6,976 results match your criteria context modern

Beyond rationality: Expanding the practice of shared decision making in modern medicine.

Soc Sci Med 2021 Apr 3;277:113900. Epub 2021 Apr 3.

Department of Social and Behavioral Sciences, College of Public Health, Temple University, 1101 W. Montgomery Avenue, Philadelphia, PA, 19122, USA. Electronic address:

The contemporary healthcare field operates according to an autonomy model of medical decision-making. This model stipulates that patients have the right to make informed choices about their care. Shared decision making (SDM) has arisen as the dominant approach for clinicians and patients to collaborate in care planning and implementation. Read More

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Life's organization between matter and form: Neo-Aristotelian approaches and biosemiotics.

Çağlar Karaca

Hist Philos Life Sci 2021 Apr 9;43(2):55. Epub 2021 Apr 9.

Department of the History of Science, Kastamonu University, Kastamonu, Turkey.

In this paper, I discuss the neo-Aristotelian approaches, which usually reinterpret Aristotle's ideas on form and/or borrow the notion of formal cause without engaging with the broader implications of Aristotle's metaphysics. In opposition to these approaches, I claim that biosemiotics can propose an alternative view on life's form. Specifically, I examine the proposals to replace the formal cause with gene-centrism, functionalism, and structuralism. Read More

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Incorporating Heisenberg's Uncertainty Principle into Quantum Multiparameter Estimation.

Phys Rev Lett 2021 Mar;126(12):120503

Zhejiang Institute of Modern Physics and Department of Physics, Zhejiang University, Hangzhou 310027, China.

The quantum multiparameter estimation is very different from the classical multiparameter estimation due to Heisenberg's uncertainty principle in quantum mechanics. When the optimal measurements for different parameters are incompatible, they cannot be jointly performed. We find a correspondence relationship between the inaccuracy of a measurement for estimating the unknown parameter with the measurement error in the context of measurement uncertainty relations. Read More

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Integrating single-molecule spectroscopy and simulations for the study of intrinsically disordered proteins.

Methods 2021 Apr 5. Epub 2021 Apr 5.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis 63110, MO, USA; Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

Over the last two decades, intrinsically disordered proteins and protein regions (IDRs) have emerged from a niche corner of biophysics to be recognized as essential drivers of cellular function. Various techniques have provided fundamental insight into the function and dysfunction of IDRs. Among these techniques, single-molecule fluorescence spectroscopy and molecular simulations have played a major role in shaping our modern understanding of the sequence-encoded conformational behavior of disordered proteins. Read More

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Identification and Ranking of Core Values in Family Medicine: A Mixed Methods Study From Ukraine.

Front Med (Lausanne) 2021 22;8:646276. Epub 2021 Mar 22.

Department of General Practice & Family Medicine, Medical Faculty, Martin-Luther University Halle, Halle, Germany.

The term core value (CV) can be defined as fundamental beliefs or principles, guiding one's behavior in a social context. Though core competencies of family medicine (FM) have been clearly defined by WONCA, there has been an ongoing debate on what the CVs are for family doctors (FDs). Ukraine is a developing country in the middle of Europe with a population of 43 million inhabitants, gained independence from the Soviet Union in 1991. Read More

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Electron transfer studies of a conventional redox probe in human sweat and saliva bio-mimicking conditions.

Sci Rep 2021 Apr 7;11(1):7663. Epub 2021 Apr 7.

Electrodics and Electrocatalysis (EEC) Division, CSIR - Central Electrochemical Research Institute (CSIR - CECRI), Karaikudi, 630003, Tamil Nadu, India.

Modern day hospital treatments aim at developing electrochemical biosensors for early diagnosis of diseases using unconventional human bio-fluids like sweat and saliva by monitoring the electron transfer reactions of target analytes. Such kinds of health care diagnostics primarily avoid the usage of human blood and urine samples. In this context, here we have investigated the electron transfer reaction of a well-known and commonly used redox probe namely, potassium ferro/ferri cyanide by employing artificially simulated bio-mimics of human sweat and saliva as unconventional electrolytes. Read More

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Midterm results of modern patellofemoral arthroplasty versus total knee arthroplasty for isolated patellofemoral arthritis: systematic review and meta-analysis of comparative studies.

Arch Orthop Trauma Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Trauma and Orthopaedic Surgery, Cork University Hospital, Wilton, Cork, Ireland.

Background: Both Patellofemoral Arthroplasty (PFA) and Total Knee Arthroplasty (TKA) are accepted surgical options for end-stage isolated patellofemoral osteoarthritis (PFOA). We performed a systematic review and meta-analysis to compare outcomes of PFA and TKA by evaluation of the patient-reported outcome measures (PROMs).

Methods: We systematically identified publications reporting on patients that underwent either TKA or modern PFA for isolated PFOA. Read More

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Integration patterns of the asymmetric components of the skull: A covariational statistical approach on a modern Greek sample.

Homo 2021 Apr 6. Epub 2021 Apr 6.

Department of Animal and Human Physiology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, GR 157 01 Athens, Greece.

The integration patterns of the asymmetric components of the skull can be informative, especially in the diagnosis and surgical treatment planning of patients. This research aims to explore the interactions of the asymmetric components between the mandible, the basicranium, and the upper face. : The sample comprises 100 skulls of Greek adults and the three-dimensional coordinates of 35 landmarks, extracted from the cranial and mandibular virtual 3D bones, were analyzed using the generalized least-squares Procrustes method. Read More

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Event-driven industrial robot control architecture for the Adept V+ platform.

PeerJ Comput Sci 2019 29;5:e207. Epub 2019 Jul 29.

Department of Electrical Engineering, Chalmers University of Technology, Gothenburg, Sweden.

Modern industrial robotic systems are highly interconnected. They operate in a distributed environment and communicate with sensors, computer vision systems, mechatronic devices, and computational components. On the fundamental level, communication and coordination between all parties in such distributed system are characterized by discrete event behavior. Read More

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Changes in the Cystic Fibrosis Airway Microbiome in Response to CFTR Modulator Therapy.

Front Cell Infect Microbiol 2021 17;11:548613. Epub 2021 Mar 17.

Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospital Heidelberg, Heidelberg, Germany.

The development of CFTR modulator therapies significantly changed the treatment scheme of people with cystic fibrosis. However, CFTR modulator therapy is still a life-long treatment, which is not able to correct the genetic defect and cure the disease. Therefore, it becomes crucial to understand the effects of such modulation of CFTR function on the airway physiology, especially on airway infections and inflammation that are currently the major life-limiting factors in people with cystic fibrosis. Read More

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Wiad Lek 2021 ;74(2):351-354


Objective: The aim: Is to study and analyze the dynamics of the indicators of the emergency medical service of the Ukrainian and the Poltava region in the context of the reforms of the healthcare system in Ukraine.

Patients And Methods: Materials and methods: In this work, the indicators of development of the emergency medical service of the Ukrainian and the Poltava region were studied and analyzed.

Conclusion: Conclusions: The provision of emergency medical care in the Poltava region is provided by the Poltava Regional Center for Emergency Medicine and Disaster Medicine. Read More

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Wiad Lek 2021 ;74(2):334-340


Objective: The aim: To analyze, summarize and substantiate modern approaches to the formation of the professional competencies of pharmacists on issues of medicine quality assurance in Ukraine.

Patients And Methods: Materials and methods: In this study, we performed systematic review, systematic and comparative analysis, content analysis, generalization, document analysis, logical and graphical modeling to address those issues.

Conclusion: Conclusions: We showed that the curriculum and program of the «Basic foundations of the functioning of quality systems in pharmacy institutions» thematic improvement cycle for pharmacists have been substantiated and developed. Read More

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VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases.

Vaccines (Basel) 2021 Mar 5;9(3). Epub 2021 Mar 5.

Immunoparasitology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.

Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need. Today, according to modern vaccinology, virus-like particle (VLP) technology is involved in many vaccines, including those undergoing studies related to COVID-19. The potential use of VLPs as vaccine adjuvants opens an opportunity for the use of protozoan antigens for the development of vaccines against diseases caused by , spp. Read More

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Recent Progress Using De Novo Design to Study Protein Structure, Design and Binding Interactions.

Life (Basel) 2021 Mar 10;11(3). Epub 2021 Mar 10.

Department of Chemistry and Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA 20110, USA.

De novo protein design is a powerful methodology used to study natural functions in an artificial-protein context. Since its inception, it has been used to reproduce a plethora of reactions and uncover biophysical principles that are often difficult to extract from direct studies of natural proteins. Natural proteins are capable of assuming a variety of different structures and subsequently binding ligands at impressively high levels of both specificity and affinity. Read More

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Complement in Tumourigenesis and the Response to Cancer Therapy.

Cancers (Basel) 2021 Mar 10;13(6). Epub 2021 Mar 10.

Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Trinity College Dublin and St. James's Hospital, Dublin 8, Ireland.

In recent years, our knowledge of the complement system beyond innate immunity has progressed significantly. A modern understanding is that the complement system has a multifaceted role in malignancy, impacting carcinogenesis, the acquisition of a metastatic phenotype and response to therapies. The ability of local immune cells to produce and respond to complement components has provided valuable insights into their regulation, and the subsequent remodeling of the tumour microenvironment. Read More

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Resequencing of Microbial Isolates: A Lab Module to Introduce Novices to Command-Line Bioinformatics.

Front Microbiol 2021 16;12:578859. Epub 2021 Mar 16.

Division of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.

Familiarity with genome-scale data and the bioinformatic skills to analyze it have become essential for understanding and advancing modern biology and human health, yet many undergraduate biology majors are never exposed to hands-on bioinformatics. This paper presents a module that introduces students to applied bioinformatic analysis within the context of a research-based microbiology lab course. One of the most commonly used genomic analyses in biology is resequencing: determining the sequence of DNA bases in a derived strain of some organism, and comparing it to the known ancestral genome of that organism to better understand the phenotypic differences between them. Read More

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"… the way we welcome them is how we will lead them to love family planning.": family planning providers in Rwanda foster compassionate relationships with clients despite workplace challenges.

BMC Health Serv Res 2021 Apr 1;21(1):293. Epub 2021 Apr 1.

Western Washington University, 516 High Street MS9118, Bellingham, WA, 98225, USA.

Background: Rwanda has markedly increased the nation's contraceptive use in a short period of time, tripling contraceptive prevalence in just 5 years between 2005 and 2010. An integral aspect of family planning programs is the interactions between family planning providers and clients. This study aims to understand the client-provider relationship in the Rwandan family planning program and to also examine barriers to those relationships. Read More

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Molecular sexing of degraded DNA from elephants and mammoths: a genotyping assay relevant both to conservation biology and to paleogenetics.

Sci Rep 2021 Mar 31;11(1):7227. Epub 2021 Mar 31.

Direction Générale Déléguée à la Recherche, à l'Expertise, la Valorisation et l'Enseignement (DGD-REVE), Muséum national d'Histoire naturelle, 57 rue Cuvier, CP 17, 75005, Paris, France.

It is important to determine the sex of elephants from their samples-faeces from the field or seized ivory-for forensic reasons or to understand population demography and genetic structure. Molecular sexing methods developed in the last two decades have often shown limited efficiency, particularly in terms of sensitivity and specificity, due to the degradation of DNA in these samples. These limitations have also prevented their use with ancient DNA samples of elephants or mammoths. Read More

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A Little Recognized Dental Implant: The First Unambiguous Example Recovered Archaeologically and Its Relevance Within the Story of Implantology.

J Hist Dent 2020 ;68(3):169-179

Honorary Research Officer University of New England Archeomaterials Science Hub Armidale, NSW 2350, Australia.

Peabody Museum, Harvard, possesses a Mayan dental artifact identified at the time of its initial examination as a dental implant. In spite of this early claim the Peabody catalogue lacks any such appellation applied to the artifact, nor does it note another significant aspect of its original description, namely that it bore dental deposits. The skeletal relationship of the artifact in its original archaeological context is not to be found in written dig records or among photographs of skeletons taken in situ, nor are the exact circumstances of the physical examination that was the basis of the initial description fully revealed. Read More

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January 2020

Human growth hormone proteoform pattern changes in pituitary adenomas: Potential biomarkers for 3P medical approaches.

EPMA J 2021 Mar 3;12(1):67-89. Epub 2021 Mar 3.

Science and Technology Innovation Center, Shandong First Medical University, 6699 Qingdao Road, Jinan, Shandong 250117 People's Republic of China.

Relevance: Human growth hormone (hGH) is synthesized, stored, and secreted by somatotroph cells in the pituitary gland, and promotes human growth and metabolism. Compared to a normal pituitary, a GH-secreting pituitary adenoma can secrete excessive GH to cause pathological changes in body tissues. GH proteoform changes would be associated with GH-related disease pathogenesis. Read More

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Ni(II) Schiff-base Complexes as Chiral Electroauxiliaries and Methodological Platform for Stereoselective Electrochemical Functionalization of Amino Acids.

T V Magdesieva

Chem Rec 2021 Mar 30. Epub 2021 Mar 30.

Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow, 119991, Russia.

The concept of chiral electroauxiliary based on the redox active chiral platform to perform transformations of a redox inactive substrate is suggested and discussed in the context of the targeted stereoselective electrochemical functionalization of amino acids. Tailor-made amino acids are essential structural features of modern medicinal chemistry and drug design; the development of efficient synthetic approaches to these compounds is of topical interest. The modified substrate (an amino acid) is included as a structural motif in the redox active complex (with a possibility to be released after modification) that integrates "a bifunctional linker" (the structural motif capable to "catch" a substrate) and a chiral moiety responsible for asymmetry induction. Read More

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The Relational Self-Schema Measure: Assessing Psychological Needs in Multiple Self-with-Other Representations.

J Pers Assess 2021 Mar 30:1-12. Epub 2021 Mar 30.

Psychology, Washington State University, Pullman, WA.

Modern self-schema theory posits multiple representations in memory of the self, with each individual self-schema possessing associative connections to relational contexts (i.e., self-with-other). Read More

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Cribriform colon cancer: a morphological growth pattern associated with extramural venous invasion, nodal metastases and microsatellite stability.

J Clin Pathol 2021 Mar 29. Epub 2021 Mar 29.

Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

Background: Cribriform comedo-type adenocarcinoma was a colon cancer subtype recognised in the previous WHO classification of tumours that is no longer included in the recent edition. Previous reports have described colon cancers with cribriform growth as having worse overall survival and being associated with microsatellite stability. We sought to validate whether cribriform carcinoma (CC) is a distinct morphological subtype with clinical relevance in the context of modern colon cancer diagnosis. Read More

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Is Malaysia Ready for Human Gene Editing: A Regulatory, Biosafety and Biosecurity Perspective.

Front Bioeng Biotechnol 2021 11;9:649203. Epub 2021 Mar 11.

Infectomics Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia.

Gene editing platforms have revolutionized the field of genetics with a direct impact on the public health system. Although there are apparent benefits, it is often accompanied by public debates over its uncertainties and risks. In the Malaysian context, modern biotechnology has raised questions about how to best govern gene editing in regulations, biosafety, and biosecurity. Read More

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Assessing uncertainties from physical parameters and modelling choices in an atmospheric large eddy simulation model.

Philos Trans A Math Phys Eng Sci 2021 May 29;379(2197):20200073. Epub 2021 Mar 29.

Centrum Wiskunde & Informatica, Amsterdam, Netherlands.

In this study, we investigate uncertainties in a large eddy simulation of the atmosphere, employing modern uncertainty quantification methods that have hardly been used yet in this context. When analysing the uncertainty of model results, one can distinguish between uncertainty related to physical parameters whose values are not exactly known, and uncertainty related to modelling choices such as the selection of numerical discretization methods, of the spatial domain size and resolution, and the use of different model formulations. While the former kind is commonly studied e. Read More

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Invited review: Disentangling residual feed intake-Insights and approaches to make it more fit for purpose in the modern context.

J Dairy Sci 2021 Mar 24. Epub 2021 Mar 24.

Université Paris-Saclay, INRAE, AgroParisTech, UMR Modélisation Systémique Appliquée aux Ruminants (MoSAR), 75005 Paris, France.

Residual feed intake (RFI) is an increasingly used trait to analyze feed efficiency in livestock, and in some sectors such as dairy cattle, it is one of the most frequently used traits. Although the principle for calculating RFI is always the same (i.e. Read More

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Investigation of the impacts of zamzam water on streptozotocin-induced diabetic nephropathy in rats. In-vivo and in-vitro study.

Biomed Pharmacother 2021 Mar 24;138:111474. Epub 2021 Mar 24.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Background: Oxidative stress is considered the main event in the pathogenesis. of diabetic nephropathy (DN). Zamzam water, being natural alkaline with exceptional characteristics, is capable of enhancing antioxidant mechanisms. Read More

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Sexual differences in human cranial morphology: Is one sex more variable or one region more dimorphic?

Anat Rec (Hoboken) 2021 Mar 26. Epub 2021 Mar 26.

Centre for Forensic Anthropology, The University of Western Australia, Crawley, Western Australia, Australia.

The quantification of cranial sexual dimorphism (CSD) among modern humans is relevant in evolutionary studies of morphological variation and in a forensic context. Despite the abundance of quantitative studies of CSD, few have specifically examined intra-sex variability. Here we quantify CSD in a geographically homogeneous sample of adult crania, which includes Italian individuals from the 19th and 20th centuries. Read More

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Bringing the vertical dimension into a planar multilevel autoregressive model: A city-level hedonic analysis of homebuyers' utilities and urban river attributes.

Sci Total Environ 2021 Jun 3;772:145547. Epub 2021 Feb 3.

Department of Geography, The University of Hong Kong, Pokfulam Road, Hong Kong; Department of Scienze delle Produzioni Vegetali, University of Bari, Via Amendola 165/A, 70126 Bari, Italy.

Throughout history, urban rivers have been regarded as valuable natural elements that satisfy various human needs and affect where people reside. With the increasing expansion of modern cities along the vertical dimension, how urban rivers affect housing values and homebuyers' purchasing decisions in a 3-D context has attracted a significant amount of attention from researchers, environmental practitioners, urban planners, and policymakers. In this paper, we attempt to estimate how homebuyers' utilities are affected by various river attributes and their interactions using the vibrant high-rise apartment housing market in Guangzhou (south China) as a case study. Read More

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Religious delusions: Definition, diagnosis and clinical implications.

Psychiatriki 2021 Mar 26. Epub 2021 Mar 26.

First Department of Psychiatry, Athens University Medical School, Eginition Hospital, Athens, Greece.

Problem gambling emerges as a serious and ever growing problem of modern societies, largely affecting adolescents as well. The etiology of gambling disorder is complex and multifaceted as it is governed by multiple and interrelated factors. In this context and in light of the pervasive financial crisis in Greece, we conducted a study in order to explore adolescents' gambling involvement in Athens region and also to identify the socio-economic characteristics of adolescents who have engaged into gambling activities. Read More

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