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Nerve Transfers after Cervical Spine Surgery: Multi-Institutional Case series and review of the literature.

World Neurosurg 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address:

Background: Up to 10% of cervical spine surgeries are complicated by postoperative weakness. Though many patients recover with non-operative management, some require surgery for restoration of function.

Objective: To present the indications and outcomes of patients undergoing nerve transfers after developing weakness secondary to cervical spine decompression. Read More

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September 2021

Targeted Clinical Interventions for Reducing Pediatric Readmissions.

Hosp Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Children's Health of Orange County, Orange, California

Background: In this interventional study, we addressed the selection and application of clinical interventions on pediatric patients identified as at risk by a predictive model for readmissions.

Methods: A predictive model for readmissions was implemented, and a team of providers expanded corresponding clinical interventions for at-risk patients at a freestanding children's hospital. Interventions encompassed social determinants of health, outpatient care, medication reconciliation, inpatient and discharge planning, and postdischarge calls and/or follow-up. Read More

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September 2021

An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial.

Pain 2021 Oct;162(10):2486-2498

Division of Pain Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA, United States.

Abstract: Chronic low back pain can be caused by impaired control and degeneration of the multifidus muscles and consequent functional instability of the lumbar spine. Available treatment options have limited effectiveness and prognosis is unfavorable. We conducted an international randomized, double-blind, sham-controlled trial at 26 multidisciplinary centers to determine safety and efficacy of an implantable, restorative neurostimulator designed to restore multifidus neuromuscular control and facilitate relief of symptoms (clinicaltrials. Read More

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October 2021

The effects of daily physical activity intervention on physical fitness in preschool children.

J Sports Sci 2021 Sep 17:1-10. Epub 2021 Sep 17.

Faculty of Sport and Physical Education, University of Niš, Niš, Serbia.

The study aimed to determine the effects of 6 months daily physical activity on physical fitness in preschool children. A total of 72 children (36 boys) and 92 children (47 boys) composed the experimental (EG) and control group (CG), respectively. We used the PREFIT battery access physical fitness. Read More

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September 2021

Implementation of a central-line bundle: a qualitative study of three clinical units.

Implement Sci Commun 2021 Sep 16;2(1):105. Epub 2021 Sep 16.

The Hospital for Sick Children, 555 University Ave., Toronto, M5G 1X8, Canada.

Background: Evidence for the central line-associated bloodstream infection (CLABSI) bundle effectiveness remains mixed, possibly reflecting implementation challenges and persistent ambiguities in how CLABSIs are counted and bundle adherence measured. In the context of a tertiary pediatric hospital that had reduced CLABSI by 30% as part of an international safety program, we aimed to examine unit-based socio-cultural factors influencing bundle practices and measurement, and how they come to be recognized and attended to by safety leaders over time in an organization-wide bundle implementation effort.

Methods: We used an interpretivist qualitative research approach, based on 74 interviews, approximately 50 h of observations, and documents. Read More

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September 2021

Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study.

J Allergy Clin Immunol 2021 Sep 13. Epub 2021 Sep 13.

Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium; Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden; First Affiliated Hospital, Sun Yat-sen University, International Airway Research Center, Guangzhou, China.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently remains uncontrolled despite maximal medical therapy and sinonasal surgery, presenting several unmet needs and challenges. Omalizumab previously demonstrated efficacy in CRSwNP in duplicate, phase 3, randomized, placebo-controlled trials (POLYP 1, POLYP 2).

Objective: This open-label extension evaluated continued efficacy, safety, and durability of response of omalizumab in adults with CRSwNP who completed POLYP 1 or 2. Read More

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September 2021

Considerations for mitigating COVID-19 related risks in schools.

Amy Gimma Sham Lal

Lancet Reg Health Am 2021 Oct 10;2:100077. Epub 2021 Sep 10.

London School of Hygiene & Tropical Medicine, Greater London UNITED KINGDOM.

As the new school year begins in the United States, school districts will be tasked with providing in-person teaching while keeping children and school staff safe, an increasingly difficult goal in the presence of the COVID-19 delta variant. We aim to provide updated interpretations of past and newly published studies to assist in assessing risk in schools, and to add additional perspectives on addressing the social determinants of learning and on the role of race and other social factors. We advocate for the continued implementation of risk mitigation strategies in schools, including mandatory mask policies, improved ventilation, and convenient access to vaccinations for those eligible, as recommended by the CDC, and to use this opportunity to make long-term improvements to our schools as a matter of urgency. Read More

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October 2021

Triamcinolone Acetonide in the Treatment of Perennial Allergic Rhinitis: A post hoc Analysis of Quality of Life during a Phase III Study.

Int Arch Allergy Immunol 2021 Sep 6:1-8. Epub 2021 Sep 6.

Medical Department, Sanofi Consumer Healthcare, São Paulo, Brazil.

Introduction: Allergic rhinitis (AR) is a disease that affects ≤24% of people in Russia, significantly impairing quality of life (QoL). Intranasal corticosteroids, such as triamcinolone acetonide (TAA), are considered effective drugs for treatment. A post hoc analysis of data (phase III NASANIF trial) examined weekly QoL changes in patients receiving TAA for the treatment of perennial AR (PAR). Read More

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September 2021

Improving quality of medical certification of causes of death in health facilities in Tanzania 2014-2019.

BMC Health Serv Res 2021 Sep 13;21(Suppl 1):214. Epub 2021 Sep 13.

Bloomberg Philanthropies Data for Health Initiative, Vital Strategies, New York, NY, USA.

Background: Monitoring medically certified causes of death is essential to shape national health policies, track progress to Sustainable Development Goals, and gauge responses to epidemic and pandemic disease. The combination of electronic health information systems with new methods for data quality monitoring can facilitate quality assessments and help target quality improvement. Since 2015, Tanzania has been upgrading its Civil Registration and Vital Statistics system including efforts to improve the availability and quality of mortality data. Read More

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September 2021

Longitudinal changes in quality of life and psychosocial problems of primary school children in a deprived urban neighborhood over the course of a school-based integrated approach.

Eur Child Adolesc Psychiatry 2021 Sep 12. Epub 2021 Sep 12.

Department of Public Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

The municipality of Amsterdam implemented a 2-year school-based integrated approach in schools in a deprived neighborhood. The integrated approach targeted the domains of education, health and poverty and the children's school, neighborhood and home environment by involving various agencies and actors. In this study, changes in children's quality of life and psychosocial problems over the course of the integrated approach were examined and evaluated. Read More

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September 2021

Grandchild Care and Well-Being: Gender Differences in Mental Health Effects of Caregiving Grandparents.

J Gerontol B Psychol Sci Soc Sci 2021 Sep 11. Epub 2021 Sep 11.

Department of Sociology at Brown University. Her research interests include aging, families, residential segregation, and inequality.

Objective: The literature on the gendered differences of mental health as a result of grandchild care has shown mixed results. Research on grandchild care further suggests that nonresidential grandchild care improves mental health outcomes, while residential grandchild care arrangements decrease mental health outcomes in grandparents. The moderating or buffering role of social engagement remains understudied in the grandchild care-mental health relationship. Read More

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September 2021

CellProfiler 4: improvements in speed, utility and usability.

BMC Bioinformatics 2021 Sep 10;22(1):433. Epub 2021 Sep 10.

Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Background: Imaging data contains a substantial amount of information which can be difficult to evaluate by eye. With the expansion of high throughput microscopy methodologies producing increasingly large datasets, automated and objective analysis of the resulting images is essential to effectively extract biological information from this data. CellProfiler is a free, open source image analysis program which enables researchers to generate modular pipelines with which to process microscopy images into interpretable measurements. Read More

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September 2021

Supporting breast cancer survivors via text messages: reach, acceptability, and utility of EMPOWER-SMS.

J Cancer Surviv 2021 Sep 9. Epub 2021 Sep 9.

Engagement and Co-design Research Hub, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Level 6 Block K Westmead Hospital, Westmead, Sydney, Australia.

Purpose: This study aims to evaluate the reach, usefulness, acceptability, and factors influencing engagement with a lifestyle-focused text message intervention to support women's mental and physical health after breast cancer treatment.

Methods: This study uses a mixed-methods process evaluation nested in the EMPOWER-SMS randomised controlled trial (n = 160; intervention n = 80, wait-list control n = 80). Data sources included screening logs, text message delivery software analytics, intervention feedback survey, and focus groups (n = 16), which were summarised thematically based on the framework approach. Read More

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September 2021

Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes: A Longitudinal Study of Master Athletes.

Calcif Tissue Int 2021 Sep 9. Epub 2021 Sep 9.

Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.

The age-related decline in muscle function, particularly muscle power, is associated with increased risk of important clinical outcomes. Physical activity is an important determinant of muscle function, and different types of physical activity e.g. Read More

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September 2021

The effect of the adapted soccer programme on motor learning and psychosocial behaviour in adolescents with Down syndrome.

J Intellect Disabil Res 2021 Sep 9. Epub 2021 Sep 9.

Faculty of Sport and Tourism, Educons University, Novi Sad, Serbia.

Background: Numerous studies have proven the significant positive impact of the regular physical activity on general health conditions and quality of life of people with intellectual disability. In practice, various adapted sports activities are used. The current study deals with the effects of the soccer programme. Read More

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September 2021

An assessment of the quality of care provided at primary health care centres in camps for internally displaced persons in Iraq in 2018.

Confl Health 2021 Sep 8;15(1):67. Epub 2021 Sep 8.

KIT Royal Tropical Institute, Amsterdam, The Netherlands.

Introduction: The humanitarian crisis in Iraq remains one of the largest and most unstable in the world. In 2014, over 2.5 million civilians were displaced in Iraq; between 2015 and 2017 more than 3 million people continued to be displaced. Read More

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September 2021

Effects of 12-week full body resistance exercise on vertical jumping with and without military equipment in Slovenian Armed Forces.

BMJ Mil Health 2021 Sep 7. Epub 2021 Sep 7.

Sports & Medicine, University of Ljubljana Faculty of Sport, Ljubljana, Slovenia.

Introduction: Jumping ability is one of the most important physical qualities in military personnel. Previous training intervention studies have shown equivocal effects on jumping ability. In this study, we assessed the effect of a 12-week resistance exercise programme on countermovement jump (CMJ) performance with and without military equipment. Read More

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September 2021

Statistical power or more precise insights into neuro-temporal dynamics? Assessing the benefits of rapid temporal sampling in fMRI.

Prog Neurobiol 2021 Sep 4:102171. Epub 2021 Sep 4.

Center for Magnetic Resonance Research, University of Minnesota, 2021 6th St SE, Minneapolis, MN, 55455, United States; Department of Neurosurgery, University of Minnesota, 500 SE Harvard St, Minneapolis, MN, 55455, United States. Electronic address:

Functional magnetic resonance imaging (fMRI), a non-invasive and widely used human neuroimaging method, is most known for its spatial precision. However, there is a growing interest in its temporal sensitivity. This is despite the temporal blurring of neuronal events by the blood oxygen level dependent (BOLD) signal, the peak of which lags neuronal firing by 4-6 seconds. Read More

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September 2021

Clinical Validation of Superficial Lip Injections Utilizing Cohesive Polydensified Matrix Hyaluronic Acid-Based Soft Tissue Fillers.

J Drugs Dermatol 2021 Sep;20(9):940-945

Background: A combination of optimal injection technique and dermal filler choice is key for improving lip architecture with natural and long-lasting results.

Objective: To investigate the positioning of Cohesive Polydensified Matrix™ (CPM) hyaluronic acid (HA) fillers after superficial lip injections and document their tissue integration and effects on lip architecture and shape.

Methods: Eligible patients underwent lip contouring and volumization using a superficial direct tissue action technique. Read More

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September 2021

A Randomized, Double-Blind, Active- and Placebo-Controlled Trial Evaluating a Novel Topical Treatment for Keloid Scars.

J Drugs Dermatol 2021 Sep;20(9):964-968

Keloid and hypertrophic scars are fibroproliferative disorders resulting from abnormal wound healing in genetically susceptible individuals. Current therapies are often ineffective. Kynurenine shows promise as a topical treatment for keloids and hypertrophic scars. Read More

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September 2021

Vagus Nerve Stimulation as a Potential Adjuvant to Rehabilitation for Post-stroke Motor Speech Disorders.

Front Neurosci 2021 19;15:715928. Epub 2021 Aug 19.

School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, United States.

Stroke often leaves lasting impairments affecting orofacial function. While speech therapy is able to enhance function after stroke, many patients see only modest improvements after treatment. This partial restoration of function after rehabilitation suggests that there is a need for further intervention. Read More

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Response to language barriers with patients from refugee background in general practice in Australia: findings from the OPTIMISE study.

BMC Health Serv Res 2021 Sep 6;21(1):921. Epub 2021 Sep 6.

Department of General Practice, School of Primary & Allied Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Melbourne, Australia.

Background: Language is a barrier to many patients from refugee backgrounds accessing and receiving quality primary health care. This paper examines the way general practices address these barriers and how this changed following a practice facilitation intervention.

Methods: The OPTIMISE study was a stepped wedge cluster randomised trial set within 31 general practices in three urban regions in Australia with high refugee settlement. Read More

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September 2021

Elective Hospitalizations for Intractable Headache: Outcomes and Response Predictors.

Neurol Clin Pract 2021 Jun;11(3):188-193

UT Southwestern Medical Center (JK), Dallas; National Neuroscience Institute (YJ), Singapore; NYU Langone Medical Center (BG); Montefiore Medical Center (JP, CEA, RBL), Bronx, NY; Hartford Healthcare Headache Center (BMG), West Hartford, CT; Columbia University Medical Center (SV), Westchester; and Weill Cornell Medicine (MSR), New York, NY.

Objective: To review our inpatient experience treating a variety of headache disorders with heterogeneous therapies and to determine outcomes and predictors of response.

Methods: We conducted an institutional review board-approved retrospective chart review of elective inpatient headache admissions from the Montefiore Headache Center from 2014 to 2018. We examined factors associated with response and outcomes at discharge and posthospitalization follow-up in an intractable population. Read More

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Impact of a coronary artery calcium-guided statin treatment protocol on cardiovascular risk at 12 months: Results from a pragmatic, randomised controlled trial.

Atherosclerosis 2021 Aug 23;334:57-65. Epub 2021 Aug 23.

Baker Heart and Diabetes Research Institute, Melbourne, Australia; Monash University, Melbourne, Australia. Electronic address:

Background And Aims: Coronary artery calcium (CAC) may encourage patients to adhere to primary prevention recommendations. This study sought to evaluate the benefit of a CAC-guided risk-management protocol in those with a family history of premature coronary artery disease (FHCAD).

Methods: In this Australian multi-centre, randomized controlled trial (Coronary Artery Calcium score: Use to Guide management of Hereditary Coronary Artery Disease, CAUGHT-CAD), asymptomatic, statin-native participants at low-intermediate cardiovascular risk with FHCAD underwent CAC assessment. Read More

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Restorative Neurostimulation for Chronic Mechanical Low Back Pain: Results from a Prospective Multi-centre Longitudinal Cohort.

Pain Ther 2021 Sep 3. Epub 2021 Sep 3.

Department of Pain Medicine, The James Cook University Hospital, Middlesbrough, UK.

Introduction: Low back pain impacts most people throughout the course of their lives and contributes significantly to the global burden of disease. In some patients, symptoms resolve with little intervention, while others are amenable to surgical intervention, some cases are intractable to current care paradigms. Restorative neurostimulation is an emerging therapy for chronic mechanical low back pain. Read More

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September 2021

Renal Function Improves After the Discontinuation of Androgen Deprivation Therapy in Japanese Patients With Prostate Cancer.

Anticancer Res 2021 Sep 1;41(9):4443-4446. Epub 2021 Sep 1.

Department of Urology, Teikyo University Chiba Medical Center, Chiba, Japan.

Background: Androgen deprivation therapy (ADT) is one of the most effective treatments for advanced prostate cancer (PCa). However, it has been reported that the use of ADT is significantly associated with an increased risk of acute kidney injury (AKI) among patients with newly diagnosed non-metastatic PCa. We investigated changes in renal function that occurred in Japanese patients with PCa after ADT was discontinued. Read More

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September 2021

Phosphoproteomics: a valuable tool for uncovering molecular signaling in cancer cells.

Expert Rev Proteomics 2021 Sep 16:1-14. Epub 2021 Sep 16.

Koch Institute for Integrative Cancer Research; Center for Precision Cancer Medicine; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, U.S.A.

Introduction: Many pathologies, including cancer, have been associated with aberrant phosphorylation-mediated signaling networks that drive altered cell proliferation, migration, metabolic regulation, and can lead to systemic inflammation. Phosphoproteomics, the large-scale analysis of protein phosphorylation sites, has emerged as a powerful tool to define signaling network regulation and dysregulation in normal and pathological conditions.

Areas Covered: We provide an overview of methodology for global phosphoproteomics as well as enrichment of specific subsets of the phosphoproteome, including phosphotyrosine and phospho-motif enrichment of kinase substrates. Read More

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September 2021

An insight into the drag effect of water, land, and energy on economic growth across space and time: the application of improved Solow growth model.

Environ Sci Pollut Res Int 2021 Aug 30. Epub 2021 Aug 30.

College of Economics and Management, Northwest Agriculture and Forestry University, Yangling, 712100, China.

Economies that depend on natural resources can experience a resource drag effect when economic growth is limited by constraints on the availability of those resources. Therefore, this study uses panel data and the improved Solow growth model to explore the resource drag effect on China's regional economic growth from 1987 to 2017 and makes innovative contributions to address these four gaps in the previous literature: the resources gap, the consistent measurement gap, the regional gap, and the temporal gap. The empirical results indicate that the resource drag effect reduced China's overall annual economic growth by 0. Read More

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Real-World Satisfaction with Secukinumab in Clearing the Skin of Patients with Plaque Psoriasis through 24 Months of Follow-Up: Results from US Dermatology Electronic Medical Records.

Dermatol Ther (Heidelb) 2021 Aug 28. Epub 2021 Aug 28.

David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Introduction: Information on the long-term treatment satisfaction with secukinumab for patients with plaque psoriasis in real-world settings is limited. The objective of this study was to describe real-world treatment satisfaction in patients with plaque psoriasis who initiated secukinumab using data from an electronic medical records-based dermatology database.

Methods: Patients aged ≥ 18 years with plaque psoriasis in Modernizing Medicine Data Services' affiliate's database who received secukinumab 3/1/2018-1/21/2020 were included. Read More

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Application of Oxford Nanopore Technology to Plant Virus Detection.

Viruses 2021 Jul 22;13(8). Epub 2021 Jul 22.

Plant Health and Environment Laboratory, Ministry for Primary Industries, P.O. Box 2095, Auckland 1140, New Zealand.

The adoption of Oxford Nanopore Technologies (ONT) sequencing as a tool in plant virology has been relatively slow despite its promise in more recent years to yield large quantities of long nucleotide sequences in real time without the need for prior amplification. The portability of the MinION and Flongle platforms combined with lowering costs and continued improvements in read accuracy make ONT an attractive method for both low- and high-scale virus diagnostics. Here, we provide a detailed step-by-step protocol using the ONT Flongle platform that we have developed for the routine application on a range of symptomatic post-entry quarantine and domestic surveillance plant samples. Read More

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