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The predictive role of Interleukin 6 in burn patients with positive blood cultures.

Int J Burns Trauma 2021 15;11(2):123-130. Epub 2021 Apr 15.

Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, St. Georg Hospital gGmbH Leipzig Germany.

Interleukin 6 (IL-6) is an established biomarker of inflammation with one of the earliest responses in sepsis. Serum levels can easily be measured within a few hours. The clinical significance of IL-6 in the early stage of sepsis in burned patients has not yet been confirmed. Read More

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A Conditional Process Model to Explain Somatization During Coronavirus Disease 2019 Epidemic: The Interaction Among Resilience, Perceived Stress, and Sex.

Front Psychol 2021 20;12:633433. Epub 2021 May 20.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

Background: More than 15% of Chinese respondents reported somatic symptoms in the last week of January 2020. Promoting resilience is a possible target in crisis intervention that can alleviate somatization.

Objectives: This study aims to investigate the relationship between resilience and somatization, as well as the underlying possible mediating and moderating mechanism, in a large sample of Chinese participants receiving a crisis intervention during the coronavirus disease 2019 epidemic. Read More

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Real-World, Single-Center Data for Lenalidomide Plus Rituximab in Relapsed or Refractory Diffuse Large B-Cell Lymphoma and Transformed Follicular Lymphoma.

Cancer Manag Res 2021 28;13:4241-4250. Epub 2021 May 28.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: This study explored the efficacy of lenalidomide plus rituximab for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) including cases of secondary central nervous system (CNS) involvement and transformed follicular lymphoma (FL) in real-world context because of anti-tumor effect and blood-brain barrier permeability of lenalidomide.

Methods: Twenty-four patients including relapsed or refractory DLBCL (n = 21) including seven patients with secondary CNS involvement and transformed FL (n = 3) were retrospectively analyzed.

Results: Based on the best response, the complete response (CR) rate was 21% (5/24) and the overall response rate (ORR) was 38% (9/24). Read More

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Updates in Forensic Pathology Education: ACGME Milestones 2.0.

Authors:

Am J Forensic Med Pathol 2021 Jun 1. Epub 2021 Jun 1.

Abstract: The Accreditation Council for Graduate Medical Education Milestones offer a framework for competency-based assessment of forensic pathology fellows. The initial forensic pathology-specific milestones (Milestones 1.0) were developed in 2014. Read More

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Use of post-mortem chest computed tomography in Covid-19 pneumonia.

Forensic Sci Int 2021 May 27;325:110851. Epub 2021 May 27.

Department of Health Care Surveillance and Bioethics, Section of Legal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background And Aim: COVID-19 is an extremely challenging disease, both from a clinical and forensic point of view, and performing autopsies of COVID-19 deceased requires adequately equipped sectorial rooms and exposes health professionals to the risk of contagion. Among one of the categories that are most affected by SARS-Cov-2 infection are the elderly residents. Despite the need for prompt diagnoses, which are essential to implement all isolation measures necessary to contain the infection spread, deceased subjects in long-term care facilities are still are often diagnosed post-mortem. Read More

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Computed tomography imaging of septic shock. Beyond the cause: the "CT hypoperfusion complex". A pictorial essay.

Insights Imaging 2021 Jun 5;12(1):70. Epub 2021 Jun 5.

Department of General and Emergency Radiology, "Antonio Cardarelli" Hospital, Antonio Cardarelli st 9, 80131, Naples, Italy.

Septic shock is a medical emergency that represents one of the most important underlying causes for presentation to the Emergency Department. Sepsis is defined as organ dysfunction, life-threatening event caused by a deregulated inflammatory host response to infection, with a mortality risk ranging from 10 to 40%. Early sepsis identification is the cornerstone of management and diagnostic imaging can play a pivotal role in this clinical context. Read More

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Examining group differences in between-participant variability in non-native speech sound learning.

Atten Percept Psychophys 2021 Jul 4;83(5):1935-1941. Epub 2021 Jun 4.

Department of Linguistics, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476, Potsdam, Germany.

Many studies on non-native speech sound learning report a large amount of between-participant variability. This variability allows us to ask interesting questions about non-native speech sound learning, such as whether certain training paradigms give rise to more or less between-participant variability. This study presents a reanalysis of Fuhrmeister and Myers (Attention, Perception, and Psychophysics, 82(4), 2049-2065, 2020) and tests whether different types of phonetic training lead to group differences in between-participant variability. Read More

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Assessment of potential strain injury to rectus capitis posterior minor muscles during whiplash type distortions of the cervical spine.

J Osteopath Med 2021 Jun 4. Epub 2021 Jun 4.

Department of Osteopathic Manipulative Medicine, Michigan State University, East Lansing, MI, USA.

Context: Whiplash type injuries resulting from a rear end motor vehicle accident (REMVA) are thought to be caused by excessive loading and displacement of structural components of the cervical spine. On impact, the seat propels the driver's torso forward relative to the head, resulting in forced flexion of the occipitoatlantal (OA) joint, accompanied by forced stretching of the rectus capitis posterior minor (RCPm) muscles. Flexion of the OA joint and stretching of the RCPm muscles continues to increase until the vehicle's headrest strikes the back of the driver's head. Read More

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Fine-Scale Air Pollution Models for Epidemiologic Research: Insights From Approaches Developed in the Multi-ethnic Study of Atherosclerosis and Air Pollution (MESA Air).

Curr Environ Health Rep 2021 Jun;8(2):113-126

Departments of Environmental and Occupational Health Sciences, Epidemiology, and Medicine, University of Washington, Seattle, WA, USA.

Purpose Of Review: Epidemiological studies of short- and long-term health impacts of ambient air pollutants require accurate exposure estimates. We describe the evolution in exposure assessment and assignment in air pollution epidemiology, with a focus on spatiotemporal techniques first developed to meet the needs of the Multi-ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Initially designed to capture the substantial variation in pollutant levels and potential health impacts that can occur over small spatial and temporal scales in metropolitan areas, these methods have now matured to permit fine-scale exposure characterization across the contiguous USA and can be used for understanding long- and short-term health effects of exposure across the lifespan. Read More

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The «Museum and Inclusive Fashion» Project. A Design for All Experience at the Balearic School of Art and Design.

Stud Health Technol Inform 2021 Jun;282:120-134

Escola d'Art i Superior de Disseny de les Illes Balears, Spain.

International regulations about Accessibility and Design for All are clear. They provide two guidelines to ensure equality, autonomy, and non-discrimination, such as Reasonable Accommodation and Universal Design (or Design for All). Reasonable Accommodation leads to Adapted Fashion, which adjusts clothing to the body (average clothes for the average consumer). Read More

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Isolation of Lipid Rafts by the Detergent-Based and Non-detergent-Based Methods for Localization of GPCRs with Immunoblotting and Laser Scanning Confocal Microscopy.

Methods Mol Biol 2021 ;2268:1-20

Division of Kidney Diseases & Hypertension, Department of Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, USA.

The understanding of how biological membranes are organized and how they function has constantly been evolving over the past decades. Instead of just serving as a medium in which specific proteins are located, certain parts of the lipid bilayer contribute to platforms that assemble signaling complexes by providing a microenvironment that facilitates effective protein-protein interactions. G protein-coupled receptors (GPCRs) and relevant signaling molecules, including the heterotrimeric G proteins, key enzymes such as kinases and phosphatases, trafficking proteins, and secondary messengers, preferentially partition to these highly organized cell membrane microdomains, called lipid rafts. Read More

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January 2021

More Is Not Better When It Comes to Treating Rectal Cancer With Multimodal Chemoradiation Beyond the Standard Radiation Dose of 5040 cGy.

Dis Colon Rectum 2021 Jun 1. Epub 2021 Jun 1.

Division of Radiation Oncology, Cross Cancer Institute, 11560 University Ave, Edmonton, AB T6G 1Z2, Canada Department of Oncology, University of Alberta, 11560 University Ave, Edmonton, AB T6G 1Z2, Canada Department of Oncology, University of Calgary - Calgary, Alberta, Canada.

Background: Radiation dose schedules for neoadjuvant chemoradiation for rectal cancers differs, with the most common dose schedule using 5040 cGy in 28 fractions.

Objectives: The aim of this retrospective study was to assess the benefit of higher radiation doses beyond 5040cGy in the context of pathological response and follow up events.

Setting: Database from a provincial tertiary cancer center in Canada. Read More

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In vivo CRISPR-Cas9 knockout screening using quantitative PCR identifies thymosin beta-4 X-linked that promotes diffuse-type gastric cancer metastasis.

Mol Carcinog 2021 Jun 3. Epub 2021 Jun 3.

Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, ChunCheon-si, Gangwon-do, South Korea.

Gastric cancer (GC) is histologically classified into intestinal-type gastric cancer (IGC) and diffuse-type gastric cancer (DGC), and the latter is poorly differentiated and highly metastatic. In this study, using quantitative real-time polymerase chain reaction, we described a complete protocol for in vivo CRISPR-Cas9-based knockout screening of essential genes for DGC metastasis. We functionally screened 30 candidate genes using our mouse DGC models lacking Smad4, p53, and E-cadherin. Read More

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Propensity-score matched analysis of the efficacy of maintenance/continuous therapy in newly diagnosed patients with multiple myeloma: a multicenter retrospective collaborative study of the Japanese Society of Myeloma.

J Cancer Res Clin Oncol 2021 Jun 2. Epub 2021 Jun 2.

Department of Hematology/Oncology, Higashi Nagoya National Hospital, Nagoya, Japan.

Background: Maintenance ± consolidation or continuous therapy is considered a standard of care for both transplant-eligible and -ineligible patients with multiple myeloma (MM). However, long-term benefits of such therapy have not yet been clarified in the context of clinical practice.

Purpose: To clarify the efficacy of maintenance/continuous approach, we retrospectively analyzed the cohort data of newly diagnosed MM patients by propensity-score matching based on age, gender, revised International Staging System (R-ISS) stage, and implementation of transplantation to reduce the bias due to confounding variables. Read More

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Integration of circulating tumor cell and neutrophil-lymphocyte ratio to identify high-risk metastatic castration-resistant prostate cancer patients.

BMC Cancer 2021 Jun 2;21(1):655. Epub 2021 Jun 2.

Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

Background: The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and circulating tumor cells (CTCs) have been associated with survival in castration-resistant prostate cancer (CRPC). However, no study has examined the prognostic value of NLR and PLR in the context of CTCs.

Methods: Baseline CTCs from mCRPC patients were enumerated using the CellSearch System. Read More

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Guiding axes for drug safety management of pharmacovigilance centres during the COVID-19 era.

Int J Clin Pharm 2021 Jun 2. Epub 2021 Jun 2.

Porto Pharmacovigilance Centre, Rua Doutor Plácido da Costa, 4200-450, Porto, Portugal.

The COVID-19 pandemic presents several challenges to the organisation and workflow of pharmacovigilance centres as a result of the massive increase in reports, the need for quick detection, processing and reporting of safety issues and the management of these within the context of lack of complete information on the disease. Pharmacovigilance centres permanently monitor the safety profile of medicines, ensuring risk management to evaluate the benefit-risk relationship. However, traditional pharmacovigilance approaches of spontaneous reporting, are not suitable in the context of a pandemic; the scientific community and regulators need information on a near real-time point. Read More

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Management of dental caries lesions in Latin American and Caribbean countries.

Braz Oral Res 2021 28;35(suppl 01):e055. Epub 2021 May 28.

Universidad Central de Venezuela, Faculty of Dentistry, Institute of Dental Research "Raul Vincentelli", Caracas, Venezuela.

Caries management at the lesion level is dependent on the lesion activity, the presence of a cavitation (either cleanable or non-cleanable), and lesion depth as evaluated via radiographic examination. A variety of non-invasive, micro-invasive, and minimally invasive treatment (with or without restoration) options are available for primary and permanent teeth. Non-invasive strategies include oral hygiene instructions, dietary counseling, and personal as well as professional use of fluoridated products that reduce demineralization and increase re-mineralization. Read More

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Classification of users' transportation modalities from mobiles in real operating conditions.

Multimed Tools Appl 2021 May 26:1-26. Epub 2021 May 26.

Department of Information Engineering, Distributed Systems and Internet Tech lab, DISIT Lab, University of Florence, Florence, Italy.

The modern mobile phones and the complete digitalization of the public and private transport networks have allowed to access useful information to understand the user's mean of transportation. This enables a plethora of old and new applications in the fields of sustainable mobility, smart transportation, assistance, and e-health. The precise understanding of the travel means is at the basis of the development of a large range of applications. Read More

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Rubber Bullet Induced Traumatic Brain Injury.

J Craniofac Surg 2021 Jun 2. Epub 2021 Jun 2.

Department of Neurosurgery Division of Plastic and Reconstructive Surgery, The Warren Alpert Medical School of Brown University, Providence, RI.

Abstract: Rubber bullets have long been known to cause, on rare occasions, traumatic brain injury (TBI). However, neurosurgical literature on this occurrence is limited, and no focused review of this injury pattern has been conducted. The authors present the case of a 28-year-old male struck by a rubber bullet in the left periorbital region, causing TBI in addition to complete left visual loss and complex facial fractures. Read More

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Multi-Solvent Extraction Procedure for the Pioneer Fecal Metabolomic Analysis-Identification of Potential Biomarkers in Stable Kidney Transplant Patients.

Diagnostics (Basel) 2021 May 26;11(6). Epub 2021 May 26.

LBVBGR_LR11ES31, High Institute of Biotechnology of Sidi Thabet, University of Manouba, Ariana 2020, Tunisia.

Metabolic alteration plays a functional role in kidney allograft complications. Metabolomics is a promising high-throughput approach in nephrology but is still limited by the lack of overlap in metabolite coverage. We performed an untargeted fecal metabolomic analysis of forty stable kidney allograft recipients and twenty non-transplant controls. Read More

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An Engineered Mutant Zebrafish Recapitulates Molecular and Behavioural Pathobiology of Sanfilippo Syndrome A/MPS IIIA.

Int J Mol Sci 2021 May 31;22(11). Epub 2021 May 31.

Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.

Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme -sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan sulfate glycosaminoglycan (HS GAG) and its accumulation in tissues. MPS IIIA represents a significant proportion of childhood dementias. This condition generally leads to patient death in the teenage years, yet no effective therapy exists for MPS IIIA and a complete understanding of the mechanisms of MPS IIIA pathogenesis is lacking. Read More

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Pan-Resistome Insights into the Multidrug Resistance of .

Antibiotics (Basel) 2021 May 18;10(5). Epub 2021 May 18.

Laboratory of Cellular and Molecular Genetics, Universidade Federal de Minas GeraisBelo Horizonte, Belo Horizonte 31270-901, MG, Brazil.

is an important Gram-negative opportunistic pathogen that is responsible for many nosocomial infections. This etiologic agent has acquired, over the years, multiple mechanisms of resistance to a wide range of antimicrobials and the ability to survive in different environments. In this context, our study aims to elucidate the resistome from the strains based on phylogenetic, phylogenomic, and comparative genomics analyses. Read More

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Molecular Interactions between Saliva and Dental Composites Resins: A Way Forward.

Materials (Basel) 2021 May 13;14(10). Epub 2021 May 13.

Department of Fixed Prosthodontics and Occlusology, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 010221 Bucharest, Romania.

Dentin and enamel loss related to trauma or especially caries is one of the most common pathological issues in dentistry that requires restoration of the teeth by using materials with appropriate properties. The composite resins represent dental materials with significant importance in today's dentistry, presenting important qualities, including their mechanical behavior and excellent aesthetics. This paper focuses on the saliva interactions with these materials and on their biocompatibility, which is continuously improved in the new generations of resin-based composites. Read More

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Understanding a Player's Decision-Making Process in Team Sports: A Systematic Review of Empirical Evidence.

Sports (Basel) 2021 May 17;9(5). Epub 2021 May 17.

Research Centre for Sport Coaching, Leeds Beckett University, Leeds LS6 3QT, UK.

Three perspectives were taken to explain decision-making within team sports (information processing, recognition primed decision-making, and ecological dynamics perspectives), resulting in conceptual tension and practical confusion. The aim of this paper was to interrogate empirical evidence to (1) understand the process of decision-making within team sports and (2) capture the characteristics of decision-making expertise in a team sport context. Nine electronic databases (SPORTDiscus, PsycINFO, PsycArticles, PsycTests, PubMed, SAGE journals online, Web of Knowledge, Academic Search Complete, and Web of Science) were searched until the final return in March 2021. Read More

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Preliminary Evidence for a Relationship between Elevated Plasma TNFα and Smaller Subcortical White Matter Volume in HCV Infection Irrespective of HIV or AUD Comorbidity.

Int J Mol Sci 2021 May 7;22(9). Epub 2021 May 7.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

Classical inflammation in response to bacterial, parasitic, or viral infections such as HIV includes local recruitment of neutrophils and macrophages and the production of proinflammatory cytokines and chemokines. Proposed biomarkers of organ integrity in Alcohol Use Disorders (AUD) include elevations in peripheral plasma levels of proinflammatory proteins. In testing this proposal, previous work included a group of human immunodeficiency virus (HIV)-infected individuals as positive controls and identified elevations in the soluble proteins TNFα and IP10; these cytokines were only elevated in AUD individuals seropositive for hepatitis C infection (HCV). Read More

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Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease.

Antioxidants (Basel) 2021 May 7;10(5). Epub 2021 May 7.

Department of Vascular and Endovascular Surgery, Angiology and Phlebology, Poznan University of Medical Sciences, 60-848 Poznan, Poland.

Currently, atherosclerosis, which affects the vascular bed of all vital organs and tissues, is considered as a leading cause of death. Most commonly, atherosclerosis involves coronary and peripheral arteries, which results in acute (e.g. Read More

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Strategies to Tackle Antimicrobial Resistance: The Example of and .

Int J Mol Sci 2021 May 6;22(9). Epub 2021 May 6.

GSK Vaccines, 53100 Siena, Italy.

Traditional antimicrobial treatments consist of drugs which target different essential functions in pathogens. Nevertheless, bacteria continue to evolve new mechanisms to evade this drug-mediated killing with surprising speed on the deployment of each new drug and antibiotic worldwide, a phenomenon called antimicrobial resistance (AMR). Nowadays, AMR represents a critical health threat, for which new medical interventions are urgently needed. Read More

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Movement Disorders in Children with a Mitochondrial Disease: A Cross-Sectional Survey from the Nationwide Italian Collaborative Network of Mitochondrial Diseases.

J Clin Med 2021 May 12;10(10). Epub 2021 May 12.

IRCCS Fondazione Stella Maris, 56018 Pisa, Italy.

Movement disorders are increasingly being recognized as a manifestation of childhood-onset mitochondrial diseases (MDs). However, the spectrum and characteristics of these conditions have not been studied in detail in the context of a well-defined cohort of patients. We retrospectively explored a cohort of individuals with childhood-onset MDs querying the Nationwide Italian Collaborative Network of Mitochondrial Diseases database. Read More

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Phenotypic Heterogeneity of Triple-Negative Breast Cancer Mediated by Epithelial-Mesenchymal Plasticity.

Cancers (Basel) 2021 May 2;13(9). Epub 2021 May 2.

Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.

Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma known for its unusually aggressive behavior and poor clinical outcome. Besides the lack of molecular targets for therapy and profound intratumoral heterogeneity, the relatively quick overt metastatic spread remains a major obstacle in effective clinical management. The metastatic colonization of distant sites by primary tumor cells is affected by the microenvironment, epigenetic state of particular subclones, and numerous other factors. Read More

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Sarcoidosis-Like Cancer-Associated Granulomatosis: Characteristics and a Case-Control Comparison with Sarcoidosis.

J Clin Med 2021 May 5;10(9). Epub 2021 May 5.

Service de Pneumologie et Soins Intensifs, Assistance Publique-Hôpitaux de Paris Centre, Hôpital Européen Georges Pompidou, 75015 Paris, France.

(1) Background: Systemic granulomatosis developed in a context of malignancy has already been reported. Our objective was to describe the clinical, radiological, functional, biological, and evolutive characteristics of sarcoidosis-like cancer-associated granulomatosis (SLCAG) and to compare them to those of sarcoidosis. (2) Methods: 38 patients with a biopsy-proven SLCAG developed after a diagnostic of malignancy were included. Read More

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