venous sinus thrombosis on MR imaging can be challenging. The aim of this study was to evaluate the diagnostic accuracy of high-resolution 3D T2 sampling perfection with application-optimized contrasts by using different flip angle evolution (SPACE) in patients with cerebral venous sinus thrombosis and to compare its performance with contrast-enhanced 3D T1-MPRAGE.

Materials And Methods: We performed a blinded retrospective analysis of T2-SPACE and contrast-enhanced MPRAGE sequences from patients with cerebral venous sinus thrombosis and a control group. Read More

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Early language intervention improves behavioral adjustment in school: Evidence from a cluster randomized trial.

J Sch Psychol 2022 Jun 7;92:334-345. Epub 2022 May 7.

University of Oxford, UK; University of Oslo, Norway.

Oral language skills are critical for psychosocial development and children with language difficulties are more likely than peers to experience behavioral problems. This study investigated the effects of an oral language intervention on behavioral adjustment. We collected teacher ratings of behavioral adjustment for 1173 children taking part in a cluster randomized trial of the Nuffield Early Language Intervention (NELI) program in 193 primary schools. Read More

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Meditation and yoga for irritable bowel syndrome: study protocol for a randomised clinical trial (MY-IBS study).

BMJ Open 2022 May 26;12(5):e059604. Epub 2022 May 26.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada

Introduction: When delivered in person, yoga has been shown to be effective in managing irritable bowel syndrome (IBS) symptoms. Research is needed to test the feasibility and effectiveness of yoga as a therapeutic option when delivered virtually. The primary aim of the mind and yoga for IBS randomised controlled trial is to determine the effects of an 8-week virtual meditation and yoga intervention on IBS symptom severity compared with an advice-only active control group. Read More

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Remote versus face-to-face home-based exercise programme in people with amyotrophic lateral sclerosis: protocol for a randomised clinical trial.

BMJ Open 2022 May 26;12(5):e056323. Epub 2022 May 26.

Department of Physical Therapy, Federal University of Rio Grande do Norte, Natal, Brazil.

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease with variable and complex clinical manifestations that requires a multidisciplinary approach. However, face-to-face treatment in this population may experience barriers, such as difficulty accessing physical therapists or other professionals. As a result, strategies (eg, telerehabilitation) emerged to facilitate treatment and physical therapy monitoring. Read More

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Postural Control Adaptations in Yoga Single-Leg Support Postures: Comparison Between Practitioners and Nonpractitioners.

Motor Control 2022 May 26:1-18. Epub 2022 May 26.

Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, RJ,Brazil.

This paper investigates whether a group of regular Yoga practitioners shows postural control differences compared with healthy controls while performing single-leg Yoga postures. Ten Yoga practitioners were compared with a control group of 10 nonpractitioners performing two single-leg support Yoga postures: Vrksasana (tree posture) and Natarajasana (dancer posture). Rambling and trembling decomposition of the center of pressure trajectories was implemented using a genetic algorithm spectral optimization that avoids using horizontal forces and was validated with bipedal posture data. Read More

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The Effects of a Physical Education Intervention Program on the Bone Properties of Second- and Third-Grade Pupils: A Cluster Randomized Controlled Trial.

J Phys Act Health 2022 May 26:1-11. Epub 2022 May 26.

School of Education, The Academic College at Wingate, Netanya,Israel.

Background: Many young children do not participate in sufficient physical activity for promoting optimal bone growth. The objective of this study was to investigate the effect of young children who participated in a school-based intervention program on bone properties. The program included structured physical activity, with a focus on the application of mechanical loads on the upper and lower limbs. Read More

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Effectiveness of photodynamic therapy with 5-aminolevulinic acid for Bowenoid papulosis: a retrospective study with long-term follow-up.

Photodiagnosis Photodyn Ther 2022 May 23:102918. Epub 2022 May 23.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Background: Bowenoid papulosis (BP) is a rare infectious skin disease that occurs in sexually active young people. BP is associated with human papillomavirus (HPV)16 and 18 infections, spreads through sexual contact, and tends to become cancerous. Currently, there are different BP treatment methods, and few reports on the efficacy of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) (ALA-PDT). Read More

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Behav Processes 2022 May 23:104661. Epub 2022 May 23.

Departamento de Psicobiologia - Universidade Federal de São Paulo - São Paulo, Brazil. Electronic address:

Sleepiness is a behavioural consequence of sleep pressure, which shows interindividual variation, a characteristic possibly related to central sleep mechanisms. However, there is a lack of evidence linking progressive sleep need and sleepiness with factors of individual variability, which could be tested by total acute and chronic sleep deprivation. Thus, the objective of the study was to investigate the development of sleepiness in sleep deprived mice. Read More

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Pattern of mobile phone and internet use among 11-15-years-old.

Enferm Clin (Engl Ed) 2022 May 23. Epub 2022 May 23.

Departamento de Salud de Gandía, Valencia, España.

Objective: To assess the pattern of problematic internet and mobile use in a sample of adolescents.

Method: Cross-sectional descriptive study in 8 primary and secondary education centres attached to a semi-rural health centre serving 21,000 inhabitants. Two-stage, cluster and systematic sampling, with a final sample size of 446 participants. Read More

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The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) and Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29) Comparison Study: Assessing for PROMIS-29 Depression and Anxiety Psychopathologic Cutoff Values Amongst Patients Undergoing Elective Complex Spine Procedures.

World Neurosurg 2022 May 23. Epub 2022 May 23.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, Texas, USA; University of Texas Southwestern Medical Center, Department of Orthopedic Surgery, Dallas, Texas, USA.

Objective: The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) and the Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29) are used to assess patient psychology, pain, and quality of life. As psychological factors, such as depression and anxiety, are associated with poor perioperative outcomes, we aim to translate MMPI-2-RF values to PROMIS-29 scores and establish cutoff values for PROMIS-29 Anxiety and Depression domains that might warrant attention preoperatively.

Methods: 70 adult patients scheduled for an elective spinal surgery between July 2018 and February 2020 who completed both the MMPI-2-RF and PROMIS-29 preoperatively at a single institution were reviewed. Read More

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Evaluation of coating uniformity for the digestion-aid tablets by portable near-infrared spectroscopy.

Int J Pharm 2022 May 23:121833. Epub 2022 May 23.

Technology and Innovation Center of Jiangxi Traditional Chinese Medicine Manufacturing and Process Quality Control, Nanchang, Jiangxi, 330004, P. R. China; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, P. R. China. Electronic address:

Process analysis can effectively stabilize pharmaceutical quality and optimize the control of production process. For the sustained-release digestion-aid tablets, the coating film thickness is an important indicator to measure the quality of products. Traditional method mainly spot-checks tablets and measures with visual microscopy, which is time-consuming and laborious. Read More

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Effects of the Clostridium butyricum on growth performance, antioxidant capacity, immunity and disease resistance of Litopenaeus Vannamei fed with cottonseed protein concentrate (CPC) replacement of fishmeal in diet.

Fish Shellfish Immunol 2022 May 23. Epub 2022 May 23.

Guangdong Evergreen Feed Industry Co.Ltd, Zhanjiang, 524088, PR China.

Clostridium butyricum (CB) is a gram-positive bacterium that secretes short-chain fatty acids such as butyric acid and so on. An 8-week feeding trial was conducted to investigate the effects of CB on the growth performance, antioxidant capacity, immunity and resistance to Vibrio parahaemolyticus in Litopenaeus Vannamei fed with cottonseed protein concentrate (CPC) replacement of fishmeal. Six iso-nitrogenous (40%) and iso-lipidic (6%) diets were formulated including a positive control group (PC, 25% fishmeal), a negative control group (NC, CPC replaced 30% of fishmeal protein), and 0. Read More

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Young population consume twice as much artificial sweetener than the general population - A wastewater-based assessment in China.

Sci Total Environ 2022 May 23:156200. Epub 2022 May 23.

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, 4102, Queensland, Australia.

Understanding artificial sweetener consumption patterns and levels in different demographics is important for formulating public health policies on controlling sugar consumption. There is a considerable knowledge gap with respect to the pattern of artificial sweetener consumption in China. To narrow this gap, wastewater analysis was used to assess the temporal patterns of consumption of seven artificial sweeteners in an urban population and a university town in a megacity in South China over a one-year period. Read More

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Impacts of anthropogenic groundwater recharge (AGR) on nitrate dynamics in a phreatic aquifer revealed by hydrochemical and isotopic technologies.

Sci Total Environ 2022 May 23:156187. Epub 2022 May 23.

Ministry of Education Key Laboratory of Groundwater Circulation and Environmental Evolution, China University of Geosciences (Beijing), Beijing 100083, China. Electronic address:

Although anthropogenic groundwater recharge (AGR) can either elevate or decline the concentration of the nitrate (NO) in the phreatic aquifer with high hydraulic conductivity, the long-term impact of AGR on NO dynamics in the phreatic aquifer and its reason is seldom disclosed. In this study, the hydrogen and oxygen stable isotopes (δH-HO and δO-HO) combined with mixing stable isotope analysis in R (MixSIAR) were used to group the study area into the dominant area of AGR by surface water (AGRSW) and the dominant area of natural groundwater recharged by precipitation (NGRP). Hydrochemical parameters and multiple stable isotopes, including δH-HO, δO-HO, δN-NO, δO-NO, and δC-DIC, were applied to explore the impacts of AGR on the concentration, biogeochemical processes, and main sources of nitrate. Read More

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EEG asymmetry and cognitive testing in MCI identification.

Int J Psychophysiol 2022 May 23. Epub 2022 May 23.

Institute of Gerontology, Wayne State University, USA; International Institute of Applied Gerontology, Ljubljana, Slovenia. Electronic address:

Background: Finding the baseline resting-state EEG markers for early identification of cognitive decline can contribute to the identification of individuals at risk of further change. Potential applications include identifying participants for clinical trials, early treatment, and evaluation of treatment, accessible even from a community setting.

Methods: Analyses were completed on a sample of 99 (ages 60-90) consensus-diagnosed, community-dwelling African Americans (58 cognitively typical/HC, and 41 mildly cognitively impaired/MCI), who were recruited from the Michigan Alzheimer's Disease Research Center (MADRC) and the Wayne State University Institute of Gerontology. Read More

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Temporal variation of the coupling relationship between methanogens and biogeochemical process in soil-microbes-rice system.

Chemosphere 2022 May 23:135099. Epub 2022 May 23.

Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province/Center for Eco-Environmental Restoration Engineering of Hainan Province/College of Ecology & Environment/State Key Laboratory of Marine Resource Utilization in South China Sea/Key Laboratory for Environmental Toxicology of Haikou, Haikou, Hainan University, Hainan, 570228, China.

Microbial community were most resilient option for methane associated mitigation strategies. Biogas slurry provides plant nutrition and affects microbial community. However, little is known about the changes of the functional guilds (methanogen and methanotroph) in the geochemical context after addition biogas slurry. Read More

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Environmentally-induced sex reversal in fish with chromosomal vs. polygenic sex determination.

Environ Res 2022 May 23:113549. Epub 2022 May 23.

Institut de Ciències del Mar, Consejo Superior de Investigaciones Científicas, Barcelona, Spain. Electronic address:

Sex ratio depends on sex determination mechanisms and is a key demographic parameter determining population viability and resilience to natural and anthropogenic stressors. There is increasing evidence that the environment can alter sex ratio even in genetically sex-determined species (GSD), as elevated temperature can cause female-to-male sex reversal (neomales). Alarmingly, neomales are being discovered in natural populations of several fish, amphibian and reptile species worldwide. Read More

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Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial.

Lancet Respir Med 2022 May 23. Epub 2022 May 23.

Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel, Basel, Switzerland; Clinic of Respiratory Medicine and Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Background: PCR-based testing has transformed the management of suspected respiratory viral infections. We aimed to determine whether multiplex bacterial PCR of bronchoalveolar lavage fluid aids antibiotic stewardship in patients with pneumonia.

Methods: This investigator-initiated, multicentre, randomised controlled trial was conducted at two tertiary care centres in Switzerland (University Hospital of Basel and Kantonsspital St Gallen). Read More

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Low level of mancozeb exposure affects ovary in mice.

Ecotoxicol Environ Saf 2022 May 23;239:113670. Epub 2022 May 23.

College of Traditional Chinese Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China. Electronic address:

Mancozeb (MCZ) is widely used as a protective fungicide. This study aimed to explore the effects of low level MCZ exposure on ovary in mice. Twenty Kunming mice were randomly divided into control and MCZ groups (10 mice each). Read More

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Evidence construction of Huangkui capsule against chronic glomerulonephritis: A systematic review and network pharmacology.

Phytomedicine 2022 May 20;102:154189. Epub 2022 May 20.

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Background: Chronic glomerulonephritis (CGN) is a relatively common primary glomerular disease. Huangkui capsule (HKC) combined with angiotensin receptor blocker (ARB) for CGN is frequently used in clinical practice, however, there is still lack of high-quality evidence-based evidence and network pharmacology to clarify the therapeutic efficacy and pharmacological mechanisms.

Purpose: Integrating evidence-based medicine and network pharmacology to explain the therapeutic efficacy and pharmacological mechanisms of ARB combined with HKC for CGN. Read More

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Different occurrence rates of centrally located cytoplasmic granulation in one cohort oocytes show distinctive embryo competence and clinical outcomes.

Reprod Biol 2022 May 23;22(3):100649. Epub 2022 May 23.

Savaid Stomatology School, Hangzhou Medical College, Hangzhou 310053, China; Bourn Hall Reproductive Medical Center, Kunming City Maternal and Child Health Hospital, Kunming 650031, China. Electronic address:

Centrally located cytoplasmic granulation (central granulation) is a common cytoplasmic dysmorphism in human oocytes retrieved after controlled ovarian hyperstimulation (COH). In order to achieve a better understanding of its formation and effects on clinical outcomes, we retrospectively analyzed 422 ICSI treatment cycles. Three groups of patients were classified according to the ratio of central granulation occurrence in one egg cohort, as partial granulation, all granulation and control groups. Read More

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Effectiveness of a process-based executive function intervention on arithmetic knowledge of children with Developmental Dyscalculia.

Res Dev Disabil 2022 May 23;127:104260. Epub 2022 May 23.

Department of psychology and Special Education, University of Tehran, Iran. Electronic address:

Background: Arithmetic knowledge has long been known as an essential factor for educational and vocational success.

Aims: This study aims to explore the effectiveness of a process-based Executive Function (EF) intervention program on the improvement of components of arithmetic.

Methods And Procedure: A goal-directed sampling method was applied in this study. Read More

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Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.

Int Immunopharmacol 2022 May 23;108:108872. Epub 2022 May 23.

College of Animal Sciences and Technology, Nanjing Agricultural University, No.1 Weigang Street, Nanjing, China. Electronic address:

This study was undertaken to investigate the protective role of trans-anethole (TA) in lipopolysaccharide (LPS)-induced rat intestinal epithelial cells (IEC-6) injury and the potential mechanisms. The cells were pretreated with TA (0 and 1 mM) for 24 h, prior to stimulation by LPS (1 mg/mL) for 24 h. Compared with the control group (CON), LPS stimulus resulted in decreased cell viability, intestinal barrier injury, increased cell apoptosis and cell cycle arrest at the G2/M phase. Read More

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Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1).

Stem Cell Res 2022 May 17;62:102815. Epub 2022 May 17.

Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg; Parkinson Research Clinic, Centre Hospitalier de Luxembourg (CHL), Luxembourg; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg. Electronic address:

We describe the generation of an isogenic control cell line DJ-1-delP GC13 from an induced pluripotent stem cell (iPSC) line DJ-1-delP LCSBi008-A that was derived from fibroblasts obtained from a Parkinson's disease (PD) patient. Using CRISPR/Cas9 technology, we corrected the disease causing c.471_473delGCC homozygous mutation in the PARK7 gene leading to p. Read More

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Effects of cryo-preservation on skeletal muscle tissues mechanical behavior under tensile and peeling tests until rupture.

J Mech Behav Biomed Mater 2022 May 17;132:105273. Epub 2022 May 17.

Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, Etablissement Francais du Sang, INSERM, U 1059 Sainbiose, Centre CIS, F, 42023, Saint-Etienne, France.

The most common method to study the mechanical behavior of soft tissue is to test animal specimens, which should be prepared as soon as possible after the death to avoid biological deterioration effects such as rigor mortis. Freezing and cryo-preservation could allow extending the time between procurement and implantation. From a mechanical perspective, tissue preservation could influence mechanical testing results. Read More

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Pre-sintering pigmentation techniques do not affect the fatigue behavior of adhesively luted 4YSZ restorations.

J Mech Behav Biomed Mater 2022 May 16;132:105270. Epub 2022 May 16.

MSciD and PhD Post-Graduate Program in Oral Science, Faculty of Dentistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil. Electronic address:

This study aims to characterize the effect of shading techniques on the fatigue behavior of a 4YSZ ceramic (4 mol% yttrium stabilized zirconia) adhesively bonded to a dentin analogue (fiber-reinforced epoxy resin). 4YSZ ceramic discs (IPS e.max ZirCAD, Ø = 10 mm and 1 mm of thickness) were allocated according to the factor 'shading technique' into 4 groups: Brush- unshaded ceramic disc (IPS e. Read More

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Structural and passive mechanical properties of the medial gastrocnemius muscle in ambulatory individuals with chronic stroke.

Clin Biomech (Bristol, Avon) 2022 May 16;96:105672. Epub 2022 May 16.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong. Electronic address:

Background: This study aimed to investigate the structural, morphological and passive mechanical properties of the medial gastrocnemius muscle among ambulating chronic stroke survivors using a computational model previously established in healthy individuals without stroke.

Methods: Individuals with chronic stroke (n = 14, age = 63.4 ± 6. Read More

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Cognitive control, motivation and fatigue: A cognitive neuroscience perspective.

Albert Kok

Brain Cogn 2022 May 23;160:105880. Epub 2022 May 23.

Emeritus Professor Physiological Psychology, Brain and Cognition Group, Psychology Department, University of Amsterdam, the Netherlands. Electronic address:

The present article provides a unified systematic account of the role of cognitive control, motivation and dopamine pathways in relation to the development of fatigue. Since cognitive fatigue is considered to be one aspect of the general control system that manages goal activity in the service of motivational requirements (Hockey, 2011), our focus is also broader than fatigue itself. The paper shall therefore first focus on the motivation-control interactions at the level of networks of the brain. Read More

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Evaluation of microalgae diets on flavor characteristics of Pacific oysters (Crassostrea gigas) during fattening.

Food Chem 2022 May 12;391:133191. Epub 2022 May 12.

College of Food Science and Engineering, Ocean University of China, No.5, Yu Shan Road, Qingdao, Shandong Province, 266003, PR China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, PR China. Electronic address:

Due to the large breeding density and the influence of seasonal changes, the quality of oysters declined. Oysters are often fattened with specific microalgae before sale to improve their quality. Here, the purpose of this study was to study the effects of different microalgae diets on the flavor characteristics of Crassostrea gigas (C. Read More

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Voluntary physical activity mitigates alveolar bone loss in mice with ligature-induced experimental periodontitis.

Arch Oral Biol 2022 May 11;140:105451. Epub 2022 May 11.

Health Sciences Department, Federal University of Lavras (UFLA), Lavras, Minas Gerais, Brazil. Electronic address:

Objective: To investigate the effect of voluntary physical activity (VPA) on inflammatory profile and the progression of experimental periodontal disease (PD) in mice.

Methods: Male C57BL/6 mice were randomly distributed into Control; VPA; PD and PD/VPA groups. We registered VPA (total volume of revolutions) and average speed (revolutions/minute) in a free running wheel for 30 days. Read More

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