Biochemistry 2018 02 26;57(6):1045-1053. Epub 2018 Jan 26.
Department of Chemistry and Center for Membrane Biology, University of Virginia , McCormick Road, Charlottesville, Virginia 22904, United States.
Bacterial outer membrane TonB-dependent transporters function by executing cycles of binding and unbinding to the inner membrane protein TonB. In the vitamin B transporter BtuB and the ferric citrate transporter FecA, substrate binding increases the periplasmic exposure of the Ton box, an energy-coupling segment. This increased exposure appears to enhance the affinity of the transporter for TonB. Read More