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Impact of Confinement in Patients under Long-Term Noninvasive Ventilation during the First Wave of the SARS-CoV-2 Pandemic: A Remarkable Resilience.

Respiration 2021 Jun 15:1-9. Epub 2021 Jun 15.

Division of Pulmonary Diseases, Geneva University Hospitals, Geneva, Switzerland.

Background: During the first wave of the SARS-CoV-2 pandemic in Switzerland, confinement was imposed to limit transmission and protect vulnerable persons. These measures may have had a negative impact on perceived quality of care and symptoms in patients with chronic disorders.

Objectives: To determine whether patients under long-term home noninvasive ventilation (LTHNIV) for chronic respiratory failure (CRF) were negatively affected by the 56-day confinement (March-April 2020). Read More

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BMP2 immune complexes promote new bone formation by facilitating the direct contact between osteoclasts and osteoblasts.

Biomaterials 2021 May 16;275:120890. Epub 2021 May 16.

Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China; Department of Oral Implantology, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China. Electronic address:

BMP2 antibody is proposed as a promising replacement for rhBMP2 in bone tissue engineering. Although studies have demonstrated its osteoinductive efficacy, the underlying osteogenic mechanism and adverse reactions of specific BMP2 antibody are not clarified yet, making it difficult to optimize the antibody for future application. By establishing BMP2 immune complexes (BMP2-ICs) ex vivo, we were able to introduce BMP2-ICs directly in vivo and found that BMP2-ICs promoted bone formation while suppressing osteoclastogenesis. Read More

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Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy.

Circ Heart Fail 2021 Jun 15;14(6):e008289. Epub 2021 Jun 15.

Department of Medicine (S.Z., Z.C., M.Z., S.S., C.T., Y.G., A.N., W.F., S.M.E., X.F.), University of California, San Diego, La Jolla.

Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in (), encoding a mitochondrial acyltransferase required for cardiolipin remodeling. Despite recent description of a mouse model of BTHS cardiomyopathy, an in-depth analysis of specific lipid abnormalities and mitochondrial form and function in an in vivo BTHS cardiomyopathy model is lacking.

Methods: We performed in-depth assessment of cardiac function, cardiolipin species profiles, and mitochondrial structure and function in our newly generated cardiomyocyte-specific knockout mice and Cre-negative control mice (n≥3 per group). Read More

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Palliative Care Nursing Development in the Middle East and Northeast Africa: Lessons From Oman.

J Cancer Educ 2021 Jun 15. Epub 2021 Jun 15.

School of Medicine and College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Nurses are on the frontline of palliative care, and in some countries, are the only contact for patients and families facing life-threatening illness. The Oman Cancer Association in the Sultanate of Oman, in collaboration with the Middle Eastern Cancer Consortium and the Oncology Nursing Society, led a palliative care initiative over the past decade to better integrate palliative care into the health care system. Components of this initiative include integrating palliative care into the health care curricula and providing palliative care education to over 400 nurses and other health care professionals within Oman. Read More

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Nickel Hypersensitivity to Atrial Septal Occluders: Smoke Without Fire?

Clin Rev Allergy Immunol 2021 Jun 15. Epub 2021 Jun 15.

First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece.

Nickel is one of the most common contact allergens worldwide; it is used as the main component of the devices used for atrial septal defects (ASDs) and patent foramen ovale (PFO) closure. Developing nickel hypersensitivity after PFO/ASD occlusion is significantly rarer described in medical literature than typical nickel contact sensitization. The exact pathophysiological mechanism of this "device syndrome" remains unknown, and many question the real incidence or even the existence of this clinical entity. Read More

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Phenotypic spectrum and mechanism analysis of Schaff Yang syndrome: A case report on new mutation of MAGEL2 gene.

Medicine (Baltimore) 2021 Jun;100(24):e26309

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University.

Rationale: The Schaaf-Yang syndrome (SYS) is an autosomal dominant multi-system genetic disease caused by melanoma antigen L2 (MAGEL2) gene mutations imprinted by mothers and expressed by fathers on the 15q11-15q13 chromosomes in the critical region of Prader-Willi. MAGEL2 is a single exon gene and one of the protein-coding genes of the Prader-Willi domain. MAGEL2 is a matrilineal imprinted gene (i. Read More

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Developing a Framework for Pandemic COVID-19 Vaccine Allocation: a Modified Delphi Consensus Study in Korea.

J Korean Med Sci 2021 Jun 14;36(23):e166. Epub 2021 Jun 14.

Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: This study presents a framework for determining the allocation and distribution of the limited amount of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: After analyzing the pandemic strategies of the major organizations and countries and with a literature review conducted by a core panel, a modified Delphi survey was administered to 13 experts in the fields of vaccination, infectious disease, and public health in the Republic of Korea. The following topics were discussed: 1) identifying the objectives of the vaccination strategy, 2) identifying allocation criteria, and 3) establishing a step-by-step vaccination framework and prioritization strategy based on the allocation criteria. Read More

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Use of Soft Contact Lens for Esthetic and Functional Rehabilitation.

Eye Contact Lens 2021 07;47(7):383-387

Eye Department of Contat lenses (P.P.Y. and V.F.S.), Hospital Sadalla Amin Ghanem, Joinville, SC, Brazil; Department of Ophthalmology (S.A.S.), Medical School, State University of Sao Paulo-UNESP, Botucatu, SP, Brazil; and Department of Biostatistic (C.R.P.), Biosciences Institute, State University of Sao Paulo-UNESP, Botucatu, SP, Brazil.

Objective: To report the outcomes and complications of colored soft contact lenses (SCLs) to improve esthetic or eye function in visually impaired (VI) or blind patients.

Methods: This retrospective study enrolled consecutive patients with unilateral or bilateral VI or blindness who had received colored SCLs to improve appearance or ocular function. Data were collected on demographics, complaints, complete ophthalmological examinations, types of SCL, follow-ups, and complications. Read More

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Three-dimensional structure of testis cords in mice and rats.

Andrology 2021 Jun 14. Epub 2021 Jun 14.

Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Background: Testis cord elongation and coiling, which occur in the final stage of testis formation, have been attributed to Sertoli cell proliferation; however, the underlying mechanisms remain unclear.

Objective: The aim of the present study was to clarify the precise three-dimensional (3D) structure of testis cords in the final stage of testis formation in mice and rats.

Materials And Methods: We reconstructed whole testis cords in the final stage of testis formation in mice (on embryonic day (E) 15. Read More

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Social dialogue triggers biobehavioral synchrony of partners' endocrine response via sex-specific, hormone-specific, attachment-specific mechanisms.

Sci Rep 2021 Jun 14;11(1):12421. Epub 2021 Jun 14.

Center for Developmental Social Neuroscience, Interdisciplinary Center Herzliya, Herzliya, Israel.

Social contact is known to impact the partners' physiology and behavior but the mechanisms underpinning such inter-partner influences are far from clear. Guided by the biobehavioral synchrony conceptual frame, we examined how social dialogue shapes the partners' multi-system endocrine response as mediated by behavioral synchrony. To address sex-specific, hormone-specific, attachment-specific mechanisms, we recruited 82 man-woman pairs (N = 164 participants) in three attachment groups; long-term couples (n = 29), best friends (n = 26), and ingroup strangers (n = 27). Read More

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Thermal injury induces early blood vessel occlusion in a porcine model of brass comb burn.

Sci Rep 2021 Jun 14;11(1):12457. Epub 2021 Jun 14.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0647, USA.

Burn wound progression is an important determinant of patient morbidity and mortality after injury. In this study, we used the brass comb contact burn to determine burn wound vertical injury progression with a focus on blood vessel occlusion and endothelial cell death. Class A 3-month-old Yorkshire pigs received a brass comb contact burn. Read More

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SARS-CoV-2 infection and transmission in the North American deer mouse.

Nat Commun 2021 06 14;12(1):3612. Epub 2021 Jun 14.

Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.

Widespread circulation of SARS-CoV-2 in humans raises the theoretical risk of reverse zoonosis events with wildlife, reintroductions of SARS-CoV-2 into permissive nondomesticated animals. Here we report that North American deer mice (Peromyscus maniculatus) are susceptible to SARS-CoV-2 infection following intranasal exposure to a human isolate, resulting in viral replication in the upper and lower respiratory tract with little or no signs of disease. Further, shed infectious virus is detectable in nasal washes, oropharyngeal and rectal swabs, and viral RNA is detectable in feces and occasionally urine. Read More

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Approach to allergic contact dermatitis caused by topical medicaments.

Can Fam Physician 2021 Jun;67(6):414-419

Medical Director of the Contact Dermatitis Clinic at St Paul's Hospital in Vancouver.

Objective: To provide an approach to identifying topical medicament ingredients that cause allergic contact dermatitis (ACD) and to recognizing common clinical scenarios in which these ingredients might present.

Sources Of Information: A retrospective chart review was conducted of patients patch tested at the Contact Dermatitis Clinic at St Paul's Hospital in Vancouver, BC, between November 2016 and June 2019. Data from the North American Contact Dermatitis Group from 2015 to 2016 and The Ottawa Hospital patch test clinic from 2000 to 2010 were also reviewed. Read More

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The link between social and emotional isolation and dementia in older black and white Brazilians.

Int Psychogeriatr 2021 Jun 15:1-7. Epub 2021 Jun 15.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Objective: To examine the link between social and emotional isolation and likelihood of dementia among older black and white Brazilians.

Design: Cross-sectional clinical-pathological cohort study.

Setting: Medical center in Sao Paulo, Brazil. Read More

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Evidence Based Approach to Capacity Assessment for Hospitalized Patients.

CNS Spectr 2021 Apr;26(2):150

Creighton University, Omaha, NE, USA.

Medical decision-making capacity (MDMC) is inherent to the legal and ethical principles of respect for autonomy and is an essential element of informed consent. Qualitative and quantitative evidence to support a final decision of capacity should be the gold standard. General hospital policies and state laws mandate that a licensed provider make the final determination of capacity, but they do not specifically mandate who is responsible for those assessments. Read More

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Parental risk factors for congenital diaphragmatic hernia - a large German case-control study.

BMC Pediatr 2021 Jun 14;21(1):278. Epub 2021 Jun 14.

Department of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, Germany.

Background: Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns.

Methods: The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. Read More

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Impact of acute total occlusion of the culprit artery on outcome in NSTEMI based on the results of a large national registry.

BMC Cardiovasc Disord 2021 Jun 14;21(1):297. Epub 2021 Jun 14.

Jagiellonian University Medical College, 1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jakubowskiego St. 2, 30-688, Kraków, Poland.

Background: The impact of acute total occlusion (TO) of the culprit artery in non-ST-segment elevation myocardial infarction (NSTEMI) is not fully established. We aimed to evaluate the clinical and angiographic phenotype and outcome of NSTEMI patients with TO (NSTEMI) compared to NSTEMI patients without TO (NSTEMI) and those with ST-segment elevation and TO (STEMI).

Methods: Demographic, clinical and procedure-related data of patients with acute myocardial infarction who underwent percutaneous coronary intervention (PCI) between 2014 and 2017 from the Polish National Registry were analysed. Read More

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Criminal Legal Involvement: A Cause and Consequence of Social Determinants of Health.

Psychiatr Serv 2021 Jun 15:appips202000741. Epub 2021 Jun 15.

Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, New York City (Rotter); Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York City (Compton). Ruth S. Shim, M.D., M.P.H., and Michael T. Compton, M.D., M.P.H., are editors of this column.

The overrepresentation of people of color and individuals with serious mental illnesses across all levels of the criminal legal system results from the effects of social and economic forces, including social determinants of health and behavioral health, as well as systemic racism. Conversely, criminal legal contact creates and exacerbates these social stresses, with associated consequences to general medical and behavioral health. In this column, the authors explore the relationship between social determinants of health and criminal legal contact through the lens of recent literature on criminal recidivism and describe the ways in which criminal legal contact is itself a social determinant that drives mental health outcomes. Read More

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Enzymes in a golden cage.

Chem Sci 2020 Mar 28;11(15):3965-3977. Epub 2020 Mar 28.

Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem Jerusalem 9190401 Israel

We describe a general method for the entrapment of enzymes within bulk metallic gold. This is a new approach for the immobilization of enzymes on metals, which is commonly carried out by 2D adsorption or covalent biding, that is, the enzyme is in contact with the metal at a specific contact zone of the enzyme, while most of the rest of it remains exposed to the environment. The 3D metallic encaging of the enzymes is quite different: the enzyme is in contact with the metallic cage walls all around it and is well protected inside. Read More

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The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds.

J Biol Chem 2021 Jun 11:100871. Epub 2021 Jun 11.

Department of Medical Biochemistry, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Mucus forms an important protective barrier that minimizes bacterial contact with the colonic epithelium. Intestinal mucus is organized in a complex network with several specific proteins, including the mucin MUC2 and the as abundant IgG Fc-binding protein, FCGBP. FCGBP is expressed in all intestinal goblet cells and is secreted into the mucus. Read More

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COVID-19 and long-term care facilities in Mexico: a debt that cannot be postponed.

Gac Med Mex 2021 ;157(1):94-96

General Management Office, Instituto Nacional de Geriatría, Mexico City, Mexico.

Since the emergence of the COVID-19 pandemic, the most affected population group has been that of older people living in long-term care facilities (LTCFs), which has accumulated between 30 and 60 % of total number of deaths in the world. In Mexico, outbreaks have been reported in LTCFs of at least eight states. Various factors make this population group and LTCFs susceptible to COVID-1 outbreaks, mainly due to coexistence in common spaces, shared bedrooms and permanent physical contact with the personnel who work there, coupled with a lack of protocols and standards of care of mandatory observance, as well as personnel training limitations. Read More

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January 2021

The contact system in liver injury.

Semin Immunopathol 2021 Jun 14. Epub 2021 Jun 14.

Institute of Clinical Chemistry and Laboratory Medicine (O26), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany.

Coagulation is controlled by a delicate balance of prothrombotic and antithrombotic mechanisms, to prevent both excessive blood loss from injured vessels and pathologic thrombosis. The liver plays a pivotal role in hemostasis through the synthesis of plasma coagulation factors and their inhibitors that, in addition to thrombosis and hemostasis, orchestrates an array of inflammatory responses. As a result, impaired liver function has been linked with both hypercoagulability and bleeding disorders due to a pathologic balance of pro- and anticoagulant plasma factors. Read More

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North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):16

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Purpose: North Carolina macular dystrophy (NCMD) is an autosomal dominant, congenital disorder affecting the central retina. Here, we report clinical and genetic findings in three families segregating NCMD and use epigenomic datasets from human tissues to gain insights into the effect of NCMD-implicated variants.

Methods: Clinical assessment and genetic testing were performed. Read More

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Prevalence of Nonheterosexual Identity and Same-Sex Sexual Contact Among High School Students in the US From 2015 to 2019.

JAMA Pediatr 2021 Jun 14. Epub 2021 Jun 14.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

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Help-seeking behaviour and subsequent patient and system delays in stroke.

Acta Neurol Scand 2021 Jun 14. Epub 2021 Jun 14.

Research Unit for General Practice, Aarhus C, Denmark.

Objectives: Prehospital delay is the main reason why only a limited number of stroke patients receive reperfusion therapy. We aimed to investigate help-seeking behaviour in patients and bystanders after onset of stroke and subsequent patient and system delay.

Materials & Methods: We conducted a cross-sectional study of 332 patients with stroke. Read More

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Maternity ward staff perceptions of exclusive breastfeeding in Finnish maternity hospitals: A cross-sectional study.

Eur J Midwifery 2021 31;5:16. Epub 2021 May 31.

Lapland University of Applied Sciences, Lapland, Finland.

Introduction: This study aimed to describe exclusive breastfeeding (EBF, Step 6 of the Baby-Friendly Hospital Initiative) in Finnish maternity hospitals and identify factors that promote or limit EBF.

Methods: A cross-sectional study design was used, and data were collected from eight maternity hospitals in Finland during a 10-day period in May 2014. The staff completed questionnaires (n=1554) from separate work shifts. Read More

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Worries, Preparedness, and Perceived Impact of Covid-19 Pandemic on Nurses' Mental Health.

Front Public Health 2021 26;9:566700. Epub 2021 May 26.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

In times of global public health emergency, such as the COVID-19 pandemic, nurses stand at the front line, working in close contact with infected individuals. Being actively engaged in fighting against COVID-19 exposes nurses to a high risk of being infected but can also have a serious impact on their mental health, as they are faced with excessive workload and emotional burden in many front-line operating contexts. The aim of the study is to analyze how risk factors such as perceived impact, preparedness to the pandemic, and worries were associated with mental health outcomes (crying, rumination and stress) in nurses. Read More

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Patient satisfaction with the emergency department services at an academic teaching hospital.

J Family Med Prim Care 2021 Apr 29;10(4):1718-1725. Epub 2021 Apr 29.

Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Introduction: Healthcare reform efforts focus on patient-centered care is measured by patient satisfaction. Emergency department (ED) satisfaction ratings are often the lowest. Since ED is the first point of contact for the patient care to receive primary care, we aimed to explore patient satisfaction related to ED healthcare services at our institution. Read More

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Micro-computed tomographic evaluation of single-cone obturation with three sealers.

Restor Dent Endod 2021 May 16;46(2):e25. Epub 2021 Apr 16.

University of New England College of Dental Medicine, Portland, ME, USA.

Objectives: This study used micro-computed tomography (µCT) to compare voids and interfaces in single-cone obturation among AH Plus, EndoSequence BC, and prototype surface pre-reacted glass ionomer (S-PRG) sealers and to determine the percentage of sealer contact at the dentin and gutta-percha (GP) interfaces.

Materials And Methods: Fifteen single-rooted human teeth were shaped using ProTaper NEXT size X5 rotary files using 2.5% NaOCl irrigation. Read More

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Workplace Violence Among Healthcare Workers in a Tertiary Medical City in Riyadh: A Cross-Sectional Study.

Cureus 2021 May 4;13(5):e14836. Epub 2021 May 4.

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.

Introduction Workplace violence is a common problem that is encountered by healthcare workers worldwide; however, it is still under-studied in Saudi Arabia. This study aims to determine the prevalence of workplace violence and to explore reasons for not reporting it among healthcare workers in a tertiary medical city in Riyadh. Methods This cross-sectional study was conducted among 404 healthcare workers who had direct contact with patients or their relatives in a tertiary care medical city in Riyadh, Saudi Arabia. Read More

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