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Phenolic Compounds of sp. as Modulators of Oral Cavity Lactoperoxidase System.

Antioxidants (Basel) 2021 Apr 26;10(5). Epub 2021 Apr 26.

Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.

Lactoperoxidase (LPO) together with its (pseudo)halogenation cycle substrates, HO and thiocyanate ions oxidized to hypothiocyanite ions, form one of the main systems involved in antimicrobial defense within the oral cavity. In bacterial diseases such as dental caries, lactoperoxidase is oxidized to a form known as Compound II, which is characterized by its inability to oxidize SCN, resulting in a decreased generation of antimicrobial products. sp. Read More

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Enhanced Biological Activity of a Novel Preparation of Essential Oil.

Molecules 2021 Apr 23;26(9). Epub 2021 Apr 23.

Ostrowieckie Centrum Medyczne Civil Partnership Anna Olech-Cudzik, Krzysztof Cudzik Iłżecka 31A, 27-400 Ostrowiec Świętokrzyski, Poland.

, one of the most popular medicinal plants, is the source of a bioactive essential oil characterized by a wide spectrum of biological activity, e.g., antiseptic, analgesic, and anticancer effects. Read More

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Resultant Information Descriptors, Equilibrium States and Ensemble Entropy .

Entropy (Basel) 2021 Apr 19;23(4). Epub 2021 Apr 19.

Department of Theoretical Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Cracow, Poland.

In this article, sources of information in electronic states are reexamined and a need for the resultant measures of the entropy/information content, combining contributions due to probability and phase/current densities, is emphasized. Probability distribution reflects the wavefunction modulus and generates contributions to Shannon's global entropy and Fisher's gradient information. The phase component of molecular states similarly determines their supplements, due to probability "convection". Read More

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Dual Switch in Lipid Metabolism in Cervical Epithelial Cells during Dysplasia Development Observed Using Raman Microscopy and Molecular Methods.

Cancers (Basel) 2021 Apr 21;13(9). Epub 2021 Apr 21.

Faculty of Chemistry, Jagiellonian University, 2 Gronostajowa Street, 30-387 Krakow, Poland.

Cellular lipid metabolism is significantly transformed during oncogenesis. To assess how dysplasia development influences lipid cellular metabolisms and what is the molecular background behind it, cervical epithelial cells of 63 patients assigned to seven groups (based on the cytological examination and HPVhr test results) were studied using a multimethodological approach including Raman microscopy and molecular methods. The consistent picture obtained studying the lipid content, cell inflammation, gene methylation (hence SREBP1 inhibition) and level of mitochondrial DNA copies (indirectly the number of mitochondria) showed that changes in lipid metabolism were multidirectional. Read More

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Graphitic nitrogen in carbon catalysts is important for the reduction of nitrite as revealed by naturally abundant N NMR spectroscopy.

Dalton Trans 2021 Apr 29. Epub 2021 Apr 29.

Department of Materials and Environmental Chemistry, Stockholm University, 10691 Stockholm, Sweden.

Metal-free nitrogen-doped carbon is considered as a green functional material, but the structural determination of the atomic positions of nitrogen remains challenging. We recently demonstrated that directly-excited solid state 15N NMR (ssNMR) spectroscopy is a powerful tool for the determination of such positions in N-doped carbon at natural 15N isotope abundance. Here we report a green chemistry approach for the synthesis of N-doped carbon using cellulose as a precursor, and a study of the catalytic properties and atomic structures of the related catalyst. Read More

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Cardiometabolic risk factors and mercury content in hair of women from a territory distant from mercury-rich geochemical zones (Cherepovets city, Northwest Russia).

Environ Geochem Health 2021 Apr 27. Epub 2021 Apr 27.

Cherepovets State University, 5 Lunacharsky Pr., Cherepovets, Vologda region, 162600, Russia.

For the first time in the Russian Federation, a study was conducted to determine the level of mercury in the hair of young and middle-aged women with or without metabolic syndrome (MS) and the Association of mercury content in hair with cardiometabolic risk factors. The studied cohort consisted of 387 women (204 with metabolic syndrome and 183 without metabolic syndrome as controls). The mercury content in the hair was determined by atomic absorption pyrolysis. Read More

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Redesigning a PhD measurement course for a new era in nursing science.

J Prof Nurs 2021 Mar-Apr;37(2):387-390. Epub 2020 Apr 30.

Hariri School of Nursing, American University of Beirut, Beirut, Lebanon; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Measurement is at the core of the research process. At the PhD level, students need to develop an in-depth understanding of measures relevant to their area of work and refine their knowledge of measurement issues. Traditionally, measurement coursework in Nursing focused on the psychometric evaluation of instruments measuring cognition and behavior. Read More

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Poor coverage and quality for poor women: Inequalities in quality antenatal in nine East African countries.

Health Policy Plan 2021 Apr 5. Epub 2021 Apr 5.

School of Public Health, Faculty of Health, University of Technology Sydney, Sydney, Australia.

The use of quality antenatal care (ANC) improves maternal and newborn health outcomes. Ensuring equity in access to quality maternal health services is a priority agenda in low- and middle-income countries. This study aimed to assess inequalities in the use of quality ANC in nine East African countries using the most recent Demographic and Health Surveys. Read More

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Paper Ageing: The Effect of Paper Chemical Composition on Hydrolysis and Oxidation.

Polymers (Basel) 2021 Mar 26;13(7). Epub 2021 Mar 26.

Natural Fibers Advanced Technologies, 42A Blekitna Str., 93-322 Lodz, Poland.

The degradation of cellulose is an important factor influencing its mechanical, optical, physical, and chemical properties and, hence, the lifetime of paper in libraries and archival collections. Regardless of the complexity of the paper material, the main chemical pathways for its degradation are hydrolysis and oxidation. This study presents an overview of the analytical techniques employed in the evaluation of the hydrolysis and oxidation processes; these techniques include size-exclusion chromatography, Fourier-transform infrared and ultraviolet-visible spectroscopy, and X-ray diffraction. Read More

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Tailoring Properties of Resol Resin-Derived Spherical Carbons for Adsorption of Phenol from Aqueous Solution.

Molecules 2021 Mar 19;26(6). Epub 2021 Mar 19.

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.

The polycondensation of resorcinol and formaldehyde in a water-ethanol mixture using the adapted Stöber method was used to obtain resol resins. An optimization of synthesis conditions and the use of an appropriate stabilizer (e.g. Read More

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Comparison of the Dielectric Properties of Ecoflex with L,D-Poly(Lactic Acid) or Polycaprolactone in the Presence of SWCN or 5CB.

Materials (Basel) 2021 Mar 31;14(7). Epub 2021 Mar 31.

Institute of Physics, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.

The main goal of this paper was to study the dielectric properties of hybrid binary and ternary composites based on biodegradable polymer Ecoflex, single walled carbon nanotubes (SWCN), and liquid crystalline 4'-pentyl-4-biphenylcarbonitrile (5CB) compound. The obtained results were compared with other created analogically to Ecoflex, hybrid layers based on biodegradable polymers such as L,D-polylactide (L,D-PLA) and polycaprolactone (PCL). Frequency domain dielectric spectroscopy (FDDS) results were analyzed taking into consideration the amount of SWCN, frequency, and temperature. Read More

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Enhanced Skin Permeation of Estradiol by Dimethyl Sulfoxide Containing Transdermal Patches.

Pharmaceutics 2021 Mar 1;13(3). Epub 2021 Mar 1.

Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn, Germany.

Dimethyl sulfoxide is a well-known and widely used dermal penetration enhancer. Its incorporation in transdermal patches would be highly desirable; however, due to its volatility this is extremely challenging. Here, we report on the feasibility of a dimethyl sulfoxide (DMSO) containing transdermal system containing estradiol as a model compound. Read More

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Sex-Linked Molecular Markers Identify Female Lines in Endosperm-Derived Kiwifruit Callus and in Regenerants.

Plants (Basel) 2021 Mar 11;10(3). Epub 2021 Mar 11.

Department of Plant Cytology and Embryology, Institute of Botany, Faculty of Biology, Jagiellonian University in Kraków, Gronostajowa 3, 30-387 Kraków, Poland.

This is the first report of molecular markers application for the analysis of endosperm-derived callus and nonaploid kiwifruit ( var. formerly: ) plants. As a source of explants, fruits of 'Hayward', the most popular cultivar, were used. Read More

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Antioxidant and Signaling Role of Plastid-Derived Isoprenoid Quinones and Chromanols.

Int J Mol Sci 2021 Mar 14;22(6). Epub 2021 Mar 14.

Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Reymonta 19, 30-059 Krakow, Poland.

Plant prenyllipids, especially isoprenoid chromanols and quinols, are very efficient low-molecular-weight lipophilic antioxidants, protecting membranes and storage lipids from reactive oxygen species (ROS). ROS are byproducts of aerobic metabolism that can damage cell components, they are also known to play a role in signaling. Plants are particularly prone to oxidative damage because oxygenic photosynthesis results in O formation in their green tissues. Read More

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Challenges faced by health workers in the use of the directly observed treatment (DOT) for tuberculosis.

Rev Inst Med Trop Sao Paulo 2021 24;63:e25. Epub 2021 Mar 24.

Universidade Estadual de Maringá, Departamento de Análises Clínicas e Biomedicina, Maringá, Paraná, Brazil.

Tuberculosis is a worldwide public health problem, which, even with available treatment, continues to cause deaths worldwide. One of the obstacles to control the disease is the multifactorial difficulty of patients to adhere to treatment, in addition to the difficulty of health workers in circumventing barriers to implement strategies such as the directly observed treatment (DOT). The aim of this study is to analyze the performance and challenges faced by health workers in the use of DOT in tuberculosis. Read More

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Comparison of deoxynivalenol and zearaleone concentration in conventional and organic cereal products in western Poland.

Ann Agric Environ Med 2021 Mar 6;28(1):44-48. Epub 2020 Feb 6.

Faculty of Physical Culture in Gorzów Wlkp. University of Physical Education, Poznan, Poland.

Introduction And Objective: Deoxynivalenol (DON, vomitoxin) and Zearalenone (ZEA) are mycotoxin contaminants of cereals and cereal products that pose a significant threat to food safety. The aim of the study was to investigate the occurrence of DON and ZEA in different organic and conventional unprocessed cereals and cereal products that are available on the Polish agricultural fields and market. A total of 78 unprocessed cereal and cereal product samples of organic and conventional production were sampled from agricultural fields situated in western Poland and from available on the Polish market packaged comercial products produced by different domestic manufacturers. Read More

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Periprosthetic Joint Infection Is Associated with an Increased Risk of Venous Thromboembolism Following Revision Total Knee Replacement: An Analysis of Administrative Discharge Data.

J Bone Joint Surg Am 2021 Mar 22. Epub 2021 Mar 22.

Hospital for Special Surgery, New York, NY.

Background: Little is known about the relationship between infection and the risk of risk of venous thromboembolism (VTE) following orthopaedic surgery. We assessed the 90-day risk of VTE following revision total knee replacement to measure the association between periprosthetic joint infection and the risk of postoperative VTE.

Methods: We used New York Statewide Planning and Research Cooperative System data to identify all New York State residents undergoing revision total knee replacement from 1998 to 2014. Read More

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Implementing the national strategy of salt reduction in Morocco: the baker´s perspective.

Pan Afr Med J 2020 11;37:337. Epub 2020 Dec 11.

Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition Associated with International Atomic Energy Agency, Ibn Tofaïl University, Kenitra, Morocco.

Introduction: Morocco launched a national salt reduction strategy in 2019. The commitment of bakeries is key in the success of this strategy. However, the evaluation of such a commitment is not yet done. Read More

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Characterization of Partially Covered Self-Expandable Metallic Stents for Esophageal Cancer Treatment: Degradation.

ACS Biomater Sci Eng 2021 04 12;7(4):1403-1413. Epub 2021 Mar 12.

Faculty of Chemistry, Jagiellonian University, 31-007 Kraków, Poland.

Partially covered self-expandable metallic esophageal stent (SEMS) placement is the most frequently applied palliative treatment in esophageal cancer. Structural characterization of explanted 16 nitinol-polyurethane SEMS (the group of 6 females, 10 males, age 40-80) was performed after their removal due to dysfunction. The adverse bulk changes in the polymer structure were identified using differential scanning calorimetry (DSC), differential mechanical thermal analysis (DMTA), and attenuated total reflectance infrared spectroscopy (ATR-IR) and discussed in terms of melting point shift (9 °C), glass-transition shift (4 °C), differences in viscoelastic behavior, and systematic decrease of peaks intensities corresponding to C-H, C═O, and C-N polyurethane structural bonds. Read More

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Influence of silicon and chitosan on growth and physiological attributes of maize in a saline field.

Physiol Mol Biol Plants 2021 Feb 15;27(2):387-397. Epub 2021 Feb 15.

Department of Soil Science, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University Multan, Multan, Pakistan.

Soil salinity is the main constraint for crop productivity in many parts of the world. Application of silicon (Si) and chitosan (Chi) can improve crop growth under saline soil conditions. The current study was aimed to examine the effects of Si and Chi on mitigation of salinity, morphological and physiological attributes as well as the antioxidant system of maize ( L. Read More

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February 2021

Chloroquine-Induced Accumulation of Autophagosomes and Lipids in the Endothelium.

Int J Mol Sci 2021 Feb 27;22(5). Epub 2021 Feb 27.

Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 14 Bobrzynskiego Str., 30-348 Krakow, Poland.

Chloroquine (CQ) is an antimalarial drug known to inhibit autophagy flux by impairing autophagosome-lysosome fusion. We hypothesized that autophagy flux altered by CQ has a considerable influence on the lipid composition of endothelial cells. Thus, we investigated endothelial responses induced by CQ on human microvascular endothelial cells (HMEC-1). Read More

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February 2021

The Foliar Application of Rice Phyllosphere Bacteria induces Drought-Stress Tolerance in (L.).

Plants (Basel) 2021 Feb 18;10(2). Epub 2021 Feb 18.

Department of Plant Pathology, Agricultural College and Research Institute, Tamil Nadu Agricultural University, Killikulam, Tuticorin 628252, India.

This study assessed the potential of PB3, PB46, and PB50 to induce drought tolerance in a susceptible rice cultivar. The leaves of the potted rice plants subjected to physical drought stress for 10 days during the flowering stage were inoculated with single-strain suspensions. Control pots of irrigated and drought-stressed plants were included in the experiment for comparison. Read More

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February 2021

Looking for Hidden Enemies of Metabarcoding: Species Composition, Habitat and Management Can Strongly Influence DNA Extraction while Examining Grassland Communities.

Biomolecules 2021 02 19;11(2). Epub 2021 Feb 19.

Polish Academy of Sciences Botanical Garden, Center for Biological Diversity Conservation in Powsin, Prawdziwka 2, 02-976 Warszawa, Poland.

Despite the raising preoccupation, the critical question of how the plant community is composed belowground still remains unresolved, particularly for the conservation priority types of vegetation. The usefulness of metabarcoding analysis of the belowground parts of the plant community is subjected to a considerable bias, that often impedes detection of all species in a sample due to insufficient DNA quality or quantity. In the presented study we have attempted to find environmental factors that determine the amount and quality of DNA extracted from total plant tissue from above- and belowground samples (1000 and 10,000 cm). Read More

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February 2021

Microbial carbon source utilization in rice rhizosphere soil with different tillage practice in a double cropping rice field.

Sci Rep 2021 Mar 3;11(1):5048. Epub 2021 Mar 3.

Hunan Soil and Fertilizer Institute, Changsha, 410125, China.

Carbon (C) plays an important role in maintaining soil fertility and increasing soil microbial community, but there is still limited information about how source utilization characteristics respond to soil fertility changes under double-cropping rice (Oryza sativa L.) system in southern China paddy field. Therefore, the effects of different short-term (5-years) tillage management on characteristics of C utilization in rice rhizosphere and non-rhizosphere soils under double-cropping rice field in southern China were investigated by using O incorporation into DNA. Read More

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Solvent- and Temperature-Driven Photoluminescence Modulation in Porous Hofmann-Type Sr-Re Metal-Organic Frameworks.

Inorg Chem 2021 Mar 3;60(6):4093-4107. Epub 2021 Mar 3.

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.

A unique family of three-dimensional (3D) luminescent Sr-Re metal-organic frameworks (MOFs), {[Sr(MeOH)][Re(CN)(N)(bpen)]·MeOH} [; N = nitrido ligand, bpen = 1,2-bis(4-pyridyl)ethane, and MeOH = methanol], {[Sr(MeOH)][Re(CN)(N)(bpee)]·2MeOH} [; bpee = 1,2-bis(4-pyridyl)ethylene], and {[Sr(bpy)(MeOH)][Re(CN)(N)(bpy)]} (; bpy = 4,4'-bipyridine), is reported. They are obtained by the molecular self-assembly of Sr ions with tetracyanidonitridorhenate(V) metalloligands, [Re(CN)(N)], and pyridine-based organic spacers (L = bpen, bpee, bpy). Such a combination of molecular precursors results in bimetallic Sr-Re cyanido-bridged layers further bonded by organic ligands into pillared Hofmann-type coordination skeletons. Read More

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Exogenous melatonin and salicylic acid alleviates cadmium toxicity in safflower (Carthamus tinctorius L.) seedlings.

Ecotoxicology 2021 Apr 23;30(3):387-401. Epub 2021 Feb 23.

ACECR-Research Institute of Applied Sciences, Shahid Beheshti University, Tehran, Iran.

The co-application of exogenous 100 µM melatonin (MT) and 100 µM salicylic acid (SA) on 21-day-old safflower seedlings grown in the presence of cadmium (Cd, 100 µM) toxicity was investigated. The application of MT, SA, or MT + SA efficiently improved toxicity symptoms and declined Cd toxicity as shown by a considerable rise in plant biomass production and chlorophyll content accompanied by decreased level of oxidative stress markers. In Cd stressed plants, the simultaneous application of MT and SA led to sharp decreases in MDA and H2O2 amounts (61. Read More

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First evidence of glyphosate and aminomethylphosphonic acid (AMPA) in the respirable dust (PM10) emitted from unpaved rural roads of Argentina.

Sci Total Environ 2021 Jun 4;773:145055. Epub 2021 Feb 4.

Institute for Earth and Environmental Sciences of La Pampa (INCITAP, CONICET-UNLPam), Argentina, cc 300, 6300 Santa Rosa, Argentina; National University of La Pampa, Faculty of Agronomy (UNLPam), Argentina, cc 300, 6300 Santa Rosa, Argentina. Electronic address:

The aim of this work was to compare the concentration of glyphosate and AMPA in the PM10 and the actual PM10 emission from agricultural soils and unpaved roads, located inside and outside farm fields. To determine the actual PM10 emission by wind erosion, the actual wind erosion was estimated using the Wind Erosion Equation, and the PM10 emission efficiency was measured with the Easy Dust Generator. PM10 was collected in an electrostatic precipitator coupled to the Easy Dust Generator. Read More

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Herpes Simplex Virus Type-2 shedding and genital ulcers during early HIV in Zimbabwean women.

J Acquir Immune Defic Syndr 2021 Feb 12. Epub 2021 Feb 12.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA Nathan Schnaper Internship Program in Translational Cancer Research, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA Beth Israel Lahey Health Beverly Hospital, Beverly MA, USA Department of Obstetrics and Gynecology, University of Zimbabwe, Harare, Zimbabwe Department of Medicine, Case Western Reserve University, Cleveland, OH, USA Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Behavioral, Epidemiologic and Clinical Sciences, FHI 360, Durham, NC, USA.

Background: Herpes Simplex Virus Type-2 (HSV-2) seropositive persons have a 3-5 fold higher risk of acquiring HIV, possibly due to HSV-2 induced inflammation and recruitment of susceptible immune cells to exposure sites. We hypothesized cervical HSV-2 activation (i.e. Read More

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February 2021

Trends in the Use of Low and No-Calorie Sweeteners in Non-Alcoholic Beverages in Slovenia.

Foods 2021 Feb 10;10(2). Epub 2021 Feb 10.

Nutrition Institute, Tržaška Cesta 40, SI-1000 Ljubljana, Slovenia.

Excessive sugar intake and the associated increased obesity risk indicate that food reformulation is needed. Non-alcoholic beverages are often high in free sugars, making reformulation with low and no-calorie sweeteners (LNCS) a common choice. Our knowledge of the use of LNCS in the European food supply is, however, very limited. Read More

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February 2021

Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets.

Materials (Basel) 2021 Jan 30;14(3). Epub 2021 Jan 30.

Department of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland.

Methods of spatiotemporal characterization of nonequilibrated polymer based matrices are still immature and imperfect. The purpose of the study was to develop the methodology for the spatiotemporal characterization of water transport and properties in alginate tablets under hydration. The regions of low water content were spatially and temporally sampled using Karl Fisher and Differential Scanning Callorimetry (spatial distribution of freezing/nonfreezing water) with spatial resolution of 1 mm. Read More

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January 2021