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Effect of oxidized β-carotene on the growth and feed efficiency of broilers.

Poult Sci 2021 Mar 4;100(6):101088. Epub 2021 Mar 4.

Avivagen, Inc., Ottawa, Ontario, Canada. Electronic address:

Fully oxidized β-carotene (OxBC) containing β-carotene-oxygen copolymers is proposed as an alternative to antimicrobial growth promoters. Two trials were conducted to determine the efficacy of OxBC in enhancing growth and feed intake (FI) in male and female Ross × Ross 308 broilers in Ontario, Canada, and in Ross 308 male broilers in the United Kingdom. In the first trial, 0, 1, 2, or 5 ppm OxBC were added to diets in a 20% cornstarch premix, whereas in the second trial, 0, 2, or 5 ppm OxBC were added in a 1% cornstarch or 1% corncob grits premix. Read More

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Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling.

J Mol Biol 2021 Apr 9:166985. Epub 2021 Apr 9.

CIRI, Centre International de Recherche en Infectiologie, (Team: Legionella pathogenesis), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France. Electronic address:

Secretion of bacterial effector proteins into host cells plays a key role in bacterial virulence. Yet, the dynamics of the secretion systems activity remains poorly understood, especially when machineries deal with the export of numerous effectors. We address the question of multi-effector secretion by focusing on the Legionella pneumophila Icm/Dot T4SS that translocates a record number of 300 effectors. Read More

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Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation.

Toxicol Appl Pharmacol 2021 Apr 9:115530. Epub 2021 Apr 9.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China. Electronic address:

Chronic Kidney Disease (CKD) is a serious threat to human health. In addition, kidney fibrosis is a key pathogenic intermediate for the progression of CDK. Moreover, excessive activation of fibroblasts is key to the development of kidney fibrosis and this process is difficult to control. Read More

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Intrinsic Electrocatalytic Activity for Oxygen Evolution of Crystalline 3d-Transition Metal Layered Double Hydroxides.

Angew Chem Int Ed Engl 2021 Apr 12. Epub 2021 Apr 12.

Technische Universität Berlin: Technische Universitat Berlin, Chemistry, GERMANY.

Layered double hydroxides (LDHs) are among the most active and studied catalysts for the oxygen evolution reaction (OER) in alkaline electrolytes. However, previous works either focused on a small number of LDHs, applied synthetic routes with limited structural control, or used non-intrinsic activity metrics. This hampered the construction of consistent structure-activity-relations. Read More

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[Development and validation of a diagnostic model of antimicrobial resistance by extended-spectrum beta-lactamases in community-acquired urinary tract infections. How to adjust the prediction in variable outcome prevalences? The usefulness of contracting predictors with LASSO regression].

Rev Chilena Infectol 2020 Dec;37(6):683-689

Departamento de Epidemiología Clínica, Universidad de Antioquia, Colombia.

Background: In the case of community-acquired urinary tract infection, the identification of Enterobacteriaceae with extended spectrum beta-lactamases (ESBL) can optimize treatment, control and follow-up strategies, however the effect of variable prevalences of this resistance pattern has affected the external validity of this type of models.

Aim: To develop a diagnostic predictive model that adjusts the prediction error in variable prevalences using the LASSO regression.

Methods: A diagnostic predictive model of community-acquired urinary tract infection by infection by ESBL producing Enterobacteriaceae was designed. Read More

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December 2020

Local Delivery of Therapeutic Boron for Bone Healing Enhancement.

J Orthop Trauma 2021 May;35(5):e165-e170

Chemical Engineering Department, Ecole Polytechnique de Montreal, Montreal, QC, Canada.

Objectives: To evaluate if local delivery of boron can accelerate bone healing and examine if the bioactive salt impacts the osteogenic response of bone-derived osteoclasts and osteoblasts by the regulation of the Wnt/β-catenin pathway.

Methods: Bilateral femoral cortical defects were created in 32 skeletally mature C57 mice. On the experimental side, boric acid (8 mg/kg concentration) was injected locally, whereas on the control side, saline was used. Read More

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Effectiveness of Theory-Based Health Information Technology Interventions on Coronary Artery Disease Self-Management Behavior: A Clinical Randomized Waitlist-Controlled Trial.

J Nurs Scholarsh 2021 Apr 12. Epub 2021 Apr 12.

Lambda Beta-at-large, Associate Professor, School of Nursing, National Defense Medical Center, Taipei, Taiwan.

Purpose: Secondary prevention of coronary artery disease, self-management behavior, and blood pressure control are important to cardiovascular event prevention and promotion of quality of life (QOL), but they are underutilized. The purpose of this study was to investigate the effects of a self-efficacy theory-based health information technology intervention implemented through blood control and patient self-management.

Design: A clinical randomized waitlist-controlled trial. Read More

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RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media.

Laryngoscope 2021 Apr 12. Epub 2021 Apr 12.

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.

Objectives: Otitis media (OM) is the most common pediatric diagnosis in the United States. However, our understanding of the molecular pathogenesis of OM remains relatively poor. Investigation of molecular pathways involved in OM may improve the understanding of this disease process and elucidate novel therapeutic targets. Read More

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Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle.

J Endocrinol Invest 2021 Apr 12. Epub 2021 Apr 12.

Centre Européen D'étude du Diabète, Unité Mixte de Recherche de L'Université de Strasbourg « Diabète et Thérapeutique », Strasbourg, France.

Fatty acids (FA) play a crucial role in glycaemia regulation in healthy and metabolic disorders conditions through various mechanisms. FA oxidation is one of the processes involved in lipid metabolism and can be modulated by exercise. Nowadays, physical activity is known to be an effective strategy for the prevention and treatment of Type 2 Diabetes. Read More

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An Effect of Education on Memory-Encoding Activation in Subjective Cognitive Decline.

J Alzheimers Dis 2021 Apr 3. Epub 2021 Apr 3.

Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Subjective cognitive decline (SCD) may be an early manifestation of pre-clinical Alzheimer's disease. Elevated amyloid-β (Aβ) is a correlate of SCD symptoms in some individuals. The underlying neural correlates of SCD symptoms and their association with Aβ is unknown. Read More

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Genome-wide analysis in unravels a high level of genetic homoplasy associated with cefotaxime resistance.

Microb Genom 2021 Apr;7(4)

Centre for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, The Netherlands.

Cefotaxime (CTX) is a third-generation cephalosporin (3GC) commonly used to treat infections caused by . Two genetic mechanisms have been associated with 3GC resistance in . The first is the conjugative transfer of a plasmid harbouring antibiotic-resistance genes. Read More

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Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic .

ACS Synth Biol 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States.

is a probiotic yeast that exhibits rapid growth at 37 °C, is easy to transform, and can produce therapeutic proteins in the gut. To establish its ability to produce small molecules encoded by multigene pathways, we measured the amount and variance in protein expression enabled by promoters, terminators, selective markers, and copy number control elements. We next demonstrated efficient (>95%) CRISPR-mediated genome editing in this strain, allowing us to probe engineered gene expression across different genomic sites. Read More

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Effects of long-acting analogues of lamprey GLP-1 and paddlefish glucagon on alpha- to beta-cell transdifferentiation in an insulin-deficient transgenic mouse model.

J Pept Sci 2021 Apr 11:e3328. Epub 2021 Apr 11.

Diabetes Research Group, School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK.

The abilities of the long-acting, dual-agonist anti-diabetic peptides [D-Ala ]palmitoyl-lamprey GLP-1 and [D-Ser ]palmitoyl-paddlefish glucagon to induce α-cell to β-cell transdifferentiation were investigated in Glu ;ROSA26-eYFP mice. These animals have been genetically engineered so that yellow fluorescent protein is specifically expressed in glucagon-producing α-cells, thereby allowing cell lineage tracing. Insulin deficiency was produced by treatment of the mice with multiple low doses of streptozotocin. Read More

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Improving Cβ-stereoselectivity of L-threonine Aldolase for Synthesis of L-threo-4-methylsulfonylphenylserine by Modulating Substrate-binding Pocket for Orientation Control of Substrate Entrance.

Chemistry 2021 Apr 11. Epub 2021 Apr 11.

Fuzhou University, college of biological science and engineering, CHINA.

L-threonine aldolase form Actinocorallia herbida (AhLTA) is an ideal catalyst for producing L-threo-4-methylsulfonylphenylserine [(2S, 3R)-1b], a key chiral precursor for florfenicol and thiamphenicol. The moderate Cβ-stereoselectivity is the main obstacle for the industrial application of AhLTA. To address this issue, combinatorial active-site saturation test (CAST) joined with sequence conservatism analysis were applied to engineer the AhLTA toward improved Cβ-stereoselectivity. Read More

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Comparison of Cytokine Expression in Human PBMCs Stimulated with Normal and Heat-Shocked Lactobacillus plantarum Cell Lysate.

Probiotics Antimicrob Proteins 2021 Apr 11. Epub 2021 Apr 11.

Biotechnology Research Center, Tehran University of Medical Sciences, 1417614411, Tehran, Iran.

Regulation of immune responses is among the beneficial effects of probiotic bacteria on human health. In this study, we aim to investigate the effect of normal and heat-shocked Lactobacillus plantarum PTCC 1058 cell lysate on cytokine expression by human PBMCs. The mid-exponential phase L. Read More

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Olfactory dysfunction in the 3xTg-AD model of Alzheimer's disease.

IBRO Neurosci Rep 2021 Jun 8;10:51-61. Epub 2021 Jan 8.

Department of Molecular Biology & Chemistry, Christopher Newport University, 1 Avenue of the Arts, Newport News, VA 23606, USA.

Alzheimer's disease (AD) is an incurable neurodegenerative disease in which the risk of development increases with age. People with AD are plagued with deficits in their cognition, memory, and basic social skills. Many of these deficits are believed to be caused by the formation of amyloid-β plaques and neurofibrillary tangles in regions of the brain associated with memory, such as the hippocampus. Read More

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Neointimal Hyperplasia after Carotid Transection and Anastomosis Surgery is Associated with Degradation of Decorin and Platelet Derived Growth Factor Signaling.

JVS Vasc Sci 2021 21;2:2-12. Epub 2020 Oct 21.

Nemours - Alfred I. duPont Hospital for Children, Wilmington, DE 19803.

Objective: Intimal hyperplasia (IH) is the expansion of the vascular intimal region after intervention, which can lead to stenosis and eventual failure of vascular grafts or interventional procedures such as angioplasty or stent placement. Our goals were to investigate the development of IH in a rabbit open surgical model and to evaluate the associated pathophysiological processes involving decorin and the platelet derived growth factor-BB / platelet derived growth factor receptor-β / mitogen activated protein kinase (PDGF/PDGFR-β/MAPK) pathway.

Methods: We conducted carotid transection and primary anastomosis on five New Zealand White rabbits to induce IH and examined the associated pathophysiological changes. Read More

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October 2020

Inhibitory Smads suppress pancreatic stellate cell activation through negative feedback in chronic pancreatitis.

Ann Transl Med 2021 Mar;9(5):384

Institute of Pancreas, Southeast University, Nanjing, China.

Background: Activation of pancreatic stellate cells (PSCs) is a key cause of chronic pancreatitis (CP), while inhibition of transforming growth factor-β (TGF-β) signaling renders PSCs inactive. Inhibitory Smads (I-Smads) impede TGF-β intracellular signaling and may provide a way to alleviate CP. Thus, we aimed to investigate the molecular mechanism of I-Smads in CP animals and freshly-isolated PSCs. Read More

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alleviates depression-like behavior through inhibiting toll-like receptor 4 (TLR4) signaling in mice.

Ann Transl Med 2021 Mar;9(5):366

Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.

Background: The intestinal flora can influence behavior through the microbiota-gut-brain axis and is closely related to the occurrence and development of nervous system diseases such as depression. Probiotics like may regulate the balance of the intestinal flora and play an active role in preventing and treating depression.

Methods: Eight-week-old C57BL/6J mice (n=32) were randomly and equally divided into a normal control group, a control + group, a model group, and a model + group. Read More

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Therapeutic Efficacy of Excretory-Secretory Products of Adult Worms on Sepsis-Induced Acute Lung Injury in a Mouse Model.

Front Cell Infect Microbiol 2021 24;11:653843. Epub 2021 Mar 24.

Department of Basic Medical College, Bengbu Medical College, Bengbu, China.

Acute lung injury (ALI) is a common complication of systemic inflammation or sepsis with high morbidity and mortality. Although many studies have confirmed that helminth-derived proteins had strong immunomodulatory functions and could be used to treat inflammatory diseases, there is no report on the therapeutic effect of excretory-secretory products of adult worms (-AES) on sepsis-induced ALI. In this study, the therapeutic efficacy of -AES on sepsis-induced ALI and the underlying immunological mechanism and the signaling pathway were investigated. Read More

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The effect of inhibiting exosomes derived from adipose-derived stem cells via the TGF-β1/Smad pathway on the fibrosis of keloid fibroblasts.

Gland Surg 2021 Mar;10(3):1046-1056

Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Background: The main mechanism of keloid formation is that keloid fibroblasts (KFs) apoptosis is inhibited, leading to excessive proliferation. Transforming growth factor-β1 (TGF-β1) is a key signal molecule in the process of regulating cell fibrosis. This paper discusses the effect of adipose-derived stem cell exosomes (ADSCs-EXO) on the proliferation and apoptosis of KFS and its possible mechanism, in order to provide reference for the clinical intervention of hypertrophic scar. Read More

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Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration.

Neurol Clin Pract 2021 Apr;11(2):105-116

Penn Frontotemporal Degeneration Center (JVZ, DJI, KR, L. Massimo, CTM, MG) and Department of Neurology (DJI, KR, L. Massimo, CTM, AC-P, LE, L. McCluskey, D. Wolk, MG), Department of Pathology and Laboratory Medicine and Center for Neurodegenerative Disease Research (EBL, LMS, VM-YL, JBT, JQT), Department of Psychiatry (D. Weintraub), University of Pennsylvania, Philadelphia; Institute of Neuroscience and Physiology (KB, HZ), Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory (KB, HZ), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (HZ); and Department of Neurodegenerative Disease (HZ), UCL Institute of Neurology, UK.

Objective: Accurate diagnosis and prognosis of frontotemporal lobar degeneration (FTLD) during life is an urgent concern in the context of emerging disease-modifying treatment trials. Few CSF markers have been validated longitudinally in patients with known pathology, and we hypothesized that CSF neurofilament light chain (NfL) would be associated with longitudinal cognitive decline in patients with known FTLD-TAR DNA binding protein ~43kD (TDP) pathology.

Methods: This case-control study evaluated CSF NfL, total tau, phosphorylated tau, and β-amyloid in patients with known FTLD-tau or FTLD-TDP pathology (n = 50) and healthy controls (n = 65) and an extended cohort of clinically diagnosed patients with likely FTLD-tau or FTLD-TDP (n = 148). Read More

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Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control.

Iran J Pharm Res 2020 ;19(4):372-386

Department of Physiology, Faculty of Veterinary Medicine, Kafr El-Sheikh University, Egypt.

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a ubiquitous multifunctional protein required in the DNA base excision repair pathway and a noteworthy reducing-oxidizing factor that regulates the activity of various transcription factors. Cyclin-dependent kinases (CDKs) assume a key role in directing the progression of the cell- cycle. The present study evaluated the synergistic efficacy of using licochalcone B (LCB) and fullerene C (FnC) nanoparticles against diethylnitrosamine (DEN)-induced hepatocarcinoma in rats and relevant signaling pathways, with APE1/Ref-1 and CDK-4, as novel anti-cancer- targeting. Read More

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January 2020

Leishmanicidal, Trypanocidal and Antioxidant Activity of Amyrin-Rich Extracts from Cambess.

Iran J Pharm Res 2020 ;19(4):343-353

Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR, Brazil.

Aims: This study aimed to characterize and evaluate leishmanicidal and trypanocidal action as well as cytotoxicity on macrophages and antioxidant ability of extracts, obtained by supercritical CO and ultrasound-assisted extractions of Uvaia () leaves.

Methods: Leaves from were submitted to supercritical CO (E1) and ultrasound-assisted (E2) extractions. The characterization of extracts was done using GC-MS and HPLC. Read More

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January 2020

Isolation and Identification of Antibacterial Bioactive Compounds From L2.

Front Microbiol 2021 24;12:645484. Epub 2021 Mar 24.

Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Collaborative Innovation Center for Mountain Ecology & Agro-Bioengineering, College of Life Sciences/Institute of Agro-bioengineering, Guizhou University, Guiyang, China.

Bacterial metabolites exhibit a variety of biologically active compounds including antibacterial and antifungal activities. It is well known that is considered to be a promising source of bioactive secondary metabolites. Most plant pathogens have an incredible ability to mutate and acquire resistance, causing major economic losses in the agricultural field. Read More

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Correlations between alterations of T-helper 17 cells and treatment efficacy after concurrent radiochemotherapy in locally advanced cervical cancer (stage IIB-IIIB): a 3-year prospective study.

Chin Med J (Engl) 2021 Apr 8. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji'nan, Shandong 250012, China Medical Management Service Center of Health Commission of Shandong Health commission, Ji'nan, Shandong 250014, China Department of Gynecological Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, Shandong 250117, China Department of Medical Record, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, Shandong 250117, China Department of Gynecological Oncology, Jinan Maternal and Child Care Hospital, Ji'nan, Shandong 250012, China Department of Gynecological Oncology, Taian Second Hospital of Traditional Chinese Medicine, Taian, Shandong 271000, China Department of Gynecology, Weifang People's Hospital, Weifang, Shandong 261000, China.

Background: Recently, T-helper 17 (Th17) cells have been proved to play an important role in promoting cervical cancer. But, till now, few study has been carried out to understand the involvement of these cells in efficacy of anti-tumor treatments. This study aimed to investigate the alterations in the percentage of circulating Th17 cells and related cytokines in locally advanced cervical cancer (LACC) patients before and after concurrent chemoradiotherapy (cCRT) and to analyze the correlations between the alterations in Th17 cells and treatment efficacy. Read More

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Cerebral amyloid angiopathy and related inflammatory disorders.

Authors:
B K Chwalisz

J Neurol Sci 2021 Mar 27:117425. Epub 2021 Mar 27.

Department of Neurology, Massachusetts General Hospital/Harvard Medical School, 15 Parkman Street, Suite 835, Boston, MA 02114, USA; Division of Neuro-Ophthalmology, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary/Harvard Medical School, Boston, MA, USA. Electronic address:

Inflammatory cerebral amyloid angiopathy is a largely reversible inflammatory vasculopathy that develops in an acute or subacute fashion in reaction to amyloid protein deposition in the central nervous system blood vessels. There are two recognized pathologically characterized variants: cerebral amyloid angiopathy-related inflammation (CAAri) and A beta-related angiitis (ABRA). Both variants produce a clinical picture that resembles primary angiitis of the CNS but is distinguished by a characteristic radiologic appearance. Read More

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Porcine ear necrosis.

Vet J 2021 May 18;271:105655. Epub 2021 Mar 18.

Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke 9820, Belgium.

Porcine ear necrosis (PEN) is a condition that mainly occurs in intensive pig production systems and mostly affects piglets after weaning. The syndrome manifests itself with lesions on the pinna, which can heal or become more severe resulting in partial loss of the ear. The pathogenesis of the condition is not fully known. Read More

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High Social Coping Self-Efficacy Associated With Lower Sweat Interleukin-6 in Older Adults With Chronic Illness.

J Appl Gerontol 2021 Apr 12:7334648211006518. Epub 2021 Apr 12.

Johns Hopkins University, Baltimore, MD, USA.

Inflammation, particularly interleukin-6 (IL-6), is associated with chronic disease in older adults, but not all older adults have the same progression of poor health outcomes. Self-efficacy may play a role in buffering the inflammatory burden in chronic disease. To evaluate associations between self-efficacy and IL-6, 159 community-dwelling older adults ( = 159, = 82 years, = 6. Read More

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Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis.

Hum Exp Toxicol 2021 Apr 12:9603271211008496. Epub 2021 Apr 12.

Pharmacology Department, 68782Faculty of Medicine, Tanta University, Tanta, Egypt.

Hepatocellular carcinoma (HCC) is the most common form of liver malignancies worldwide. Alogliptin is an anti-diabetic that may have effective anticancer properties against many types of malignancies. Taxifolin is a flavonoid that has potent antioxidant, and anti-inflammatory properties. Read More

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