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2D confinement freestanding graphene oxide composite membranes with enriched oxygen vacancies for enhanced organic contaminants removal via peroxymonosulfate activation.

J Hazard Mater 2021 May 8;417:126028. Epub 2021 May 8.

Institute of Green Chemistry and Chemical Technology, Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu Province, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Introducing membrane filtration into advanced oxidation processes to decrease energy and cost consumption has been considered as a promising direction in environmental remediation. In this work, we firstly developed a kind of novel lawn-like FeO@CoFe@nitrogen-doped reduced graphene oxide@carbon nanotube composites (FeCo@GCTs) through in-situ pyrolysis of self-assembly of Prussian blue analogues and GO, followed through a vacuum-assisted filtration strategy to fabricate 2D confinement freestanding GO composite membrane. Electrochemical analysis and H-TPR revealed the superiority of FeCo@GCTs as ideal electron acceptor, and this unique lawn-like structure concentrated active sites with a confined space and enriched oxygen vacancies that realized 98. Read More

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Poorer diversity but tougher species in old ballast water: Biosecurity challenges explored from visual and molecular techniques.

Mar Pollut Bull 2021 May 12;168:112465. Epub 2021 May 12.

Department of Functional Biology, University of Oviedo, C/ Julian Claveria s/n, 33006 Oviedo, Spain.

Millions of tons of water cross the oceans inside ships' ballast tanks every day. Planktonic species hitch-hike with water and some may pose risks to ecosystems and economies if get released and establish outside their native range. We monitored ballast water in different trans-equatorial travels, visually and using molecular techniques, and found significant increases of potential nuisance taxa over travel duration, despite evident diversity depletion. Read More

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Increasing age and methamphetamine use.

J Forensic Leg Med 2021 May 8;80:102181. Epub 2021 May 8.

Adelaide Medical School, The University of Adelaide, Frome Road, SA, 5000, Australia; Forensic Science SA, 21 Divett Place, Adelaide, SA, 5005, Australia. Electronic address:

Analysis: of autopsy files at Forensic Science SA was undertaken over a 20-year period (2000-2019) in five representative time periods to determine the average ages for all adults (≥18 years) where methamphetamine was detected. There were 239 cases with statistically significant increased mean ages over the time of the study ranging from 32.6yrs in 2000 to 42. Read More

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A new evaluation framework for nature-based solutions (NBS) projects based on the application of performance questions and indicators approach.

Sci Total Environ 2021 May 7;787:147615. Epub 2021 May 7.

GEMMA-Group of Environmental Engineering and Microbiology, Department of Civil and Environmental Engineering, Universitat Politècnica de Catalunya-BarcelonaTech, c/ Jordi Girona 1-3, Building D1, E-08034 Barcelona, Spain. Electronic address:

One of the key features of nature-based solutions (NBSs) is their high effectiveness and economic and resource efficiency in solving problems compared to traditional grey interventions. These aspects, however, have so far attracted little attention in the literature but should be considered, as the evaluation of NBS projects before implementation provides an opportunity to use them as practical tools. This paper aims to present a new evaluation framework of NBS projects (at the stage of solution selection) based on the application of performance questions and the indicators approach. Read More

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Metal nanoparticles: Phytotoxicity on tomato and effect on symbiosis with the Fusarium solani FsK strain.

Sci Total Environ 2021 May 8;787:147606. Epub 2021 May 8.

School of Environmental Engineering, Technical University of Crete, 73100 Chania, Greece.

The effect of copper (Cu-NPs, CuO-NPs), silver (Ag-NPs) and zinc oxide (ZnO-NPs) nanoparticles (NPs) on plant growth, physiological properties of tomato plants and their symbiotic relationships with the endophytic Fusarium solani FsK strain was investigated. Fungitoxicity tests revealed that the FsK strain was significantly more sensitive to Cu-NPs and ZnO-NPs than CuO-NPs and Ag-NPs both in terms of mycelial growth and spore germination. All NPs were more toxic to FsK compared to their bulk counterparts except for AgNO, which was 8 to 9-fold more toxic than Ag-NPs. Read More

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Is the water disinfection by-product dichloroacetic acid biosynthesized in the edible mushroom Russula nigricans?

Chemosphere 2021 May 10;281:130819. Epub 2021 May 10.

Institute of Chemistry, University of Graz, Universitaetsplatz 1, 8010, Graz, Austria.

We report the first halogen speciation analysis study by high performance liquid chromatography coupled with inductively coupled plasma tandem mass spectrometry (HPLC-ICPMS/MS) in the fruiting bodies of various mushroom species. Non-targeted speciation analysis revealed the occurrence of dichloroacetic acid (DCAA) in the edible mushroom Russula nigricans. Multiple samples of this mushroom (n = 5) collected from different geographic non-industrial regions in two different countries confirmed the consistent presence of this species at a relatively narrow concentration range (23-37 mg kg), whereas no other chlorinated acetic acid (e. Read More

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An evaluation of undergraduate student nurses' gameful experience while playing an escape room game as part of a community health nursing course.

Nurse Educ Today 2021 May 4;103:104948. Epub 2021 May 4.

Department of Physiatry and Nursing, Faculty of Health Sciences, University of Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain; Research group Water and Environmental Health (B43_20R), University Institute of Research in Environmental Science of Aragón, University of Zaragoza, Zaragoza, Spain. Electronic address:

Background: The integration of innovative strategies to teaching and learning in higher education, such as escape room games, can enhance the acquisition of key professional competencies including communication, teamwork and critical thinking.

Objectives: This study aimed to evaluate undergraduate student nurses' gameful experience while playing an escape room game as part of a nursing course.

Design: Cross-sectional descriptive study. Read More

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An intervention to increase hepatitis C virus diagnosis and treatment uptake among people in custody in Iran.

Int J Drug Policy 2021 May 12;95:103269. Epub 2021 May 12.

Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Iran is among countries with high opioid agonist therapy (OAT) coverage in prisons, which provides an infrastructure to increase feasibility of HCV programs. We aimed to evaluate the impact of an intervention to improve HCV screening, diagnosis, and treatment, including alongside the provision of OAT, in an Iranian prison.

Methods: During July-December 2018, in the Gorgan prison, all incarcerated adults (>18 years) received HCV antibody rapid testing and, if positive, provided a venepuncture sample for HCV RNA testing. Read More

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Improving river hydromorphological assessment through better integration of riparian vegetation: Scientific evidence and guidelines.

J Environ Manage 2021 May 12;292:112730. Epub 2021 May 12.

Centro de Estudos Florestais, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017, Lisboa, Portugal.

River hydromorphology has long been subjected to huge anthropogenic pressures with severe negative impacts on related ecosystems' functioning and water quality. Therefore, improving river hydromorphological conditions represents a priority task in sustainable river management and requires proper assessment tools. It is well known that riparian vegetation plays a crucial role in sustaining river hydromorphological conditions. Read More

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Neighborhood social cohesion, religious participation and sexual risk behaviors among cisgender black sexual minority men in the southern United States.

Soc Sci Med 2021 May 12;279:113913. Epub 2021 May 12.

Us Helping Us, Inc., Washington, DC, USA.

Background: Few studies have examined associations between neighborhood social cohesion and sexual risk behaviors among gay, bisexual, and other sexual minority men (SMM), and none have among Black SMM in the southern U.S. The purpose of the current study is to examine associations between neighborhood social cohesion and sexual risk behaviors among Black SMM in the southern U. Read More

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Novel criteria for global robust stability of dynamical neural networks with multiple time delays.

Authors:
Emel Arslan

Neural Netw 2021 May 7;142:119-127. Epub 2021 May 7.

Department of Computer Engineering, Faculty of Engineering Istanbul University-Cerrahpasa, Avcılar, Istanbul, Turkey. Electronic address:

This research article considers the problem regarding global robust asymptotic stability of the general type of dynamical neural networks involving multiple constant time delays. Some new sufficient criteria are proposed for the existence, uniqueness and global asymptotic stability of the equilibrium point of this neural network model whose network parameters possess uncertainties. This paper will first address the existence and uniqueness problem for equilibrium points by utilizing the Homomorphic transformation theory. Read More

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Influence of age on treatment and prognosis of invasive cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2021 May 1;262:68-72. Epub 2021 May 1.

Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: Invasive cervical cancer is considered a young women's disease, however up to 20 % of cases develop cervical cancer at advanced ages. The aim was to characterize invasive cervical cancer in women aged 65 and older assessing age-specific survival differences.

Study Design: A retrospective study including cervical cancer patients was conducted at Hospital del Mar Barcelona from July-2007 to December-2016. Read More

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Coblation Discoplasty Alleviates Cervical Chest Pain after Positive Ultrasound-Guided Nerve Root Block: A Retrospective Study.

World Neurosurg 2021 May 12. Epub 2021 May 12.

Department of Pain Management, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.

Objective: The cervical chest pain (CCP), as one atypical symptom associated with cervical spondylosis, often overlaps with other chest-related diseases. If CCP obviously relieved after ultrasound-guided cervical nerve root block nearby herniated disc, which should be considered as a potential pathological source. The purpose of this study is to investigate whether coblation discoplasty can alleviate CCP after positive ultrasound-guided nerve root block. Read More

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Anti-trypanosomal and anthelminthic properties of ethanol and aqueous extracts of Tetrapleura tetraptera Taub.

Vet Parasitol 2021 May 10;294:109449. Epub 2021 May 10.

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Trypanosomosis and helminthosis, considered as part of neglected tropical diseases, are parasitic infections of public health importance, especially in Africa. Medicinal plants have been used in most parts of Africa, to treat these parasitic infections. The study aims to determine the anti-trypanosomal and anthelminthic properties of Tetrapleura tetraptera (fruit and stembark). Read More

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Pre-transplant red blood cell and platelet transfusion burden in de novo myelodysplastic syndrome undergoing allogeneic transplantation: Pre-transplant red blood cell and platelet transfusion burden in de novo MDS after allogeneic transplantation.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Most patients of myelodysplastic syndrome (MDS) require red blood cell (RBC) and/or platelet transfusion during their disease courses, which could cause an increased risk of iron overload and alloimmunization. However, it remains less clear whether pre-transplant RBC or platelet transfusion burden affects transplant outcomes in patients with MDS.

Objective: The objective was to examine the significance of pre-transplant RBC and platelet transfusion burden on transplant outcomes after allogeneic HCT for adults with de novo MDS. Read More

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Early predictive factors of visual loss at 1-year in neovascular age-related macular degeneration under anti-VEGF in the GEFAL study.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Université Lyon 1, Lyon, France; UMR-CNRS 5510 Matéis, Villeurbane, France.

Purpose: To evaluate early predictive factors of visual loss in patients treated with anti-vascular endothelial growth factor (VEGF) injections under as-needed regimen for neovascular age-related macular degeneration (AMD).

Design: Post-hoc analysis from the randomized controlled trial GEFAL, comparing ranibizumab versus bevacizumab for neovascular AMD.

Participants: 393 patients aged ≥50 years with neovascular AMD. Read More

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Deep Recurrent Model for Individualized Prediction of Alzheimer's Disease Progression.

Neuroimage 2021 May 12:118143. Epub 2021 May 12.

Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea; Department of Artificial Intelligence, Korea University, Seoul 02841, Republic of Korea.

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of developing AD in its earliest time. While many of the previous works considered cross-sectional analysis, more recent studies have focused on the diagnosis and prognosis of AD with longitudinal or time series data in a way of disease progression modeling. Read More

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Effect of local anesthetics on postoperative pain in patients undergoing gynecological laparoscopy: A systematic review and meta-analysis of randomized trials.

J Minim Invasive Gynecol 2021 May 12. Epub 2021 May 12.

King's Fertility, Fetal Medicine Research Institute, London, United Kingdom.

Objective: Pain remains a common complication following gynecological laparoscopy. Use of local anesthesia may be beneficial in reducing postoperative pain. We performed a systematic review and meta-analysis to assess whether local anesthetic decreases postoperative pain following laparoscopic gynecological procedures. Read More

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Ni and Cr impurities profile in Valeriana officinalis L., radix-based herbal medicinal product available in Polish pharmacies due to ICH Q3D guideline.

Regul Toxicol Pharmacol 2021 May 12:104945. Epub 2021 May 12.

Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland.

Elemental impurities (EIs) profiling in final pharmaceutical products is often not adequately treated, however it is crucial problem in pharmaceutical analysis by reason of the various regulatory authorities (like ICH Q3D guideline). EIs in pharmaceuticals may arise from numerous sources of which the herbal ingredients are not a frequent subject of pharmaceutical analyses. However, based on number of traditional use registrations per year for herbal medicinal products (HMPs) in the EU, it can be stated that monocomponent HMPs are still very popular for use. Read More

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Pesticides and Parkinson's disease: Current and future perspective.

J Chem Neuroanat 2021 May 12:101966. Epub 2021 May 12.

Dept. of Tissue Engineering and Applied Cell Sciences, Tehran University of Medical Sciences, Iran. Electronic address:

Inappropriate use of pesticides has globally exposed mankind to a number of health hazards. Still their production is rising at the rate of 11 % annually and, has already exceeded more than 5 million tons in 2000 (FAO 2017). Plenty of available data reveals that pesticides exposures through agricultural use and food-preservative residue consumption may lead to neurodegenerative disorders like Parkinson's and Alzheimer's diseases. Read More

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The reversal of chemotherapy-induced multidrug resistance by nanomedicine for cancer therapy.

J Control Release 2021 May 12. Epub 2021 May 12.

Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China. Electronic address:

Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists have considered the overexpressed efflux transporters responsible for MDR and chemotherapy failure. MDR extremely limits the therapeutic effect of chemotherapy in cancer treatment. Read More

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Recent progress in green and biopolymer based photocatalysts for the abatement of aquatic pollutants.

Environ Res 2021 May 12:111324. Epub 2021 May 12.

Laboratorio de Investigaciones Ambientales Zonas Áridas, Departamento de Ingeniería Mecánica, Facultad de Ingeniería, Universidad de Tarapacá, Avda. General Velásquez 1775, Arica, Chile.

Enormous research studies on the abatement of anthropogenic aquatic pollutants including organic dyes, pesticides, cosmetics, antibiotics and inorganic species by using varieties of semiconductor photocatalysts have been reported in recent decades. Besides, many of these photocatalysts suffer in real applications owing to their high production cost and low stability. In many cases, the photocatalysts themselves are being considered as secondary pollutants. Read More

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Rescue of striatal long-term depression by chronic mGlu5 receptor negative allosteric modulation in distinct dystonia models.

Neuropharmacology 2021 May 12:108608. Epub 2021 May 12.

Department of Brain and Behavioral Sciences, University of Pavia, Italy; IRCCS Mondino Foundation, Pavia, Italy. Electronic address:

An impairment of long-term synaptic plasticity is considered as a peculiar endophenotype of distinct forms of dystonia, a common, disabling movement disorder. Among the few therapeutic options, broad-spectrum antimuscarinic drugs are utilized, aimed at counteracting abnormal striatal acetylcholine-mediated transmission, which plays a crucial role in dystonia pathophysiology. We previously demonstrated a complete loss of long-term synaptic depression (LTD) at corticostriatal synapses in rodent models of two distinct forms of isolated dystonia, resulting from mutations in the TOR1A (DYT1), and GNAL (DYT25) genes. Read More

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Impact of Parental Illness and Injury on Pediatric Disorders of Gut-Brain Interaction.

J Pediatr 2021 May 12. Epub 2021 May 12.

Department of Pediatrics. Uniformed Services University of the Health Sciences. Bethesda, MD.

Objective: To evaluate the relationship between parental injury and illness and disorders of gut brain interaction (DGBI) in children.

Study Design: A self-controlled case series using data from the Military Health System Data Repository compared ICD-9 identified DGBI related outpatient visits and prescriptions in 442,651 children ages 3-16 years in the two-years before and the two-years after the injury and/or illness of their military parent. Negative binomial regression was used to compare visit rates for constipation, fecal incontinence, abdominal pain, irritable bowel syndrome, and a composite of these before and after parental injury and/or illness. Read More

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Invasive Fungal Infections in Immunocompromised Children: Novel Insight Following a National Study.

J Pediatr 2021 May 12. Epub 2021 May 12.

Institute of Pediatric Hematology and Oncology, Hospices Civils de Lyon, University-Lyon1, Lyon, France; Apoptosis, Cancer and Development Laboratory - INSERM U1052-CNRS UMR5286, CRCL, Lyon, France.

Objective: To obtain a national overview of the epidemiology and management of invasive fungal infections (IFIs) in France for severe immunocompromised children who were treated for acute leukemia or had undergone an allogeneic hematopoietic stem cell transplantation (a-HSCT).

Study Design: We performed a national multicenter retrospective study to collect epidemiologic data for proven and probable IFI in children with acute leukemia under first line or relapse treatment or who had undergone an a-HSCT. We also conducted a prospective practice survey to provide a national overview of IFI management in pediatric hematology units. Read More

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Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV‑201): a multicentre, single-arm, phase 2 trial.

Lancet Oncol 2021 May 12. Epub 2021 May 12.

Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA.

Background: Locally advanced or metastatic urothelial carcinoma is generally incurable and has scarce treatment options, especially for cisplatin-ineligible patients previously treated with PD-1 or PD-L1 therapy. Enfortumab vedotin is an antibody-drug conjugate directed at Nectin-4, a protein highly expressed in urothelial carcinoma. We aimed to evaluate the efficacy and safety of enfortumab vedotin in the post-immunotherapy setting in cisplatin-ineligible patients. Read More

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A novel nano therapeutic using convalescent plasma derived exosomal (CP) for COVID-19: A combined hyperactive immune modulation and diagnostics.

Chem Biol Interact 2021 May 12:109497. Epub 2021 May 12.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton Heights, Newcastle, NSW 2305, Australia.

Extracellular vesicles like exosomes are important therapeutic tactics for treating COVID -19. By utilizing convalescent plasma derived exosomes (CP) from COVID-19 recovered persistence could accelerate the treatment strategies in the current state of affairs. Adequate literature has shown that administering the exosome to the in vivo system could be beneficial and could target the pathogens in an effective and precise manner. Read More

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Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study.

J Complement Integr Med 2021 May 14. Epub 2021 May 14.

Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Current modalities for treating polycystic ovary syndrome (PCOS) are not curative and using them for a long period is associated with adverse effects. According to Persian Medicine recommendations, wet cupping on calf muscles can induce menstrual bleeding. In the present study, the effect of wet-cupping (traditional bleeding from capillary vessels) was assessed on menstrual cycles (as primary outcome), hirsutism, and laboratory manifestation of PCOS. Read More

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Adolescent-adult nonmetastatic Ewing sarcoma-Experience from a large developing country.

Pediatr Blood Cancer 2021 May 15:e29081. Epub 2021 May 15.

Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India.

Background: Outcome and toxicity data in adolescent-adult Ewing sarcoma (AA-ES) patients are sparse and merits exploration.

Methods: Histopathologically confirmed, nonmetastatic AA-ES patients, who received standard institutional combination chemotherapy regimen (Ewing's family of tumors-2001 [EFT-2001]) comprising of ifosfamide plus etoposide and vincristine, doxorubicin plus cyclophosphamide, lasting a total of 12 months between 2013 and 2018, were analyzed for treatment-related toxicities, event-free survival (EFS), and overall survival (OS).

Results: There were 235 patients (primary safety cohort [PSC]) with median age of 23 (15-61) years; 159 (67. Read More

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