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Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study.

Nanomaterials (Basel) 2021 May 7;11(5). Epub 2021 May 7.

Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory of Nanophotonic Materials and Devices, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Ambient Particles Health Effects and Prevention Techniques, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China.

Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, and easy surface modification. These unique properties have increasingly attracted researchers to apply bacterial magnetosomes (BMs) in the fields of biology and medicine as MRI imaging contrast agents. Due to the concern of biosafety, a long-term follow-up of the distribution and clearance of BMs after entering the body is necessary. Read More

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Medication administration errors: A concept analysis.

Nurs Forum 2021 May 30. Epub 2021 May 30.

Family, Community, and Health System Department, The University of Alabama at Birmingham School of Nursing, Birmingham, Alabama, USA.

Aim: To provide an analysis of the concept of medication errors that occur during the nursing task of medication administration.

Background: Medication errors occurring during medication administration have an increased risk for an adverse patient outcome. Many terms are associated with medication errors, with limited clarification for a medication administration error at the point of care delivery. Read More

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Selective H-N Distance Measurements by N Overtone Solid-State NMR Spectroscopy at Fast MAS.

Front Mol Biosci 2021 8;8:645347. Epub 2021 Apr 8.

NMR Science and Development Division, RIKEN SPring-8 Center, Nano-Crystallography Unit, RIKEN-JEOL Collaboration Center, Yokohama, Japan.

Accurate distance measurements between proton and nitrogen can provide detailed information on the structures and dynamics of various molecules. The combination of broadband phase-modulated (PM) pulse and rotational-echo saturation-pulse double-resonance (RESPDOR) sequence at fast magic-angle spinning (MAS) has enabled the measurement of multiple H-N distances with high accuracy. However, complications may arise when applying this sequence to systems with multiple inequivalent N nuclei, especially a single H sitting close to multiple N atoms. Read More

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Porous block copolymer separation membranes for 21st century sanitation and hygiene.

Chem Soc Rev 2021 Jun;50(11):6333-6348

Institut für Chemie neuer Materialien and CellNanOs, Universität Osnabrück, Barbarastr. 7, 49076 Osnabrück, Germany.

Removing hazardous particulate and macromolecular contaminants as well as viruses with sizes from a few nm up to the 100 nm-range from water and air is crucial for ensuring sufficient sanitation and hygiene for a growing world population. To this end, high-performance separation membranes are needed that combine high permeance, high selectivity and sufficient mechanical stability under operating conditions. However, design features of separation membranes enhancing permeance reduce selectivity and vice versa. Read More

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The structure of the native cardiac thin filament at systolic Ca levels.

Proc Natl Acad Sci U S A 2021 Mar;118(13)

Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507;

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments orchestrated by rising and falling Ca levels. Thin filaments are comprised of two actin strands, each harboring equally separated troponin complexes, which bind Ca to move tropomyosin cables away from the myosin binding sites and, thus, activate systolic contraction. Recently, structures of thin filaments obtained at low (pCa ∼9) or high (pCa ∼3) Ca levels revealed the transition between the Ca-free and Ca-bound states. Read More

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Complete Mitochondrial Genome of from and .

Life (Basel) 2021 Feb 6;11(2). Epub 2021 Feb 6.

Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Calle San Fernando, 4, 41004 Sevilla, Spain.

Trichuriasis is among the most prevalent worldwide parasitism caused by helminths. For many years, spp. have been described with a relatively narrow range of both morphological and biometrical features. Read More

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February 2021

Recent advances on immunosuppressive drugs and remyelination enhancers for the treatment of multiple sclerosis.

Curr Pharm Des 2021 Jan 27. Epub 2021 Jan 27.

Departamento de Bioquímica y Biología Molecular. Instituto de Neurociencias de Castilla y León (INCYL). Universidad de Salamanca. Instituto de Investigación Biomédica de Salamanca (IBSAL). Spain.

Mammalian nervous systems depend crucially on myelin sheaths covering the axons. In the central nervous system, myelin sheaths consist of lipid structures which are generated from the membrane of oligodendrocytes (OL). These sheaths allow fast nerve transmission, protect axons and provide them metabolic support. Read More

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January 2021

The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation.

AAPS J 2021 01 7;23(1):20. Epub 2021 Jan 7.

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

Alcohol dehydrogenases (ADHs) are most known for their roles in oxidation and elimination of ethanol. Although less known, ADHs also play a critical role in the metabolism of a number of drugs and metabolites that contain alcohol functional groups, such as abacavir (HIV/AIDS), hydroxyzine (antihistamine), and ethambutol (antituberculosis). ADHs consist of 7 gene family numbers and several genetic polymorphic forms. Read More

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January 2021

Population Structure and Genetic Diversity of Based on Genome-Wide High-Quality SNPs.

Plants (Basel) 2020 Dec 29;10(1). Epub 2020 Dec 29.

Department of Bioresources Engineering, Sejong University, Seoul 05006, Korea.

Pumpkins () are one of the most important economic crops in genus worldwide. They are a popular food resource and an important rootstock resource for various Cucurbitaceae. Especially, is widely used as a rootstock for the commercial production of bloomless cucumbers in East Asia. Read More

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December 2020

Narrow-energy gap conjugated polymers based on benzobisthiadiazole and thiadiazoloquinoxaline: DFT and TDDFT study.

J Mol Model 2020 Sep 27;26(10):289. Epub 2020 Sep 27.

, İstanbul, Turkey.

Herein, the HOMO-LUMO energy gaps (Eg) and UV spectra of benzo[1,2-c:4,5-c']bis([1,2,5]thiadiazole (BBT) and [1,2,5]thiadiazolo[3,4-g]quinoxaline (TQ)-based donor-acceptor-donor type-conjugated polymers were computed by using density functional theory (DFT) and time-dependent density functional theory (TD-DFT) at B3LYP/6-31G(d,p) level. The donor groups consist of thiophene (TH), 3,4-ethylenedioxythiophene (EDOT), and 3,4-propylene dioxythiophene (ProDOT) units and the bisthiadiazole and thiadiazoloquinoxaline were chosen as electron acceptor groups. To examine the effects of the alkyl side chain on the molecular structure and Eg of the polymer, methyl groups were added at the 3,4-, 2,3-, and 3,3-positions of TH, EDOT, and ProDOT donor groups, respectively. Read More

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September 2020

Luminescent Colloidal InSb Quantum Dots from Generated Single-Source Precursor.

ACS Nano 2020 Oct 16;14(10):13146-13160. Epub 2020 Sep 16.

Condensed Matter and Interfaces, Debye Institute for Nanomaterials Science, Utrecht University, P.O. Box 80000, 3508 TA Utrecht, The Netherlands.

Despite recent advances, the synthesis of colloidal InSb quantum dots (QDs) remains underdeveloped, mostly due to the lack of suitable precursors. In this work, we use Lewis acid-base interactions between Sb(III) and In(III) species formed at room temperature from commercially available compounds (, InCl, Sb[NMe] and a primary alkylamine) to obtain InSb adduct complexes. These complexes are successfully used as precursors for the synthesis of colloidal InSb QDs ranging from 2. Read More

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October 2020

Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar.

BMC Genet 2020 09 1;21(1):95. Epub 2020 Sep 1.

Nakamura Laboratory, Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.

Background: Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 gene, a genetic locus that has been linked to the immune response, in Myanmar cattle populations.

Methods: Blood samples (n = 294) were taken from two native breeds (Pyer Sein, n = 163 and Shwe Ni, n = 69) and a cattle crossbreed (Holstein-Friesian, n = 62) distributed across six regions of Myanmar (Bago, n = 38; Sagaing, n = 77; Mandalay, n = 46; Magway, n = 46; Kayin, n = 43; Yangon, n = 44). Read More

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September 2020

Heterometallic Seed-Mediated Growth of Monodisperse Colloidal Copper Nanorods with Widely Tunable Plasmonic Resonances.

Nano Lett 2020 10 11;20(10):7263-7271. Epub 2020 Sep 11.

Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.

We report a heterometallic seed-mediated synthesis method for monodisperse penta-twinned Cu nanorods using Au nanocrystals as seeds. Elemental analyses indicate that resultant nanorods consist predominantly of copper with a gold content typically below 3 atom %. The nanorod aspect ratio can be readily adjusted from 2. Read More

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October 2020

Clinical manifestations of 11 children with fronto-ocular syndrome (FOS): a case series.

Childs Nerv Syst 2021 May 18;37(5):1779-1784. Epub 2020 Aug 18.

Department of Medical Genetics, Konya Training and Research Hospital, Konya, Turkey.

Fronto-ocular syndrome (FOS) is a rarely seen trigonocephaly syndrome in which metopic synostosis features are unique. This report presents six cases with FOS. Clinical manifestations mainly involve skull and facial findings. Read More

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Investigating the Formation of MoSe and TiSe Films from Artificially Layered Precursors.

Inorg Chem 2020 Sep 12;59(17):12536-12544. Epub 2020 Aug 12.

Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, United States.

The reaction of ultrathin layers of Mo and Ti with Se was investigated, and significantly different reaction pathways were found. However, in both systems postdeposition annealing results in smooth dichalcogenide films with specific thicknesses determined by the precursor. X-ray diffraction (XRD) patterns of as-deposited Mo|Se films around a 1:2 ratio of Mo to Se contain weak, broad reflections from small and isolated MoSe crystallites that nucleated during deposition and a sharper intensity maximum resulting from the composition modulation created from the alternating deposition of Mo and Se layers. Read More

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September 2020

Phenotypically distinguishing ESBL-producing pathogens using paper-based surface enhanced Raman sensors.

Anal Chim Acta 2020 Aug 11;1127:207-216. Epub 2020 Jul 11.

Fischell Department of Bioengineering, 8278 Paint Branch Drive, University of Maryland, College Park, MD, USA. Electronic address:

Antimicrobial stewardship practices are critical in preventing the further erosion of treatment options for bacterial infections. Yet, at the same time, determination of an infection's antimicrobial susceptibility requires multiple rounds of culture and expensive lab automation systems. In this work, we report the use of paper-based surface enhanced Raman spectroscopy (SERS) sensors and portable instrumentation to phenotypically discriminate multi-drug resistance with fewer culture steps than conventional clinical microbiology. Read More

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Early Glottic Cancer Treated by Transoral Laser Surgery Using Toluidine Blue for the Definition of the Surgical Margins: A Pilot Study.

Medicina (Kaunas) 2020 Jul 3;56(7). Epub 2020 Jul 3.

Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, 95100 Catania, Italy.

: Transoral laser microsurgery (TLM) is widely accepted for its advantages, which consist of a brief hospital stay, rapid functional recovery, low management costs and the fact that it can be easily repeated in cases of recurrence. However, a high incidence of positive or narrow surgical margins has been reported in the literature, even if controversy still exists on the prognostic significance of positive resection margins. The aim of the study was to evaluate the utility of toluidine blue staining in defining the resection margins of early glottic cancer (T1a-T2) treated with TLM. Read More

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Stereoretentive Ring-Opening Metathesis Polymerization to Access All- Poly(-phenylenevinylene)s with Living Characteristics.

J Am Chem Soc 2020 07 2;142(28):11983-11987. Epub 2020 Jul 2.

Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.

Poly(-phenylenevinylene)s (PPVs), a staple of the conductive polymer family, consist of alternating alkene and phenyl groups in conjugation. The physical properties of this organic material are intimately linked to the / configuration of the alkene groups. While many synthetic methods afford PPVs with all- stereochemistry, very few deliver the all- congeners. Read More

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Privacy-preserving architecture for providing feedback to clinicians on their clinical performance.

BMC Med Inform Decis Mak 2020 06 22;20(1):116. Epub 2020 Jun 22.

Norwegian Centre for E-health Research, University Hospital of North Norway, 9019, Tromsø, Norway.

Background: Learning from routine healthcare data is important for the improvement of the quality of care. Providing feedback on clinicians' performance in comparison to their peers has been shown to be more efficient for quality improvements. However, the current methods for providing feedback do not fully address the privacy concerns of stakeholders. Read More

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Urban moth communities suggest that life in the city favours thermophilic multi-dimensional generalists.

Proc Biol Sci 2020 06 10;287(1928):20193014. Epub 2020 Jun 10.

Ecology and Evolution in Microbial Model Systems, EEMIS, Department of Biology and Environmental Science, Linnaeus University, 39182 Kalmar, Sweden.

Biodiversity is challenged worldwide by exploitation, global warming, changes in land use and increasing urbanization. It is hypothesized that communities in urban areas should consist primarily of generalist species with broad niches that are able to cope with novel, variable, fragmented, warmer and unpredictable environments shaped by human pressures. We surveyed moth communities in three cities in northern Europe and compared them with neighbouring moth assemblages constituting species pools of potential colonizers. Read More

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Unprecedentedly Low CO Transport through Vertically Aligned, Conical Silicon Nanotube Membranes.

Nano Lett 2020 Jul 8;20(7):4754-4760. Epub 2020 Jun 8.

Department of Energy Engineering, Hanyang University, Seoul 04763, Republic of Korea.

Nanotube membranes could show significantly enhanced permeance and selectivity for gas separations. Up until now, studies have primarily focused on applying carbon nanotubes to membranes to achieve ultrafast mass transport. Here, we report the first preparation of silicon nanotube (SiNT) membranes via a template-assisted method and investigate the gas transport behavior through these SiNT membranes using single- and mixed-gas permeation experiments. Read More

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Deposition of Ag Films on Liquid Substrates via Thermal Evaporation for Surface-Enhanced Raman Scattering.

ACS Omega 2020 Apr 25;5(13):7440-7445. Epub 2020 Mar 25.

Department of Applied Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.

Surface-enhanced Raman scattering (SERS) substrates were prepared by depositing Ag atoms on liquid surfaces via thermal evaporation at room temperature. These free-sustained substrates result in the formation of uniform Ag films, in which ramified Ag aggregates consist of substantial Ag nanoclusters with narrow gaps of several nanometers in between. SERS spectra of rhodamine 6G were investigated for this substrate to evaluate the SERS performance of this characteristic film morphology, and the results indicated that the SERS intensity from the closely-packed Ag nanostructures and small intervals were significantly enhanced. Read More

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Controlled Quantum Dot Formation in Atomically Engineered Graphene Nanoribbon Field-Effect Transistors.

ACS Nano 2020 May 6;14(5):5754-5762. Epub 2020 Apr 6.

Empa, Swiss Federal Laboratories for Materials Science and Technology, CH-8600 Dübendorf, Switzerland.

Graphene nanoribbons (GNRs) have attracted strong interest from researchers worldwide, as they constitute an emerging class of quantum-designed materials. The major challenges toward their exploitation in electronic applications include reliable contacting, complicated by their small size (<50 nm), and the preservation of their physical properties upon device integration. In this combined experimental and theoretical study, we report on the quantum dot behavior of atomically precise GNRs integrated in a device geometry. Read More

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Eosinophilic Esophagitis: Diagnosis and Current Management.

J Gastrointestin Liver Dis 2020 Mar 13;29(1):85-97. Epub 2020 Mar 13.

Department of Health Sciences, United Campus of Malta, Msida, MSD 9024, Malta; Faculty of Medicine, Chinese University of Hong Kong, ShaTin, Hong Kong.

Eosinophilic esophagitis (EoE) is an eosinophil-rich, Th2 antigen-mediated disease of increasing worldwide prevalence. Originally considered common in children and young adults, it can be seen at any age, with the highest prevalence between 30 and 40 years. Symptoms reflect esophageal dysfunction, and typical endoscopic pictures consist of rings, furrows, exudates and edema. Read More

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Fabrication of MEMS Directional Acoustic Sensors for Underwater Operation.

Sensors (Basel) 2020 Feb 25;20(5). Epub 2020 Feb 25.

Department of Physics, Naval Postgraduate School, Monterey, CA 93943, USA.

In this work, microelectromechanical systems (MEMS)-based directional acoustic sensors operating in an underwater environment are explored. The studied sensors consist of a free-standing single wing or two wings pivoted to a substrate. The sensors operate in a narrow frequency band determined by the resonant frequency of the mechanical structure. Read More

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February 2020

Ordered Assembly of Tau Protein and Neurodegeneration.

Adv Exp Med Biol 2019 ;1184:3-21

Clifford Allbutt Building, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Tau filaments with distinct morphologies and/or isoform compositions underlie a large number of human neurodegenerative diseases. Their formation is important, because dominantly inherited mutations in MAPT, the tau gene, cause frontotemporal dementia with abundant filamentous tau inclusions. Assembly of tau may begin in a specific region of the brain, from where it spreads to other areas. Read More

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Desmoplastic Trichoepithelioma: An Uncommon but Diagnostically Problematic Benign Adnexal Tumor.

Acta Dermatovenerol Croat 2019 Dec;27(4):282-284

Vladimír Bartoš, MD, PhD, MPH, Deapartment of Pathology Faculty Hospital in Žilina, Vojtecha Spanyola 43, 012 07 Žilina, Slovakia;

Dear Editor, I read an interesting recent article by Karimzadeh et al. (1) in an earlier issue of your journal, who provided a comprehensive review addressing a relatively rare benign tumor originating from the hair follicles - trichoepithelioma (TE). They rightly claimed that trichoepithelioma can be divided into the following 3 subgroups: a) multiple familiar TE, b) solitary non-hereditary TE, and c) desmoplastic trichoepithelioma (DTE). Read More

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December 2019

Skeletal ciliopathies: a pattern recognition approach.

Jpn J Radiol 2020 Mar 21;38(3):193-206. Epub 2020 Jan 21.

Center for Intractable Diseases, Saitama University Hospital, Saitama, Japan.

Ciliopathy encompasses a diverse group of autosomal recessive genetic disorders caused by mutations in genes coding for components of the primary cilia. Skeletal ciliopathy forms a subset of ciliopathies characterized by distinctive skeletal changes. Common skeletal ciliopathies include Jeune asphyxiating thoracic dysplasia, Ellis-van Creveld syndrome, Sensenbrenner syndrome, and short-rib polydactyly syndromes. Read More

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From LASER physics to the para-hydrogen pumped RASER.

Prog Nucl Magn Reson Spectrosc 2019 Oct - Dec;114-115:1-32. Epub 2019 May 28.

Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, D-52056 Aachen, Germany.

The properties of the LASER with respect to self-organization are compared with the key features of the p-H pumped RASER. According to LASER theory the equations of motion for the LASER can be derived from the enslaving principle, i.e. Read More

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