J Acquir Immune Defic Syndr 2021 Feb 12. Epub 2021 Feb 12.
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA Nathan Schnaper Internship Program in Translational Cancer Research, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA Beth Israel Lahey Health Beverly Hospital, Beverly MA, USA Department of Obstetrics and Gynecology, University of Zimbabwe, Harare, Zimbabwe Department of Medicine, Case Western Reserve University, Cleveland, OH, USA Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Behavioral, Epidemiologic and Clinical Sciences, FHI 360, Durham, NC, USA.
Background: Herpes Simplex Virus Type-2 (HSV-2) seropositive persons have a 3-5 fold higher risk of acquiring HIV, possibly due to HSV-2 induced inflammation and recruitment of susceptible immune cells to exposure sites. We hypothesized cervical HSV-2 activation (i.e. Read More