4,624 results match your criteria contralateral breast

Reply: Occult Breast Carcinoma Is More Common in Women Undergoing Breast Reduction after Contralateral Cancer: A Systematic Review and Meta-Analysis.

Plast Reconstr Surg 2021 Jul 26. Epub 2021 Jul 26.

Plastic and Reconstructive Surgery Department Westmead Private Hospital Westmead, New South Wales, Australia.

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Target coverage and cardiopulmonary sparing with the updated ESTRO-ACROP contouring guidelines for postmastectomy radiation therapy after breast reconstruction: a treatment planning study using VMAT and proton PBS techniques.

Acta Oncol 2021 Jul 27:1-12. Epub 2021 Jul 27.

Harvard Radiation Oncology Program, Boston, MA, USA.

Background: The European Society for Therapeutic Radiology and Oncology Advisory Committee in Radiation Oncology Practice (ESTRO-ACROP) recently released new contouring guidelines for postmastectomy radiation therapy (PMRT) after implant-based reconstruction (IBR). As compared to prior ESTRO guidelines, the new guidelines primarily redefined the chest wall (CW) target to exclude the breast prosthesis. In this study, we assessed the impact of these changes on treatment planning and dosimetric outcomes using volumetric-modulated arc therapy (VMAT) and proton pencil-beam scanning (PBS) therapy. Read More

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Molecular Imaging Reveals a High Degree of Cross-Seeding of Spontaneous Metastases in a Novel Mouse Model of Synchronous Bilateral Breast Cancer.

Mol Imaging Biol 2021 Jul 26. Epub 2021 Jul 26.

Robarts Research Institute, University of Western Ontario, London, ON, Canada.

Purpose: Synchronous bilateral breast cancer (SBBC) patients present with cancer in both breasts at the time of diagnosis or within a short time interval. They show higher rates of metastasis and lower overall survival compared to women with unilateral breast cancer. Here we established the first preclinical SBBC model and used molecular imaging to visualize the patterns of metastasis from each primary tumor. Read More

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Contralateral prophylactic mastectomy in male breast cancer: where do we stand?

Future Sci OA 2021 Sep 2;7(8):FSO746. Epub 2021 Jul 2.

Oncology Unit, Hospital 'Andrea Tortora', ASL Salerno, Pagani, Italy.

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September 2021

Seat belt breast injury: a reconstructive approach to managing unilateral bisected breast deformity.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Plastic Surgery Department, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK.

Seat belt breast deformity can result in significant aesthetic, functional and psychosocial sequelae. Although seat belt breast deformity is well documented, there is a lack of literature describing their reconstructive management. We describe the surgical management of a 63-year-old woman presenting with stage 2b seat belt breast deformity, who underwent scar revision, repositioning of the nipple-areola complex and contralateral breast reduction using Wise-pattern incisions based on superior pedicles. Read More

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Contralateral Axillary Nodal Metastases: Stage IV Disease or a Manifestation of Progressive Locally Advanced Breast Cancer?

Ann Surg Oncol 2021 Jul 21. Epub 2021 Jul 21.

Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Background: Contralateral axillary nodal metastases (CAM) is classified as stage IV disease, although many centers treat CAM with curative intent. We hypothesized that patients with CAM, treated with multimodality therapy, would have improved overall survival (OS) versus patients with distant metastatic disease (M1) and similar OS to those with locally advanced breast cancer (LABC).

Methods: Using the NCDB (2004-2016), we categorized adult patients with node-positive breast cancer into three study groups: LABC, CAM, and M1. Read More

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Dosimetric Comparison of Whole Breast Radiotherapy Using Field-in-Field and Volumetric Modulated Arc Therapy Techniques in Left-Sided Breast Cancer Patients.

Cureus 2021 Jun 18;13(6):e15732. Epub 2021 Jun 18.

Department of Clinical and Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Introduction The radiotherapy of left-sided breast cancers is challenging because of neighboring critical organs, posing an increased risk of complications. Various radiation delivery techniques have been used to deliver the desired dose of radiation to the target area while keeping the doses to nearby structures within constraints. The main aim of this study is to quantify doses delivered to the organs at risk (OARs) including heart, left lung, spinal cord, and contralateral breast, and to the planning target volume (PTV) using Field-in-Field (FIF) and Volumetric Modulated Arc Therapy (VMAT). Read More

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Preoperative diagnosis of BRCA1/2 mutation impacts decision-making for risk-reducing mastectomy in breast cancer patients.

Sci Rep 2021 Jul 20;11(1):14747. Epub 2021 Jul 20.

Division of Breast Surgery, Department of Surgery, Samsung Medical Center Cancer Hospital, Sungkyunkwan University School of Medicine, 5th Floor Breast-Endocrine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Decision to undergo risk-reducing mastectomy (RRM) needs to consider several factors, including patient's preference, surgeon's preference, family history, and genetic predisposition. The aim of this study was to examine whether preoperative diagnosis of BRCA1/2 mutation status could influence surgical decision-making in newly diagnosed breast cancer patients. We retrospectively reviewed ipsilateral breast cancer patients with BRCA1/2 mutation who underwent primary surgery between January 2008 and November 2019 at a single institution in Korea. Read More

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A multicentre study of the relationship between abdominal flap and mastectomy weights in immediate unilateral free flap breast reconstruction and the effect of adjuvant radiotherapy.

J Plast Reconstr Aesthet Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; School of Medicine, Anglia Ruskin University, Cambridge and Chelmsford, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. Electronic address:

Abdominal free flaps are considered the gold standard for post-mastectomy autologous breast reconstruction. A key element of outcome assessment is breast symmetry often achieved by approximating the reconstructed breast dimensions such as weight (wt) to those of the mastectomy. However, the ideal relationship between these two entities remains unclear. Read More

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Accounting for Surgical Confounding Factors Affecting Dual-Energy X-ray Absorptiometry in a Large Clinical Trial.

J Clin Densitom 2021 Jun 17. Epub 2021 Jun 17.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital (BWH), Harvard Medical School, Boston MA, USA. Electronic address:

Joint replacements are among the most common orthopedic procedures performed in the U.S. and will continue to increase with the aging population. Read More

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Risk and influencing factors for subsequent primary lung cancer after treatment of breast cancer: a systematic review and two meta-analyses based on four million cases.

J Thorac Oncol 2021 Jul 10. Epub 2021 Jul 10.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Purpose: To compare the risk of developing lung cancer between breast cancer patients and the general population and explore the risk factors for the development of primary lung cancer after treatment for breast cancer.

Methods: The PubMed, EMBASE and Web of Science databases were searched from the establishment date to October 11, 2020. Two separate meta-analyses were performed: one focused on studies reporting the risk of subsequent lung cancer after breast cancer and one focused on studies exploring the risk factors for subsequent lung cancer in breast cancer patients. Read More

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Hispanic Ethnicity and Breast Cancer: Disaggregating Surgical Management and Mortality by Race.

J Racial Ethn Health Disparities 2021 Jul 12. Epub 2021 Jul 12.

Division of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH, USA.

Objective: Breast cancer is the leading cause of cancer death among Hispanic women. Unfortunately, few studies disaggregate Hispanic patients by race to understand its implications on treatment and clinical outcomes such as mortality. The aim of this study is to examine surgical management and overall mortality among different subgroups of women who self-identify as Hispanic. Read More

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Surgical Decision-Making Surrounding Contralateral Prophylactic Mastectomy: Comparison of Treatment Goals, Preferences, and Psychosocial Outcomes from a Multicenter Survey of Breast Cancer Patients.

Ann Surg Oncol 2021 Jul 12. Epub 2021 Jul 12.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.

Background: Differences in patient characteristics and decision-making preferences have been described between those who elect breast-conserving surgery (BCS), unilateral mastectomy (UM), or contralateral prophylactic mastectomy (CPM) for breast cancer. However, it is not known whether preferred and actual decision-making roles differ across these surgery types, or whether surgery choice reflects a woman's goals or achieves desired outcomes.

Methods: Women diagnosed with stage 0-III unilateral breast cancer across eight large medical centers responded to a mailed questionnaire regarding treatment decision-making goals, roles, and outcomes. Read More

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Tolerability of Breast Radiotherapy Among Carriers of Germline Variants.

JCO Precis Oncol 2021 19;5. Epub 2021 Jan 19.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.

, a gene that controls repair of DNA double-strand breaks, confers an excess lifetime risk of breast cancer among carriers of germline pathogenic variants (PV). PV homozygotes are particularly sensitive to DNA damage caused by ionizing radiation. Consequently, there is concern that adjuvant radiotherapy (RT) may cause excess morbidity among heterozygous carriers of PV. Read More

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January 2021

Correlation Between F-FDG Uptake and Immune Cell Infiltration in Metastatic Brain Lesions.

Front Oncol 2021 24;11:618705. Epub 2021 Jun 24.

Department of Pathology, Ajou University School of Medicine, Suwon, South Korea.

Background: The purpose of this study was to investigate the correlation between F-fluorodeoxyglucose (FDG) uptake and infiltrating immune cells in metastatic brain lesions.

Methods: This retrospective study included 34 patients with metastatic brain lesions who underwent brain F-FDG positron emission tomography (PET)/computed tomography (CT) followed by surgery. F-FDG uptake ratio was calculated by dividing the standardized uptake value (SUV) of the metastatic brain lesion by the contralateral normal white matter uptake value. Read More

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Immobilization-assisted abdominal deep inspiration breath-hold in post-mastectomy radiotherapy of left-sided breast cancer with internal mammary chain coverage.

Quant Imaging Med Surg 2021 Jul;11(7):3314-3326

Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: Whether to prophylactically irradiate the ipsilateral internal mammary chain (IMC) in post-mastectomy radiotherapy (PMRT) remains controversial because of equivocal clinical benefits against the added toxicities. Our previous study revealed that the cardiac dose was decreased during left-sided breast radiotherapy with abdominal deep inspiration breath-hold (aDIBH) as compared with free-breathing (FB) and thoracic deep inspiration breath-hold (tDIBH). Here we present the dosimetric advantage of aDIBH for patients undergoing PMRT with IMC coverage. Read More

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From to Polygenic Risk Scores: Mutation-Associated Risks in Breast Cancer-Related Genes.

Breast Care (Basel) 2021 Jun 31;16(3):202-213. Epub 2021 Mar 31.

Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.

Background: There has been huge progress over the last 30 years in identifying the familial component of breast cancer.

Summary: Currently around 20% is explained by the high-risk genes and , a further 2% by other high-penetrance genes, and around 5% by the moderate risk genes and . In contrast, the more than 300 low-penetrance single-nucleotide polymorphisms (SNP) now account for around 28% and they are predicted to account for most of the remaining 45% yet to be found. Read More

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Development of U-Net Breast Density Segmentation Method for Fat-Sat MR Images Using Transfer Learning Based on Non-Fat-Sat Model.

J Digit Imaging 2021 Jul 9. Epub 2021 Jul 9.

Department of Radiological Sciences, University of California, Irvine, CA, USA.

To develop a U-net deep learning method for breast tissue segmentation on fat-sat T1-weighted (T1W) MRI using transfer learning (TL) from a model developed for non-fat-sat images. The training dataset (N = 126) was imaged on a 1.5 T MR scanner, and the independent testing dataset (N = 40) was imaged on a 3 T scanner, both using fat-sat T1W pulse sequence. Read More

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Sequential occurrence of different subtypes of nonpuerperal mastitis in contralateral breasts: a report of two cases.

Int J Clin Exp Pathol 2021 15;14(6):782-785. Epub 2021 Jun 15.

Department of Breast Surgery, People's Hospital Changzhi 046000, Shanxi, China.

Background: Nonpuerperal mastitis (NPM) is a nonspecific chronic inflammation in the breast. The two most common pathologic subtypes are idiopathic granulomatous mastitis (IGM) and plasma cell mastitis (PCM). The cause of NPM is unknown, and the recurrence rate is high; however, the sequential development of two different pathologic subtypes of NPM in contralateral breasts of the same patient is rare. Read More

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The successful application of pyrotinib in the treatment of primary trastuzumab-resistant HER-2-positive breast cancer with bilateral axillary lymph node metastasis: a case report.

Ann Palliat Med 2021 Jun;10(6):7138-7145

Department of Chemotherapy, Jiangsu Cancer Hospital &Jiangsu Institute of Cancer Research &The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing China.

Breast cancer patients with synchronous contralateral axillary lymph node metastasis (CAM) are very rare, and there is a lack of published treatment guidelines for this kind of patients. We presented a human epidermal growth factor receptor 2 (HER-2)-positive breast cancer case, who was diagnosed as CAM with primary trastuzumab resistance. In this case report, we describes a 47-year-old woman diagnosed with HER-2 positive breast cancer with regional lymph nodes metastasis. Read More

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Cutaneous Metastases as Initial Presentation of Lung Carcinoma.

Cureus 2021 May 31;13(5):e15344. Epub 2021 May 31.

Department of Nuclear Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

Breast cancer, in women, and lung cancer, in men, are the most common origins of cutaneous metastasis. Lung cancer can metastasize to any organ but mostly to the contralateral lung, liver, adrenal gland, bones, and brain. Over 1-12% of patients with lung cancer can develop skin metastasis. Read More

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What Can Proton Beam Therapy Achieve for Patients with Pectus Excavatum Requiring Left Breast, Axilla and Internal Mammary Nodal Radiotherapy?

Clin Oncol (R Coll Radiol) 2021 Jul 2. Epub 2021 Jul 2.

The Royal Marsden Hospital, London, UK; The Institute of Cancer Research, London, UK.

Aims: Exposure of the heart to radiation increases the risk of ischaemic heart disease, proportionate to the mean heart dose (MHD). Radiotherapy techniques including proton beam therapy (PBT) can reduce MHD. The aims of this study were to quantify the MHD reduction achievable by PBT compared with volumetric modulated arc therapy in breath hold (VMAT-BH) in patients with pectus excavatum (PEx), to identify an anatomical metric from a computed tomography scan that might indicate which patients will achieve the greatest MHD reductions from PBT. Read More

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Diffuse optical tomography breast imaging measurements are modifiable with pre-surgical targeted and endocrine therapies among women with early stage breast cancer.

Breast Cancer Res Treat 2021 Aug 2;189(1):297-304. Epub 2021 Jul 2.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Purpose: Diffuse optical tomography breast imaging system (DOTBIS) non-invasively measures tissue concentration of hemoglobin, which is a potential biomarker of short-term response to neoadjuvant chemotherapy. We evaluated whether DOTBIS-derived measurements are modifiable with targeted therapies, including AKT inhibition and endocrine therapy.

Methods: We conducted a proof of principle study in seven postmenopausal women with stage I-III breast cancer who were enrolled in pre-surgical studies of the AKT inhibitor MK-2206 (n = 4) or the aromatase inhibitors exemestane (n = 2) and letrozole (n = 1). Read More

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Dose measurements in a thorax phantom at 3DCRT breast radiation therapy.

Rep Pract Oncol Radiother 2021 14;26(2):242-250. Epub 2021 Apr 14.

Department of Nuclear Engineering, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Background: The anthropomorphic and anthropometric phantom developed by the research group NRI (Núcleo de Radiações Ionizantes) can reproduce the effects of the interactions of radiation occurring in the human body. The whole internal radiation transport phenomena can be depicted by film dosimeters in breast RT. Our goal was to provide a dosimetric comparison of a radiation therapy (RT) plan in a 4MV 3D-conformal RT (4MV-3DCR T) and experimental data measured in a breast phantom. Read More

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Pilot Clinical Study Investigating the Thermal Physiology of Breast Cancer via High-Resolution Infrared Imaging.

Bioengineering (Basel) 2021 Jun 22;8(7). Epub 2021 Jun 22.

Department of Mechanical Engineering, The University of Texas at Dallas, 800 W Campbell Rd, Mailstop ECW-31, Richardson, TX 75080, USA.

This descriptive study investigates breast thermal characteristics in females histologically diagnosed with unilateral breast cancer and in their contralateral normal breasts. The multi-institutional clinical pilot study was reviewed and approved by the Institutional Review Boards (IRBs) at participating institutions. Eleven female subjects with radiologic breast abnormalities were enrolled in the study between June 2019 and September 2019 after informed consent was obtained. Read More

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Comparing Local and Systemic Control between Partial- and Whole-Breast Radiotherapy in Low-Risk Breast Cancer-A Meta-Analysis of Randomized Trials.

Cancers (Basel) 2021 Jun 13;13(12). Epub 2021 Jun 13.

Department of Radiation Oncology, Heinrich Heine University, 40225 Dusseldorf, Germany.

Purpose/objective: The standard treatment for localized low-risk breast cancer is breast-conserving surgery, followed by adjuvant radiotherapy and appropriate systemic therapy. As the majority of local recurrences occur at the site of the primary tumor, numerous trials have investigated partial-breast irradiation (PBI) instead of whole-breast treatment (WBI) using a multitude of irradiation techniques and fractionation regimens. This meta-analysis addresses the impact on disease-specific endpoints, such as local and regional control, as well as disease-free survival of PBI compared to that of WBI in published randomized trials. Read More

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Results of Adrenalectomy for Isolated, Metachronous Metastasis of Breast Cancer: A Retrospective Cohort Study.

Front Surg 2021 9;8:671424. Epub 2021 Jun 9.

Department of Surgery, "Pietro Valdoni", University of Rome "La Sapienza", Rome, Italy.

Metachronous, isolated adrenal metastases from breast cancer are extremely rare. The aim of this study was to evaluate the results of adrenalectomy as a treatment of this uncommon condition. Twelve female patients (median age: 68 years) underwent 13 adrenalectomies for isolated, metachronous metastases of breast cancer. Read More

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Immediate breast reconstruction with expander following recurrent lesion resection and exchange to silicon breast implant in a pregnant triple negative breast cancer patient: case report.

Gland Surg 2021 May;10(5):1792-1799

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan.

A 39-year-old gravida 1 para 1 pregnant Japanese woman underwent skin-sparing mastectomy and axillary lymph node dissection with immediate breast reconstruction (IBR) using a tissue expander (TE) at 32 weeks of pregnancy under general anesthesia. Inserted TE (300 cc) was expanded during breast feeding while the volume was 240 cc of the resected breast tissue. One month after delivery, 2 months after surgery, the contralateral healthy breast increased in size and the inframammary line was deviated toward a caudal site which was larger than 300 cc-inflated TE. Read More

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