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Comparative evaluation of the conventional tube test and column agglutination technology for ABO antibody titration in healthy individuals: a report from India.

Immunohematology 2021 Mar;37(1):25-32

Tata Medical Center , Kolkata , India .

Determination of accurate anti-A/-B titers is important for treatment selection in ABO-incompatible stem cell and solid-organ transplants. The standard method for ABO antibody titration is the conventional tube test (CTT). Dithiothreitol (DTT) is commonly used to inactivate the IgM antibody component. Read More

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Clinical outcome after anti-tumour necrosis factor therapy discontinuation in 1000 patients with inflammatory bowel disease: the EVODIS long-term study.

Aliment Pharmacol Ther 2021 May 7. Epub 2021 May 7.

Madrid, Spain.

Background: The long-term outcome of patients after antitumour necrosis factor alpha (anti-TNF) discontinuation is not well known.

Aims: To assess the risk of relapse in the long-term after anti-TNF discontinuation.

Methods: This was an extension of the evolution after anti-TNF discontinuation in patients with inflammatory bowel disease (EVODIS) study (Crohn's disease or ulcerative colitis patients treated with anti-TNFs in whom these drugs were withdrawn after achieving clinical remission) based in the same cohort of patients whose outcome was updated. Read More

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Combining urine antigen and blood polymerase chain reaction for the diagnosis of disseminated histoplasmosis in hospitalized patients with advanced HIV disease.

Med Mycol 2021 May 7. Epub 2021 May 7.

Laboratório de Biologia Molecular de Parasitas e Fungos, Instituto Adolfo Lutz, São Paulo 01246-000, Brazil.

Disseminated histoplasmosis (DH) is endemic in Latin America and the Caribbean where diagnostic tools are restricted. We carried-out a 1-year prospective cohort study at a referral hospital in São Paulo, Brazil. Participants had > or =18 years old, were hospitalized due to any indication and had CD4+ < 200 cells/µl. Read More

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Spinal column shortening for secondary tethered cord syndrome: radiographic, clinical, patient-reported, and urodynamic short-term outcomes.

J Neurosurg Pediatr 2021 May 7:1-10. Epub 2021 May 7.

1Section of Pediatric Neurosurgery, Department of Neurological Surgery, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis.

Objective: Tethered cord syndrome (TCS) is a clinical and radiographic diagnosis of pathological stretching of the spinal cord leading to progressive loss of neurological function. The gold standard treatment for TCS is a tethered cord release. However, detethering involves significant risks of spinal cord injury and high rates of retethering. Read More

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Incidence of concussion and recovery of neurocognitive dysfunction on ImPACT assessment among youth athletes with premorbid depression or anxiety taking antidepressants.

J Neurosurg Pediatr 2021 May 7:1-7. Epub 2021 May 7.

1Neurosurgery Department, Icahn School of Medicine at Mount Sinai, New York.

Objective: Concussions in youth sports comprise an estimated 1.6-3.8 million annual injuries in the US. Read More

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Effects of skin-to-skin care on electrical activity of the diaphragm in preterm infants during neurally adjusted ventilatory assist.

Early Hum Dev 2021 Apr 29;157:105379. Epub 2021 Apr 29.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan. Electronic address:

Background: Skin-to-skin care (SSC) reduces neonatal mortality and morbidity and is widely implemented in the neonatal intensive care unit. However, changes in respiratory effort during SSC in ventilated preterm infants remain unclear.

Aims: To evaluate the effect of SSC on electrical activity of the diaphragm (Edi) and vital signs in premature infants who are intubated and under neurally adjusted ventilatory assist ventilation. Read More

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Cortical responsive neurostimulation in a baboon with genetic generalized epilepsy.

Epilepsy Behav 2021 May 4;120:107973. Epub 2021 May 4.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, United States; Department of Animal Science, University of Wyoming, Laramie, WY, United States.

Objective: To evaluate the efficacy of cortical responsive neurostimulation (CRN) in a male baboon with epilepsy and with genetic generalized epilepsy (GGE), as well as the alteration of seizure patterns and their circadian rhythms due to treatment.

Methods: The baboon was implanted with two subdural frontoparietal strips, bridging the medial central sulci bilaterally. Electrocorticography (ECoG) data were downloaded daily during a three-month baseline, then every 2-3 days over a five-month treatment period. Read More

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A systematic review of population pharmacokinetic analyses of polyclonal immunoglobulin G therapy.

Int Immunopharmacol 2021 May 4;97:107721. Epub 2021 May 4.

Centre for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Electronic address:

Background: Population pharmacokinetics (popPK) using the nonlinear mixed-effect (NLME) modeling approach is an essential tool for guiding dose individualization. Several popPK analyses using the NLME have been conducted to characterize the pharmacokinetics of immunoglobulin G (IgG).

Objective: To summarize the current information on popPK of polyclonal IgG therapy. Read More

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A clinical investigation into the ability of subjects with lung disease to provide breath specimens using the EvidenzerIRL evidential breath analyser in alcohol intoxicant driving in criminal justice evidence.

J Forensic Leg Med 2021 Apr 28;80:102175. Epub 2021 Apr 28.

Medical Bureau of Road Safety, Health Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

The EvidenzerIRL instrument has been in use as an evidential breath analyser in the application of drink driving laws in the Republic of Ireland since 2011. The result of the analysis is used as evidence in prosecutions before the Courts in per se offences of driving under the influence of alcohol as distinct from screening results at the roadside. This study aims to assist doctors, lawyers and judges in assessing drivers' failure to provide valid evidential breath specimens. Read More

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Molecular characterisation and epidemiology of enterovirus-associated aseptic meningitis in the Western and Eastern Cape Provinces, South Africa 2018-2019.

J Clin Virol 2021 Apr 24;139:104845. Epub 2021 Apr 24.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa and the National Health Laboratory Service, Anzio Road, Observatory, Cape Town, South Africa.

Background: Enteroviruses are amongst the most common causes of aseptic meningitis. Between November 2018 and May 2019, an outbreak of enterovirus-associated aseptic meningitis cases was noted in the Western and Eastern Cape Provinces, South Africa.

Objectives: To describe the epidemiology and phylogeography of enterovirus infections during an aseptic meningitis outbreak in the Western and Eastern Cape Provinces of South Africa. Read More

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Comparing the inter-observer reliability of the Tada formula among neurosurgeons while estimating the intracerebral haematoma volume.

Clin Neurol Neurosurg 2021 May 1;205:106668. Epub 2021 May 1.

The First Affiliated Hospital of Xia'men University, 55# Zhenhai Road, Xia'men, Fujian 361003, China. Electronic address:

Objective: To compare the inter-observer reliability among neurosurgeons while estimating the intracerebral haematoma (ICH) volume by the Tada formula and assess its influence on predicting the severity and prognosis of various ICHs.

Methods: We obtained clinical data from 262 consecutive patients with spontaneous ICH. The haematoma volume was independently calculated and compared by 3D Slicer and eight neurosurgeons. Read More

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A meta-analysis on potential modifiers of LITT efficacy for mesial temporal lobe epilepsy: Seizure-freedom seems to fade with time.

Clin Neurol Neurosurg 2021 Apr 20;205:106644. Epub 2021 Apr 20.

Departments of Neurosurgery, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Background: The efficacy of laser interstitial thermal therapy (LITT) in mesial temporal lobe epilepsy (MTLE) has not been clearly established yet.

Objective: We conducted a meta-analysis to estimate the efficacy of LITT for TLE (Q1). We also examined the effect of the patient's age (Q2), the total ablation volume (TAV) (Q3), the strength of the MRI unit (Q4), the type of the utilized stereotactic platform (Q5), and the follow up period (Q6) on the patient's outcome. Read More

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Long term outcomes of idiopathic intracranial hypertension: Observational study and literature review.

Clin Neurol Neurosurg 2021 Jan 5;205:106463. Epub 2021 Jan 5.

Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address:

Background: Idiopathic intracranial hypertension (IIH) is an unexplained increase in intracranial pressure often associated with obesity. The aim of this study was to conduct a retrospective observational study of the long term clinical, visual, and treatment outcomes in IIH patients.

Methods: A retrospective observational study of patients diagnosed with IIH over a 12-year period at a single centre was completed via database review. Read More

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January 2021

Natural history of EBV replication and viral load dynamics after alemtuzumab based allogeneic stem cell transplantation.

Transplant Cell Ther 2021 May 4. Epub 2021 May 4.

Department of Haematology, UCL Cancer Institute, University College London, London, UK; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.

Background: Epstein-Barr virus (EBV) load monitoring post-allogeneic haematopoietic stem cell transplantation (HSCT) enables earlier detection of EBV replication and is often used as a trigger for pre-emptive therapies aiming to reduce EBV-related diseases. Our institutional strategy is to treat patients with clinical signs of EBV-related disease accompanied by a rising viral load, rather than to intervene solely based on viral load. This affords an opportunity to study the natural history of EBV replication and to assess if our strategy reduces over-treatment without compromising outcomes. Read More

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Biomarkers of the severity of honeybee sting reactions and the severity and threshold of systemic adverse events during immunotherapy.

J Allergy Clin Immunol Pract 2021 May 4. Epub 2021 May 4.

University Hospital of Respiratory and Allergic Diseases, Golnik, Slovenia. Electronic address:

Background: A biomarker that could identify individuals at high risk for severe honeybee sting allergic reaction and/or systemic adverse events (SAEs) during venom immunotherapy (VIT) would improve the management of patients with honeybee (HB) venom allergy.

Objective: To identify biomarkers for risk of severe sting reactions or SAEs during VIT.

Methods: We recruited 332 patients undergoing honeybee VIT. Read More

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Dalbavancin treatment for prosthetic joint infections in real-life: a national cohort study and literature review.

J Glob Antimicrob Resist 2021 May 4. Epub 2021 May 4.

Infectious Disease Unit, Raymond-Poincaré University Hospital, AP-HP Paris Saclay University, Garches, France. Electronic address:

Background: Dalbavancin is a long-lasting lipoglycopeptide active against gram-positive bacteria, especially methicillin-resistant staphylococci. Few data are available on dalbavancin use for prosthetic joint infection (PJI) treatment. We aimed to describe a cohort of patients treated for PJI with dalbavancin and review the literature concerning this condition. Read More

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Fluorescence and thermal imaging of non-melanoma skin cancers before and during photodynamic therapy.

Photodiagnosis Photodyn Ther 2021 May 4:102327. Epub 2021 May 4.

Photobiology Unit, NHS Tayside, Ninewells Hospital and Medical School, Dundee, UK; The Scottish Photodynamic Therapy Centre, Dundee, UK; School of Medicine, University of Dundee, Dundee, UK.

Background: Photodynamic therapy (PDT) has been shown to be less effective on the extremities. Protoporphyrin-IX (PpIX) fluorescence and skin surface temperature are variables that have been implicated in the differences in efficacy with body site, but objective studies have not been undertaken.

Objectives: To further investigate observations from our previous study that temperature and fluorescence during pro-drug incubation are correlated, through a prospective objective investigation of the relationships between fluorescence and skin surface temperature before and during PDT and relationships with body site and efficacy. Read More

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Tenofovir Alafenamide for Drug-Resistant Hepatitis B: A Randomized Trial for Switching from Tenofovir Disoproxil Fumarate.

Clin Gastroenterol Hepatol 2021 May 4. Epub 2021 May 4.

Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background & Aims: It remains unknown whether tenofovir alafenamide (TAF) could replace tenofovir disoproxil fumarate (TDF) in patients with drug-resistant hepatitis B virus (HBV).

Methods: In this multi-center randomized non-inferiority trial, 174 patients with HBV resistant to multiple drugs (lamivudine, entecavir, and/or adefovir) under TDF monotherapy for ≥96 weeks were randomized 1:1 to switch to TAF (n=87) or continue TDF (n=87) for 48 weeks. The primary endpoint was proportion of patients with HBV DNA<60 IU/mL at week 48. Read More

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Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes. Results from a multicentre prospective cohort in Spain (PRO-BAC study).

Int J Antimicrob Agents 2021 May 4:106352. Epub 2021 May 4.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla, Sevilla, Spain.

Background: The epidemiology of bloodstream infections (BSI) is dynamic because it depends on microbiological, host, and healthcare system factors. The aim of this study is to update the information about the epidemiology of BSI in Spain considering the types of acquisition.

Methods: An observational, prospective cohort study in 26 Spanish hospitals from October 2016 throughout March 2017 including all episodes of BSI in adults was performed. Read More

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Genicular artery embolization for refractory hemarthrosis following total knee arthroplasty: technique, safety, efficacy, and patient-reported outcomes.

J Vasc Interv Radiol 2021 May 4. Epub 2021 May 4.

The Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, United States.

Purpose: This single institution study describes the technique, safety, and efficacy of genicular artery embolization (GAE) for treatment of refractory hemarthrosis following total knee arthroplasty (TKA) with a focus on patient-reported outcomes.

Material And Methods: Patients who underwent GAE between January 2010 and March 2020 at the authors' institution were included if they had undergone TKA and subsequently experienced recurrent hemarthrosis. Embolization was performed using spherical microparticles. Read More

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Hydroxychloroquine reduces interleukin-6 levels after myocardial infarction: The randomized, double-blind, placebo-controlled OXI pilot trial.

Int J Cardiol 2021 May 4. Epub 2021 May 4.

Heart and Lung Center, Helsinki University Hospital, Helsinki University, Helsinki, Finland. Electronic address:

Objectives: To determine the anti-inflammatory effect and safety of hydroxychloroquine after acute myocardial infarction.

Method: In this multicenter, double-blind, placebo-controlled OXI trial, 125 myocardial infarction patients were randomized at a median of 43 h after hospitalization to receive hydroxychloroquine 300 mg (n = 64) or placebo (n = 61) once daily for 6 months and, followed for an average of 32 months. Laboratory values were measured at baseline, 1, 6, and 12 months. Read More

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Antiarrhythmic therapy and risk of cumulative ventricular arrhythmias in arrhythmogenic right ventricle cardiomyopathy.

Int J Cardiol 2021 May 4. Epub 2021 May 4.

Cardiothoracovascular Department, Cattinara Hospital, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy.

Objectives: The aim of our study was to investigate the benefit of antiarrhythmic drugs (AAD) - beta-blockers, sotalol or amiodarone - in a cohort of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) patients with long-term longitudinal follow up.

Background: AAD are prescribed in ARVC to prevent ventricular arrhythmias and control symptoms. However, there are no controlled clinical trials and knowledges regarding the efficacy of AAD in ARVC are limited. Read More

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Kidney Transplantation in Monoclonal Immunoglobulin Deposition Disease: A Report of 6 Cases.

Am J Kidney Dis 2021 May 4. Epub 2021 May 4.

Nephrology and Renal Transplantation Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Amyloidosis and Myeloma Unit.Hospital Clínic de Barcelona; Centro de Referencia en Enfermedad Glomerular Compleja del Sistema Nacional de Salud (CSUR), Barcelona, Spain. Electronic address:

Monoclonal immunoglobulin deposition disease (MIDD) usually leads to kidney failure. Treatment of patients with a bortezomib-based regimen followed by autologous stem cell transplantation has been increasingly used, with improvements in the response rates and the allograft outcomes in kidney transplant recipients. The objective of this report was to analyze the outcomes of 6 patients who underwent kidney transplantation in our institution after treatment of MIDD between 2010 and 2019. Read More

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Differential Expression of HIV Envelope Epitopes on the Surface of HIV-Infected Macrophages and CD4+ T cells.

Antiviral Res 2021 May 4:105085. Epub 2021 May 4.

Life Sciences Discipline, Burnet Institute, Melbourne, VIC, Australia; School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

HIV-infected macrophages contribute to persistence of HIV reservoirs in people living with HIV receiving antiretroviral therapy. A potential strategy to eliminate reservoirs is the use of antibody-dependent cellular cytotoxicity (ADCC) against infected cells expressing the HIV envelope (Env) protein on their surface. Designing ADCC strategies requires knowledge of exposed Env epitopes on the cell surface and identifying antibodies capable of opsonising infected cells, yet little is known regarding the ability of HIV-infected macrophages to be targeted with such strategies. Read More

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Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a Single Institutional Experience with Clinicopathological and Molecular Characteristics.

Hum Pathol 2021 May 4. Epub 2021 May 4.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905. Electronic address:

Aims: Low-grade oncocytic tumor of the kidney (LOT) is characterized by cytoplasmic eosinophilia and a CK7-positive/CD117-negative immunophenotype. Morphologically, they exhibit overlapping features with oncocytoma and chromophobe renal cell carcinoma (chRCC). Our aim was to obtain long-term clinical follow-up data, clinicopathological and molecular characteristics, and incidence of LOT. Read More

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Left Thoracotomy Beating Heart Repair of Mitral Periprosthetic Regurgitation.

Ann Thorac Surg 2021 May 4. Epub 2021 May 4.

Division of Pediatric Cardiovascular Surgery, Masonic Children's Hospital Department of Surgery, University of Minnesota, Minneapolis, MN 55454. Electronic address:

Left thoracotomy is a recognized, albeit not a commonly utilized approach for mitral valve exposure. This approach represents a good alternative to repeat median sternotomy and repeat right thoracotomy especially in cases of hostile mediastinum. We present a 72-year-old woman who underwent a beating heart left thoracotomy repair of recurrent severe mitral periprosthetic regurgitation in the presence of a porcelain aorta. Read More

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Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial.

Lancet Oncol 2021 May 4. Epub 2021 May 4.

National Cancer Center Hospital East, Kashiwa, Japan. Electronic address:

Background: HER2 amplification has been identified in 2-3% of patients with colorectal cancer, although there are currently no approved HER2-targeted therapies for colorectal cancer. We aimed to study the antitumour activity and safety of trastuzumab deruxtecan (an antibody-drug conjugate of humanised anti-HER2 antibody with topoisomerase I inhibitor payloads) in patients with HER2-expressing metastatic colorectal cancer.

Methods: DESTINY-CRC01 is an open-label, phase 2 study that recruited patients from 25 clinics and hospitals in Italy, Japan, Spain, the UK, and the USA. Read More

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Treatment and outcomes of Multidrug-resistant tuberculosis in Auckland 1995-2018.

Intern Med J 2021 May 7. Epub 2021 May 7.

Department of Infectious Disease, Auckland City Hospital, Auckland, New Zealand.

Introduction: New Zealand has a low burden of tuberculosis, however multidrug-resistant tuberculosis (MDR-TB) still represents a challenge for clinicians. This is the first description of clinical aspects of MDR-TB in New Zealand.

Methods: Clinical data were obtained for patients treated for MDR-TB at Auckland District Health Board (ADHB). Read More

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Prediction of reproductive function recovery after microsurgical varicocelectomy in men from infertile couples: Clinical and laboratory predictors.

Andrologia 2021 May 7:e14101. Epub 2021 May 7.

Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia.

The objective was to reveal predictors for fertility recovery after varicocelectomy in subfertile men. This retrospective study recruited 93 men with clinical varicocele and pathozoospermia who underwent microsurgical varicocelectomy. Stepwise discriminant analysis was performed to identify predictors of spontaneous pregnancy (SP) after surgery. Read More

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Elevated sperm DNA fragmentation does not predict recurrent implantation failure.

Andrologia 2021 May 7:e14094. Epub 2021 May 7.

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

In this study, we sought to determine whether sperm DNA fragmentation (DFI%) and high DNA stainability (HDS%) evaluated by sperm chromatin structure assay (SCSA) predict recurrent implantation failure (RIF) or pregnancy rate. A retrospective study was performed of consecutive cycles of ICSI treatment from 2009 to 2018. A total of 386 couples that underwent 1,216 frozen embryo transfer (FET) cycles were analysed. Read More

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