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Integrated global analysis reveals a vitamin E-vitamin K1 sub-network, downstream of COLD1, underlying rice chilling tolerance divergence.

Cell Rep 2021 Jul;36(3):109397

Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China. Electronic address:

Rice, a staple food with tropical/subtropical origination, is susceptible to cold stress, one of the major constraints on its yield and distribution. Asian cultivated rice consists of two subspecies with diverged chilling tolerance to adapt to different environments. The mechanism underlying this divergence remains obscure with a few known factors, including membrane protein CHILLING-TOLERANCE DIVERGENCE 1 (COLD1). Read More

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Utero-placental apoplexy during induction of therapeutic abortion in a 18-week pregnancy.

Eur Rev Med Pharmacol Sci 2021 Jul;25(13):4456-4458

Department of Gynecology and Obstetrics - University of L'Aquila (Italy), Medical School, University of L'Aquila, L'Aquila, Italy.

Utero-Placental Apoplexy, or Couvelaire Uterus, is a third-trimester major obstetrical complication, occurring especially during labor. It consists of placental abruption followed by an acute intradecidual hemorrhage produced by the rupture of the uterus-placental spiral arterioles leading to a retroplacental hematoma. This hemorrhage infiltrates the uterine wall up to intra- and retro-peritoneal areas. Read More

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SpheroidPicker for automated 3D cell culture manipulation using deep learning.

Sci Rep 2021 Jul 20;11(1):14813. Epub 2021 Jul 20.

Synthetic and Systems Biology Unit, Biological Research Centre (BRC), Eötvös Loránd Research Network (ELKH), Temesvári körút 62, Szeged, 6726, Hungary.

Recent statistics report that more than 3.7 million new cases of cancer occur in Europe yearly, and the disease accounts for approximately 20% of all deaths. High-throughput screening of cancer cell cultures has dominated the search for novel, effective anticancer therapies in the past decades. Read More

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Clinical Features, Natural History and Outcomes of Intraneural Perineuriomas: A Systematic Review of the Literature.

World Neurosurg 2021 Jul 17. Epub 2021 Jul 17.

Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN. Electronic address:

Introduction: Intraneural perineurioma is a rare peripheral nerve sheath tumor characterized by localized proliferation of perineurial cells. Current literature consists predominantly of case reports and institutional series, with inconsistent and confusing nomenclature. Herein, we present a pooled analysis of all of the current reported cases of intraneural perineurioma in the literature. Read More

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Automated Landslide-Risk Prediction Using Web GIS and Machine Learning Models.

Sensors (Basel) 2021 Jul 5;21(13). Epub 2021 Jul 5.

Center of Excellence for Natural Disaster Management (CENDIM), Chiang Mai University, Chiang Mai 50200, Thailand.

Spatial susceptible landslide prediction is the one of the most challenging research areas which essentially concerns the safety of inhabitants. The novel geographic information web (GIW) application is proposed for dynamically predicting landslide risk in Chiang Rai, Thailand. The automated GIW system is coordinated between machine learning technologies, web technologies, and application programming interfaces (APIs). Read More

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Healthy Minds: Group Cognitive-Behavioral Intervention for Sustainable Return to Work After a Sick Leave Due to Depression.

J Occup Rehabil 2021 Jul 19. Epub 2021 Jul 19.

Research Center of the Institut universitaire en santé mentale de Montréal, Montreal, Canada.

Background Depression is one of the major causes for sick leave and loss of productivity at work. Many studies have investigated return to work (RTW) interventions for people with common mental disorders. However, a paucity of studies has targeted depressive symptoms in the workplace, as well as work productivity. Read More

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Humanized Mediator Release Assay as a Read-Out for Allergen Potency.

J Vis Exp 2021 Jun 29(172). Epub 2021 Jun 29.

Department of Biosciences, University of Salzburg;

Mediator release assays analyze in vitro immunoglobulin E (IgE)-mediated degranulation and secretion of mediators by effector cells, such as mast cells and basophils, upon stimulation with serial dilutions of putative allergens. Therefore, these assays represent an essential tool that mimics the in vivo degranulation process, which occurs upon allergen exposure in sensitized patients or in skin prick tests. Additionally, these assays are usually employed to investigate the allergenic potential of proteins and the reactivity of patients' sera's reactivity. Read More

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The Significance of the Mediterranean Diet in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review.

Cureus 2021 Jun 13;13(6):e15618. Epub 2021 Jun 13.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Non-alcoholic fatty liver disease (NAFLD) is the accumulation of intrahepatic fat occurring in the absence of alcohol abuse. The fatty changes in the liver are often the beginning of sequelae of complications, potentially causing steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. The Mediterranean diet is not only a way of eating but is considered a lifestyle and primarily consists of a plant-based diet, with olive oil as the primary lipid. Read More

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Get ready for the CRISPR/Cas system: A beginner's guide to the engineering and design of guide RNAs.

J Gene Med 2021 Jul 16:e3377. Epub 2021 Jul 16.

Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, China.

The clustered regularly interspaced short palindromic repeats (CRISPR) system is a state-of-the-art tool for versatile genome editing that has advanced basic research dramatically, with great potential for clinic applications. The system consists of two key molecules: a CRISPR-associated (Cas) effector nuclease and a single guide RNA. The simplicity of the system has enabled the development of a wide spectrum of derivative methods. Read More

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Pairing of orthogonal chaperones with a cytochrome P450 enhances terpene synthesis in Saccharomyces cerevisiae.

Biotechnol J 2021 Jul 16:e2000452. Epub 2021 Jul 16.

Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan, Republic of Korea.

The supply of terpenes is often limited by their low extraction yield from natural resources, such as plants. Thus, microbial biosynthesis has emerged as an attractive platform for the production of terpenes. Many strategies have been applied to engineer microbes to improve terpene production capabilities; however, functional expression of heterologous proteins such as cytochrome P450 enzymes (P450s) in microbes is a major obstacle. Read More

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Interactions between risk assessors and risk managers during three major food incidents in Europe.

J Food Sci 2021 Jul 15. Epub 2021 Jul 15.

Business Economics Group, Wageningen University & Research, Wageningen, The Netherlands.

Risk analysis consists of risk assessment (RA), risk management (RM), and risk communication (RC). In most countries, RA and RM of food safety are separated to achieve a high scientific integrity, and typically occur in sequential order. However, in case of a food safety incident, even though being separate processes, RA and RM are performed simultaneously due to great time pressure and expected high impacts. Read More

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A novel bowel rehabilitation programme after total mesorectal excision for rectal cancer: the BOREAL pilot study.

Colorectal Dis 2021 Jul 15. Epub 2021 Jul 15.

Colorectal Unit, Department of Digestive Surgery, Haut-Lévêque Hospital, Bordeaux University Hospital, Pessac, France.

Aim: Low anterior resection syndrome (LARS) following sphincter-preserving surgery for rectal cancer has a high prevalence, with an impact on long-term bowel dysfunction and quality of life. We designed the bowel rehabilitation programme (BOREAL) as a proactive strategy to assess and treat patients with LARS. The BOREAL programme consists of a stepwise approach of escalating treatments: medical management (steps 0-1), pelvic floor physiotherapy, biofeedback and transanal irrigation (step 2), sacral nerve neuromodulation (step 3), percutaneous endoscopic caecostomy and anterograde enema (step 4) and definitive colostomy (step 5). Read More

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High resolution monolithic LYSO detector with 6-layer depth-of-interaction for clinical PET.

Phys Med Biol 2021 Jul 14. Epub 2021 Jul 14.

ELIS-MEDISIP, Universiteit Gent, St-Pietersnieuwstraat 41, 9000, Ghent, BELGIUM.

The system spatial resolution of whole-body positron emission tomography (PET) is limited to around 2 mm due to positron physics and the large diameter of the bore. To stay below this 'physics'-limit a scintillation detector with an intrinsic spatial resolution of around 1.3 mm is needed. Read More

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An annotated image dataset of downy mildew symptoms on Merlot grape variety.

Data Brief 2021 Aug 29;37:107250. Epub 2021 Jun 29.

Univ. Bordeaux, IMS UMR 5218, F-33405 Talence, France.

This article introduces a dataset of high-resolution colour images of grapevines. It contains 99 images acquired in the vineyard from a cruising tractor. Each image includes the full foliage of a grapevine plant. Read More

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Ancient Gene Capture and Recent Gene Loss Shape the Evolution of Orthopoxvirus-Host Interaction Genes.

mBio 2021 Jul 13:e0149521. Epub 2021 Jul 13.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Instutes of Health, Bethesda, Maryland, USA.

The survival of viruses depends on their ability to resist host defenses and, of all animal virus families, the poxviruses have the most antidefense genes. (ORPV), a genus within the subfamily , infect diverse mammals and include one of the most devastating human pathogens, the now eradicated smallpox virus. ORPV encode ∼200 genes, of which roughly half are directly involved in virus genome replication and expression as well as virion morphogenesis. Read More

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Assessment of the Grisotti oncoplastic procedure for the management of central breast tumors.

Breast J 2021 Jul 12;27(7):595-602. Epub 2021 Jul 12.

Department of Surgical Oncology, Institut Godinot, Reims, France.

Introduction: The Grisotti technique consists to excise central breast tumor with nipple areolar and mobilize a dermo-glandular flap which is de-epithelized in order to reshape the breast and recreate an areola. The objective was to assess oncological results, postoperative side-effects, and patient and surgeon satisfaction rates resulting from this technique.

Materials And Methods: From September 2016 to December 2019, 38 patients have been treated with a central breast tumor using the Grisotti technique. Read More

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Telerobotic Operation of Intensive Care Unit Ventilators.

Front Robot AI 2021 24;8:612964. Epub 2021 Jun 24.

Laboratory for Computational Sensing and Robotics, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.

Since the first reports of a novel coronavirus (SARS-CoV-2) in December 2019, over 33 million people have been infected worldwide and approximately 1 million people worldwide have died from the disease caused by this virus, COVID-19. In the United States alone, there have been approximately 7 million cases and over 200,000 deaths. This outbreak has placed an enormous strain on healthcare systems and workers. Read More

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Autoencoder based self-supervised test-time adaptation for medical image analysis.

Med Image Anal 2021 08 19;72:102136. Epub 2021 Jun 19.

Dept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

Deep neural networks have been successfully applied to medical image analysis tasks like segmentation and synthesis. However, even if a network is trained on a large dataset from the source domain, its performance on unseen test domains is not guaranteed. The performance drop on data obtained differently from the network's training data is a major problem (known as domain shift) in deploying deep learning in clinical practice. Read More

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Advances in Cell Wall Matrix Research With a Focus on Mixed Linkage Glucan.

Plant Cell Physiol 2021 Jul 10. Epub 2021 Jul 10.

Great Lakes Bioenergy Research Center, Michigan State University, East Lansing, MI 48824.USA.

Mixed β(1,3;1,4) linkage glucan (MLG) is commonly found in the monocot lineage, at particularly high levels in the Poaceae family, but also in the evolutionally distant genus, Equisetum. MLG has several properties that make it unique from other plant cell wall polysaccharides. It consists of β1,4-linked polymers of glucose interspersed with β1,3-linkages, but the presences of β1,3-linkages provide quite different physical properties compared to its closest form of cell wall component, cellulose. Read More

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Development of a thin high-frequency and high-precision magnetic probe array in Sino-United Spherical Tokamak.

Rev Sci Instrum 2021 May;92(5):053518

Department of Engineering Physics, Tsinghua University, Beijing 10084, People's Republic of China.

Since the major/minor radius of the Sino-United Spherical Tokamak (SUNIST) is 0.3/0.23 m, respectively, the space left for magnetic diagnostics in the high field side (HFS) is quite limited. Read More

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differentiation of human cardiac fibroblasts into myofibroblasts: characterization using electrical impedance.

Biomed Phys Eng Express 2021 Jul 9. Epub 2021 Jul 9.

IMS Laboratory, CNRS UMR 5218, University of Bordeaux College of Science and Technology, 351 cours de la liberation, Talence, Aquitaine, 33400, FRANCE.

Cardiac arrhythmias represent about 50% of the cardiovascular diseases which are the first cause of mortality in the world. Implantable medical devices play a major role for treating these arrhythmias. Nevertheless the leads induce an unwanted biological phenomenon called fibrosis. Read More

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Conformational dynamics of a multidomain protein by neutron scattering and computational analysis.

Biophys J 2021 Jul 7. Epub 2021 Jul 7.

2 J-PARC Center, Japan Atomic Energy Agency, Tokai, Ibaraki, Japan.

The flexible conformations of a multidomain protein are responsible for its biological functions. Although MurD, a 47-kDa protein that consists of three domains, sequentially changes its domain conformation from an open form to a closed form through a semiclosed form in its enzymatic reaction, the domain dynamics in each conformation remains unclear. In this study, we verify the conformational dynamics of MurD in the corresponding three states (apo and ATP- and inhibitor-bound states) with a combination of small-angle x-ray and neutron scattering (SAXS and SANS), dynamic light scattering (DLS), neutron backscattering (NBS), neutron spin echo (NSE) spectroscopy, and molecular dynamics (MD) simulations. Read More

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Sperm-binding regions on bovine egg zona pellucida glycoprotein ZP4 studied in a solid supported form on plastic plate.

PLoS One 2021 9;16(7):e0254234. Epub 2021 Jul 9.

Department of Chemistry, Graduate School of Science, Chiba University, Chiba, Japan.

The zona pellucida (ZP) is a transparent envelope that surrounds the mammalian oocyte and mediates species-selective sperm-oocyte interactions. The bovine ZP consists of the glycoproteins ZP2, ZP3, and ZP4. Sperm-binding mechanisms of the bovine ZP are not yet fully elucidated. Read More

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Early-Onset Osteoporosis.

Calcif Tissue Int 2021 Jul 8. Epub 2021 Jul 8.

Department of Internal Medicine, Erasmus University Medical Center, 3015, Rotterdam, The Netherlands.

Osteoporosis is a skeletal disorder with enhanced bone fragility, usually affecting the elderly. It is very rare in children and young adults and the definition is not only based on a low BMD (a Z-score < - 2.0 in growing children and a Z-score ≤ - 2. Read More

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What Makes Deprescription of Psychotropic Drugs in Nursing Home Residents with Dementia so Challenging? A Qualitative Systematic Review of Barriers and Facilitators.

Drugs Aging 2021 Jul 7. Epub 2021 Jul 7.

Department of General Practice, University of Copenhagen, Copenhagen, Denmark.

Background: Behavioral and psychological symptoms of dementia are frequently experienced in the nursing home setting and place a substantial burden on patients, relatives, and nursing home staff. Despite guidelines recommending non-pharmacological treatments, psychotropic drugs are often prescribed to address these symptoms. This is the case despite their effects being limited, and there being a risk of side effects and adverse events for the patient. Read More

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Immunotherapy in rare ovarian cancer.

Curr Opin Oncol 2021 Jul 6. Epub 2021 Jul 6.

Division of Gynecological Oncology, Department of Gynecology and Obstetrics and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

Purpose Of Review: Ovarian cancer (OC) is a heterogeneous disease and a mounting body of evidence shows that a 'one-size-fits-all' approach is obsolete. Differences in epidemiology, tumor biology, genetic profiles and treatment responses of these different types necessitate a tumor and patient-specific approach. Ninety percentage consists of epithelial OC with 70% being high-grade serous OC. Read More

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Multimodal Treatment of Primary Advanced Ovarian Cancer.

Anticancer Res 2021 Jul 5;41(7):3253-3260. Epub 2021 Jul 5.

Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Epithelial ovarian cancer is the second most common malignancy of the female genital tract, with approximately 7,400 new cases annually in Germany. With 5,500 deaths per year, ovarian cancer is the leading gynecologic cause of death. Epithelial ovarian cancer is characterized by morphologic heterogeneity with 4 molecular biological subtypes (immunoreactive-like, differentiated-like, proliferative-like, mesenchymal-like) with different prognosis. Read More

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Implication of wide surgical excision in minimizing positive margins and consequential secondary excision - a retrospective comparative study involving 106 basal cell carcinoma cases.

Eur Rev Med Pharmacol Sci 2021 Jun;25(12):4283-4288

Department of Functional Sciences, Physiology, Centre of Immuno-Physiology and Biotechnologies (CIFBIOTEH), "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Objective: The use of current surgical techniques in the management of skin cancers that are not amenable to other treatment options has become the cornerstone of dermatological surgical intervention. Among the many benign lesions and malignant lesions, such as squamous cell carcinomas, melanomas, and Merkel cell carcinomas, the tumors that are commonly excised surgically are the basal cell carcinomas (BCC). Although the majority of BCC lesions spread locally and are rarely metastatic, these lesions may recur, especially, if the excised tissue consists of positive surgical margins. Read More

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Structure and Function of Major SARS-CoV-2 and SARS-CoV Proteins.

Bioinform Biol Insights 2021 22;15:11779322211025876. Epub 2021 Jun 22.

Department of Biotechnology, Kathmandu University, Dhulikhel, Nepal.

SARS-CoV-2 virus, the causative agent of COVID-19 pandemic, has a genomic organization consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory proteins. Relative of SARS-CoV-2, SARS-CoV, has genomic organization, which is very similar. In this article, the function and structure of the proteins of SARS-CoV-2 and SARS-CoV are described in great detail. Read More

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Is a simple model based on two mixing reservoirs able to reproduce the intra-annual dynamics of DOC and NO stream concentrations in an agricultural headwater catchment?

Sci Total Environ 2021 Jun 26;794:148715. Epub 2021 Jun 26.

UMR SAS, INRAE, Institut Agro, 35000 Rennes, France.

Agriculture disturbs the biogeochemical cycles of major elements, which alters the elemental stoichiometry of surface stream waters, with potential impacts on their ecosystems. However, models of catchment hydrology and water quality remain relatively disconnected, even though the observation that dissolved organic carbon (DOC) and nitrate (NO) have opposite spatial and temporal patterns seems relevant for improving our representation of hydrological transport pathways within catchments. We tested the ability of a parsimonious model to simultaneously reproduce intra-annual dynamics of stream flow, DOC and NO concentrations using 15 years of daily data from a small headwater agricultural catchment (AgrHyS observatory). Read More

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