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Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates.

J Med Chem 2021 Jul 27. Epub 2021 Jul 27.

Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, NO-9037 Tromsø, Norway.

We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These ,'-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold with two cationic groups and two lipophilic side chains. Minimum inhibitory concentrations of 2-8 μg/mL were achieved against 30 multi-resistant clinical isolates of Gram-positive and Gram-negative bacteria, including isolates with extended spectrum β-lactamase-carbapenemase production. Read More

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Interconvertible Living Radical and Cationic Polymerization using a Dual Photoelectrochemical Catalyst.

J Am Chem Soc 2021 Jul 27. Epub 2021 Jul 27.

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, United States.

The necessity of well-tuned reactivity for successful controlled polymer synthesis often comes with the price of limited monomer substrate scope. We demonstrate here the on-demand interconversion between living radical and cationic polymerization using two orthogonal stimuli and a dual responsive single catalyst. The dual photo- and electrochemical reactivity of 10-phenylphenothiazine catalyst provides control of the polymer's molar mass and composition by orthogonally activating the common dormant species toward two distinct chemical routes. Read More

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Myxadazoles, Myxobacterium-Derived Isoxazole-Benzimidazole Hybrids with Cardiovascular Activities.

Angew Chem Int Ed Engl 2021 Jul 27. Epub 2021 Jul 27.

Shandong University, State Key Laboratory of Microbial Technology, Binhai Road No. 72, 266237, Qingdao, CHINA.

There is a continuous need for novel microbial natural products to fill the drying-up drug development pipeline. Herein, we report myxadazoles from Myxococcus sp. SDU36, a family of novel chimeric small molecules that consist of N-ribityl 5,6-dimethylbenzimidazole and a linear fatty acid chain endowed with an isoxazole ring. Read More

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Ionotronic Tough Adhesives with Intrinsic Multifunctionality.

ACS Appl Mater Interfaces 2021 Jul 27. Epub 2021 Jul 27.

Department of Mechanical Engineering, McGill University, Montreal, Quebec H3A 0C3, Canada.

Ionotronic hydrogels find wide applications in flexible electronics, wearable/implantable devices, soft robotics, and human-machine interfaces. Their performance and practical translation have been bottlenecked by poor adhesiveness, limited mechanical properties, and the lack of biological functions. The remedies are often associated with complex formulations and sophisticated processing. Read More

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Efficient DNA-Driven Nanocavities for Approaching Quasi-Deterministic Strong Coupling to a Few Fluorophores.

ACS Nano 2021 Jul 27. Epub 2021 Jul 27.

Department of Photonics, National Cheng Kung University, Tainan, Taiwan 70101.

Strong coupling between light and matter is the foundation of promising quantum photonic devices such as deterministic single photon sources, single atom lasers, and photonic quantum gates, which consist of an atom and a photonic cavity. Unlike atom-based systems, a strong coupling unit based on an emitter-plasmonic nanocavity system has the potential to bring these devices to the microchip scale at ambient conditions. However, efficiently and precisely positioning a single or a few emitters into a plasmonic nanocavity is challenging. Read More

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Effect of brominated flame retardant on the pyrolysis products of polymers originating in WEEE.

Environ Sci Pollut Res Int 2021 Jul 26. Epub 2021 Jul 26.

Laboratory of Polymers and Dyes Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24, Thessaloniki, Greece.

Chemical recycling is an environmentally friendly method, which is often used for the recycling of plastics included in waste electric and electronic equipment (WEEE), since fuels and secondary valuable materials can be produced. Brominated flame retardants (BFRs) are usually added into these plastics to reduce their flammability; but they are toxic substances. The aim of this work is to examine the thermal behaviour and the products obtained after pyrolysis of polymer blends that consist of acrylonitrile-butadiene-styrene (ABS), high-impact polystyrene (HIPS), polycarbonate (PC) and polypropylene (PP) with composition that simulates real WEEE, in the absence and presence of a common BFR, tetrabromobisphenol A (TBBPA), in order to investigate its effect on pyrolysis products. Read More

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Last Year of Life Study-Cologne (LYOL-C) (Part II): study protocol of a prospective interventional mixed-methods study in acute hospitals to analyse the implementation of a trigger question and patient question prompt sheets to optimise patient-centred care.

BMJ Open 2021 Jul 26;11(7):e048681. Epub 2021 Jul 26.

Department of Palliative Medicine, University of Cologne, Faculty of Medicine and University Hospital, Cologne, Germany.

Introduction: The Last Year of Life Study-Cologne Part I (LYOL-C I) has identified general hospital units as the most important checkpoints for transitions in the last year of life of patients. Yet, satisfaction with hospitals, as reported by bereaved relatives, is the lowest of all health service providers. Thus, the LYOL-C Part II (LYOL-C II) focuses on optimising patient-centred care in acute hospitals for patients identified to be in their last year of life. Read More

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Propolis Can Improve Caudal Fin Regeneration in Zebrafish () Induced by The Combined Administration of Alloxan and Glucose.

Zebrafish 2021 Jul 23. Epub 2021 Jul 23.

Parasitology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Hyperglycemia, a primary symptom in diabetes mellitus, is associated with difficulties in wound healing and regeneration. This condition is due to the length of the inflammatory phase and free radicals. Furthermore, there is evidence that molecular pathogenesis is involved in impaired wound healing in diabetics. Read More

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Structural characterization and antitumor activity of a polysaccharide from Dendrobium wardianum.

Carbohydr Polym 2021 Oct 28;269:118253. Epub 2021 May 28.

Guangdong Provincial Key Lab of Ornamental Plant Germplasm Innovation and Utilization, Environmental Horticulture Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, China. Electronic address:

Through hot water extraction, protein removal and chromatographic purification, DWPP-Is was found to be the major polysaccharide present in the stem of D. wardianum. The Mn and Mw of DWPP-Is were 29. Read More

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October 2021

Systematized Review of Psychotherapeutic Components of Psilocybin-Assisted Psychotherapy.

Am J Psychother 2021 Jul 23:appipsychotherapy20200055. Epub 2021 Jul 23.

Department of Allied Health Sciences, University of North Carolina, Chapel Hill.

Objective: This systematized review sought to fill a gap in psilocybin research by investigating the structure and format of psilocybin-assisted psychotherapy (PAP), with a focus on the counseling components of the treatment.

Methods: A systematized review of PAP was conducted by using the PubMed and PsycInfo databases to search for peer-reviewed studies of human clinical trials, published within the past 25 years, in which psilocybin was administered with psychological support in a clinical setting.

Results: Eleven articles matched the criteria necessary for inclusion in this review. Read More

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Storage Capacity of Quaternion-Valued Hopfield Neural Networks With Dual Connections.

Masaki Kobayashi

Neural Comput 2021 Jul;33(8):2226-2240

Mathematical Science Center, University of Yamanashi, Kofu, Yamanashi 400-8511, Japan

A complex-valued Hopfield neural network (CHNN) is a multistate Hopfield model. A quaternion-valued Hopfield neural network (QHNN) with a twin-multistate activation function was proposed to reduce the number of weight parameters of CHNN. Dual connections (DCs) are introduced to the QHNNs to improve the noise tolerance. Read More

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[Distribution and Sources of Microplastics in Farmland Soil Along the Fenhe River].

Huan Jing Ke Xue 2021 Aug;42(8):3894-3903

Shanxi Laboratory for Yellow River, School of Environment and Resources, Shanxi University, Taiyuan 030006, China.

This study investigated the distribution and sources of microplastics smaller than 1 mm in farmland soil along the Fenhe River. Microplastics in soil samples were separated and extracted using the traditional density centrifugation method. The quantity and type of microplastics were examined with a stereomicroscope. Read More

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The origins of goals in the German Bundesliga.

J Sports Sci 2021 Jul 25:1-20. Epub 2021 Jul 25.

Machine Learning Group, Institute of Information Systems,Leuphana University of Lüneburg, Germany.

We propose to analyse the origin of goals in professional football (soccer) in a purely data-driven approach. Based on positional and event data of 3,457 goals from two seasons German Bundesliga and 2nd Bundesliga (2018/20,219 and 2019/2020), we devise a rich set of 37 features that can be extracted automatically and propose a hierarchical clustering approach to identify group structures. The results consist of 50 interpretable clusters revealing insights into scoring patterns. Read More

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Microfluidic Transport of Hybrid Optoplasmonic Particles for Repeatable SERS Detection.

Anal Chem 2021 Jul 26. Epub 2021 Jul 26.

Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.

For its ultrahigh sensitivity, the microfluidic system combined with surface-enhanced Raman spectroscopy (SERS) becomes one of the most interesting topics in integrated online monitoring related fields. In previous reports, the commonest surface plasmon-enhanced substrates in microfluidics consist of immobilized metal nanostructures on the channel surface to overcome the disturbance of Brownian motion. In this work, a hybrid optoplasmonic microfluidic conveyer is developed, in which the movable, highly ordered optoplasmonic particles are delivered to the detection spot for SERS detection. Read More

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Nonrefoldability is Pervasive Across the Proteome.

J Am Chem Soc 2021 Jul 26. Epub 2021 Jul 26.

Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.

Decades of research on protein folding have primarily focused on a subset of small proteins that can reversibly refold from a denatured state. However, these studies have generally not been representative of the complexity of natural proteomes, which consist of many proteins with complex architectures and domain organizations. Here, we introduce an experimental approach to probe protein refolding kinetics for whole proteomes using mass spectrometry-based proteomics. Read More

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Biogenic Synthesis and Catalytic Efficacy of Silver Nanoparticles Based on Peel Extracts of Fruit.

ACS Omega 2021 Jul 9;6(28):18260-18268. Epub 2021 Jul 9.

Department of Chemistry and Chemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16, Jonan, Yonezawa, Yamagata 992-8510, Japan.

Biogenically synthesized silver nanoparticles (AgNP) increase the fascination over chemical ones due to their facile and green synthetic process. This study reports the development of an eco-friendly and cost-effective synthesis of AgNPs using an aqueous extract of fruit peel, an agricultural waste, as a sole agent with both reducing and capping abilities. The formation of AgNPs was verified by the surface plasmon resonance peak at 426 nm in the UV-vis spectrum, X-ray diffraction pattern, and transmission electron micrography images. Read More

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The use of YouTube in developing the speaking skills of Jordanian EFL university students.

Heliyon 2021 Jul 12;7(7):e07543. Epub 2021 Jul 12.

Applied Science Private University, Department of English Language and Translation, Amman, 11192, Jordan.

This study examines the effectiveness of using YouTube videos in teaching the speaking skills among English as a Foreign Language (EFL) students in Jordan. The study sample comprised 80 students attending Oral Skills classes in the English Language and Literature Department at a private university in Jordan. The participants were equally divided into a control group and an experimental group of 40 students each. Read More

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Persian Validation and Cultural Adaptation of the Body Dysmorphic Disorder Questionnaire-Aesthetic Surgery for Iranian Rhinoplasty Patients.

World J Plast Surg 2021 May;10(2):55-60

ENT and Head & Neck Research Center, The Five Senses Health Institute, Iran University of Medical Sciences, Tehran, Iran.

Background: Body dysmorphic disorder (BDD) is one of the obsessive-compulsive disorders (OCD) which is very common in populations. However, the diagnosis rate is lower than the reality. BDD may lead to loneliness, jobless, avoidance of daily life and public activities. Read More

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Lifespan-Associated Gene Expression Signatures of Recombinant BXD Mice Implicates and in Longevity.

Front Genet 2021 9;12:694033. Epub 2021 Jul 9.

Laboratory of Extracellular Matrix Regeneration, Department of Health Sciences and Technology, Institute of Translational Medicine, ETH Zürich, Schwerzenbach, Switzerland.

Although genetic approaches have identified key genes and pathways that promote longevity, systems-level approaches are less utilized. Here, we took advantage of the wealth of omics data characterizing the BXD family of mice. We associated transcript and peptide levels across five tissues from both female and male BXD isogenic lines with their median lifespan. Read More

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Evolutionary Perspective and Expression Analysis of Intronless Genes Highlight the Conservation of Their Regulatory Role.

Front Genet 2021 9;12:654256. Epub 2021 Jul 9.

Centro de Investigacioìn y de Estudios Avanzados del IPN, Unidad Irapuato, Guanajuato, Mexico.

The structure of eukaryotic genes is generally a combination of exons interrupted by intragenic non-coding DNA regions (introns) removed by RNA splicing to generate the mature mRNA. A fraction of genes, however, comprise a single coding exon with introns in their untranslated regions or are intronless genes (IGs), lacking introns entirely. The latter code for essential proteins involved in development, growth, and cell proliferation and their expression has been proposed to be highly specialized for neuro-specific functions and linked to cancer, neuropathies, and developmental disorders. Read More

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SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns.

Front Immunol 2021 7;12:708264. Epub 2021 Jul 7.

Molecular Biomedicine Department, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain.

There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles during infection are still not completely understood. Here, a review on the current knowledge of SARS-CoV-2 accessory proteins is summarized updating new research that could be critical in understanding SARS-CoV-2 interaction with the host. Read More

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Drug Shortage: Causes, Impact, and Mitigation Strategies.

Front Pharmacol 2021 9;12:693426. Epub 2021 Jul 9.

Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Drug shortage is a global issue affecting low, middle, and high-income countries. Many countries have developed various strategies to overcome the problem, while the problem is accelerating, affecting the whole world. All types of drugs, such as essential life-saving drugs, oncology medicines, antimicrobial drugs, analgesics, opioids, cardiovascular drugs, radiopharmaceutical, and parenteral products, are liable to the shortage. Read More

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The Effect of Augmented Reality based applications on achievement and attitude towards science course in distance education process.

Educ Inf Technol (Dordr) 2021 Jul 14:1-19. Epub 2021 Jul 14.

Curriculum and Instruction in Education, Faculty of Education, Siirt University, Siirt, Turkey.

This study aims to enrich a theme in the science course in the distance education process with augmented reality-based applications and to examine the effects of these applications on students' achievement and attitudes in science courses. A single group pretest and posttest experimental design was used in this research. The research group consisted of 15 third grade students attending at a school in Siirt during the 2020-2021 academic year. Read More

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Methods of assessing categorical agreement between correlated screening tests in clinical studies.

J Appl Stat 2021 9;48(10):1861-1881. Epub 2020 Jun 9.

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Advances in breast imaging and other screening tests have prompted studies to evaluate and compare the consistency between experts' ratings of existing with new screening tests. In clinical settings, medical experts make subjective assessments of screening test results such as mammograms. Consistency between experts' ratings is evaluated by measures of inter-rater agreement or association. Read More

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Continuities and Changes in the Processes of Mexican Migration and Return.

Ann Am Acad Pol Soc Sci 2019 Jul 8;684(1):212-226. Epub 2019 Jul 8.

University of Pennsylvania 3718 Locust Walk, Suite 353 Philadelphia, PA 19104.

This article examines continuities and changes in the prevalence and determinants of first migration and return between Mexico and the United States. Results show a dramatic decline over time in the likelihood of migrants' making a first trip. The empirical design distinguishes processes affecting migrating cohorts from those emanating from period conditions, paying particular attention to changes in educational selectivity and the legal status of the flows. Read More

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Elevated levels of neopterin and pentraxin 3 in patients with rheumatoid arthritis.

Horm Mol Biol Clin Investig 2021 Jul 26. Epub 2021 Jul 26.

Department of Rheumatology, Selcuk University Faculty of Medicine, Konya, Turkey.

Objectives: As a systemic inflammatory disease, rheumatoid arthritis (RA) is the most common inflammatory arthritis in the population and there is no specific diagnostic marker in laboratory tests. The purpose of the study was to determine whether serum neopterin and pentraxin 3 (PTX3) levels may be a marker of increased inflammation in RA patients.

Materials And Methods: The study were consist of 30 RA patients and 30 healthy controls who were admitted to the department of rheumatology. Read More

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Three-dimensional missense tolerance ratio analysis.

Genome Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

A wealth of genetic information is available describing single-nucleotide variants in the human population that appear to be well-tolerated and in and of themselves do not confer disease. These variant data sets contain signatures about the protein structure-function relationships and provide an unbiased view of various protein functions in the context of human health. This information can be used to determine regional intolerance to variation, defined as the missense tolerance ratio (MTR), which is an indicator of stretches of the polypeptide chain that can tolerate changes without compromising protein function in a manner that impacts human health. Read More

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Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine.

Sci Adv 2021 Jul 23;7(30). Epub 2021 Jul 23.

Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC, USA.

Bile salt synthesis, secretion into the intestinal lumen, and resorption in the ileum occur in all vertebrate classes. In mammals, bile salt composition is determined by host and microbial enzymes, affecting signaling through the bile salt-binding transcription factor farnesoid X receptor (Fxr). However, these processes in other vertebrate classes remain poorly understood. Read More

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An Update Review on -Type Layered Oxyselenide Thermoelectric Materials.

Materials (Basel) 2021 Jul 13;14(14). Epub 2021 Jul 13.

School of Materials Science and Engineering, Beihang University, Beijing 100191, China.

Compared with traditional thermoelectric materials, layered oxyselenide thermoelectric materials consist of nontoxic and lower-cost elements and have better chemical and thermal stability. Recently, several studies on -type layered oxyselenide thermoelectric materials, including BiCuSeO, BiOSe and BiCuSeO, were reported, which stimulates us to comprehensively summarize these researches. In this short review, we begin with various attempts to realize an -type BiCuSeO system. Read More

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Facile Synthesis of Uniform Mesoporous NbO Micro-Flowers for Enhancing Photodegradation of Methyl Orange.

Materials (Basel) 2021 Jul 6;14(14). Epub 2021 Jul 6.

Institute for Energy Research, Jiangsu University, Zhenjiang 212013, China.

The removal of organic pollutants using green environmental photocatalytic degradation techniques urgently need high-performance catalysts. In this work, a facile one-step hydrothermal technique has been successfully applied to synthesize a NbO photocatalyst with uniform micro-flower structure for the degradation of methyl orange (MO) under UV irradiation. These nanocatalysts are characterized by transmission and scanning electron microscopies (TEM and SEM), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) method, and UV-Vis diffuse reflectance spectroscopy (DRS). Read More

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