479 results match your criteria contributing detoxification

Highly deregulated lncRNA LOC is associated with overall worse prognosis in Hepatocellular Carcinoma patients.

J Cancer 2021 30;12(11):3098-3113. Epub 2021 Mar 30.

Dept of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Although numerous long non-coding RNAs (lncRNAs) were reported to be deregulated in Hepatocellular Carcinoma (HCC), experimentally characterized, and/or associated with patient's clinical characteristics, there is, thus far, minimal concerted research strategy to identify deregulated lncRNAs that modulate prognosis of HCC patients. Here, we present a novel strategy where we identify lncRNAs, which are not only de-regulated in HCC patients, but are also associated with pertinent clinical characteristics, potentially contributing to the prognosis of HCC patients. LOC101926913 (LOC) was further characterized because it is the most highly differentially expressed amongst those that are associated with the most number of clinical features (tumor-stage, vascular and tumor invasion and poorer overall survival). Read More

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Eusocial insect declines: Insecticide impairs sperm and feeding glands in bumblebees.

Sci Total Environ 2021 Apr 10;785:146955. Epub 2021 Apr 10.

Institute of Bee Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Agroscope, Swiss Bee Research Centre, Bern, Switzerland. Electronic address:

Insecticides are contributing to global insect declines, thereby creating demand to understand the mechanisms underlying reduced fitness. In the eusocial Hymenoptera, inclusive fitness depends on successful mating of male sexuals (drones) and efficient collaborative brood care by female workers. Therefore, sublethal insecticide effects on sperm and glands used in larval feeding (hypopharyngeal glands (HPG)) would provide key mechanisms for population declines in eusocial insects. Read More

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Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1.

Sci Bull (Beijing) 2021 Mar 28;66(5):478-489. Epub 2020 Oct 28.

Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.

Maternal stress during pregnancy is prevailing worldwide, which exposes fetuses to intrauterine hyper glucocorticoids (GC), programming offspring to obesity and metabolic diseases. Despite the importance of brown adipose tissue (BAT) in maintaining long-term metabolic health, impacts of prenatal hyper GC on postnatal BAT thermogenesis and underlying regulations remain poorly defined. Pregnant mice were administrated with synthetic GC dexamethasone (DEX) at levels comparable to fetal GC exposure of stressed mothers. Read More

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Heavy metal-associated oxidative stress and glutathione S-transferase polymorphisms among E-waste workers in Pakistan.

Environ Geochem Health 2021 Apr 19. Epub 2021 Apr 19.

Environmental Health Laboratory, Department of Environmental Sciences, Quaid-I-Azam University, Islamabad, Pakistan.

Increased E-waste generation during recent times has become a global concern, especially for developing countries that are at receiving end from the developed countries. Their improper handling and lacking management practices in developing countries including Pakistan are contributing enormous addition of toxicants into the environment and affecting the health of exposed workers associated with E-waste recycling activities. A systematic cross-sectional study was designed comprising workers associated with E-waste recycling activities in Peshawar city, Pakistan. Read More

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Mechanisms underlying the phytotoxicity and genotoxicity of aluminum and their alleviation strategies: A review.

Chemosphere 2021 Mar 28;278:130384. Epub 2021 Mar 28.

School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur, 492 010, India. Electronic address:

Aluminum (Al) is considered as a potential limiting factor for plant growth in acidic environment. At lower concentration, Al promotes plant growth by facilitating the phosphorous availability, while, at higher concentration, it causes rhizotoxicity by inhibiting the nutrient transportation system. Cellular membrane is identified as the first site of Al toxicity, which is consequent to Al-induced reactive oxygen species prompted lipid catabolism. Read More

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Multistage Defense System Activated by Tetrachlorobiphenyl and its Hydroxylated and Methoxylated Derivatives in .

Environ Sci Technol 2021 04 22;55(8):4889-4898. Epub 2021 Mar 22.

College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Crops can initiate various defense responses to environmental stresses. The process is often accompanied by extensive transcriptional and metabolic changes to reallocate metabolites. However, it remains unclear how organic pollutants activate the defense systems to reallocate metabolites in crops. Read More

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Systemic deletion of Atp7b modifies the hepatocytes' response to copper overload in the mouse models of Wilson disease.

Sci Rep 2021 Mar 11;11(1):5659. Epub 2021 Mar 11.

Department of Physiology, Johns Hopkins Medical Institutes, 725 N Wolfe street, Baltimore, MD, 21205, USA.

Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in hepatocyte recapitulate various aspects of human disease. However, their phenotypes vary, and neither the common response to copper overload nor factors contributing to variability are well defined. Read More

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Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation.

J Clin Invest 2021 Apr;131(8)

Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, and.

Although cancer cells are frequently faced with a nutrient- and oxygen-poor microenvironment, elevated hexosamine-biosynthesis pathway (HBP) activity and protein O-GlcNAcylation (a nutrient sensor) contribute to rapid growth of tumor and are emerging hallmarks of cancer. Inhibiting O-GlcNAcylation could be a promising anticancer strategy. The gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1 (PCK1) is downregulated in hepatocellular carcinoma (HCC). Read More

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Elements in the LftR Repressor Operator Interface Contributing to Regulation of Aurantimycin Resistance in Listeria monocytogenes.

J Bacteriol 2021 Apr 21;203(10). Epub 2021 Apr 21.

FG11 Division of Enteropathogenic Bacteria and Legionella, Robert Koch Institute, Wernigerode, Germany

The bacterium ubiquitously occurs in the environment but can cause severe invasive disease in susceptible individuals when ingested. We recently identified the genes and , encoding a multidrug resistance ABC transporter and a regulatory module, respectively. These genes jointly mediate resistance against aurantimycin, an antibiotic produced by the soil-dwelling species , and thus contribute to the survival of in its natural habitat, the soil. Read More

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Remediation of emerging environmental pollutants: A review based on advances in the uses of eco-friendly biofabricated nanomaterials.

Chemosphere 2021 Jul 15;275:129975. Epub 2021 Feb 15.

Laboratory of Plant Healthcare and Diagnostics, PG Department of Biotechnology and Microbiology, Karnataka University, Dharwad, 580 003, Karnataka, India. Electronic address:

The increased environmental pollutants due to anthropogenic activities are posing an adverse effects and threat on various biotic forms on the planet. Heavy metals and certain organic pollutants by their toxic persistence in the environment are regarded as significant pollutants worldwide. In recent years, pollutants exist in various forms in the environment are difficult to eliminate by traditional technologies due to various drawbacks. Read More

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Use of Hemoadsorption in Patients With Severe Intoxication Requiring Extracorporeal Cardiopulmonary Support-A Case Series.

ASAIO J 2021 Feb 9. Epub 2021 Feb 9.

From the Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Berlin Institute of Health, Clinic for Nephrology and Intensive Care Medicine, Humboldt-Universität zu Berlin, Berlin, Germany.

Drugs intoxications often lead to severe vasoplegia and cardiogenic shock, and VA-ECMO represents a viable therapy option. However, as cardiopulmonary support is not contributing to the removal of the causal agent from the blood, detoxification by a new hemoadsorption device (CytoSorb) could represent a potential therapeutic tool due to its highly efficient elimination capacity of endogenous but also exogenous hydrophobic substances for which otherwise no effective antidote exist. In this case series, four anecdotal cases of acute intoxications requiring VA-ECMO support used as extracorporeal cardiopulmonary resuscitation after intoxication-induced out-of-hospital cardiac arrest (OHCA) are presented, who were additionally treated with CytoSorb hemoadsorption in combination with renal replacement therapy. Read More

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February 2021

Strigolactone GR24 improves cadmium tolerance by regulating cadmium uptake, nitric oxide signaling and antioxidant metabolism in barley (Hordeum vulgare L.).

Environ Pollut 2021 Jan 15;273:116486. Epub 2021 Jan 15.

Department of Agronomy, Zhejiang Key Laboratory of Crop Germplasm, College of Agriculture and Biotechnology, Zijingang Campus, Zhejiang University, Hangzhou, 310058, China; Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, Yangzhou, 225009, China. Electronic address:

Cadmium (Cd) in the food chain poses a serious hazard to human health. Therefore, a greenhouse hydroponic experiment was conducted to examine the potential of exogenously strigolactone GR24 in lessening Cd toxicity and to investigate its physiological mechanisms in the two barley genotypes, W6nk2 (Cd-sensitive) and Zhenong8 (Cd-tolerant). Exogenous application of 1 μM GR24 (strigol analogue) reduced the suppression of growth caused by 10 μM Cd, lowered plant Cd contents, increased the contents of other nutrient elements, protected chlorophyll, sustained photosynthesis, and markedly reduced Cd-induced HO and malondialdehyde accumulation in barley. Read More

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January 2021

Transcriptomic analysis reveals resistance mechanisms of Klebsiella michiganensis to copper toxicity under acidic conditions.

Ecotoxicol Environ Saf 2021 Mar 19;211:111919. Epub 2021 Jan 19.

Engineering Laboratory for Water Pollution Control and Resources of National Environmental Protection, School of Environment, Northeast Normal University, No. 2555, Jingyue Street, Changchun 130117, Jilin, PR China. Electronic address:

The aim of this study was to elucidate the effect of pH on bacterial resistance mechanisms to copper (Cu) stress by genomic and transcriptomic analysis. Klebsiella michiganensis cells were exposed to 0.5 mM CuCl at pH 4 and 5. Read More

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Effects of ketogenic diet and ketone monoester supplement on acute alcohol withdrawal symptoms in male mice.

Psychopharmacology (Berl) 2021 Mar 7;238(3):833-844. Epub 2021 Jan 7.

Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Rigshospitalet, Mental Health Services-Capital Region of Denmark, Edel Sauntes Allé 10, DK-2100, Copenhagen, Denmark.

Rationale: After alcohol ingestion, the brain partly switches from consumption of glucose to consumption of the alcohol metabolite acetate. In heavy drinkers, the switch persists after abrupt abstinence, leading to the hypothesis that the resting brain may be "starved" when acetate levels suddenly drop during abstinence, despite normal blood glucose, contributing to withdrawal symptoms. We hypothesized that ketone bodies, like acetate, could act as alternative fuels in the brain and alleviate withdrawal symptoms. Read More

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Identifying Personalized Metabolic Signatures in Breast Cancer.

Metabolites 2020 Dec 30;11(1). Epub 2020 Dec 30.

Institute for Systems Biology, Seattle, WA 98109, USA.

Cancer cells are adept at reprogramming energy metabolism, and the precise manifestation of this metabolic reprogramming exhibits heterogeneity across individuals (and from cell to cell). In this study, we analyzed the metabolic differences between interpersonal heterogeneous cancer phenotypes. We used divergence analysis on gene expression data of 1156 breast normal and tumor samples from The Cancer Genome Atlas (TCGA) and integrated this information with a genome-scale reconstruction of human metabolism to generate personalized, context-specific metabolic networks. Read More

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December 2020

Neural bases for attenuation of morphine withdrawal by Heantos-4: role of l-tetrahydropalmatine.

Sci Rep 2020 12 4;10(1):21275. Epub 2020 Dec 4.

Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada.

Severe withdrawal symptoms triggered by cessation of long-term opioid use deter many individuals from seeking treatment. Opioid substitution and α2-adrenergic agonists are the current standard of pharmacotherapy for opioid use disorder in western medicine; however, each is associated with significant complications. Heantos-4 is a non-opioid botanical formulation used to facilitate opioid detoxification in Vietnam. Read More

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December 2020

Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy.

Sci Total Environ 2021 Feb 20;757:143757. Epub 2020 Nov 20.

Geriatrics and Metabolic Bone Diseases, AOU Città della Salute e della Scienza of Turin, Italy.

A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective of this work is to investigate whether any correlations exist between the spatial distribution of COVID-19 cases and deaths in the different Italian regions and the amount of solar ultraviolet (UV) radiation at the Earth's surface. Read More

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February 2021

Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam.

Toxicol Lett 2021 Mar 27;338:10-20. Epub 2020 Nov 27.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, United States. Electronic address:

Meloxicam is a thiazole-containing NSAID that was approved for marketing with favorable clinical outcomes despite being structurally similar to the hepatotoxic sudoxicam. Introduction of a single methyl group on the thiazole results in an overall lower toxic risk, yet the group's impact on P450 isozyme bioactivation is unclear. Through analytical methods, we used inhibitor phenotyping and recombinant P450s to identify contributing P450s, and then measured steady-state kinetics for bioactivation of sudoxicam and meloxicam by the recombinant P450s to determine relative efficiencies. Read More

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Hypothyroidism Increases Cholesterol Gallstone Prevalence in Mice by Elevated Hydrophobicity of Primary Bile Acids.

Thyroid 2021 Jan 5. Epub 2021 Jan 5.

Department of Endocrinology, Diabetes and Metabolism and Clinical Chemistry, Division of Laboratory Research, University of Duisburg-Essen, Essen, Germany.

Thyroid hormone (TH) deficiency has been associated with increased cholesterol gallstone prevalence. Hypothyroidism impacts hepatic lipid homeostasis, biliary secretion, gallbladder motility, and gallstone (LITH) gene expression, all potential factors contributing to cholesterol gallstone disease (CGD). However, how TH deficiency may lead to gallstone formation is still poorly understood. Read More

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January 2021

Comprehensive insights into arsenic- and iron-redox genes, their taxonomy and associated environmental drivers deciphered by a meta-analysis.

Environ Int 2021 01 9;146:106234. Epub 2020 Nov 9.

Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil. Electronic address:

In nature, arsenic (As) and iron (Fe) biotransformation are interconnected, influencing local As mobility and toxicity. While As- or Fe-metabolizing microorganisms are widely documented, knowledge concerning their cycling genes, associated with geophysicochemical data and taxonomic distribution, remains scarce. We performed a meta-analysis to explore the distribution and environmental importance of As- and Fe-redox genes (AsRGs and FeRGs) and predict their significant correlations and hosts. Read More

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January 2021

Stacking for future: Pyramiding genes to improve drought and salinity tolerance in rice.

Physiol Plant 2020 Nov 12. Epub 2020 Nov 12.

Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Abiotic stresses, such as drought and salinity, adversely affect rice production and cause a severe threat to food security. Conventional crop breeding techniques alone are inadequate for achieving drought stress tolerance in crop plants. Using transgenic technology, incremental improvements in tolerance to drought and salinity have been successfully attained via manipulation of gene(s) in several crop species. Read More

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November 2020

Combined high-throughput library screening and next generation RNA sequencing uncover microRNAs controlling human cardiac fibroblast biology.

J Mol Cell Cardiol 2021 01 28;150:91-100. Epub 2020 Oct 28.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany; REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany. Electronic address:

Background: Myocardial fibrosis is a hallmark of the failing heart, contributing to the most common causes of deaths worldwide. Several microRNAs (miRNAs, miRs) controlling cardiac fibrosis were identified in recent years; however, a more global approach to identify miRNAs involved in fibrosis is missing.

Methods And Results: Functional miRNA mimic library screens were applied in human cardiac fibroblasts (HCFs) to identify annotated miRNAs inducing proliferation. Read More

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January 2021

microRNA expression variation as a potential molecular mechanism contributing to adaptation to hydrogen sulphide.

J Evol Biol 2020 Oct 29. Epub 2020 Oct 29.

Division of Biology, Kansas State University, Manhattan, KS, USA.

microRNAs (miRNAs) are post-transcriptional regulators of gene expression and can play an important role in modulating organismal development and physiology in response to environmental stress. However, the role of miRNAs in mediating adaptation to diverse environments in natural study systems remains largely unexplored. Here, we characterized miRNAs and their expression in Poecilia mexicana, a species of small fish that inhabits both normal streams and extreme environments in the form of springs rich in toxic hydrogen sulphide (H S). Read More

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October 2020

A Comparative Transcriptome Analysis, Conserved Regulatory Elements and Associated Transcription Factors Related to Accumulation of Fusariotoxins in Grain of Rye ( L.) Hybrids.

Int J Mol Sci 2020 Oct 8;21(19). Epub 2020 Oct 8.

Nordic Seed A/S: Grindsnabevej 25, 8300 Odder, Denmark.

Detoxification of fusariotoxin is a type V Fusarium head blight (FHB) resistance and is considered a component of type II resistance, which is related to the spread of infection within spikes. Understanding this type of resistance is vital for FHB resistance, but to date, nothing is known about candidate genes that confer this resistance in rye due to scarce genomic resources. In this study, we generated a transcriptomic resource. Read More

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October 2020

Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages.

Acta Pharmacol Sin 2020 Oct 7. Epub 2020 Oct 7.

School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.

Metabolic reprogramming is associated with NLRP3 inflammasome activation in activated macrophages, contributing to inflammatory responses. Tanshinone IIA (Tan-IIA) is a major constituent from Salvia miltiorrhiza Bunge, which exhibits anti-inflammatory activity. In this study, we investigated the effects of Tan-IIA on inflammation in macrophages in focus on its regulation of metabolism and redox state. Read More

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October 2020

Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence.

Trials 2020 Sep 16;21(1):796. Epub 2020 Sep 16.

Addictions Department, National Addiction Centre, Institute of Psychiatry, King's College London, 4 Windsor Walk, London, SE5 8BB, UK.

Background: Alcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol withdrawal are associated with cognitive deficits and symptoms of depression. Current treatments are only successful for a small proportion of people and do not target cognitive deficits and symptoms of depression experienced by those who are alcohol dependent. Read More

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September 2020

Microphysiological system modeling of ochratoxin A-associated nephrotoxicity.

Toxicology 2020 11 6;444:152582. Epub 2020 Sep 6.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, 98195, USA; Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, 98104, USA. Electronic address:

Ochratoxin A (OTA) is one of the most abundant mycotoxin contaminants in food stuffs and possesses carcinogenic, nephrotoxic, teratogenic, and immunotoxic properties. Specifically, a major concern is severe nephrotoxicity, which is characterized by degeneration of epithelial cells of the proximal tubules and interstitial fibrosis. However, the mechanism of OTA toxicity, as well as the genetic risk factors contributing to its toxicity in humans has been elusive due to the lack of adequate models that fully recapitulate human kidney function in vitro. Read More

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November 2020

Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells.

Cancers (Basel) 2020 Sep 1;12(9). Epub 2020 Sep 1.

Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.

Despite the leaps and bounds in achieving success in the management and treatment of breast cancers through surgery, chemotherapy, and radiotherapy, breast cancer remains the most frequently occurring cancer in women and the most common cause of cancer-related deaths among women. Systemic therapeutic approaches, such as chemotherapy, although beneficial in treating and curing breast cancer subjects with localized breast tumors, tend to fail in metastatic cases of the disease due to (a) an acquired resistance to the chemotherapeutic drug and (b) the development of intrinsic resistance to therapy. The existence of cancer stem cells (CSCs) plays a crucial role in both acquired and intrinsic chemoresistance. Read More

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September 2020

Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer.

Cancers (Basel) 2020 Aug 12;12(8). Epub 2020 Aug 12.

Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.

Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with distinct phenotypical and morphological characteristics. These are based on their gene expression profiles, which divide BC into different subtypes, among which the triple-negative breast cancer (TNBC) subtype is the most aggressive one. Read More

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Cognitive impairment in chronic ketamine abusers.

Psychiatry Res 2020 09 8;291:113206. Epub 2020 Jun 8.

Department of Psychiatry, the Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:

Background: The treatment of ketamine users is substantially challenged by high dropout rates, raising questions regarding contributing factors. A number of studies have highlighted the potential of greater focus on the clinical significance of cognitive impairments in ketamine users. The present study hypothesized that cognitive deficits would play a role in greater risk for treatment dropout in chronic ketamine users. Read More

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September 2020