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Demographic and social determinants of cognitive dysfunction following hospitalization for COVID-19.

J Neurol Sci 2022 Jan 7:120146. Epub 2022 Jan 7.

Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address:

Background: Persistent cognitive symptoms have been reported following COVID-19 hospitalization. We investigated the relationship between demographics, social determinants of health (SDOH) and cognitive outcomes 6-months after hospitalization for COVID-19.

Methods: We analyzed 6-month follow-up data collected from a multi-center, prospective study of hospitalized COVID-19 patients. Read More

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January 2022

Development and validation of a risk nomogram for postoperative acute kidney injury in older patients undergoing liver resection: a pilot study.

BMC Anesthesiol 2022 Jan 13;22(1):22. Epub 2022 Jan 13.

Medical School of Chinese PLA, 28th Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Postoperative acute kidney injury (AKI) is associated with poor clinical outcomes. Early identification of high-risk patients of developing postoperative AKI can optimize perioperative renal management and facilitate patient survival. The present study aims to develop and validate a nomogram to predict postoperative AKI after liver resection in older patients. Read More

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January 2022

Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells.

Int Immunopharmacol 2022 Jan 10;104:108521. Epub 2022 Jan 10.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

CD4+T cell-mediated acute rejection remains a major factor that affects the early survival of transplanted organs post-transplantation. Here, we reveal that nuclear receptor subfamily 4 Group A member 1 (Nr4A1) was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+T cells. Nr4A1 acts as a transcription factor with an important role in CD4+T cell apoptosis, differentiation and T cell dysfunction, which indicates that Nr4A1 may play a critical role in transplant rejection. Read More

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January 2022

Risk for Newly Diagnosed Diabetes >30 Days After SARS-CoV-2 Infection Among Persons Aged <18 Years - United States, March 1, 2020-June 28, 2021.

MMWR Morb Mortal Wkly Rep 2022 Jan 14;71(2):59-65. Epub 2022 Jan 14.

The COVID-19 pandemic has disproportionately affected people with diabetes, who are at increased risk of severe COVID-19.* Increases in the number of type 1 diabetes diagnoses (1,2) and increased frequency and severity of diabetic ketoacidosis (DKA) at the time of diabetes diagnosis (3) have been reported in European pediatric populations during the COVID-19 pandemic. In adults, diabetes might be a long-term consequence of SARS-CoV-2 infection (4-7). Read More

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January 2022

The effect of the GoodSAM volunteer first-responder app on survival to hospital discharge following out-of-hospital cardiac arrest.

Eur Heart J Acute Cardiovasc Care 2022 Jan;11(1):20-31

Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.

Aims: Bystander cardiopulmonary resuscitation and defibrillation can double survival to hospital discharge in out-of-hospital cardiac arrest. Mobile phone applications, such as GoodSAM, alerting nearby volunteer first-responders about out-of-hospital cardiac arrest could potentially improve bystander cardiopulmonary resuscitation and defibrillation, leading to better patient outcomes. The aim of this study was to determine GoodSAM's effect on survival to hospital discharge following out-of-hospital cardiac arrest. Read More

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January 2022

Cost-effectiveness of thrombectomy in patients with minor stroke and large vessel occlusion: effect of thrombus location on cost-effectiveness and outcomes.

J Neurointerv Surg 2022 Jan 12. Epub 2022 Jan 12.

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA

Background: To evaluate the cost-effectiveness of endovascular thrombectomy (EVT) to treat large vessel occlusion (LVO) in patients with acute, minor stroke (National Institute of Health Stroke Scale (NIHSS) <6) and impact of occlusion site.

Methods: A Markov decision-analytic model was constructed accounting for both costs and outcomes from a societal perspective. Two different management strategies were evaluated: EVT and medical management. Read More

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January 2022

Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltration.

Aging (Albany NY) 2022 Jan 11;14(undefined). Epub 2022 Jan 11.

Ministry of Education Key Laboratory of Molecular and Cellular Biology, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050024, China.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread around the world and became a global pandemic in 2020. One promising drug target for SARS-CoV-2 is the transmembrane protease serine 2 (TMPRSS2). This study was designed to explore the expression status, prognostic significance and molecular functions of TMPRSS2 in lung cancer. Read More

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January 2022

Long-Term Outcomes for Patients With Acute Coronary Syndrome and Nonvalvular Atrial Fibrillation.

Am J Cardiol 2022 Jan 7. Epub 2022 Jan 7.

Division of Cardiology, University of Alberta, Edmonton, Canada; Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada; Smidt Heart Institute, Cedars-Sinai Hospital, Los Angeles, California. Electronic address:

Short-term outcomes are worse for patients with acute coronary syndrome (ACS) with a history of nonvalvular atrial fibrillation (NVAF). However, long-term prognosis remains unclear. We linked administrative health databases to identify patients hospitalized with ACS (ST-elevation myocardial infarction [STEMI], non-STEMI [NSTEMI], and unstable angina) between 2008 and 2019 in Alberta, Canada. Read More

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January 2022

Identification of Unique Key miRNAs, TFs, and mRNAs in Virulent MTB Infection Macrophages by Network Analysis.

Int J Mol Sci 2021 Dec 29;23(1). Epub 2021 Dec 29.

The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.

Although (MTB) has existed for thousands of years, its immune escape mechanism remains obscure. Increasing evidence signifies that microRNAs (miRNAs) play pivotal roles in the progression of tuberculosis (TB). RNA sequencing was used to sequence miRNAs in human acute monocytic leukemia cells (THP-1) infected by the virulent MTB-1458 strain and the avirulent vaccine strain Bacillus Calmette-Guérin (BCG). Read More

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December 2021

Criteria for judging the immune markers of COVID-19 disease vaccines.

MedComm (2020) 2022 Jan 31;3(1):1-12. Epub 2021 Dec 31.

Laboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University Chengdu China.

As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sweeping the world, effective and affordable vaccines are in urgent need. A reliable system for the assessment of SARS-CoV-2 vaccines would boost the development of vaccines and reduce the research cost. We constructed a logistic regression model and analyzed the relationship between antibody (Ab) level and efficacy of different vaccine types. Read More

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January 2022

Incidence, Risk Factors and Outcomes of Postoperative Headache After Stanford Type a Acute Aortic Dissection Surgery.

Front Cardiovasc Med 2021 23;8:781137. Epub 2021 Dec 23.

Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Postoperative headache (POH) is common in clinical practice, however, no studies about POH after Stanford type A acute aortic dissection surgery (AADS) exist. This study aims to describe the incidence, risk factors and outcomes of POH after AADS, and to construct two prediction models. Adults who underwent AADS from 2016 to 2020 in four tertiary hospitals were enrolled. Read More

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December 2021

An Integrated Platform for Serological Detection and Vaccination of COVID-19.

Front Immunol 2021 23;12:771011. Epub 2021 Dec 23.

Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.

Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is an ongoing pandemic. Detection and vaccination are essential for disease control, but they are distinct and complex operations that require significant improvements. Here, we developed an integrated detection and vaccination system to greatly simplify these efforts. Read More

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December 2021

Development and Validation of a Prediction Model for Survival in Diabetic Patients With Acute Kidney Injury.

Front Endocrinol (Lausanne) 2021 22;12:737996. Epub 2021 Dec 22.

Geriatric Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Objective: We aimed to analyze the risk factors affecting all-cause mortality in diabetic patients with acute kidney injury (AKI) and to develop and validate a nomogram for predicting the 90-day survival rate of patients.

Methods: Clinical data of diabetic patients with AKI who were diagnosed at The First Affiliated Hospital of Guangxi Medical University from April 30, 2011, to April 30, 2021, were collected. A total of 1,042 patients were randomly divided into a development cohort and a validation cohort at a ratio of 7:3. Read More

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December 2021

The Construction of a Risk Prediction Model Based on Neural Network for Pre-operative Acute Ischemic Stroke in Acute Type A Aortic Dissection Patients.

Front Neurol 2021 23;12:792678. Epub 2021 Dec 23.

Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

To establish a pre-operative acute ischemic stroke risk (AIS) prediction model using the deep neural network in patients with acute type A aortic dissection (ATAAD). Between January 2015 and February 2019, 300 ATAAD patients diagnosed by aorta CTA were analyzed retrospectively. Patients were divided into two groups according to the presence or absence of pre-operative AIS. Read More

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December 2021

Predictive value of neutrophil-to-lymphocyte ratio in terms of need for intensive care unit and mortality in maintenance hemodialysis patients with COVID-19.

Hemodial Int 2022 Jan 9. Epub 2022 Jan 9.

Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, University of Health Sciences, Ankara, Turkey.

Introduction: The transmission risk of Severe Acute Respiratory Syndrome Coronavirus-2 virus infection is increased in maintenance hemodialysis (MHD) patients, and also the disease causes much higher mortality than the normal population. The aim of this study is to define the predictive value of neutrophil-to-lymphocyte ratio (NLR) in terms of worse outcomes in MHD patients.

Methods: A total of 123 MHD patients who had received inpatient care due to COVID-19 infection were included in this multicentered retrospective study. Read More

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January 2022

Development of deep learning models for predicting in-hospital mortality using an administrative claims database.

JMIR Med Inform 2022 Jan 2. Epub 2022 Jan 2.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 HongoBunkyo-ku, Tokyo, JP.

Background: Administrative claims databases have been used widely in studies because they have large sample sizes and are easily available. However, studies using administrative databases lack the severity of the disease, so a risk adjustment method needs to be developed.

Objective: To develop and validate deep learning-based prediction models for in-hospital mortality of acute-care patients. Read More

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January 2022

Health-related quality of life in adults treated for paediatric acute lymphoblastic leukaemia: a cross-sectional and longitudinal cohort study.

BMJ Open 2022 Jan 7;12(1):e048325. Epub 2022 Jan 7.

School of Health and Welfare, Halmstad University, Halmstad, Sweden

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common form of cancer in children. Although treatment methods have improved and resulted in significant improvement of survival and reduction in late effects and late mortality risk, the health-related quality of life (HRQOL) of survivors might be affected. To introduce new interventions in clinical practice with the potential to support positive HRQOL outcomes, more knowledge is needed on how HRQOL in this group is constructed and stimulated. Read More

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January 2022

Ascorbic acid-mediated organic photoelectrochemical transistor sensing strategy for highly sensitive detection of heart-type fatty acid binding protein.

Biosens Bioelectron 2022 Jan 2;201:113958. Epub 2022 Jan 2.

Shenzhen Key Laboratory of Special Functional Materials & Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China. Electronic address:

Heart-type fatty acid binding protein (H-FABP) has been regarded as a promising biomarker for early diagnosis of acute myocardial infarction (AMI). Developing fast and reliable method for H-FABP detection is still highly desirable but challenging. Herein, an ascorbic acid (AA)-mediated organic photoelectrochemical transistor (OPECT) sensing strategy was reported for the detection of H-FABP in phosphate buffer saline (PBS) solution and human serum. Read More

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January 2022

Quality of life and cost consequence of delays in endovascular treatment for acute ischemic stroke in China.

Health Econ Rev 2022 Jan 6;12(1). Epub 2022 Jan 6.

School of Public Health (Shenzhen), Sun Yat-sen University, Room 215, Mingde Garden #6, Sun Yat-sen University, 132 East Outer Ring Road, Panyu District, Guangzhou, Guangdong, China.

Background: Although endovascular therapy (EVT) improves clinical outcomes in patients with acute ischemic stroke, the time of EVT initiation significantly influences clinical outcomes and healthcare costs. This study evaluated the impact of EVT treatment delay on cost-effectiveness in China.

Methods: A model combining a short-term decision tree and long-term Markov health state transition matrix was constructed. Read More

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January 2022

Risk factor analysis and nomogram for predicting in-hospital mortality in ICU patients with sepsis and lung infection.

BMC Pulm Med 2022 Jan 7;22(1):17. Epub 2022 Jan 7.

Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong Province, People's Republic of China.

Background: Lung infection is a common cause of sepsis, and patients with sepsis and lung infection are more ill and have a higher mortality rate than sepsis patients without lung infection. We constructed a nomogram prediction model to accurately evaluate the prognosis of and provide treatment advice for patients with sepsis and lung infection.

Methods: Data were retrospectively extracted from the Medical Information Mart for Intensive Care (MIMIC-III) open-source clinical database. Read More

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January 2022

Sequential Data-Based Patient Similarity Framework for Patient Outcome Prediction: Algorithm Development.

J Med Internet Res 2022 Jan 6;24(1):e30720. Epub 2022 Jan 6.

School of Biomedical Engineering, Capital Medical University, Beijing, China.

Background: Sequential information in electronic medical records is valuable and helpful for patient outcome prediction but is rarely used for patient similarity measurement because of its unevenness, irregularity, and heterogeneity.

Objective: We aimed to develop a patient similarity framework for patient outcome prediction that makes use of sequential and cross-sectional information in electronic medical record systems.

Methods: Sequence similarity was calculated from timestamped event sequences using edit distance, and trend similarity was calculated from time series using dynamic time warping and Haar decomposition. Read More

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January 2022

Development and validation of a procedure-based organ failure assessment model for patients in the intensive care unit: an administrative database study.

Acute Med Surg 2021 Jan-Dec;8(1):e719. Epub 2021 Dec 22.

Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo Tokyo Japan.

Aim: To develop a procedure-based organ failure assessment model for intensive care unit (ICU) patients and to examine the ability of this model to predict in-hospital mortality, with reference to the Sequential Organ Failure Assessment (SOFA) score.

Methods: Using the Japanese nationwide Diagnosis Procedure Combination database, we identified patients aged ≥15 years who were admitted to the ICUs April 2018-March 2019. Since April 2018, Japanese health care providers have been required to input ICU patients' SOFA scores into this database. Read More

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December 2021

Clinical Nomogram to Predict Major Adverse Cardiac Events in Acute Myocardial Infarction Patients within 1 Year of Percutaneous Coronary Intervention.

Cardiovasc Ther 2021 13;2021:3758320. Epub 2021 Dec 13.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

The purpose of this study was to summarize the clinical characteristics and risk factors of major adverse cardiovascular events (MACEs) in patients who had had acute myocardial infarction (AMI) within 1 year of percutaneous coronary intervention (PCI). A total of 421 AMI patients who were treated with PCI and experienced MACEs within 1 year of their admission were included in this retrospective study. In addition, patients were matched for age, sex, and presentation with 561 patients after AMI who had not had MACEs. Read More

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January 2022

A 12-hospital prospective evaluation of a clinical decision support prognostic algorithm based on logistic regression as a form of machine learning to facilitate decision making for patients with suspected COVID-19.

PLoS One 2022 5;17(1):e0262193. Epub 2022 Jan 5.

Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America.

Objective: To prospectively evaluate a logistic regression-based machine learning (ML) prognostic algorithm implemented in real-time as a clinical decision support (CDS) system for symptomatic persons under investigation (PUI) for Coronavirus disease 2019 (COVID-19) in the emergency department (ED).

Methods: We developed in a 12-hospital system a model using training and validation followed by a real-time assessment. The LASSO guided feature selection included demographics, comorbidities, home medications, vital signs. Read More

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January 2022

Developing an Amplification Refractory Mutation System-Quantitative Reverse Transcription-PCR Assay for Rapid and Sensitive Screening of SARS-CoV-2 Variants of Concern.

Microbiol Spectr 2022 Jan 5:e0143821. Epub 2022 Jan 5.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virologygrid.439104.b, Chinese Academy of Sciences, Wuhan, China.

With the emergence and wide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), such as the Delta variant (B.1.617. Read More

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January 2022

Biodigester Cookstove Interventions and Child Diarrhea in Semirural Nepal: A Causal Analysis of Daily Observations.

Environ Health Perspect 2022 Jan 5;130(1):17002. Epub 2022 Jan 5.

Division of Environmental Health Sciences, University of California, Berkeley School of Public Health, Berkeley, California, USA.

Background: Hundreds of thousands of biodigesters have been constructed in Nepal. These household-level systems use human and animal waste to produce clean-burning biogas used for cooking, which can reduce household air pollution from woodburning cookstoves and prevent respiratory illnesses. The biodigesters, typically operated by female caregivers, require the handling of animal waste, which may increase domestic fecal contamination, exposure to diarrheal pathogens, and the risk of enteric infections, especially among young children. Read More

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January 2022

FGF21 alleviates acute liver injury by inducing the SIRT1-autophagy signalling pathway.

J Cell Mol Med 2022 Jan 4. Epub 2022 Jan 4.

The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Liver injury can lead to different hepatic diseases, which are the mainly causes of high global mortality and morbidity. Autophagy and Sirtuin type 1 (SIRT1) have been shown protective effects in response to liver injury. Previous studies have showed that Fibroblast growth factor 21 (FGF21) could alleviate acute liver injury (ALI), but the mechanism remains unclear. Read More

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January 2022

The recombinant pseudorabies virus expressing porcine deltacoronavirus spike protein is safe and effective for mice.

BMC Vet Res 2022 Jan 4;18(1):16. Epub 2022 Jan 4.

College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.

Background: Porcine deltacoronavirus (PDCoV) is a new pathogenic porcine intestinal coronavirus, which has appeared in many countries since 2012. PDCoV disease caused acute diarrhea, vomiting, dehydration and death in piglets, resulted in significant economic loss to the pig industry. However, there is no commercially available vaccine for PDCoV. Read More

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January 2022

Differential mRNA and long noncoding RNA expression profiles in pediatric B-cell acute lymphoblastic leukemia patients.

BMC Pediatr 2022 Jan 3;22(1):10. Epub 2022 Jan 3.

Department of hematology & oncology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, Wuxi, 214000, Jiangsu, China.

Background: Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nt) that are involved in the pathogenesis and development of various cancers including B cell acute lymphoblastic leukemia (B-ALL). To determine the potential roles of lncRNAs involved in pathogenesis of B-ALL, we analyzed the expression profile of lncRNAs and mRNAs in B-ALL, respectively, and constructed lncRNAs/mRNAs interaction network.

Methods: We performed RNA sequencing of 10 non-leukemic blood disease donors and 10 B-ALL patients for Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Read More

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January 2022

Differences in patient outcomes after outpatient gastrointestinal endoscopy across settings: a statewide matched cohort study.

Gastrointest Endosc 2021 Dec 31. Epub 2021 Dec 31.

Betsy Lehman Center for Patient Safety, Commonwealth of Massachusetts, Boston, MA USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA USA.

Background And Aims: Outpatient gastrointestinal endoscopy has been shifting from hospital outpatient departments (HOPDs) to ambulatory surgery centers (ASCs) in recent years. However, evidence on whether patient outcomes after endoscopic procedures are comparable across settings is limited. This study compares the incidence of unplanned hospital visits after gastrointestinal endoscopy performed in ASCs versus HOPDs. Read More

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December 2021