15,304 results match your criteria contrast-enhanced studies


Radiomics analysis of contrast-enhanced CT for classification of hepatic focal lesions in colorectal cancer patients: its limitations compared to radiologists.

Eur Radiol 2021 May 10. Epub 2021 May 10.

Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Objective: To evaluate diagnostic performance of a radiomics model for classifying hepatic cyst, hemangioma, and metastasis in patients with colorectal cancer (CRC) from portal-phase abdominopelvic CT images.

Methods: This retrospective study included 502 CRC patients who underwent contrast-enhanced CT and contrast-enhanced liver MRI between January 2005 and December 2010. Portal-phase CT images of training (n = 386) and validation (n = 116) cohorts were used to develop a radiomics model for differentiating three classes of liver lesions. Read More

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A meta-analysis evaluating contrast-enhanced intraoperative ultrasound (CE-IOUS) in the context of surgery for colorectal liver metastases.

Abdom Radiol (NY) 2021 May 9. Epub 2021 May 9.

Department of Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.

Background: This study aimed to assess the outcomes of contrast-enhanced intraoperative ultrasound (CE-IOUS) for patients with colorectal liver metastases (CRLMs) undergoing surgery.

Method: A thorough literature search was performed in PubMed, Scopus, and Cochrane databases, in accordance with the PRISMA guidelines. The Odds Ratio, Weighted Mean Difference, and 95% Confidence Interval were evaluated, by means of Random-Effects model. Read More

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Effective Control of Brain Metastases Irrespective of Distance from Isocenter in Single-isocenter Multitarget Stereotactic Radiosurgery.

Anticancer Res 2021 May;41(5):2575-2581

Department of Radiology, Shiga University of Medical Science, Otsu, Japan.

Background/aim: Few previous studies have evaluated the effectiveness of single-isocenter multitarget (SIMT) stereotactic radiosurgery (SRS) in clinical practice.

Patients And Methods: Gross tumor volumes of 113 metastases in 13 patients were measured by contrast-enhanced magnetic resonance imaging. Prescribed doses were set at 20-24 Gy. Read More

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Current Status of Ultrasound in Acute Rejection After Renal Transplantation: A Review with a Focus on Contrast-Enhanced Ultrasound.

Ann Transplant 2021 May 4;26:e929729. Epub 2021 May 4.

Department of Nephrology, Chongqing Southwest Hospital, Chongqing, China (mainland).

Renal transplantation has developed into the best treatment for end-stage renal disease, but severe cases can even lead to loss of renal allograft function due to rejection and complications caused by surgical procedures. If a series of postoperative complications can be reduced or even avoided, the quality of life of recipients will be significantly improved. Acute rejection in a transplanted kidney is one of the main complications after renal transplantation. Read More

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Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor.

Pancreas 2021 Apr;50(4):537-543

CalciMedica, Inc, La Jolla, CA.

Objectives: To assess the safety of Auxora in patients with acute pancreatitis (AP), systemic inflammatory response syndrome (SIRS), and hypoxemia, and identify efficacy endpoints to prospectively test in future studies.

Methods: This phase 2, open-label, dose-response study randomized patients with AP, accompanying SIRS, and hypoxemia (n = 21) to receive low-dose or high-dose Auxora plus standard of care (SOC) or SOC alone. All patients received pancreatic contrast-enhanced computed tomography scans at screenings, day 5/discharge, and as clinically required 90 days postrandomization; scans were blinded and centrally read to determine AP severity using computed tomography severity index. Read More

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Quantification of Pancreas Surface Lobularity on CT: A Feasibility Study in the Normal Pancreas.

Korean J Radiol 2021 Apr 23. Epub 2021 Apr 23.

Department of Radiology, Hôpital Beaujon, Clichy, France.

Objective: To assess the feasibility and reproducibility of pancreatic surface lobularity (PSL) quantification derived from abdominal computed tomography (CT) in a population of patients free from pancreatic disease.

Materials And Methods: This retrospective study included 265 patients free from pancreatic disease who underwent contrast-enhanced abdominal CT between 2017 and 2019. A maximum of 11 individual PSL measurements were performed by two abdominal radiologists (head [5 measurements], body, and tail [3 measurements each]) using dedicated software. Read More

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Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor.

Pancreas 2021 Apr 29. Epub 2021 Apr 29.

From the Departments of Critical Care Medicine Emergency Medicine, Regions Hospital, HealthPartners, St. Paul, MN Departments of Emergency Medicine Internal Medicine, Henry Ford Hospital System Department of Emergency Medicine, Wayne State University, Detroit, MI Departments of Pulmonary Medicine Critical Care Medicine, Riverside Methodist Hospital, Columbus, OH Department of Radiology, St. Antonius Hospital, Nieuwegein, The Netherlands CalciMedica, Inc, La Jolla, CA.

Objectives: To assess the safety of Auxora in patients with acute pancreatitis (AP), systemic inflammatory response syndrome (SIRS), and hypoxemia, and identify efficacy endpoints to prospectively test in future studies.

Methods: This phase 2, open-label, dose-response study randomized patients with AP, accompanying SIRS, and hypoxemia (n = 21) to receive low-dose or high-dose Auxora plus standard of care (SOC) or SOC alone. All patients received pancreatic contrast-enhanced computed tomography scans at screenings, day 5/discharge, and as clinically required 90 days postrandomization; scans were blinded and centrally read to determine AP severity using computed tomography severity index. Read More

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Improving performance and generalizability in radiogenomics: a pilot study for prediction of IDH1/2 mutation status in gliomas with multicentric data.

J Med Imaging (Bellingham) 2021 May 29;8(3):031905. Epub 2021 Apr 29.

Clinical Computational Imaging Group, Champalimaud Research, Champalimaud Foundation, Lisboa, Portugal.

Radiogenomics offers a potential virtual and noninvasive biopsy. However, radiogenomics models often suffer from generalizability issues, which cause a performance degradation on unseen data. In MRI, differences in the sequence parameters, manufacturers, and scanners make this generalizability issue worse. Read More

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Differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced ultrasound: A systematic review and meta-analysis.

Clin Hemorheol Microcirc 2021 Apr 28. Epub 2021 Apr 28.

Zhongshan Hospital, Fudan University, Shanghai, China.

Aim: To explore the diagnostic ability of contrast-enhanced ultrasound (CEUS) in distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC).

Materials And Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies reporting the diagnostic accuracy of CEUS in differentiating ICC from HCC. The diagnostic ability of CEUS was assessed based on the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the curve (AUC) with 95% confidence intervals (CIs). Read More

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Can dynamic contrast enhanced MRI predict gleason score in prostate cancer? a systematic review and meta analysis.

Urol Oncol 2021 Apr 29. Epub 2021 Apr 29.

Department of Radiology and Nuclear Medicine, University of Magdeburg, Magdeburg, Germany.

Background And Objectives: Multiparametric MRI has become a corner stone in diagnosis of prostate cancer (PC). DCE-MRI is used to quantify the influx of contrast media into tissues, which was shown to correlate with histopathology features. The present analysis sought to correlate DCE-MRI parameters with Gleason score (GS) based upon a large patient sample. Read More

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A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Instituto de Ciencia Molecular (ICMol), Universitat de València, c/Catedrático José Beltrán 2, Paterna, 46980 Valencia, Spain.

The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. Read More

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Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids-Efficiency Assessment with the Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and the Potential Role of the Administration of Uterotonic Drugs.

Diagnostics (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.

Objective: The assessment of the usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) when qualifying patients with uterine fibroids (UFs) for magnetic resonance-guided high-intensity ultrasound (MR-HIFU).

Material And Methods: This retrospective, single center study included 283 women who underwent DCE-MRI and were treated with MR-HIFU. The patients were divided according to non-perfused volume (NPV) as well as by the type of curve for patients with a washout curve in the DCE-MRI study and patients without a washout curve. Read More

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Fiducial marker migration following computed tomography-guided placement in the liver: a case report.

AME Case Rep 2021 25;5:15. Epub 2021 Apr 25.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Radiation therapy for liver tumors has been shown to provide a local control and overall survival benefit in patients with primary or oligometastatic liver tumors. However, accurate delineation of the target volume in intraabdominal tumors can be limited by diaphragmatic motion. In addition to image guidance during radiation therapy, computed tomography (CT)-guided fiducial marker placement can improve the accuracy of radiation treatment and optimize tumor control. Read More

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A free time point model for dynamic contrast enhanced exploration.

Magn Reson Imaging 2021 Apr 24;80:39-49. Epub 2021 Apr 24.

Université de Paris, PARCC, INSERM, Paris F-75015, France; Université de Paris, Plateforme d'Imageries du Vivant, F-75015, France. Electronic address:

Dynamic-Contrast-Enhanced (DCE) Imaging has been widely studied to characterize microcirculatory disorders associated with various diseases. Although numerous studies have demonstrated its diagnostic interest, the physiological interpretation using pharmacokinetic models often remains debatable. Indeed, to be interpretable, a model must provide, at first instance, an accurate description of the DCE data. Read More

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Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging.

J Biomater Appl 2021 Apr 25:8853282211011766. Epub 2021 Apr 25.

School of Pharmacy, Hubei University of Science and Technology, Xianning, China.

In this experiment, a new amphiphilic chitosan-poly(lactide) graft copolymer was synthesized and characterized by IR, H-NMR, XRD, TGA. The obtained chitosan-poly (lactide) graft copolymer was used as the matrix material to prepare nanodroplets (NDs) encapsulating with liquid PFP by double-emulsion and solvent evaporation method. The resulting NDs were characterized by photon correlation spectroscopy and transmission electron microscopy (TEM). Read More

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Image Findings of Acute to Subacute Craniocervical Arterial Dissection on Magnetic Resonance Vessel Wall Imaging: A Systematic Review and Proportion Meta-Analysis.

Front Neurol 2021 7;12:586735. Epub 2021 Apr 7.

Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

This systematic review and meta-analysis aimed to evaluate the pooled proportion of image findings of acute to subacute craniocervical arterial dissection (AD) direct signs on magnetic resonance vessel wall imaging (MR-VWI) and to identify factors responsible for the heterogeneity across the included studies. A systematic literature search in the Ovid-MEDLINE and EMBASE databases was performed for studies published on the relevant topic before April 14, 2020. Pooled sensitivity and specificity values and their 95% confidence intervals (CIs) were calculated using bivariate random-effects modeling. Read More

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The diagnostic utility of diffusion weighted MRI imaging and ADC ratio to distinguish benign from malignant renal masses: sorting the kittens from the tigers.

BMC Urol 2021 Apr 22;21(1):67. Epub 2021 Apr 22.

Faculty of Medicine, University of NSW, Kensington, NSW, Australia.

Background: MRI is playing an increasing role in risk stratification and non-invasive diagnosis of the undifferentiated small renal mass. This study was designed to assess the reliability of MRI in diagnostic evaluation of renal masses, specifically characterising lesions with diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) values.

Methods: This is a retrospective analysis of patients undergoing MRI as part of their clinical workup for a renal mass suspicious for renal cell carcinoma (RCC) on CT or ultrasound followed by biopsy and/or surgical excision. Read More

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The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review.

Cancer Imaging 2021 Apr 20;21(1):36. Epub 2021 Apr 20.

Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands.

Background: Diagnostic and treatment response criteria for the JAK2/CALR/MPL mutation-related myeloproliferative neoplasms (MPNs) are largely based on bone marrow (BM) biopsy results. However, these biopsies have several limitations, such as the risk of sampling error. Also, the prognostic impact of BM abnormalities is largely unclear. Read More

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Mapping functional gradients of the striatal circuit using simultaneous microelectric stimulation and ultrahigh-field fMRI in non-human primates.

Neuroimage 2021 Apr 18;236:118077. Epub 2021 Apr 18.

Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea,. Electronic address:

Advances in functional magnetic resonance imaging (fMRI) have significantly enhanced our understanding of the striatal system of both humans and non-human primates (NHP) over the last few decades. However, its circuit-level functional anatomy remains poorly understood, partly because in-vivo fMRI cannot directly perturb a brain system and map its casual input-output relationship. Also, routine 3T fMRI has an insufficient spatial resolution. Read More

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Implementation of a novel 288-element dual-frequency array for acoustic angiography: in vitro & in vivo characterization.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Apr 19;PP. Epub 2021 Apr 19.

Acoustic angiography is a superharmonic contrast-enhanced ultrasound imaging method that produces high-resolution, three-dimensional maps of the microvasculature. Previous acoustic angiography studies have used two-element, annular, mechanically actuated transducers (called "wobblers") to image microvasculature in preclinical tumor models with high contrast-to-tissue ratio and resolution, but these early wobbler transducers could not achieve the depth and sensitivity required for clinical acoustic angiography. In this work, we present a system for performing acoustic angiography with a novel dual-frequency transducer - a coaxially stacked dual-frequency array. Read More

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Contrast enhanced ultrasound quantitative parameters for assessing neoadjuvant chemotherapy response in patients with locally advanced breast cancer.

Br J Radiol 2021 May 16;94(1121):20201160. Epub 2021 Apr 16.

Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Objectives: To evaluate the role of contrast-enhanced ultrasound (CEUS) quantitative parameters in predicting neoadjuvant chemotherapy (NACT) response in patients with locally advanced breast cancer (LABC).

Methods: 30 patients with histologically proven LABC scheduled for NACT were recruited. CEUS was performed using a contrast bolus of 4. Read More

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Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment.

BMC Neurol 2021 Apr 15;21(1):159. Epub 2021 Apr 15.

Radiology Department, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, South Gongti Road, Chaoyang District, Beijing, 100020, P.R. China.

Background: Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild cognitive impairment (vMCI), has only been validated by a few studies. The aim of this study was to investigate whether compromised BBB integrity is involved in vMCI patients, and detect the relationship between BBB breakdown and cognitive function. BBB leakage in vMCI was explored, and the relationship between BBB leakage and cognitive function was discussed in this study. Read More

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3D dissimilar-siamese-u-net for hyperdense Middle cerebral artery sign segmentation.

Comput Med Imaging Graph 2021 Mar 14;90:101898. Epub 2021 Mar 14.

Department of Radiology and Imaging, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, Hong Kong.

The hyperdense middle cerebral artery sign (HMCAS) representing a thromboembolus has been declared as a vital CT finding for intravascular thrombus in the diagnosis of acute ischemia stroke. Early recognition of HMCAS can assist in patient triage and subsequent thrombolysis or thrombectomy treatment. A total of 624 annotated head non-contrast-enhanced CT (NCCT) image scans were retrospectively collected from multiple public hospitals in Hong Kong. Read More

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Assessing locoregional treatment response to Hepatocellular Carcinoma: comparison of hepatobiliary contrast agents to extracellular contrast agents.

Abdom Radiol (NY) 2021 Apr 15. Epub 2021 Apr 15.

Department of Diagnostic, Molecular and Interventional Radiology, BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cross-sectional imaging with contrast-enhanced magnetic resonance imaging (MRI) is routinely performed in patients with hepatocellular carcinoma (HCC) to assess tumor response to locoregional therapy (LRT). Current response assessment algorithms, such as the Liver Imaging Reporting and Data System (LI-RADS) treatment response algorithm (TRA), allow assessment using conventional gadolinium-based extracellular contrast agents (ECA) for accurate tumor response assessment following LRT. MRI with hepatobiliary agents (HBA) allows an acquisition of hepatobiliary phase (HBP), which is proven to increase sensitivity for detection of observations in at-risk patients, particularly for findings < 2 cm. Read More

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Real-life assessment of standardized contrast-enhanced ultrasound (CEUS) and CEUS algorithms (CEUS LI-RADS®/ESCULAP) in hepatic nodules in cirrhotic patients-a prospective multicenter study.

Eur Radiol 2021 Apr 15. Epub 2021 Apr 15.

Universitätsklinikum Erlangen, Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Medizinische Klinik 1, Erlangen, Germany.

Objectives: Hepatocellular carcinoma (HCC) can be diagnosed non-invasively with contrast-enhanced ultrasound (CEUS) in cirrhosis if the characteristic pattern of arterial phase hyperenhancement followed by hypoenhancement is present. Recent studies suggest that diagnosis based on this "hyper-hypo" pattern needs further refinement. This study compares the diagnostic accuracies of standardized CEUS for HCC according to the current guideline definition and following the newly developed CEUS algorithms (CEUS LI-RADS®, ESCULAP) in a prospective multicenter real-life setting. Read More

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Constrained generative adversarial network ensembles for sharable synthetic medical images.

J Med Imaging (Bellingham) 2021 Mar 10;8(2):024004. Epub 2021 Apr 10.

The Ohio State University, College of Medicine, Department of Radiology, Columbus, Ohio, United States.

Sharing medical images between institutions, or even inside the same institution, is restricted by various laws and regulations; research projects requiring large datasets may suffer as a result. These limitations might be addressed by an abundant supply of synthetic data that (1) are representative (i.e. Read More

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Cognitive improvement effect of gintonin might be associated with blood-brain barrier permeability enhancement: dynamic contrast-enhanced MRI pilot study.

Transl Clin Pharmacol 2021 Mar 10;29(1):21-32. Epub 2021 Mar 10.

Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.

Along with the multiple neuroprotective effect, recent studies suggest that gintonin might increase the blood brain barrier permeability. We evaluated the effect of gintonin on the vascular permeability changes in different brain segments, using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). In this 8-week, randomized, open label pilot study, ten participants with subjective memory impairment but preserved cognitive function assigned to gintonin-enriched fraction (GEF) 300 mg/day or placebo groups. Read More

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Intestinal ultrasound in pediatrics.

Radiologia 2021 May-Jun;63(3):291-304. Epub 2020 Oct 21.

Área de Imagen Médica, Sección Pediatría, Hospital La Fe, Valencia, España.

Ultrasonography is the imaging technique of choice for studying the digestive tract in pediatric patients from the neonatal period to adolescence. Its dynamic character, absence of radiation, and scant preparation required make ultrasonography preferable to contrast-enhanced fluoroscopy, computed tomography, or magnetic resonance imaging. Technical advances in ultrasound, including high-resolution multifrequency probes, panoramic studies, color Doppler, Doppler with microvascularization, elastography, and contrast agents for use in children, have increased the sensitivity and specificity of this technique. Read More

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October 2020

Letter to the Editor: Non-selective bilateral internal iliac artery embolization is a safe and effective way in hemorrhage control for hemodynamically unstable pelvic fractures.

Authors:
Hui Li Ping Hu

BMC Musculoskelet Disord 2021 Apr 14;22(1):355. Epub 2021 Apr 14.

Department of Traumatology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, 1 Jiankang Road, 400014, Yuzhong District, Chongqing, China.

A recently published article by Lai et al. in BMC Musculoskeletal Disorders trying to show that patients with pelvic fractures undergoing non-selective internal iliac artery embolization may lead to a higher rate of surgical site infection. The authors also noted that only a small percentage of patients with contrast extravasation detected by emergency contrast-enhanced CT were subsequently confirmed by angiography, thus, considered that the value of enhanced CT in predicting arterial injury was limited. Read More

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Diagnostic value of MDCT in determining the perinephric fat tissue and renal sinus invasion in patients with clear cell renal cell carcinoma.

Niger J Clin Pract 2021 Apr;24(4):489-495

Lutfi Kirdar Kartal Education and Research Hospital, Cevizli mh. Şemsi Denizer cad. E-5 Karayolu Cevizli Mevkii, 34890 Kartal, İstanbul, Turkey.

Aims: To investigate the accuracy of multidetector computed tomography (MDCT) findings, and the effect of tumor volume in determining the perinephric and renal sinus invasion in clear cell renal cell carcinomas (ccRCCs).

Method: Fifty patients with ccRCCs underwent non-contrast and nephrographic-phase contrast-enhanced MDCT examination before total nephrectomy. The following MDCT features were used to diagnose perinephric fat tissue invasion: perinephric stranding, perinephric vascularity, and irregular contour. Read More

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