234,832 results match your criteria constructed saliency

"Under great anxiety": Pregnancy experiences of Vietnamese women with physical disabilities seen through an intersectional lens.

Soc Sci Med 2021 Jul 15;284:114231. Epub 2021 Jul 15.

Institute for Community Health Research, Hue University, Hue, 47000, Viet Nam; Australian Centre for Health Law Research, Faculty of Business and Law, Queensland University of Technology, Brisbane, 4059, Australia.

Background: There is scant research on pregnancy experiences of women with physical disabilities in low and middle-income countries. This qualitative study used an intersectional lens to explore pregnancy experiences of women with physical disabilities in northern Vietnam. Specifically, socio-cultural, economic, and environmental influences were analysed, drawing upon their lived experiences. Read More

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A new strategy for the development of efficient impedimetric tobramycin aptasensors with metallo-covalent organic frameworks (MCOFs).

Food Chem 2021 Jul 12;366:130575. Epub 2021 Jul 12.

College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, PR China. Electronic address:

Two bimetallic CoNi-based metallo-covalent organic frameworks (MCOFs) were prepared and explored as the sensitive platforms of impedimetric aptasensors for efficient detection of tobramycin (TOB). The two CoNi-MCOFs were constructed using metallophthalocyanine tetra-amine (MPc-TA, M = Co or Ni) and 4,4'-(1,10-phen-anthroline-2,9-diyl) dibenzaldehyde (PTD) as building units and further coordinating to the secondary metal ions (Ni or Co) by phenanthroline. Interestingly, the immobilization ability of CoPc-TA-PTD(Ni) to TOB-targeted aptamer is higher than that of NiPc-TA-PTD(Co) due to its stronger binding interactions to aptamer. Read More

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Associations of genetically predicted circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with bladder cancer risk.

Mol Carcinog 2021 Jul 22. Epub 2021 Jul 22.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Insulin-like growth factors (IGF) play important roles in carcinogenesis. The associations of circulating IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3) with the risks of bladder cancer remain unclear. In this large case control study of 2011 bladder cancer cases and 2369 heathy controls, we assessed the associations of circulating IGF-1 and IGFBP-3 with bladder cancer risks using a Mendelian randomization approach, which uses genetic variants as instruments to study causal relationship between risk factors and diseases. Read More

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Identification of microRNA-like RNAs from Trichoderma asperellum DQ-1 during its interaction with tomato roots using bioinformatic analysis and high-throughput sequencing.

PLoS One 2021 22;16(7):e0254808. Epub 2021 Jul 22.

Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests (Hainan University), Ministry of Education, Haikou, Hainan, PR China.

MicroRNA-like small RNAs (milRNAs) and their regulatory roles in the interaction between plant and fungus have recently aroused keen interest of plant pathologists. Trichoderma spp., one of the widespread biocontrol fungi, can promote plant growth and induce plant disease resistance. Read More

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Research on efficiency measurement and spatiotemporal disparity of rural public health services in China.

PLoS One 2021 22;16(7):e0252871. Epub 2021 Jul 22.

College of Public Management & Law, Hunan Agricultural University, Changsha, Hunan, China.

Objective: Based on the rural public health services of 29 regions in China, a service efficiency evaluation index system consisting of input and output dimensions was constructed, and the coupling, coordination and disparity efficiencies of rural public health services in China were studied, providing information to redress the imbalance in the interregional coordinated development.

Methods: The efficiency, spatiotemporal disparity pattern, spatial correlation and evolutionary trend of the coordinated development of rural public health services of 29 regions in China from 2004 to 2018 were analyzed using efficiency and spatial analysis methods such as Data Envelopment Analysis (DEA), kernel density estimation and Moran's Ⅰ analysis.

Result: Nowadays, there are problems of unbalanced and insufficient development between the fields and regions in the development of rural public health services in China. Read More

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A Framework for the Use of Biological Medicines in the Free State Province, South Africa.

Pharmacoepidemiol Drug Saf 2021 Jul 22. Epub 2021 Jul 22.

Department of Biostatistics, University of the Free State, Bloemfontein, South Africa.

Purpose: The use of biological medicines (BM) has increased worldwide owing to their effectiveness in the treatment of many chronic diseases. However, in South Africa, access to BM remains limited, hence, there is a need to develop strategies that will enable timely access to BM by all patients who need them.

Objective: To develop a framework for the use of BM in South Africa. Read More

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Using Deep Learning Segmentation for Endotracheal Tube Position Assessment.

J Thorac Imaging 2021 Jul 21. Epub 2021 Jul 21.

Sidney Kimmel Medical College, Thomas Jefferson University Department of Radiology, Thomas Jefferson University Hospital, Sidney Kimmel Jefferson Medical College, Philadelphia, PA.

Purpose: The purpose of this study was to determine the efficacy of using deep learning segmentation for endotracheal tube (ETT) position on frontal chest x-rays (CXRs).

Materials And Methods: This was a retrospective trial involving 936 deidentified frontal CXRs divided into sets for training (676), validation (50), and 2 for testing (210). This included an "internal test" set of 100 CXRs from the same institution, and an "external test" set of 110 CXRs from a different institution. Read More

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Contemporary psychological perspectives of personality disorders.

Curr Opin Psychiatry 2021 Jul 20. Epub 2021 Jul 20.

Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia.

Purpose Of Review: The aim of this study was to review the recent literature on contemporary psychological perspectives of personality disorders, including novel psychotherapeutic interventions aimed at these vulnerable individuals.

Recent Findings: Among the various psychological theories and models of personality disorders, still the most popular and researched are psychodynamic, cognitive and interpersonal perspectives. More specifically, object relations theory, cognitive schema conceptualization and interpersonal circumplex model have produced the most empirical investigations of personality disorders in recent years. Read More

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Factors associated with sports participation amongst people with spinal cord injury in a Malaysian tertiary hospital.

J Spinal Cord Med 2021 Jul 22:1-8. Epub 2021 Jul 22.

Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Objective: To identify factors that are associated with sports participation following spinal cord injury (SCI).

Study Design: Case-control study.

Setting: Spinal Rehabilitation outpatient clinic in a tertiary hospital in Kuala Lumpur, Malaysia. Read More

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Needle-based confocal laser endomicroscopy for diagnosis of pancreatic cystic lesions: a meta-analysis.

Minim Invasive Ther Allied Technol 2021 Jul 22:1-11. Epub 2021 Jul 22.

Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, China.

Background And Aim: The role of needle-based confocal laser endomicroscopy (nCLE) in the diagnosis of pancreatic cystic lesions (PCLs) remains controversial. This study aimed to systematically evaluate the diagnostic accuracy and adverse effects of nCLE in the detection of pathological subtypes in patients with PCLs.

Material And Methods: We conducted a comprehensive literature search using MEDLINE, EMBASE, and Cochrane for identifying studies that reported the use of nCLE for PCLs diagnosis (dated prior to 10 October 2020). Read More

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Testing potential mechanisms underlying test-potentiated new learning.

J Exp Psychol Learn Mem Cogn 2021 Jul 22. Epub 2021 Jul 22.

Division of Psychology and Language Sciences.

An emerging body of studies demonstrates that practicing retrieval of studied information, by comparison with restudying or no treatment, can facilitate subsequent learning and retrieval of new information, a phenomenon termed the (FTE) or . Several theoretical explanations have been proposed to account for the FTE. A release-from-PI theory proposes that interpolated testing induces context changes and enhances event segregation, which in turn protect new learning from proactive interference (PI). Read More

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Electrochemical Radical δ-H Sulfonylation Reaction for the Synthesis of 4-((Aryl,Arylsul fonyl)methylene)-2,5-Cyclohexadiene Derivatives.

J Org Chem 2021 Jul 22. Epub 2021 Jul 22.

Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116, People's Republic of China.

A novel and efficient electrochemical radical δ-H sulfonylation reaction of -quinone methides (-QMs) and sodium sulfinates has been achieved under common laboratory conditions. In this strategy, a new C(sp)-S bond was constructed for the synthesis of 4-((aryl,arylsulfonyl)methylene)-2,5-cyclohexadiene derivatives with a broad substrate scope, good functional group tolerance, and mild conditions. Further studies showed that the reaction had an excellent regional selectivity. Read More

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Conceptual Developments of Aryldiazonium Salts as Modifiers for Gold Colloids and Surfaces.

Langmuir 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, College of Sciences, University of Sharjah, Sharjah 27272, UAE.

Modified colloids and flat surfaces occupy an important place in materials science research due to their widespread applications. Interest in the development of modifiers that adhere strongly to surfaces relates to the need for stability under ambient conditions in many applications. Diazonium salts have evolved as the primary choice for the modification of surfaces. Read More

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Highly Selective Entrapment of His-Tagged Enzymes on Superparamagnetic Zirconium-Based MOFs with Robust Renewability to Enhance pH and Thermal Stability.

ACS Biomater Sci Eng 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

Metal-organic frameworks (MOFs), as a kind of poriferous nanoparticle, are promising candidates for enzyme immobilization to enhance their stability and reusability. However, most MOFs could not specifically immobilize enzymes and regenerate easily, which inevitably leads to serious high consumption and environmental pollution. In this study, renewable and magnetic MOFs were first constructed to specially immobilize His-tagged enzymes from the cell lysates without purification. Read More

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Effect of gene mutation of plants on their mechano-sensibility: the mutant of influences the buckling of trichomes.

Analyst 2021 Jul 22. Epub 2021 Jul 22.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China. and Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China.

With the development of molecular biology, more and more mutants of plants have been constructed, where gene mutants have been found to influence not only the biological processes but also biophysical behaviors of plant cells. Trichomes are an important appendage, which has been found to act as an active mechanosensory switch transducing mechanical signals into physiology changes, where the mechanical property of trichomes is vital for such functions. Up to now, over 40 different genes have been found with the function of regulating trichome cell morphogenesis; however, the effect of gene mutants on trichome mechanosensory function remains elusive. Read More

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Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle.

Drug Deliv 2021 Dec;28(1):1585-1593

Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan.

We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type immune induction after subcutaneous administration. For prophylaxis of respiratory infections, however, mucosal immunity should be induced. In this study, we investigated the effect of pulmonary administration of a nanoparticle comprising ovalbumin (OVA) as a model antigen, BK, and γ-PGA on induction of mucosal immunity in the lungs and serum. Read More

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December 2021

Talking about chronic pain: Misalignment in discussions of the body, mind and social aspects in pain clinic consultations.

Jana Declercq

Health (London) 2021 Jul 22:13634593211032875. Epub 2021 Jul 22.

University of Groningen, Netherlands.

In Western societies, human existence and illness are mostly constructed from the perspective of mind-body dualism: body and mind are considered to function independently, and the body/the physical as primary and more real. Research shows, however, that mind-body dualism is no longer tenable, especially in healthcare contexts. This led to the rise the biopsychosocial model, in which bodily experiences, including illness, are seen an interplay of the physical and the psychological, and the social. Read More

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Development and validation of an immune gene set-based prognostic signature in cutaneous melanoma.

Future Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

We aimed to fully understand the landscape of the skin cutaneous melanoma (SKCM) microenvironment and develop an immune prognostic signature that can predict the prognosis for SKCM patients. RNA sequencing data and clinical information were downloaded from the Cancer Genome Atlas and Gene Expression Omnibus databases. The immune-prognostic signature was constructed by LASSO Cox regression analysis. Read More

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Cathode-Anode Spatial Division Photoelectrochemical Platform Based on a One-Step DNA Walker for Monitoring of miRNA-21.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P.R. China.

Photoelectrochemical (PEC) biosensors carried out the whole reaction process in the same solution, which would limit the sensitivity and selectivity of detection in the sensing system. Herein, we reported a promising new cathode-anode spatial division PEC platform based on the two-electrode synergistic enhancement strategy. With the photoanode and photocathode integrated in the same current circuit, the platform exhibited an increased photocurrent response, as well as an improved anti-interference ability led by separating the two electrodes spatially. Read More

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Elabela gene therapy promotes angiogenesis after myocardial infarction.

J Cell Mol Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

This study was aimed at investigating whether Elabela (ELA) gene therapy can promote angiogenesis in the treatment of myocardial infarction (MI). The fusion expression plasmid pAAV-3 × Flag/ELA-32 was successfully constructed using molecular cloning technique. The model of acute MI was established by ligating the left anterior descending coronary artery in mice. Read More

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Cardiac surgery simulation: A low-cost feasible option in an Australasian setting.

ANZ J Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Cardiothoracic Surgery, Waikato Cardiothoracic Surgery Unit, Hamilton, New Zealand.

Background: Simulation training is a useful adjunct to surgical training and education (SET) in Cardiothoracic Surgery yet training opportunities outside the Royal Australasian College of Surgery or industry-sponsored workshops are rare due to high cost and limited training faculty, time, assessment tools or structured curricula. We describe our experience in establishing a low-cost cardiac simulation programme.

Methods: We created low-cost models using hospital facilities, hardware stores, abattoirs and donations from industry. Read More

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Accurate prediction and genome-wide association analysis of digital intramuscular fat content in longissimus muscle of pigs.

Anim Genet 2021 Jul 21. Epub 2021 Jul 21.

National Key Laboratory for Swine Genetic Improvement and Production Technology, Ministry of Science and Technology of China, Jiangxi Agricultural University, Nanchang, Jiangxi Province, 330045, China.

Intramuscular fat (IMF) content is a critical indicator of pork quality that affects directly the purchasing desire of consumers. However, to measure IMF content is both laborious and costly, preventing our understanding of its genetic determinants and improvement. In the present study, we constructed an accurate and fast image acquisition and analysis system, to extract and calculate the digital IMF content, the proportion of fat areas in the image (PFAI) of the longissimus muscle of 1709 animals from multiple pig populations. Read More

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A rapid and nondestructive approach for forensic identification of cigarette inner liner papers using shift-excitation Raman difference spectroscopy and chemometrics.

J Forensic Sci 2021 Jul 22. Epub 2021 Jul 22.

Nanjing Jianzhi Instrument and Equipment Co Ltd, Nanjing, China.

In forensic science, cigarettes are considered as crucial physical evidence because it helps to establish the connection between the criminal and the crime scene. In the present study, SERDS has been used for the examination of 25 different brands or series of cigarette inner liner paper. The discrimination power is calculated by using three methods, i. Read More

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A single nucleotide polymorphism electrochemical sensor based on DNA-functionalized Cd-MOFs-74 as cascade signal amplification probes.

Mikrochim Acta 2021 Jul 21;188(8):266. Epub 2021 Jul 21.

College of Chemistry and Chemical Engineering, Yunnan Normal University, Yunnan, Kunming, 650500, People's Republic of China.

An ultrasensitive electrochemical sensor has been constructed for the detection of single nucleotide polymorphisms (SNPs) based on DNA-functionalized Cd-MOFs-74 as cascade signal amplification probe under enzyme-free conditions. Interestingly, the introduction of an auxiliary probe did not disturb the detection of SNP targets, but could bind more Cd-MOFs-74 signal elements to enhance the different pulse voltammetry electrochemical signal 2~3 times as compared to sensing system without auxiliary probe, which obviously improves the sensitivity of the proposed sensor. Experimental results taking p53 tumor suppressor gene as SNP model demonstrated that the proposed method can be employed to sensitively and selectively detect target p53 gene fragment with a linear response ranging from 0. Read More

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Development of a predictive model for extragastric recurrence after curative resection for early gastric cancer.

Gastric Cancer 2021 Jul 21. Epub 2021 Jul 21.

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Background: Stratification of patients who undergo curative resection for early gastric cancer (EGC) is warranted due to the heterogeneity in the risk of developing extragastric recurrence (EGR). Therefore, we aimed to stratify the need for postoperative surveillance for EGR detection in patients with EGC by developing a model for predicting EGR-free survival.

Methods: This retrospective cohort study included patients who underwent postoperative surveillance after curative resection of EGC (n = 4149). Read More

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Codependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data.

Nucleic Acids Res 2021 Jul 22. Epub 2021 Jul 22.

Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Single-cell RNA-seq (scRNA-seq) can be used to characterize cellular heterogeneity in thousands of cells. The reconstruction of a gene network based on coexpression patterns is a fundamental task in scRNA-seq analyses, and the mutual exclusivity of gene expression can be critical for understanding such heterogeneity. Here, we propose an approach for detecting communities from a genetic network constructed on the basis of coexpression properties. Read More

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Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs.

Front Vet Sci 2021 5;8:702821. Epub 2021 Jul 5.

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.

Thrombosis is common in critically ill dogs and causes considerable morbidity and mortality. The direct factor Xa inhibitor apixaban is safe, efficacious, and convenient in humans. This study aimed to determine the pharmacokinetics (PK), bioactivity, protein binding, and bioavailability of apixaban following intravenous (IV) and oral (PO) administration to healthy dogs. Read More

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EMERGE Modular Robot: A Tool for Fast Deployment of Evolved Robots.

Front Robot AI 2021 5;8:699814. Epub 2021 Jul 5.

REAL Lab, IT University of Copenhagen, Copenhagen, Denmark.

This work presents a platform for evolution of morphology in full cycle reconfigurable hardware: The EMERGE (Easy Modular Embodied Robot Generator) modular robot platform. Three parts necessary to implement a full cycle process, i.e. Read More

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An Immune-Gene-Based Classifier Predicts Prognosis in Patients With Cervical Squamous Cell Carcinoma.

Front Mol Biosci 2021 5;8:679474. Epub 2021 Jul 5.

Department of Gynecology and Obstetrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Immunity plays a vital role in the human papilloma virus (HPV) persistent infection, and closely associates with occurrence and development of cervical squamous cell carcinoma (CSCC). Herein, we performed an integrated bioinformatics analysis to establish an immune-gene signature and immune-associated nomogram for predicting prognosis of CSCC patients. The list of immunity-associated genes was retrieved from ImmPort database. Read More

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A Novel Ferroptosis-Related Biomarker Signature to Predict Overall Survival of Esophageal Squamous Cell Carcinoma.

Front Mol Biosci 2021 5;8:675193. Epub 2021 Jul 5.

Cardiovascular Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Esophageal squamous cell carcinoma (ESCC) accounts for the main esophageal cancer (ESCA) type, which is also associated with the greatest malignant grade and low survival rates worldwide. Ferroptosis is recently discovered as a kind of programmed cell death, which is indicated in various reports to be involved in the regulation of tumor biological behaviors. This work focused on the comprehensive evaluation of the association between ferroptosis-related gene (FRG) expression profiles and prognosis in ESCC patients based on The Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Read More

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