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Development of a theory-based intervention to increase cognitively able frail elders' engagement with advance care planning using the behaviour change wheel.

BMC Health Serv Res 2021 Jul 20;21(1):712. Epub 2021 Jul 20.

St Christopher's Hospice, London, UK.

Background: Advance care planning (ACP) conversations support people to think about, discuss and document their beliefs, values and preferences regarding future care. This process means that should the person loose capacity in the future, care can be provided, consistent with their personal values and beliefs. The ACP process is particularly relevant for older people living with frailty (frail elders) as they are vulnerable to sudden deterioration. Read More

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Dual Pitch Screw Design Provides Equivalent Fixation to Upsized Screw Diameter in Revision Pedicle Screw Instrumentation: A Cadaveric Biomechanical Study.

Spine J 2021 Jul 15. Epub 2021 Jul 15.

Norton Leatherman Spine Center, 210 East Gray Street, Suite 900, Louisville, Kentucky 40202; Department of Orthopaedic Surgery, University of Louisville School of Medicine, 550 S. Jackson Street, 1st Floor ACB, Louisville, Kentucky 40202.

Background Context: There are situations that require the replacement of pedicle screws. They are often exchanged when loose or broken or to accommodate a different sized rod or pedicle screw system. Traditionally, pedicle screws are replaced by up-sizing the core diameter until an interference fit is obtained. Read More

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Invited review: The welfare of dairy cattle housed in tiestalls compared to less-restrictive housing types: A systematic review.

J Dairy Sci 2021 Jul 9. Epub 2021 Jul 9.

Animal Welfare Program, Faculty of Land and Food Systems, University of British Columbia, 2357 Main Mall, Vancouver, BC, V6T 1Z4 Canada. Electronic address:

Many dairy cattle worldwide are housed in tiestalls, meaning that they are tethered by the neck to individual stalls. On some farms, tied cattle are permitted seasonal access to pasture, but otherwise their movements are restricted compared with cows housed in freestall barns or other loose housing systems. The aim of this systematic review is to summarize the scientific literature pertaining the welfare of tied dairy cattle through comparison with less-restrictive housing systems. Read More

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Approximations of density matrices in N-electron valence state second-order perturbation theory (NEVPT2). II. The full rank NEVPT2 (FR-NEVPT2) formulation.

J Chem Phys 2021 Jun;154(21):214113

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany.

In Paper I, the performances of pre-screening (PS), extended PS (EPS), and cumulant (CU) approximations to the fourth-order density matrix were examined in the context of second-order N-electron valence state perturbation theory (NEVPT2). It has been found that the CU, PS, and even EPS approximations with loose thresholds may introduce intruder states. In the present work, the origin of these "false intruder" states introduced by approximated density matrices is discussed. Read More

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Clinical features of gastroenteritis during a large waterborne Campylobacter outbreak in Askøy, Norway.

Infection 2021 Jul 3. Epub 2021 Jul 3.

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Purpose: Outbreaks of Campylobacter infection are common, but studies exploring the clinical features of acute illness in the outbreak setting are scarce in existing literature. The main purpose of the present study was to investigate the clinical features of self-reported acute illness in gastroenteritis cases during a large waterborne Campylobacter outbreak in Askøy municipality, Norway, in 2019.

Methods: A web-based self-administered questionnaire, and invitation to participate was sent by the municipality of Askøy as text message to mobile phones using the municipality's warning system to the inhabitants during the ongoing outbreak. Read More

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Osteogenesis Imperfecta in Two Finnish Lapphund Puppies.

Vet Med (Auckl) 2021 17;12:177-185. Epub 2021 Jun 17.

Cornell University College of Veterinary Medicine, Department of Biomedical Sciences, Section of Anatomic Pathology, Ithaca, NY, 14853, USA.

Two 8-week-old Finnish Lapphund dogs presented with pain on manipulation, abnormal long bone conformation, retrognathism, and stunted growth compared to their litter mates. Multiple long bone fractures were evident on radiographs. Clinical pathology showed an atypically normal serum alkaline phosphatase activity for dogs this age. Read More

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Effect of ultrasonic pre-treatment on Ara h 1 in peanut sprouts.

Ultrason Sonochem 2021 Jul 25;75:105607. Epub 2021 May 25.

Institute of Food and Processing, Liaoning Academy of Agricultural Sciences, Shenyang 110161, China. Electronic address:

Ara h 1 is the most abundant sensitizing protein in peanuts; it has high thermal stability and is difficult to degrade. The peanut sprout is a high-quality, natural food that has various beneficial effects and lower allergenicity than peanut seeds. In this study, ultrasonication (US) of peanut sprouts was used to alter their Ara h 1 content. Read More

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Symptomatic Aseptic Loosening of a Short Humeral Stem Following Anatomic Total Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 May 18. Epub 2021 May 18.

Washington University, St. Louis, MO, USA.

Introduction: The rate of aseptic humeral component loosening with standard-length stems is historically so low (0.3%) that presence of humeral loosening was given substantial weight in predicting defining periprosthetic shoulder infection by the International Consensus Meeting (ICM) in 2018. This study aims to confirm that the historically low rate of humeral stem aseptic loosening is not affected by the adoption of a novel short humeral stem. Read More

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Incremental value of three-dimensional and contrast echocardiography in the evaluation of endocardial fibroelastosis and multiple cardiovascular thrombi: A case report.

World J Clin Cases 2021 May;9(14):3365-3371

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Background: Endocardial fibroelastosis (EFE) is a rare heart disease characterized by thickening of the endocardium caused by massive proliferation of collagenous and elastic tissue, usually leading to impaired cardiac function. Multimodality cardiovascular imaging for the evaluation of EFE with thrombi is even rarer.

Case Summary: We report a rare case of EFE associated with multiple cardiovascular thrombi. Read More

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Reversible multilayered vesicle-like structures with fluid hydrophobic and interpolyelectrolyte layers.

J Colloid Interface Sci 2021 Oct 20;599:313-325. Epub 2021 Apr 20.

Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Prague 2, Czech Republic. Electronic address:

Hydrophobic blocks of amphiphilic block copolymers often form glassy micellar cores at room temperature with a rigid structure that limits their applications as nanocapsules for targeted delivery. Nevertheless, we prepared and analyzed core/shell micelles with a soft core, formed by a self-assembled block copolymer consisting of a hydrophobic block and a polycation block, poly(lauryl acrylate)-block-poly(trimethyl-aminoethyl acrylate) (PLA-QPDMAEA), in aqueous solution. By light and small-angle neutron scattering, by transmission electron microscopy and by fluorescence spectroscopy, we showed that these core/shell micelles are spherical and cylindrical with a fluid-like PLA core and a positively charged outer shell and that they can encapsulate and release hydrophobic solutes. Read More

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October 2021

Characterization of the Micelle Formed by a Hydrophobically Modified Pullulan in Aqueous Solution: Size Exclusion Chromatography.

Polymers (Basel) 2021 Apr 11;13(8). Epub 2021 Apr 11.

Department of Macromolecular Science, Osaka University, Toyonaka Osaka 560-0043, Japan.

Size exclusion chromatography equipped with a multi-angle, light-scattering online detector (SEC-MALS) measurements were carried out on a hydrophobically modified pullulan (PUL-OSA) with degrees of substitution () of 0.14, 0.2, and 0. Read More

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Tracheal chondrosarcoma in a blue tegu (Salvator merianae).

J Vet Med Sci 2021 Jul 28;83(6):981-983. Epub 2021 Apr 28.

Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa 252-0880, Japan.

An 8-year-and-1-month-old female blue tegu (Salvator merianae) was brought to a clinician with severe cough. The patient died 11 days later despite supportive care, and necropsy was performed by a clinician. The lumen of the distal trachea was almost completely occluded by a milk-white, hard mass measuring 1 cm in diameter. Read More

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Leaf spot disease of Orychophragmus violaceus caused by Alternaria tenuissima in China.

Plant Dis 2021 Apr 5. Epub 2021 Apr 5.

Northeast Agricultural University, 12430, No. 59, Mucai street, harbin, China, 150030;

Orychophragmus violaceus (L.) O. E. Read More

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Foodborne Disease outbreak associated with eating at a Wedding - Palghar District, Maharashtra, India, 2018.

Indian J Public Health 2021 Jan;65(Supplement):S10-S13

State Surveillance Officer, Office of Joint Director of Health Services, Maharashtra, India.

Background: A foodborne disease outbreak among wedding attendees from Makunsar village, Palghar district, Maharashtra state, India, was reported on February 18, 2018.

Objectives: The outbreak investigation was conducted to find out the epidemiology of the outbreak and to identify the etiologic agent and risk factors.

Methods: A case-control study was carried out, where cases (patients), controls, and food handlers were interviewed and leftover foods were collected for culture. Read More

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January 2021

Bowel-associated dermatosis-arthritis syndrome in a child with very early onset inflammatory bowel disease.

Pediatr Dermatol 2021 May 21;38(3):697-698. Epub 2021 Mar 21.

Section of Pediatric Dermatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

A 6-year-old boy with severe very early-onset inflammatory bowel disease (VEO-IBD) was admitted for 1 week of high fevers, loose stools, joint pains, and myalgias. He subsequently developed a progressive, papular, and vesiculopustular eruption on his face with rapid spread to his trunk and extremities. Histopathology demonstrated dense dermal neutrophilic inflammation. Read More

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Differences in the Central Energy Metabolism of Cancer Cells between Conventional 2D and Novel 3D Culture Systems.

Int J Mol Sci 2021 Feb 11;22(4). Epub 2021 Feb 11.

Department of Urology, Shiga University of Medical Science, Otsu 520-2192, Japan.

The conventional two-dimensional (2D) culture is available as an in vitro experimental model. However, the culture system reportedly does not recapitulate the in vivo cancer microenvironment. We recently developed a tissueoid cell culture system using Cellbed, which resembles the loose connective tissue in living organisms. Read More

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February 2021

Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study.

Otol Neurotol 2021 08;42(7):e849-e857

Frequency Therapeutics, Woburn, MA & Farmington, CT.

Objectives: There are no approved pharmacologic therapies for chronic sensorineural hearing loss (SNHL). The combination of CHIR99021+valproic acid (CV, FX-322) has been shown to regenerate mammalian cochlear hair cells ex vivo. The objectives were to characterize the cochlear pharmacokinetic profile of CV in guinea pigs, then measure FX-322 in human perilymph samples, and finally assess safety and audiometric effects of FX-322 in humans with chronic SNHL. Read More

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Structural changes induced by direct current magnetic field improve water holding capacity of pork myofibrillar protein gels.

Food Chem 2021 May 10;345:128849. Epub 2020 Dec 10.

College of Life Science, Yangtze University, Jingzhou, Hubei 434023, PR China; Jingchu Food Research and Development Center, Yangtze University, Jingzhou, Hubei 434025, PR China. Electronic address:

The study was to investigate the role of direct current magnetic field (DC-MF) for water-holding capacity (WHC) of myofibrillar protein gels and to understand potential mechanisms. Samples were subjected to DC-MF with different intensities (3.5, 3. Read More

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A multi-organ infection involving a left adrenal gland abscess in a diabetic dog.

Can Vet J 2021 02;62(2):154-159

Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan Ringgold Standard Institution, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5A2.

A 14-year-old, intact male, American cocker spaniel dog was presented with a 5-day history of lethargy, inappetence, loose stools, abdominal pain, and hematuria. The dog had a 4-year history of diabetes mellitus and was in remission for immune-mediated hemolytic anemia. Abdominal ultrasonography and computed tomography scan revealed diffuse left adrenomegaly, splenic nodules, prostatomegaly, bilateral testicular cysts, and a hepatic mass. Read More

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February 2021

Suspected Metal Allergy and Femoral Loosening After Total Knee Arthroplasty: A Diagnostic Dilemma.

Arthroplast Today 2021 Feb 15;7:114-119. Epub 2021 Jan 15.

Harbor-UCLA Department of Orthopaedic Surgery, Torrance, CA, USA.

Metal sensitivity is increasingly prevalent and is associated with negative outcomes after total knee arthroplasty (TKA). Currently, there is no consensus on diagnostic criteria for TKA failure from immune reaction. We present a patient who had pain and aseptic effusion 2 years after TKA. Read More

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February 2021

Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process.

J Biol Chem 2021 Jan-Jun;296:100223. Epub 2020 Dec 25.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Cytochrome P450 (P450) 3A4 is the enzyme most involved in the metabolism of drugs and can also oxidize numerous steroids. This enzyme is also involved in one-half of pharmacokinetic drug-drug interactions, but details of the exact mechanisms of P450 3A4 inhibition are still unclear in many cases. Ketoconazole, clotrimazole, ritonavir, indinavir, and itraconazole are strong inhibitors; analysis of the kinetics of reversal of inhibition with the model substrate 7-benzoyl quinoline showed lag phases in several cases, consistent with multiple structures of P450 3A4 inhibitor complexes. Read More

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December 2020

3D metal lattice structure manufacturing with continuous rods.

Sci Rep 2021 Jan 11;11(1):434. Epub 2021 Jan 11.

Department of Mechanical Engineering, The University of Maine, 5711 Boardman Hall, Orono, ME, 04469-5711, USA.

In this paper, a new possibility of fabricating a metal lattice structure with a continuous rod is demonstrated. A multi-layer, periodic, and aperiodic lattice structure can be manufactured with a continuous thin rod by bending it with a repetitive pattern. However, joining their nodes are challenging and an important problem to solve. Read More

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January 2021

Desmoplastic Small Round Cell Tumors: A review with focus on clinical management and therapeutic options.

Cancer Treat Rev 2021 Feb 24;93:102140. Epub 2020 Dec 24.

Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital, University of Wuerzburg, Oberduerrbacherstr. 2, 97080 Wuerzburg, Germany; Comprehensive Cancer Centre Mainfranken, University of Wuerzburg Medical Center, Josef-Schneiderstr. 6, 97080 Wuerzburg, Germany; Department of Biochemistry and Molecular Biology, University of Wuerzburg, Germany. Electronic address:

Desmoplastic Small Round Cell Tumors (DSRCTs) are an entity of rare, aggressive soft tissue sarcomas described by Gerald and Rosai in 1989. It predominantly affects male adolescents and young adults, with a peak incidence between an age of 20 and 30 years. Typically, DSRCT demonstrate as multiple small tumor nodules within the abdominal cave, retroperitoneum and pelvis. Read More

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February 2021

Fibrous osteodystrophy in a dromedary camel.

J Vet Diagn Invest 2021 Jan 14;33(1):144-148. Epub 2020 Oct 14.

Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA.

A 6-y-old female dromedary camel ( L.) was presented for assessment of firm, bilateral swellings rostral and ventral to the eyes. Serum biochemistry revealed hyperglycemia (28. Read More

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January 2021

Hyalinizing clear cell carcinoma of the soft palate: a review of literature review.

Autops Case Rep 2020 May 6;10(2):e2020156. Epub 2020 May 6.

Ascension St. John Hospital, Department of Pathology. Detroit, Michigan, USA.

Hyalinizing clear cell carcinoma (HCCC), also known as clear cell carcinoma, not otherwise specified [CCC, (NOS)], is a rare minor salivary gland tumor characterized by proliferation of clear cells, organized in trabecular cords, or solid nests within loose to densely hyalinized stroma. It is considered a diagnosis of exclusion by the World Health Organization (WHO) because other salivary tumors may also have a clear cell component. Hence, there is a wide differential diagnosis. Read More

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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Cell 2021 01 19;184(1):64-75.e11. Epub 2020 Nov 19.

MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Read More

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January 2021

New Clinicopathologic Scenarios of EBV+ Inflammatory Follicular Dendritic Cell Sarcoma: Report of 9 Extrahepatosplenic Cases.

Am J Surg Pathol 2021 06;45(6):765-772

Department of Pathology, Fudan University Shanghai Cancer Center.

EBV+ inflammatory follicular dendritic cell (FDC) sarcoma is an indolent malignant neoplasm of spindled FDCs with a rich lymphoplasmacytic infiltrate and a consistent association with Epstein-Barr virus (EBV). It occurs exclusively in the liver and spleen, with the exception of a few colonic examples. In this study, we report 9 extrahepatosplenic cases, including 4 occurring in previously undescribed sites, but all apparently anatomically related to the aerodigestive tract. Read More

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Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex.

Pain 2021 05;162(5):1322-1333

Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States.

Abstract: Pain experience can change the central processing of nociceptive inputs, resulting in persistent allodynia and hyperalgesia. However, the underlying circuit mechanisms remain underexplored. Here, we focus on pain-induced remodeling of the projection from the mediodorsal thalamus (MD) to the anterior cingulate cortex (ACC), a projection that relays spinal nociceptive input for central processing. Read More

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Bone Cement Fixation of Stapedotomy Prostheses: Long-term Outcomes in Primary and Revision Stapes Surgery.

Ann Otol Rhinol Laryngol 2021 Jul 12;130(7):769-774. Epub 2020 Nov 12.

Department of Neurotology, Michigan Ear Institute, St. John Providence Hospital and Medical Centers, Farmington Hills, MI, USA.

Objectives: To describe audiologic outcomes following hydroxyapatite bone cement fixation of stapedotomy prostheses.

Methods: A retrospective case review at a tertiary neurotology referral center was performed of patients undergoing primary or revision stapedotomy between 2010 and 2017. Patients with hydroxyapatite bone cement fixation of stapes prostheses were assessed. Read More

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Arthroscopic Management of Synovial Chondromatosis of the Ankle Joint: A Systematic Review of the Literature.

JBJS Rev 2020 09;8(9):e2000045

1Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada.

Background: Synovial chondromatosis (SC) of the ankle is a rare disorder in which metaplastic proliferation of synovia, tendon sheaths, and/or bursae leads to the formation of loose cartilaginous bodies within the joint space. While SC itself is a benign condition, its sequelae can be chronic and debilitating if left untreated, or if there is postoperative recurrence. Arthritic degeneration and malignant transformation to chondrosarcoma are among the more serious complications in the natural history of the disease; the latter occurs in approximately 5% of cases. Read More

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September 2020