134 results match your criteria contained comorbid


LSD use in the United States: Trends, correlates, and a typology of us.

Drug Alcohol Depend 2021 Jun 20;223:108715. Epub 2021 Apr 20.

School of Social Work, Boston College, Chestnut Hill, MA, 02467, United States.

Background: Recent years have witnessed an increased interest in LSD. This study investigates current information on the trends and correlates of LSD use from years 2002-2018 and seeks to develop an initial typology of use and misuse.

Methods: Data is taken from the NSDUH (National Survey on Drug Use and Health) collected between 2002 and 2018 and trends and correlates of LSD use were analyzed with a survey adjusted logistic regression. Read More

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Profile of Substance Misuse among Adolescent and Young Adult Gabapentinoid Users: A Register-Based Follow-up Study of Former Adolescent Psychiatric Inpatients.

Subst Use Misuse 2021 4;56(5):598-605. Epub 2021 Mar 4.

Department of Psychiatry, Oulu University Hospital, Oulu, Finland.

Aims: Our study examined characteristics of adolescent and young adult study participants using gabapentinoids (gabapentin, pregabalin), with previous history of adolescent psychiatric inpatient hospitalization. Particular focus was on temporal association of age, at first prescription for gabapentinoids, to age at tobacco smoking initiation, regular alcohol use, diagnosis of substance dependence and prescriptions for benzodiazepines and opioids. : The initial study population contained 508 adolescents (300 females, 208 males) admitted to psychiatric inpatient care in Oulu University hospital between the ages 13-17 years. Read More

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Physiological sensation word usage in social anxiety disorder with and without comorbid depression.

J Behav Ther Exp Psychiatry 2021 Jun 12;71:101638. Epub 2021 Jan 12.

Department of Psychology, University of Maryland, Baltimore County, Math/Psyc Building, 3rd Floor, 1000 Hilltop Circle, Baltimore, MD, 21250, USA. Electronic address:

Background & Objectives: Social anxiety disorder (SAD) is characterized by a fear of showing anxiety symptoms, which may manifest in greater physiological sensation (PS) word usage, especially when describing their anxious experiences. However, the role of comorbid major depressive disorder (MDD) is unknown. Given blunted physiological arousal in MDD, the SAD only group (SAD) may use more PS words than the comorbid (COM) group with SAD and MDD when discussing anxious memories. Read More

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Clinical Manifestations of Overactive Bladder With Migraine as a Comorbidity: A Prospective Cross-Sectional Study.

Int Neurourol J 2020 Dec 9;24(4):375-381. Epub 2020 Dec 9.

Department of Neurology, Hitit University School of Medicine, Corum, Turkey.

Purpose: The aim of this study was to investigate the clinical manifestations of overactive bladder (OAB) with migraine as a comorbidity and to shed light on possible new treatment strategies.

Methods: This study included patients aged 18 years and older who were admitted to urology and neurology outpatient clinics between March 1, 2019 and March 1, 2020 for OAB and migraine. The study questionnaire contained 3 sections: (1) questions on demographic characteristics, (2) a migraine ID test, and (3) the Overactive Bladder Inquiry Form - V8 (OAB-V8) form. Read More

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December 2020

Real-world mapping of allergy immunotherapy in the United States: The argument for improving adherence.

Allergy Asthma Proc 2021 01 23;42(1):55-64. Epub 2020 Dec 23.

IBM Watson Health, Cambridge, Massachusetts.

There is a dearth of real-world evidence studies focused on allergy immunotherapy (AIT) use among patients with allergic rhinitis (AR). This study examined claims data of AR patients residing in the United States to assess patient characteristics and health outcomes. AR patients were identified in the IBM MarketScan database between January 1, 2014, and March 31, 2017. Read More

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January 2021

Comparison of health service use and costs in stroke with and without comorbidities: a cross-sectional analysis using China urban medical claims data.

BMJ Open 2020 12 10;10(12):e037032. Epub 2020 Dec 10.

China Center for Health Development Studies, Peking University, Beijing, China

Objectives: Stroke is the leading cause of death and disability in China, but there is scare of evidence on whether and to what extent comorbidity affects the stroke-related costs in health system. We examined the association between comorbidity and stroke-related health service utilisation and costs in urban China.

Settings: The data used in this study were extracted by a 5% random sampling from claims data of China Urban Employees' Basic Medical Insurance and Urban Residents' Basic Medical Insurance from 2013 to 2016, which covered more than 93% of residents in urban China. Read More

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December 2020

Pediatric Intensive Care Unit Admissions for COVID-19: Insights Using State-Level Data.

Int J Pediatr 2020 18;2020:9680905. Epub 2020 Nov 18.

Sections of Critical Care Medicine and Cardiology, Texas Children's Hospital, Houston, TX, USA.

Introduction: Intensive care has played a pivotal role during the COVID-19 pandemic as many patients developed severe pulmonary complications. The availability of information in pediatric intensive care units (PICUs) remains limited. The purpose of this study is to characterize COVID-19 positive admissions (CPAs) in the United States and to determine factors that may impact those admissions. Read More

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November 2020

Health-Related Quality of Life in Patients with Philadelphia-Negative Myeloproliferative Neoplasms: A Nationwide Population-Based Survey in Denmark.

Cancers (Basel) 2020 Nov 28;12(12). Epub 2020 Nov 28.

Danish Knowledge Centre for Rehabilitation and Palliative Care, University of Southern Denmark and Odense University Hospital, 5800 Nyborg, Denmark.

Previous studies have clarified that many patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) have burdensome symptom profiles and accordingly impaired functioning and quality of life (QoL). In Denmark, all MPN patients are affiliated with public hospitals and because of a healthcare system financed by taxpayers these patients do not have any financial costs related to the hematological disease. Diagnoses are recorded for all patients in hospitals, and diagnosis codes are communicated to the National Patient Register (NPR). Read More

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November 2020

Caecal volvulus in an incisional hernia.

J Surg Case Rep 2020 Oct 31;2020(10):rjaa422. Epub 2020 Oct 31.

Department of Surgery, The Queen Elizabeth Hospital, Woodville South, Australia.

Caecal volvulus represents 25-40% of all colonic volvulus. Symptoms include abdominal distension, constipation, nausea and vomiting where it may be intermittent. Abdominal X-rays and computed tomography (CTs) may help with diagnosis and recommended treatment is resection of mobile caecum. Read More

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October 2020

The effect of different dietary structure on gastrointestinal dysfunction in children with cerebral palsy and epilepsy based on gut microbiota.

Brain Dev 2021 Feb 16;43(2):192-199. Epub 2020 Oct 16.

Department of Pediatrics, Bao'an District Fuyong People's Hospital, China. Electronic address:

Background: Gastrointestinal (GI) difficulties are very common among children with cerebral palsy (CP) and comorbid epilepsy. GI function is influenced by dietary structure on gut microbiota. The aim of this study was to compare gut microbiota differences in two dietary groups of this population and examine whether such differences are related to GI dysfunction. Read More

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February 2021

Disease burden and direct medical costs of incident adult ADHD: A retrospective longitudinal analysis based on German statutory health insurance claims data.

Eur Psychiatry 2020 10 1;63(1):e86. Epub 2020 Oct 1.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.

Background: Adult attention-deficit/hyperactivity disorder (aADHD) is still a largely unrecognized psychiatric condition despite its strong impact on individuals' well-being. Here, we describe the healthcare situation of individuals with incident aADHD over 4 years before and 4 years after initial administrative diagnosis.

Methods: A retrospective, longitudinal cohort analysis was conducted using German claims data. Read More

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October 2020

Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy.

Acta Neuropathol 2020 11 14;140(5):659-674. Epub 2020 Aug 14.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA.

To better understand clinical and neuropathological features of TDP-43 proteinopathies, data were analyzed from autopsied research volunteers who were followed in the National Alzheimer's Coordinating Center (NACC) data set. All subjects (n = 495) had autopsy-proven TDP-43 proteinopathy as an inclusion criterion. Subjects underwent comprehensive longitudinal clinical evaluations yearly for 6. Read More

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November 2020

Trends in systemic sclerosis and systemic sclerosis-related pulmonary arterial hypertension mortality in the USA.

ERJ Open Res 2020 Apr 15;6(2). Epub 2020 Jun 15.

Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.

There are limited data nationwide on the burden of systemic sclerosis (SSc)-related mortality. We aimed to determine recent trends in SSc and SSc-related pulmonary arterial hypertension (PAH) mortality overall and across population subgroups. Using death certificate data from the National Center for Health Statistics, we computed the age-adjusted mortality rates of SSc and SSc-SSc-PAH, a lethal prevailing complication, across demographic groups, geographic regions and comorbid cardiorespiratory conditions, and used Joinpoint regression analysis to calculate the average annual percentage change (APC) in mortality. Read More

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Incidence and Classification of Nonroutine Events during Anesthesia Care.

Anesthesiology 2020 07;133(1):41-52

From the Geriatric Research Education and Clinical Center, Tennessee Valley Veterans Affairs Healthcare System, Nashville (J.S.L., J.M.S., M.B.W.) the Center for Research and Innovation in Systems Safety, Vanderbilt University Medical Center (J.S.L., J.M.S., G.W., M.S.S., E.P., M.B.W.) the Departments of Anesthesiology (all authors); Biomedical Informatics (M.B.W.) Biostatistics (M.S.S.), Vanderbilt University School of Medicine and Vanderbilt University Medical Center, Nashville, Tennessee.

Background: A nonroutine event is any aspect of clinical care perceived by clinicians or trained observers as a deviation from optimal care based on the context of the clinical situation. The authors sought to delineate the incidence and nature of intraoperative nonroutine events during anesthesia care.

Methods: The authors prospectively collected audio, video, and relevant clinical information on 556 cases at three academic hospitals from 1998 to 2004. Read More

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Pediatric Abdominal X-rays in the Acute Care Setting - Are We Overdiagnosing Constipation?

Cureus 2020 Mar 15;12(3):e7283. Epub 2020 Mar 15.

Internal Medicine, Sanford Health, Fargo, USA.

Introduction Constipation represents 3% of all office visits to pediatricians and 10% - 45% of consultations with pediatric gastroenterologists. It has been reliably established that the role of abdominal x-rays (AXR) in the diagnosis of constipation in pediatrics is limited; yet, significant overdiagnosis of constipation exists when plain abdominal x-rays are used in the acute setting for abdominal pain or to screen for other disorders. This results in loss of time, resources, exposure to unnecessary radiation, and potentially missing the primary diagnosis. Read More

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Acute Complications in Total Wrist Arthroplasty: A National Surgical Quality Improvement Program Review.

J Wrist Surg 2020 Apr 26;9(2):124-128. Epub 2019 Nov 26.

Department of Orthopaedics, William Beaumont Army Medical Center, El Paso, Texas.

 The study sought to assess the patient-based variables, surgical risk factors, and postoperative conditions associated with readmission after total wrist arthroplasty (TWA).  All patients undergoing TWA were identified from the National Surgical Quality Improvement Program dataset from 2005 to 2016. Patient demographics, medical comorbidities, surgical characteristics, and outcomes were examined to isolate predictors for readmission within 30 days postoperatively. Read More

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Surgical outcomes and prognosis of non-small-cell lung cancer in patients with chronic lung diseases: a retrospective analysis.

Eur J Cardiothorac Surg 2020 08;58(2):357-364

Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: Lung cancer treatment in patients with chronic lung diseases is challenging because postoperative care is difficult and surgical outcomes are poorer than in patients with healthy lungs. This study aimed to examine postsurgical outcomes of patients with comorbid lung diseases treated for lung cancer.

Methods: This retrospective study enrolled 1526 patients who underwent curative surgical resection for non-small-cell lung cancer at a single centre between October 2008 and April 2017. Read More

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Comorbidity Clusters and Healthcare Use in Individuals With COPD.

Respir Care 2020 Aug 3;65(8):1120-1127. Epub 2020 Mar 3.

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

Background: Individuals who share the same comorbidity profile are usually similar with regard to their disease severity, use of health care, and clinical outcomes. The identification of comorbidity clusters therefore bears prognostic information. The objective of this study was to identify and characterize comorbidity clusters in individuals with COPD in Denmark. Read More

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Influence of comorbid knee osteoarthritis on surgical outcome and sagittal spinopelvic/lower-extremity alignment in elderly patients with degenerative lumbar spondylolisthesis undergoing transforaminal lumbar interbody fusion.

J Neurosurg Spine 2020 Jan 24:1-9. Epub 2020 Jan 24.

4Department of Orthopaedic Surgery, Yokohama City University Hospital, Yokohama, Kanagawa, Japan.

Objective: This retrospective study aimed to clarify the influence of comorbid severe knee osteoarthritis (KOA) on surgical outcome in terms of sagittal spinopelvic/lower-extremity alignment in elderly patients with degenerative lumbar spondylolisthesis (DLS).

Methods: In total, 110 patients aged at least 65 years (27 men, 83 women; mean age 74.0 years) who underwent short-segment lumbar fusion were included in the present study. Read More

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January 2020

Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma.

Am J Kidney Dis 2020 07 20;76(1):63-71. Epub 2020 Jan 20.

Renal Division, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA. Electronic address:

Rationale & Objective: Cytokine release syndrome is a well-known complication of chimeric antigen receptor T-cell (CAR-T) therapy and can lead to multiorgan dysfunction. However, the nephrotoxicity of CAR-T therapy is unknown. We aimed to characterize the occurrence, cause, and outcomes of acute kidney injury (AKI), along with the occurrence of electrolyte abnormalities, among adults with diffuse large B-cell lymphoma receiving CAR-T therapy. Read More

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Carbonic anhydrase, obstructive sleep apnea and hypertension: Effects of intervention.

J Sleep Res 2020 04 6;29(2):e12956. Epub 2019 Dec 6.

Center for Sleep and Vigilance Disorders, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Whole blood carbonic anhydrase activity (CAa) is increased in patients with obstructive sleep apnea (OSA). Our study investigated the influence of positive airway pressure (PAP) or CA inhibitor acetazolamide (ACT) therapy on CAa, OSA and blood pressure. Thirty-three OSA patients (21 hypertensive, body mass index (BMI) 37 ± 7 kg/m and apnea-hypopnea index (AHI) of 47 ± 31 events/hr) were followed-up after PAP treatment (compliance, 4. Read More

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Preventive Care: How Mammography Utilization Changes as Women Age.

J Am Coll Radiol 2020 Feb 16;17(2):238-247. Epub 2019 Oct 16.

Redwood Radiology Group, Santa Rosa, California.

Objective: To evaluate the impact of comorbid conditions and age on mammography use.

Methods: We used data from the 2011 to 2015 Medical Expenditure Panel Survey, which contained records for 40,752 women over the age of 40. Use was defined as a mammogram within the previous 1 or 2 years, analyzed separately. Read More

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February 2020

Correction to: Role of Delayed Neuroglial Activation in Impaired Cerebral Blood Flow Restoration Following Comorbid Injury.

Cell Mol Neurobiol 2020 04;40(3):381-382

Department of Pathology and Laboratory Medicine, University of Western Ontario, London, N6A 5C1, Canada.

The original version of this article contained a random order of part labels for Fig. 4. The correct caption of Fig. Read More

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A Two-Interval, Forced-Choice, Observer-Based Procedure for Evaluating Hearing Sensitivity in Children With Motor and Developmental Impairments.

Am J Audiol 2019 Sep 18;28(3):714-723. Epub 2019 Jul 18.

Center for Hearing Research, Boys Town National Research Hospital, Omaha, NE.

Purpose It can be challenging to collect reliable behavioral responses to sound from individuals with significant motor or developmental impairments, the most common types of comorbid disability found in children with hearing loss (e.g., Gallaudet Research Institute, 2011). Read More

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September 2019

The effects of comorbid Tourette symptoms on distress caused by compulsive-like behavior in very young children: a cross-sectional study.

Child Adolesc Psychiatry Ment Health 2019 28;13:28. Epub 2019 Jun 28.

3Department of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan.

Background: Many children 4 to 6 years old exhibit compulsive-like behavior, often with comorbid Tourette symptoms, making this age group critical for investigating the effects of having comorbid Tourette symptoms with compulsive-like behavior. However, these effects have not yet been elucidated: it is unclear whether having comorbid tics with compulsive-like behavior leads to lower quality of life. This cross-sectional study aims to investigate the effect of comorbid Tourette symptoms on distress caused by compulsive-like behavior in very young children. Read More

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Obstetric Comorbidity and Severe Maternal Morbidity Among Massachusetts Delivery Hospitalizations, 1998-2013.

Matern Child Health J 2019 Sep;23(9):1152-1158

Massachusetts Department of Public Health, 250 Washington Street, 5th Floor, Boston, MA, 02108, USA.

Objectives: The rate of severe maternal morbidity in the United States increased approximately 200% during 1993-2014. Few studies have reported on the health of the entire pregnant population, including women at low risk for maternal morbidity. This information might be useful for interventions aimed at primary prevention of pregnancy complications. Read More

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September 2019

Clinical Characteristics of Diagnosis for Internet Gaming Disorder: Comparison of DSM-5 IGD and ICD-11 GD Diagnosis.

J Clin Med 2019 Jun 28;8(7). Epub 2019 Jun 28.

Department of Psychiatry, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Gyeonggi 11765, Korea.

The American Psychiatric Association (APA) included internet game disorder (IGD) in section III of the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) on the condition that it guaranteed more clinical research and experience. The World Health Organization (WHO) also included Game Disorder (GD) in the 11th final revision of the International Classification of Diseases (ICD-11) and recently recognized it as a diagnosis code. This study aims to compare clinical characteristics and gaming behavior patterns between the IGD diagnosis criteria proposed by the DSM-5 and the GD diagnosis criteria proposed by the ICD-11 based on clinical cohort data (c-CURE: clinic-Cohort for Understanding of internet addiction Rescue factors in Early life) obtained in the Republic of Korea. Read More

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Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases.

J Am Coll Cardiol 2019 06;73(23):2932-2942

Deutsches Herzzentrum München, Klinik für Herz und Kreislauferkrankungen, Technische Universität München, Munich, Germany; Deutsches Zentrum für Herz und Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.

Background: The taxonomy of cardiovascular (CV) diseases is divided into a broad spectrum of clinical entities. Many such diseases coincide in specific patient groups and suggest shared predisposition.

Objectives: This study focused on coronary artery disease (CAD) and investigated the genetic relationship to CV and non-CV diseases with reported CAD comorbidity. Read More

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Agreement between retrospectively assessed health-related quality of life collected 1 week and 12 months post-injury: an observational follow-up study.

Health Qual Life Outcomes 2019 Apr 23;17(1):70. Epub 2019 Apr 23.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000, CA, Rotterdam, The Netherlands.

Background: Retrospective assessment of pre-injury health-related quality of life (HRQL) is frequently used to measure change from pre- to post-injury HRQL. However, retrospective measurement may be confounded by recall bias. It is assumed that presence of recall bias is influenced by several factors, such as the measurement scale or the instrument that is used, the measurement schedule, and the presence of a substantial health event during the follow up period. Read More

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[The influence of comorbid mental disorders on quality of life in patients with chronic rhinosinusitis].

HNO 2019 Jul;67(7):534-541

Fachbereiche Psychologie und Psychotherapiewissenschaften, Siegmund-Freud-Universität Wien, Wien, Österreich.

Background: In recent years, the international literature has contained numerous reports indicating a high prevalence of depression and anxiety symptoms in patients with chronic rhinosinusitis (CRS). Measurement of subjective health-related quality of life in CRS patients, also as an assessment of treatment outcome, has received increasing attention in the past two decades.

Objective: The aim of this study was to investigate the correlation between results of screening tests for the two most frequent mental disorders in Germany and the results of the Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) in patients with CRS. Read More

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