866 results match your criteria constituents rhizome


[Research progress on chemical constituents and pharmacological effects of Glycyrrhizae Radix et Rhizoma and discussion of Q-markers].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2660-2676

College of Pharmacy,Anhui University of Chinese Medicine Hefei 230012,China Anhui Province Key Laboratory of Chinese Medicinal Formula Hefei 230012,China Anhui Province Key Laboratory of New Technology and Research and Development of Traditional Chinese Medicine Decoction Pieces Hefei 230012,China.

Glycyrrhizae Radix et Rhizoma, a traditional Chinese herbal medicine, mainly contains triterpenoids, flavonoids, polysaccharides, coumarins and volatile oils with many pharmacological activities such as anti-tumor, anti-bacterial, anti-viral, anti-inflammatory, immune regulatory and anti-fibrotic effects. The widespread applications of Glycyrrhizae Radix et Rhizoma in food, medicine and chemical industries make its demand increase gradually. Therefore, the quality guarantee of the medicinal is of great value. Read More

View Article and Full-Text PDF

Ethanol extract of Bergenia ciliata (Haw.) Sternb. (rhizome) impedes the propagation of the malaria parasite.

J Ethnopharmacol 2021 Jul 12;280:114417. Epub 2021 Jul 12.

Parasitology Laboratory, Department of Zoology, Panjab University, Chandigarh, 160014, India. Electronic address:

Ethnopharmacological Relevance: The increasing resistant cases even against artemisinin-based combination therapy have necessitated the need to develop new antimalarials. Phytomedicinal therapy is a benchmark for malaria in the Himalayan region. As the dialect and traditional variations have been seen along with this, usage of medicinal plant, its portion (shoot and root system) and mode of preparation also varies. Read More

View Article and Full-Text PDF

Suppression of Proinflammatory Cytokines by (A.D.) Poulsen Rhizome Extract and Its Antibacterial Properties.

Adv Pharmacol Pharm Sci 2021 17;2021:5570073. Epub 2021 Jun 17.

Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, Southeast Sulawesi, Indonesia.

is one of the plants that has not been studied intensively. Plants that belong to the same genus have similar constituents and pharmacological activities. Thus, we aim to investigate the chemical composition and pharmacological activities, namely, anti-inflammatory and antibacterial properties, of rhizome extract (EA). Read More

View Article and Full-Text PDF

Exploring the antifungal activity and mechanism of action of Zingiberaceae rhizome extracts against Malassezia furfur.

J Ethnopharmacol 2021 Jun 23;279:114354. Epub 2021 Jun 23.

Department of Biology, Faculty of Science and Technology, Chiang Mai Rajabhat University, Chiang Mai, Thailand. Electronic address:

Ethnopharmacological Relevance: Rhizomes from members of Zingiberaceae have long been used in Thai traditional medicine to treat cutaneous fungal infections, including Malassezia-related skin disorders. Alpinia galanga, Curcuma longa, Zingiber cassumunar, and Zingiber officinale are particularly popular in folk remedies.

Aim Of The Study: On account of the application background in traditional medicine, the present study aims to screen and determine the composition and possible mechanism of the rhizome extracts of selected Zingiberaceae and corresponding fractions against M. Read More

View Article and Full-Text PDF

Turmeric and its bioactive constituents trigger cell signaling mechanisms that protect against diabetes and cardiovascular diseases.

Mol Cell Biochem 2021 Jun 9. Epub 2021 Jun 9.

Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, Canada.

Turmeric, the rhizome of Curcuma longa plant belonging to the ginger family Zingiberaceae, has a history in Ayurvedic and traditional Chinese medicine for treatment of chronic diseases, including metabolic and cardiovascular diseases (CVD). This parallels a prevalence of age- and lifestyle-related diseases, especially CVD and type 2 diabetes (T2D), and associated mortality which has occurred in recent decades. While the chemical composition of turmeric is complex, curcuminoids and essential oils are known as two major groups that display bioactive properties. Read More

View Article and Full-Text PDF

The traditional uses, phytochemistry, and pharmacological properties of Paris L. (Liliaceae): A review.

J Ethnopharmacol 2021 Oct 5;278:114293. Epub 2021 Jun 5.

Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China. Electronic address:

Ethnopharmacological Relevance: Paris L. (Liliaceae) consisted of 33 species, of which the study focused on Paris polyphylla Smith, P. polyphylla var. Read More

View Article and Full-Text PDF
October 2021

Mass spectral analysis of secondary metabolites from Zingiber montanum rhizome extract using UHPLC-HR-ESI-QTOF-MS/MS.

Phytochem Anal 2021 May 30. Epub 2021 May 30.

Department of Pharmacognosy and Center of Innovative Pharmacy for Pharmaceutical and Herbal Product Development, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

Introduction: Zingiber montanum (J.Koenig) Link ex A.Dietr. Read More

View Article and Full-Text PDF

[Effective components of Shengxian Decoction and its mechanism of action in treating chronic heart failure based on UHPLC-Q-TOF-MS integrated with network pharmacology].

Zhongguo Zhong Yao Za Zhi 2021 May;46(10):2489-2500

Department of Pharmacy, Changzheng Hospital, Second Military Medical University Shanghai 200003, China Institute of Chinese Materia Madica, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.

This study aimed to elucidate the effective components of Shengxian Decoction and its mechanism of action in treating chronic heart failure. Firstly, UHPLC-Q-TOF-MS was established to identify the main chemical constituents in the rat serum after intragastric administration with Shengxian Decoction. Secondly, the absorbed components in serum were then used for the network pharmacology analysis to infer the mechanism and effective components. Read More

View Article and Full-Text PDF

Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation.

Phytomedicine 2021 Jul 18;87:153576. Epub 2021 Apr 18.

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, Taiwan; Department of Pharmacy, National Taiwan University, Taipei 10050, Taiwan. Electronic address:

Background: Gastrodiae Rhizoma (Tianma), the dried tuber of Gastrodia elata Bl. (Orchidaceae), is listed as a top-grade herbal medicine in Shen-nong Ben-ts'ao Jing and has been used for treating headaches, dizziness, vertigo and convulsion. It has a neuroprotective effect and extends the lifespan in mouse models of Huntington's disease and Niemann-Pick type C disease. Read More

View Article and Full-Text PDF

Antiviral screening on , and extracts against HIV-infected MT-4 cells.

Heliyon 2021 Apr 8;7(4):e06710. Epub 2021 Apr 8.

Department of Biology, Faculty of Science, Tadulako University, Palu 94118, Indonesia.

K. Schum A.D. Read More

View Article and Full-Text PDF

Anthelmintic effect of essential rhizome oil from Hedychium coronarium Koenig (Zingiberaceae) introduced in Northeastern Brazil.

Acta Trop 2021 Jun 4;218:105912. Epub 2021 Apr 4.

Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, 65080-805 São Luís, MA, Brazil. Electronic address:

Hedychium coronarium is native to Tropical Asia and has been introduced into several Brazilian biomes. Significant biological properties described for the essential oil (EO) from this species' rhizomes include antimicrobial, larvicidal, anti-inflammatory, antioxidant, phytotoxic, and anthelmintic activities. The primary constituents identified in this study by GC-MS in the EO were monoterpenes 1,8-cineole (33. Read More

View Article and Full-Text PDF

Comparative Analysis of Chemical Constituents in Different Parts of Lotus by UPLC and QToF-MS.

Molecules 2021 Mar 25;26(7). Epub 2021 Mar 25.

School of Pharmaceutical Sciences, Jilin University, Fujin Road 1266, Changchun 130021, China.

Six parts of lotus (seeds, leaves, plumule, stamens, receptacles and rhizome nodes) are herbal medicines that are listed in the Chinese Pharmacopoeia. Their indications and functions have been confirmed by a long history of clinical practice. To fully understand the material basis of clinical applications, UPLC-QToF-MS combined with the UNIFI platform and multivariate statistical analysis was used in this study. Read More

View Article and Full-Text PDF

[Research advances of Zaoren Anshen prescription preparations].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1301-1326

State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines,School of Pharmaceutical Sciences,Health Science Center,Peking University Beijing 100191,China.

Zaoren Anshen prescription preparations(ZRASs), which are prepared from three traditional Chinese herb medicines, namely fried Zizyphi Spinosae Semen, Salvia Miltiorrhizae Radix et Rhizoma and vinegar-processed Schisandrae Chinensis Fructus, are a series of proprietary Chinese medicines for the treatment of insomnia, amnesia and dizzy in clinic. In recent years, pharmacodynamic effect, chemical constituents and quality control of ZRASs had been extensively studied for the purpose of ensuring their safety, efficacy and stability, and a great progress had been made. However, there is no review of the research advance of ZRASs up to date. Read More

View Article and Full-Text PDF

"Force iteration molecular designing" strategy for the systematic characterization and discovery of new protostane triterpenoids from Alisma Rhizoma by UHPLC/LTQ-Orbitrap-MS.

Anal Bioanal Chem 2021 Mar 1;413(6):1749-1764. Epub 2021 Feb 1.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road #501, Shanghai, 201203, China.

Comprehensive analysis and identification of chemical components are of great significance for evaluating the efficacy and safety of herbal medicines, as well as for drug exploitation and development. Here we developed a "force iteration molecular designing" strategy, by combing a database-based in-house software for a precursor ion list (PIL) and PIL-triggered collision-induced dissociation-MS and high-energy C-trap dissociation-MS (PIL-CID/MS-HCD/MS) on an LTQ-Orbitrap mass spectrometer, aiming for the systematic characterization and discovery of new protostane triterpenoids (PTs) from Alisma Rhizoma (AR). AR was a well-known herbal remedy widely used for diarrhea, but its systematic characterization and comparison between two botanical origins have not been reported. Read More

View Article and Full-Text PDF

Characterization of Volatile Organic Compounds in Mango Ginger ( Roxb.) from Myanmar.

Metabolites 2020 Dec 30;11(1). Epub 2020 Dec 30.

Faculty of Life and Environmental Science, University of Tsukuba, Ibaraki 305-8572, Japan.

Roxb. (Zingiberaceae), commonly known as mango ginger because its rhizome and foliar parts have a similar aroma to mango. The rhizome has been widely used in food industries and alternative medicines to treat a variety of internal diseases such as cough, bronchitis, indigestion, colic, loss of appetite, hiccups, and constipation. Read More

View Article and Full-Text PDF
December 2020

Chemical Composition, Antibacterial, Anti-Inflammatory, and Enzyme Inhibitory Activities of Essential Oil from Rhizome.

Molecules 2020 Dec 31;26(1). Epub 2020 Dec 31.

National & Local Joint Engineering Research Center for the Exploition of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China.

W. W. Smith, an edible, medicinal, and ornamental plant, is mainly cultivated in China and Myanmar. Read More

View Article and Full-Text PDF
December 2020

Anti-inflammatory constituents in the root and rhizome of Polygonum cuspidatum by UPLC-PDA-QTOF/MS and lipopolysaccharide-activated RAW264.7 macrophages.

J Pharm Biomed Anal 2021 Feb 26;195:113839. Epub 2020 Dec 26.

The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China. Electronic address:

The root and rhizome of Polygonum cuspidatum (Hu-Zhang) has been used for treatment of various inflammatory disorders in China. In our pervious study, we found that three fractions (HZE-30, HZE-60 and HZE-95) from the ethanol extract of Hu-Zhang (HZE) all could inhibit NO production, and HZE-60 shows the most potent anti-inflammatory activity. In order to understand the major contribution constituents of Hu-Zhang responsible for its anti-inflammatory effect, quantitative composition-activity relationship method was performed. Read More

View Article and Full-Text PDF
February 2021

In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents.

Malar J 2021 Jan 1;20(1). Epub 2021 Jan 1.

Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Kniphofia foliosa is a flamboyant robust perennial herb which has dense clumps and tick upright rhizomes with leaves at the base. In Ethiopia, it has several vernacular names including Abelbila, Ashenda, Amelmela, Yeznjero Ageda, Shemetmetie and Yezinjero Ageda. The plant is endemic to Ethiopian highlands, where its rhizomes are traditionally used for the treatment of malaria, abdominal cramps and wound healing. Read More

View Article and Full-Text PDF
January 2021

[Phenylpropanoid glycosides from Sophorae Tonkinensis Radix et Rhizoma].

Zhongguo Zhong Yao Za Zhi 2020 Nov;45(22):5525-5529

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.

Three phenylpropanoid glycosides were purified by extensive chromatographic techniques including column chromatography over microporous resin, MCI, diol, sephadex LH-20, reverse phase C_(18) from water-extracts of Sophorae Tonkinensis Radix et Rhizoma. Their planar structures were elucidated by combination of various spectroscopic method, such as IR, UV, MS, and NMR. The absolute configuration of aglycone was determined by quantum chemical calculations. Read More

View Article and Full-Text PDF
November 2020

Qualitative analysis on chemical constituents from different polarity extracted fractions of the pulp and peel of ginger rhizomes by ultra-high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Rapid Commun Mass Spectrom 2021 Apr;35(8):e9029

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.

Rationale: Ginger pulp is the dried rhizome scraped off the skin which originates from Zingiber officinale Rosc., a Zingiberaceae plant. Ginger peel is the dried rhizome skin of Zingiber officinale Rosc. Read More

View Article and Full-Text PDF

Canna x generalis L.H. Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress, inflammation, and TLR4/ NF-ҡB and NLRP3 inflammasome pathways.

J Ethnopharmacol 2021 Apr 8;269:113670. Epub 2020 Dec 8.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr Al Aini Street, Cairo, P.O. Box 11562, Egypt.

Ethnopharmacological Relevance: Genus Canna is used in folk medicine as demulcent, diaphoretic, antipyretic, mild laxative and in gastrointestinal upsets therapy. Canna x generalis (CG) L.H. Read More

View Article and Full-Text PDF

Quality control and long-term stability study of ginger from different geographical origins using chemometrics.

J Sci Food Agric 2021 Jun 18;101(8):3429-3438. Epub 2020 Dec 18.

Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Background: Ginger rhizome (Zingiber officinale) is a well-known spice and medicinal plant that is widely used in the Egyptian market as a spice, flavor and medicinal herb for different diseases. Since it is not cultivated as rhizomes in Egypt, ginger is imported from other countries, which may impact its quality. In this study, UV spectroscopy and high-performance liquid chromatography (HPLC) were applied as efficient available techniques for the discrimination and quality control of ginger collected from different geographical origins in combination with chemometrics. Read More

View Article and Full-Text PDF

Comparative Analysis of Anti-inflammatory Activity of the Constituents of the Rhizome of Cnidium officinale Using Rat Hepatocytes.

Biol Pharm Bull 2020 ;43(12):1867-1875

Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University.

The rhizome of Cnidium officinale (Umbelliferae) (known as Senkyu in Japan; COR) has been used as a crude drug in Japanese Kampo formulas, such as Jumihaidokuto (to treat eczema and urticaria) and Kakkontokasenkyushin'i (to treat rhinitis). COR contains phthalides, which are thought to be potent principal constituents. Few studies have been reported about the comparison of anti-inflammatory activity of COR constituents. Read More

View Article and Full-Text PDF
January 2020

Transcriptome analysis of Curcuma wenyujin from Haikou and Wenzhou, and a comparison of the main constituents and related genes of Rhizoma Curcumae.

PLoS One 2020 30;15(11):e0242776. Epub 2020 Nov 30.

Haikou Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Haikou Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou, China.

For more than a thousand years, Rhizoma Curcumae (known as E zhu), a Chinese herbal medicine, has been used to eradicate blood stasis and relieve aches. The plant Curcuma wenyujin, which is grown primarily in Wenzhou, China, is considered the best source of Rhizoma Curcumae. In this study, we sought to ascertain differences in transcript profiles of C. Read More

View Article and Full-Text PDF
January 2021

Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis.

Cancer Manag Res 2020 6;12:11309-11320. Epub 2020 Nov 6.

Department of Peripheral Vascular Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China.

Background: Tanshinone IIA (TIIA) is one of the active constituents derived from the rhizome of Danshen, a traditional Chinese herbal. Recently, microRNAs (miRNAs) have been suggested to be associated with the anticancer role of TIIA. However, it remains vague of the interaction between miRNAs and TIIA in glioma, a common aggressive brain tumor in humans. Read More

View Article and Full-Text PDF
November 2020

[Research progress on chemical compositions of Coptidis Rhizoma and pharmacological effects of berberine].

Zhongguo Zhong Yao Za Zhi 2020 Oct;45(19):4561-4573

College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine Kunming 650500, China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.

Coptidis Rhizoma was a commonly used antipyretic and dampening drug in clinic, which was first recorded in the Shennong's Herbal Classic of Materia Medica and which was listed as one of the highest grade herb in traditional Chinese medicine. Traditionally, Coptidis Rhizoma was used to treat dampness with distention and fullness, vomiting with acid regurgitation, acne, heartbum, etc. At present, a total of 133 chemical components have been isolated and identified from Coptidis Rhizoma, which can be divided into alkaloids(44 species), lignans(32 species), flavonoids(9 species), phenylpropionic acid and its derivatives(26 species) and other compounds(22 species) according to the differences in structure types. Read More

View Article and Full-Text PDF
October 2020

Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.

J Evid Based Integr Med 2020 Jan-Dec;25:2515690X20967323

Faculty of Science and Technology, Department of Life Sciences, 4921University of Westminster, London, UK.

Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian ( L.) is a popular herbal medicine used as a sleep aid, however the outcomes of previous clinical studies are inconsistent. Read More

View Article and Full-Text PDF
October 2020

Phytochemical Analysis, Antioxidant, Antibacterial, Cytotoxic, and Enzyme Inhibitory Activities of Rhizome.

Front Pharmacol 2020 17;11:572659. Epub 2020 Sep 17.

Guizhou Engineering Center for Innovative Traditional Chinese Medicine and Ethnic Medicine, Guizhou University, Guiyang, China.

Roxb., a medicinal, edible, and ornamental plant, is widely cultivated throughout China, India, and Southeast Asia. The rhizome from this plant has been used for food flavoring and in traditional Chinese medicine to treat diverse diseases, but the detailed constituents and bioactivities are still limited known. Read More

View Article and Full-Text PDF
September 2020

Ethnomedicinal uses, biological activities, phytochemistry and conservation of African ginger (Siphonochilus aethiopicus): A commercially important and endangered medicinal plant.

J Ethnopharmacol 2021 Feb 8;266:113459. Epub 2020 Oct 8.

Indigenous Knowledge Systems Centre, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho, 2790, North West Province, South Africa; School of Life Sciences, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, Pietermaritzburg, South Africa.

Ethnopharmacological Relevance: In sub-Saharan Africa, African ginger (Siphonochilus aethiopicus) is used for treating common illnesses including colds, coughs, inflammation and related symptoms. The available literature survey on this plant provided scarce anecdotal information, particularly in western and eastern Africa, with a few reports on its bioactivity. In addition, the indigenous knowledge and conservation strategies of this economically important and critically endangered species are currently fragmented. Read More

View Article and Full-Text PDF
February 2021

Total alkaloids from the rhizomes of a review of chemical analysis and pharmacological activities.

Nat Prod Res 2020 Oct 9:1-18. Epub 2020 Oct 9.

Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Rhizome Chuanxiong (RCX), the dried rhizomes of DC., is a geoauthentic TCM herb distributed in Sichuan province of China that possesses efficacy in promoting blood circulation, removing blood stasis and alleviating pain. Rhizome Chuanxiong total alkaloids (RCXTAs) are one of the major characteristic constituents of RCX with the effects of antimigraine, neuroprotective, cardioprotective and other cardiovascular and cerebrovascular diseases. Read More

View Article and Full-Text PDF
October 2020