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Modelling the precipitation of nanoparticles in a closed medium in the presence of seeds: Application to amorphous silica synthesis.

J Colloid Interface Sci 2021 Apr 6;601:843-852. Epub 2021 Apr 6.

Université de Strasbourg/EOST, CNRS, Institut Terre et Environnement Strasbourg, 5 rue René Descartes, Strasbourg Cedex F-67084, France.

Seed-mediated methods are widely used in industrial or academic laboratories for the synthesis of nanoparticles of controlled shape and size. In the natural medium, precipitation of secondary minerals also often take place on seeds. In this context, we have devised a formalism which accounts for the competition between seed growth and nucleation and growth of secondary particles in an initially over-saturated aqueous solution. Read More

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Acupuncture as an adjunctive treatment for pain in hospitalized children with sickle cell disease.

J Pain Symptom Manage 2021 Jun 9. Epub 2021 Jun 9.

Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington DC; Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital, Washington DC. Electronic address:

Context: Acute episodes of pain associated with sickle cell disease (SCD) account for over 100,000 hospitalizations and expenses of nearly 1 billion dollars annually in the United States. New treatment approaches are needed as the current opioid based therapy is often inadequate in controlling pain, resulting in prolonged inpatient stays and high rates of readmission.

Objectives: To evaluate acceptability of acupuncture as an adjunctive therapy and explore the impact of acupuncture on pain related outcomes in a population of youth with SCD hospitalized for management of acute pain. Read More

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Attention modulates repetition effects in a context of low periodicity.

Brain Res 2021 Jun 9:147559. Epub 2021 Jun 9.

Centre National de la Recherche Scientifique (CNRS), Integrative Neuroscience and Cognition Center (INCC), Unité Mixte de Recherche, 8002, 75006 Paris, France; Université de Paris, 75006 Paris, France; Fondation Ophtalmologique Rothschild, Paris, France. Electronic address:

Stimulus repetition can result in a reduction in neural responses (i.e., repetition suppression) in neuroimaging studies. Read More

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Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

J Mol Cell Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Biomedical Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address:

Controlling fibrosis is an essential part of regenerating the post-ischemic heart. In the post-ischemic heart, fibroblasts differentiate to myofibroblasts that produce collagen-rich matrix to physically stabilize the infarct area. Infarct models in adult mice result in permanent scarring unlike newborn animals which fully regenerate. Read More

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Nighttime sleep benefits the prospective component of prospective memory.

Mem Cognit 2021 Jun 11. Epub 2021 Jun 11.

Institute for Experimental Psychology, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, Geb. 23.02., 40225, Düsseldorf, Germany.

Studies suggest that sleep benefits event-based prospective memory, which involves carrying out intentions when particular events occur. Prospective memory has a prospective component (remembering that one has an intention), and a retrospective component (remembering when to carry it out). As effects of sleep on retrospective memory are well established, the effect of sleep on prospective memory may thus be due exclusively to an effect of sleep on its retrospective component. Read More

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Assessing Early Cardiac Outflow Tract Adaptive Responses Through Combined Experimental-Computational Manipulations.

Ann Biomed Eng 2021 Jun 11. Epub 2021 Jun 11.

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 304 Weill Hall, Ithaca, NY, 14853-7202, USA.

Mechanical forces are essential for proper growth and remodeling of the primitive pharyngeal arch arteries (PAAs) into the great vessels of the heart. Despite general acknowledgement of a hemodynamic-malformation link, the direct correlation between hemodynamics and PAA morphogenesis remains poorly understood. The elusiveness is largely due to difficulty in performing isolated hemodynamic perturbations and quantifying changes in-vivo. Read More

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Sad, Sadder, Saddest: Recognition of Sad and Happy Emotional Intensity, Adverse Childhood Experiences and Depressive Symptoms in Preschoolers.

Child Psychiatry Hum Dev 2021 Jun 11. Epub 2021 Jun 11.

Department of Psychiatry, Washington University School of Medicine, 4444 Forest Park, Suite 2100, St. Louis, MO, 63108, USA.

Adverse childhood experiences (ACES) have repeatedly been associated with depression. The ability to differentiate emotional intensity is a protective factor for psychopathology and in the context of life stressors, poor negative emotion differentiation (ED) is associated with depressive symptoms. However, little is known about whether the ability to recognize negative emotional intensity, a theorized developmental prerequisite of ED, influences the relationship between ACES and depressive symptoms in early childhood. Read More

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AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections.

Sci Rep 2021 Jun 11;11(1):12387. Epub 2021 Jun 11.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294-0012, USA.

Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial quality control mitophagy that prevents unwanted inflammatory responses. However, it is not known if this evolutionarily conserved mechanism has been coopted by the host immune defense to eradicate bacterial pathogens and influence post-sepsis immunosuppression. Read More

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COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies.

J Immunother Cancer 2021 Jun;9(6)

Department. of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Comprehensive Cancer Center, Stockholm, Sweden.

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. COVID-19 has highly variable disease severity and a bimodal course characterized by acute respiratory viral infection followed by hyperinflammation in a subset of patients with severe disease. This immune dysregulation is characterized by lymphocytopenia, elevated levels of plasma cytokines and proliferative and exhausted T cells, among other dysfunctional cell types. Read More

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The Relationship Between COVID-19 Confinement, Psychological Adjustment, and Sexual Functioning, in a Sample of Portuguese Men and Women.

J Sex Med 2021 Apr 21. Epub 2021 Apr 21.

CPUP: Center for Psychology of Porto University, Faculty of Psychology and Educational Sciences, Porto University, Porto, Portugal.

Background: Past research has revealed the detrimental effects of social isolation and physical distancing measures in health related outcomes. However, only recently COVID-19 confinement measures provided a context to test whether such detrimental effects exist in the human sexuality domain.

Aim: This study was aimed at testing the relationship between COVID-19 confinement levels and sexual functioning domains in men and women, while accounting for the mediating role of psychological adjustment during lockdown. Read More

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Cost-effectiveness analysis of resorbable biosynthetic mesh in contaminated ventral hernia repair.

J Visc Surg 2021 Jun 8. Epub 2021 Jun 8.

Clinical Epidemiology Unit, Clinical Investigation Center, INSERM, CIC1432, Dijon University Hospital; INSERM, LNC UMR1231, University Bourgogne Franche-Comté, Dijon, France.

Background: The aim of this study was to compare, in terms of cost and serious complications, the use of biosynthetic resorbable parietal mesh with biologic mesh in patients undergoing contaminated ventral hernia repair (modified Ventral Hernia Working Group grade 3). Poly-4-hydroxy-butyrate (P4HB) biosynthetic mesh has rarely been the subject of comparative studies in the context of contamination. Data are required to confirm the effects of a transition from biological mesh to biosynthetic resorbable mesh. Read More

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Intensive care nurse-family engagement from a global perspective: A qualitative multi-site exploration.

Intensive Crit Care Nurs 2021 Jun 8:103081. Epub 2021 Jun 8.

College of Allied Health and Nursing, Glen Taylor Nursing Institute for Family and Society, Minnesota State University, 360 Wissink Hall and 351 7700 France, Mankato, MN 56001, USA. Electronic address:

Background: Critical illness is distressing for families, and often results in negative effects on family health that influence a family's ability to support their critically ill family member. Although recent attention has been directed at improving care and outcomes for families of critically ill patients, the manner in which nurses engage with families is not fully understood.

Objectives: To describe nurses' perceptions and practices of family engagement in adult intensive care units from a global perspective. Read More

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Perception and experiences of sexual harassment among women working in hospitality workplaces of Bahir Dar city, Northwest Ethiopia: a qualitative study.

BMC Public Health 2021 Jun 11;21(1):1119. Epub 2021 Jun 11.

Department of Population and Family Health, Faculty of Public Health, Jimma University, Jimma, Ethiopia.

Background: Workplace sexual harassment is a public health problem that depends on gender, context, and perceived ideology. Although studies have documented the prevalence and consequences of workplace sexual harassment worldwide, victims' perceptions and experiences are still poorly understood in low and middle-income countries, particularly Ethiopia. Female workers in the hospitality industry, including hotels, bars, restaurants, fast-food restaurants, and cafeterias, are particularly affected. Read More

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The causal role of DLPFC top-down control on the acquisition and the automatic expression of implicit learning: State of the art.

Cortex 2021 May 12;141:293-310. Epub 2021 May 12.

Department of Experimental Psychology and Mind, Brain and Behaviour Research Center, University of Granada, Spain. Electronic address:

Implicit learning refers to the incidental acquisition and expression of knowledge that is not accompanied by full awareness of its contents. Implicit sequence learning (ISL) represents one of the most useful paradigms to investigate these processes. In this paradigm, participants are usually instructed to respond to the location of a target that moves regularly through a set of possible locations. Read More

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Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Faculty of Dentistry, McGill University, Montreal, Quebec, H3A 0G1, Canada; Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, H3A 0G1, Canada; Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba, Japan, 260-8677; Faculty of Medicine, Departments of Pharmacology and Toxicology, Anesthesiology and Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3A 0G1, Canada; Faculty of Medicine, Department of Anesthesiology, University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address:

Background Context: Chronic low back pain (LBP) is a multifactorial disorder with complex underlying mechanisms, including associations with intervertebral disc (IVD) degeneration in some individuals. It has been demonstrated that epigenetic processes are involved in the pathology of IVD degeneration. Epigenetics refers to several mechanisms, including DNA methylation, that have the ability to change gene expression without inducing any change in the underlying DNA sequence. Read More

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Which traumatic spinal injury creates which degree of instability? A systematic quantitative review.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Institute of Orthopaedic Research and Biomechanics, Trauma Research Centre Ulm, Ulm University, Ulm, Germany. Electronic address:

Background Context: Traumatic spinal injuries often require surgical fixation. Specific three-dimensional degrees of instability after spinal injury, which represent criteria for optimum treatment concepts, however, are still not well investigated.

Purpose: The aim of this review therefore was to summarize and quantify multiplanar instability increases due to spinal injury from experimental studies. Read More

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Modulatory Potential of Cannabidiol on the Opioid-Induced Inflammatory Response.

Cannabis Cannabinoid Res 2021 Jun;6(3):211-220

Department of Psychological & Brain Science, Indiana University, Bloomington, Indiana, USA.

Opioids are effective analgesics; however, there are many negative consequences of chronic use. One important side effect of chronic opioid use is the continuous engagement of the immune response that can exacerbate chronic pain. The opioid, morphine, initiates a Toll-like receptor 4 (TLR4) signaling cascade that drives the activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome proteins, resulting in cytokine production and effectively creating a positive feedback loop for continuous TLR4 activation. Read More

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Oxylipin profiles and levels vary by skeletal muscle type, dietary fat and sex in young rats.

Appl Physiol Nutr Metab 2021 Jun 11. Epub 2021 Jun 11.

University of Manitoba Faculty of Agricultural and Food Sciences, 98691, Human Nutritional Sciences, Winnipeg, Manitoba, Canada.

PUFA-derived bioactive lipid mediators called oxylipins have been shown to influence muscle growth, inflammation and repair in select muscles. Since individual oxylipins have varying effects and potencies, broad profiling in differing muscle types is required to further understand their overall effects. In addition, diet and sex are key determinants of oxylipin levels. Read More

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Beneficial role of Pistacia lentiscus aqueous extract in experimental colitis: anti-inflammatory and potential therapeutic effects.

Inflammopharmacology 2021 Jun 11. Epub 2021 Jun 11.

Team "Cytokines and NO Synthases", LBCM (Laboratory of Cellular and Molecular Biology), FSB (Faculty of Biological Science), USTHB (University of Sciences and Technology Houari Boumediene), BP 32, El-Alia, 16111, Algiers, Algeria.

Background: Pistacia lentiscus L. (PL) is a flowering plant traditionally used in the treatment of gastrointestinal disorders. The extracts of this plant are endowed with strong pharmacological activities. Read More

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Correlations among visit to visit blood pressure variability and treatment with antihypertensive medication with long term adverse outcomes in a large veteran cohort.

Am J Hypertens 2021 Jun 11. Epub 2021 Jun 11.

Population Health, University of North Dakota School of Medicine and Health Sciences.

Background: Blood pressure variability (BPV) is associated with adverse events (AE) independently of hypertension. It has been suggested that calcium channel blockers (CCB) may reduce BPV, and thus be particularly valuable in hypertensives with high BPV. We sought to investigate how CCB affect BPV progression and whether long- term adverse effects of BPV differ after CCB treatment than after treatment with other anti-hypertensives. Read More

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An Environmental Scan of Virtual "Walk-In" Clinics in Canada: Comparative Study.

J Med Internet Res 2021 Jun 11;23(6):e27259. Epub 2021 Jun 11.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.

Background: Canada has been slow to implement virtual care relative to other countries. However, in recent years, the availability of on-demand, "walk-in" virtual clinics has increased, with the COVID-19 pandemic contributing to the increased demand and provision of virtual care nationwide. Although virtual care facilitates access to physicians while maintaining physical distancing, there are concerns regarding the continuity and quality of care as well as equitable access. Read More

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Anti-inflammatory effects of paeoniflorin caused by regulation of the hif1a/miR-210/caspase1/GSDMD signaling pathway in astrocytes: a novel strategy for hypoxia-induced brain injury in rats.

Immunopharmacol Immunotoxicol 2021 Jun 11:1-9. Epub 2021 Jun 11.

The First Clinical Medical College, Lanzhou University, Lanzhou, China.

Hypoxia-induced injury is a classic symptom of obstructive sleep apnea hypopnea syndrome (OSAHS), which is a risk factor of various diseases, such as hypertension, heart failure and stroke. However, there is no effective therapy for hypoxia-induced injury or OSAHS due to the elusive mechanism involved. This study aimed to assess the effects of paeoniflorin on hypoxia-induced injury and explore the underlying mechanism. Read More

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[Nutrition and mental health - how findings from genetic studies can support the identification of dietary effects].

Z Kinder Jugendpsychiatr Psychother 2021 Jun 11:1-10. Epub 2021 Jun 11.

Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universität Duisburg-Essen.

Nutrition and mental health - how findings from genetic studies can support the identification of dietary effects Numerous studies indicate that dietary interventions could be an important approach to the prevention and treatment of mental disorders. However, conventional nutritional epidemiological approaches (e. g. Read More

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Mindfulness-Based Couple Interventions: A Systematic Literature Review.

Fam Process 2021 Jun 11. Epub 2021 Jun 11.

Institute of Medical Psychology, Medical Faculty, Heidelberg University, Heidelberg, Germany.

Over the past decades, mindfulness-based interventions have been shown to improve individual health and well-being in clinical and nonclinical settings. More recently, secular contemplative trainings were adapted to the couple context as research showed satisfying couple relationships to be one of the strongest predictors of physical and mental health. Mindfulness-based interventions hence seem to be a promising treatment in couple counseling and therapy in both clinical and nonclinical settings. Read More

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The evolutionary ecology of fatty-acid variation: Implications for consumer adaptation and diversification.

Ecol Lett 2021 Jun 10. Epub 2021 Jun 10.

Department of Fish Ecology and Evolution, Eawag, Center of Ecology, Evolution and Biochemistry, Swiss Federal Institute of Aquatic Science and Technology, Kastanienbaum, Switzerland.

The nutritional diversity of resources can affect the adaptive evolution of consumer metabolism and consumer diversification. The omega-3 long-chain polyunsaturated fatty acids eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) have a high potential to affect consumer fitness, through their widespread effects on reproduction, growth and survival. However, few studies consider the evolution of fatty acid metabolism within an ecological context. Read More

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Building capacity in times of crisis: Increasing cultural competence of healthcare professionals in the context of the COVID-19.

J Clin Nurs 2021 Jun 10. Epub 2021 Jun 10.

Department of Nursing, Recanati School for Community Health Professions, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Nurses are the frontline healthcare professionals fighting the medical and social effects of the current COVID-19 pandemic. Although they work with diverse populations, there is a lack of literature on culturally competent education during an emergency such as a pandemic.

Aims And Objectives: To examine the effectiveness of an online education programme aimed at increasing cultural competence among rescue teams and healthcare professionals facing the challenges of the COVID-19 pandemic. Read More

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Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU.

Front Neurosci 2021 25;15:643115. Epub 2021 May 25.

Institute of Human Genetics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

In the adult human brain, six isoforms of the microtubule-associated protein TAU are expressed, which result from alternative splicing of exons 2, 3, and 10 of the gene. These isoforms differ in the number of N-terminal inserts (0N, 1N, 2N) and C-terminal repeat domains (3R or 4R) and are differentially expressed depending on the brain region and developmental stage. Although all TAU isoforms can aggregate and form neurofibrillary tangles, some tauopathies, such as Pick's disease and progressive supranuclear palsy, are characterized by the accumulation of specific TAU isoforms. Read More

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Experts prioritize osteoarthritis non-surgical interventions from Cochrane systematic reviews for translation into "Evidence4Equity" summaries.

Int J Equity Health 2021 Jun 10;20(1):136. Epub 2021 Jun 10.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.

Objective: Osteoarthritis generates substantial health and socioeconomic burden, which is particularly marked in marginalized groups. It is imperative that practitioners have ready access to summaries of evidence-based interventions for osteoarthritis that incorporate equity considerations. Summaries of systematic reviews can provide this. Read More

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Empowering patient education on self-care activity among patients with colorectal cancer - a research protocol for a randomised trial.

BMC Nurs 2021 Jun 10;20(1):94. Epub 2021 Jun 10.

Department of Nursing Science, University of Turku|, Joukahaisenkatu 3-5, 20014, Turku, Finland.

Background: Chemotherapy-induced side effects may have a negative effect on nutrition intake, thus increasing the risk of malnutrition and consequently, other serious complications for patients with cancer. The prevalence of malnutrition is common among patients with colorectal cancer. Nurse-led empowering education may have a positive effect on self-care activity in this patient group. Read More

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Relevant essential oil components: a minireview on increasing applications and potential toxicity.

Toxicol Mech Methods 2021 Jun 10:1-27. Epub 2021 Jun 10.

Laboratory of Toxicology, Faculty of Pharmacy, Universitat de València. Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.

Phenolic compounds carvacrol, thymol, eugenol and vanillin are four of the most thoroughly investigated essential oil components given their relevant biological properties. These compounds are generally considered safe for consumption and have been used in a wide range of food and non-food applications. Significant biological properties, including antimicrobial, antioxidant, analgesic, anti-inflammatory, anti-mutagenic or anti-carcinogenic activity, have been described for these components. Read More

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