71,834 results match your criteria considered severe

Immediate rehabilitation of a rheumatoid arthritis patient with single-piece implants.

Int J Surg Case Rep 2021 Apr 7;82:105874. Epub 2021 Apr 7.

Dr Hedgewar Smruti Rugna Sewa Mandal Dental College and Hospital, Hingoli, India.

Introduction And Importance: The aim of this article is to report the long-term outcome of full mouth rehabilitation with single piece, smooth surface implants following immediate loading protocol on a patient suffering with RA and severe unilateral condylar resorption.

Case Presentation: Here, we present a challenging case of a patient suffering from Rheumatoid Arthritis who was stabilized and completed successfully with a 4 year follow-up period. Prosthetic management optimized the inter-occlusal relationship to maintain both function and esthetic integrity. Read More

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Comparing respiratory polygraphy with pulse transit time analysis versus overnight polysomnography in the diagnosis of obstructive sleep apnoea in children.

Sleep Med 2021 Mar 1;81:457-462. Epub 2021 Mar 1.

FHKAM(Otolaryngology), Department of Otolaryngology, Tuen Mun Hospital, Hong Kong.

Objective: Obstructive sleep apnea syndrome in children is associated with significant morbidity. Polysomnography is the main diagnostic tool but is time consuming and requires skilled manpower to supervise the patient overnight and hence long referral to diagnosis time. However, there are limitations and underestimation of the apnoea hyponea index (AHI) with alternative home sleep apnoea testing (HSAT), such as type 3 respiratory polygraphy (RP). Read More

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Plasma proteomics analysis of adolescent idiopathic scoliosis patients revealed by Quadrupole-Orbitrap mass spectrometry.

Proteomics Clin Appl 2021 Apr 17:e2100002. Epub 2021 Apr 17.

Objective: We aim to investigate the changes of plasma proteome among mild, severe AIS patients and healthy controls.

Methods: In this retrospective study, 84 individuals including 56 confirmed AIS patients (27 follow-up AIS patients and 29 surgical AIS patients) and another 28 healthy teenagers. Plasma samples were obtained and Quadrupole-Orbitrap Mass Spectrometer was performed to identify proteins in AIS patients and control group. Read More

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Gut Microbiota in Lupus: a Butterfly Effect?

Curr Rheumatol Rep 2021 Apr 16;23(4):27. Epub 2021 Apr 16.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuai-Fu-Yuan, Dong-Cheng District, Beijing, 100730, China.

Purpose Of Review: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that typically displays chronic inflammatory tissue damage and miscellaneous circulatory autoantibodies, as well as distinctive type 1 interferon signatures. The etiology of SLE is unclear and currently is attributed to genetic predisposition and environmental triggers. Gut microbiota has recently been considered a critical environmental pathogenic factor in immune-related disorders, and studies are ongoing to uncover the key pathogens and the imputative mechanisms. Read More

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Amoxicillin oral provocation challenge in a primary care clinic: a descriptive analysis.

CMAJ Open 2021 Apr-Jun;9(2):E394-E399. Epub 2021 Apr 16.

Department of Family Medicine (Gateman), McMaster University, Kitchener, Ont.; Department of Family Medicine (Gateman), Western University, Kitchener, Ont.; North Perth Family Health Team (Rumble), Listowel, Ont.; Departments of Pediatrics and Child Health, and Food and Human Nutritional Sciences (Protudjer), University of Manitoba; George & Fay Yee Centre for Healthcare Innovation (Protudjer); The Children's Hospital Research Institute of Manitoba (Protudjer), Winnipeg, Man.; Department of Medicine (Kim), Western University; Department of Medicine (Kim), McMaster University, Kitchener, Ont.

Background: Penicillin is the most frequently reported drug allergen; however, most of these allergies are not true allergies and do not justify the prescription of alternative, less effective and more expensive antibiotic drugs. We aimed to show that patients at low risk of amoxicillin allergy can safely and efficiently undergo oral provocation challenge (OPC) by their primary care physician.

Methods: In this descriptive analysis, we conducted a retrospective chart review of all primary care patients who had undergone OPC from November 2017 to October 2019 in the Amoxicillin Allergy Clinic at the North Perth Family Health Team, Listowel, Ontario. Read More

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Point: patients with native aortic regurgitation can be treated with transcatheter aortic valve implantation.

Heart 2021 Apr 16. Epub 2021 Apr 16.

Division of Cardiology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA

Approximately 2% of people between the ages of 70 and 83 suffer from moderate or greater aortic regurgitation (AR) in the United States. Left untreated, this disease is progressive and fatal; however, up to 8% of patients with AR, who meet the criteria for surgical intervention, do not receive treatment. As such, there is a pressing need to address the lack of treatment options for the thousands of patients with AR who meet a class I indication for aortic valve replacement but who still do not receive surgery. Read More

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Management and infection control practices in a Taiwanese radiology department during the COVID-19 outbreak.

J Microbiol Immunol Infect 2021 Mar 30. Epub 2021 Mar 30.

Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

The radiology department was categorized as a "high risk area" during the severe acute respiratory syndrome (SARS) outbreak in 2003 and is similarly considered a "high risk area" during the current coronavirus (COVID-19) pandemic. The purpose of infection control is to isolate patients with suspected or confirmed COVID-19 from uninfected people by utilizing separate equipment, spaces, and healthcare workers. Infection control measures should be prioritized to prevent the nosocomial spread of infection. Read More

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Babesiosis in the Emergency Department: A Case Report.

J Emerg Med 2021 Apr 13. Epub 2021 Apr 13.

Department of Emergency Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Background: Babesiosis, a tick-borne illness spread by Ixodes scapularis, is an emerging infectious disease in the Northeastern and upper Midwestern United States. Infection can present as a flu-like illness with anemia, thrombocytopenia, and jaundice. This disease can even be fatal in the immunocompromised or highly infected patient. Read More

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Understanding low chemoprevention uptake by women at high risk of breast cancer: findings from a qualitative inductive study of women's risk-reduction experiences.

BMC Womens Health 2021 Apr 16;21(1):157. Epub 2021 Apr 16.

Division of Health Services Management and Policy, College of Public Health, The Ohio State University, Columbus, OH, USA.

Background: Chemoprevention is one of several methods that have been developed to help high-risk women reduce their risk of breast cancer. Reasons for the low uptake of chemoprevention are poorly understood. This paper seeks a deeper understanding of this phenomenon by drawing on women's own narratives about their awareness of chemoprevention and their risk-related experiences. Read More

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Surgical management of diaphragmatic and thoracic endometriosis': a French multicentric descriptive study.

J Gynecol Obstet Hum Reprod 2021 Apr 13:102147. Epub 2021 Apr 13.

Department of gynecology, Croix Rousse University Hospital, Hospices civils de Lyon (HCL), 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France. Electronic address:

Introduction: Surgical management of Diaphragmatic and thoracic endometriosis (DTE) is still controversial, a thoracic or an abdominal approach can be proposed.

Methods: We conducted a multicentric retrospective study in 8 thoracic, gynecology or digestive surgery units in 5 French university hospitals. The main objective was to review the current management of DTE. Read More

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Imported scrub typhus in Europe: report of three cases and a literature review.

Travel Med Infect Dis 2021 Apr 13:102062. Epub 2021 Apr 13.

Department of Infectious/Tropical Diseases and Microbiology (DITM), IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy. Electronic address:

Background: Scrub typhus is a vector-borne rickettsial infection, which can cause relevant morbidity and mortality. While the number of cases is around a million per year globally, the infection is seldom diagnosed in travellers from Europe.

Methods: We herein report three cases diagnosed in Italian travellers and review the literature about imported cases in Europe in the last 60 years. Read More

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Characteristics of Patients with Severe Asthma Who Experienced Treatment Failure with Omalizumab.

Pulm Pharmacol Ther 2021 Apr 13:102032. Epub 2021 Apr 13.

Department of Respiratory Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Allergy Medical Center, Tokyo Women's Medical University Hospital, Tokyo, Japan. Electronic address:

Background: Omalizumab, an anti-IgE antibody, has been widely used in many countries, including Japan. However, some patients do not respond to omalizumab, and the cause of treatment failure has not been fully elucidated.

Objective: This study aimed to evaluate the characteristics of adult asthma patients who failed to achieve disease control with omalizumab in a real-world setting. Read More

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Admission levels of Soluble Urokinase Plasminogen Activator Receptor (suPAR) Associate with Development of Severe Complications in Hospitalised COVID-19 Patients: A Prospective Cohort Study.

Int J Infect Dis 2021 Apr 13. Epub 2021 Apr 13.

Zayed Center for Health Sciences, United Arab Emirates University, United Arab Emirates; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Austria.

Objective: To examine the association between plasma levels of the soluble urokinase plasminogen activator receptor (suPAR) and the incidence of severe complications of COVID-19.

Methods: 403 RT-PCR-confirmed COVID-19 patients were recruited and prospectively followed-up at a major hospital in the United Arab Emirates. The primary endpoint was time from admission until the development of a composite outcome, including acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, or death from any cause. Read More

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Juvenile haemochromatosis.

Lancet Child Adolesc Health 2021 Apr 13. Epub 2021 Apr 13.

Liver Unit, Birmingham Women's and Children's NHS Trust and University of Birmingham, Birmingham, UK.

Juvenile haemochromatosis is a severe inherited iron-loading disorder that can present in children and adolescents. Typical manifestations include heart failure, endocrine failure (including diabetes and hypogonadism), cirrhosis, and arthropathy. Compared with HFE haemochromatosis, juvenile haemochromatosis affects female and male individuals similarly, presents at a younger age, and causes multiple organ dysfunction; the principle of iron loading into tissues from the gut is shared by both forms, but the process is far more rapid in juvenile haemochromatosis. Read More

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CRISPR genotyping as complementary tool for epidemiological surveillance of Erwinia amylovora outbreaks.

PLoS One 2021 16;16(4):e0250280. Epub 2021 Apr 16.

Faculty of Sciences of University of Porto, Porto, Portugal.

Fire blight is a destructive plant disease caused by Erwinia amylovora affecting pome fruit trees, and responsible for large yield declines, long phytosanitary confinements, and high economic losses. In Portugal, the first major fire blight outbreaks occurred in 2010 and 2011, and although later considered eradicated, the emergence of other outbreaks in recent years stressed the need to characterize the E. amylovora populations associated with these outbreaks. Read More

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Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination.

N Engl J Med 2021 Apr 16. Epub 2021 Apr 16.

From the Department of Haematology, University College London Hospitals NHS Foundation Trust (M.S., M.L.), National Institute for Health Research University College London Hospitals Biomedical Research Centre (M.S., M.L.), Special Coagulation, Health Services Laboratories (D.S.), Great Ormond Street Institute of Child Health, University College London (D.G.), and National Institute for Health Research Great Ormond Street Biomedical Research Centre (D.G.), London, the Department of Haematology, University Hospital Southampton, Southampton (R.L.), National Health Service Blood and Transplant, Bristol (A.P.), National Institute for Health Research Health Protection Research Unit, University of Liverpool, Liverpool (T.S.), the Department of Haematology, Mid Essex Hospitals, Chelmsford (P.K.), the Department of Haematology, Addenbrookes Hospital, Cambridge (W.T.), and the Department of Haematology, University Hospitals Birmingham, and Institute of Cardiovascular Sciences, University of Birmingham, Birmingham (W.L.) - all in the United Kingdom; and the Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam (M.L.).

Background: The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered. Reporting of adverse events is a critical postmarketing activity. Read More

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Two subsequent seminal productions: a good strategy to treat very severe oligoasthenoteratozoospermic (OAT) infertile couples.

Andrology 2021 Apr 16. Epub 2021 Apr 16.

Infertility and IVF Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Background: sexual abstinence is considered one of the several factors that influence sperm quality. Recent studies show that a shortening of the abstinence period could be beneficial mostly in oligoasthenoteratozoospermic (OAT) patients.

Objective: retrospective study to verify the efficacy of a second semen sample after a short abstinence to treat severe OAT infertile patients. Read More

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Adverse childhood experiences and repetitive negative thinking in adulthood: A systematic review.

Clin Psychol Psychother 2021 Apr 16. Epub 2021 Apr 16.

Department of Psychology, Sigmund Freud University, Milan, Italy.

Background: It has been proposed that repetitive negative thinking (worry and rumination) may be more common among adults who have been exposed to childhood adverse experiences, leading to emotional disorders and other adverse outcomes. The current study aims to present a comprehensive evaluation of the literature examining the relationship between the exposure to childhood adversities, repetitive negative thinking and clinical outcomes in adulthood.

Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, a search was conducted on PubMed and Ebsco. Read More

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Prominent Anterior Inferior Iliac Spine Morphologies Are Common in Patients with Acetabular Dysplasia Undergoing Periacetabular Osteotomy.

Clin Orthop Relat Res 2021 May;479(5):991-999

D. Nestorovski, L. M. Fowler, J. C. Clohisy, J. J. Nepple, Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Background: The anterior inferior iliac spine (AIIS) prominence is increasingly recognized in the setting of femoroacetabular impingement (FAI). The AIIS prominence may contribute to decreased hip flexion after acetabular reorientation in patients with acetabular dysplasia. AIIS morphologies have been characterized in numerous populations including asymptomatic, FAI, and athletic populations, but the morphology of the AIIS in patients with symptomatic acetabular dysplasia undergoing periacetabular osteotomy (PAO) has not been studied. Read More

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Lateral compression type 1 (LC1) pelvic ring injuries: a spectrum of fracture types and treatment algorithms.

Eur J Orthop Surg Traumatol 2021 Apr 16. Epub 2021 Apr 16.

Department of Trauma and Orthopaedics, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.

Lateral compression type 1 (LC1) fractures are the commonest pelvic ring injury. However, they represent a heterogenous spectrum of injury mechanisms and fracture patterns, resulting in a lack of strong evidence for a universally agreed treatment algorithm. Although consensus exists that LC1 fractures have a preserved posterior ligamentous complex and are vertically stable, controversy persists around defining internal rotational instability. Read More

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COVID-19: Is There a Link between Alcohol Abuse and SARS-CoV-2-Induced Severe Neurological Manifestations?

ACS Pharmacol Transl Sci 2021 Apr 19;4(2):1024-1025. Epub 2021 Mar 19.

Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.

For the first time, it is shown that severe COVID-19 associated genes (, , , , , , and ) were also upregulated in the brain tissue of chronic alcoholics. It is proposed that chronic alcohol abuse should be considered as an important factor in COVID-19-associated neurological complications. Read More

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Molecular optimization, docking, and dynamic simulation profiling of selective aromatic phytochemical ligands in blocking the SARS-CoV-2 S protein attachment to ACE2 receptor: an approach of targeted drug designing.

J Adv Vet Anim Res 2021 Mar 5;8(1):24-35. Epub 2021 Mar 5.

Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna, Bangladesh.

Objectives: The comprehensive study aims to figure out the most effective aromatic phytochemical ligands among a number from a library, considering their pharmacokinetic efficacies in blocking "angiotensin-converting enzyme 2 (ACE2) receptor-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S protein" complex formation as part of a target-specific drug designing.

Materials And Methods: A library of 57 aromatic pharmacophore phytochemical ligands was prepared from where the top five ligands depending on Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) and quantitative structure-activity relationship (QSAR)-based pharmacokinetic properties were considered. The selected ligands were optimized for commencing molecular docking and dynamic simulation as a complex with the ACE2 receptor to compare their blocking efficacy with the control drug. Read More

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Osteopathic Manipulative Treatment to Optimize the Glymphatic Environment in Severe Traumatic Brain Injury Measured With Optic Nerve Sheath Diameter, Intracranial Pressure Monitoring, and Neurological Pupil Index.

Cureus 2021 Mar 11;13(3):e13823. Epub 2021 Mar 11.

Neurosurgery, Arrowhead Regional Medical Center, Colton, USA.

Background Traumatic brain injury (TBI) has a complex pathophysiology that has historically been poorly understood. New evidence on the pathophysiology, molecular biology, and diagnostic studies involved in TBI have shed new light on optimizing rehabilitation and recovery. The goal of this study was to assess the effect of osteopathic manipulative treatment (OMT) on peripheral and central glial lymphatics in patients with severe TBI, brain edema, and elevated intracranial pressure (ICP) by measuring changes in several parameters regularly used in management. Read More

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Diabetes Mellitus and COVID-19: Associations and Possible Mechanisms.

Int J Endocrinol 2021 1;2021:7394378. Epub 2021 Apr 1.

Department of Geratology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China.

Coronavirus disease 2019 (COVID-19) is a recently emerged disease with formidable infectivity and high mortality. Emerging data suggest that diabetes is one of the most prevalent comorbidities in patients with COVID-19. Although their causal relationship has not yet been investigated, preexisting diabetes can be considered as a risk factor for the adverse outcomes of COVID-19. Read More

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A guideline to limit indoor airborne transmission of COVID-19.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139.

The current revival of the American economy is being predicated on social distancing, specifically the Six-Foot Rule, a guideline that offers little protection from pathogen-bearing aerosol droplets sufficiently small to be continuously mixed through an indoor space. The importance of airborne transmission of COVID-19 is now widely recognized. While tools for risk assessment have recently been developed, no safety guideline has been proposed to protect against it. Read More

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Energy drink-induced cardiomyopathy.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Cardiology and Division of Cardiovascular Sciences, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK

We report a case of severe biventricular heart failure potentially related to excessive energy drink consumption in a 21-year-old man. The patient presented with a 4-month history of shortness of breath on exertion, orthopnoea and weight loss. Transthoracic echocardiography demonstrated severely impaired biventricular systolic function and bilateral ventricular thrombi, subsequently confirmed on cardiac magnetic resonance imaging, which found in addition no oedema, inflammation or focal fibrosis. Read More

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Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings.

Appl Environ Microbiol 2021 Apr 15. Epub 2021 Apr 15.

Department of Medicine, Division of Infectious Diseases, University of Virginia Health System, Charlottesville, VA 22908, USA

Wastewater-based monitoring for SARS-CoV-2 at individual building-level could be an efficient, passive means of early detection of new cases in congregate living settings, but this approach has not been validated. Preliminary samples were collected from a hospital and a local municipal wastewater treatment plant. Molecular diagnostic methods were compared side-by-side to assess feasibility, performance and sensitivity. Read More

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Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study.

J Pharmacol Sci 2021 May 10;146(1):49-57. Epub 2021 Mar 10.

Laboratory of Pharmacology & Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, Japan. Electronic address:

We performed clinical retrospective study in female cancer patients and fundamental experiments in mice, in order to clarify risk factors for paclitaxel-induced peripheral neuropathy (PIPN). In the clinical study, 131 of 189 female outpatients with cancer undergoing paclitaxel-based chemotherapy met inclusion criteria. Breast cancer survivors (n = 40) showed significantly higher overall PIPN (grades 1-4) incidence than non-breast cancer survivors (n = 91). Read More

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Common Compression Neuropathies.

Clin Geriatr Med 2021 May 23;37(2):241-252. Epub 2021 Mar 23.

Florida Atlantic University, Charles E. Schmidt College of Medicine, Boca Raton, FL, USA; Marcus Neuroscience Institute, Boca Raton Regional Hospital, 800 Meadow Road, Boca Raton, FL 33486, USA.

Compression neuropathies, also known as entrapment neuropathies, are common neurologic conditions seen in medicine. These often are due to mechanical injury, either compression or stretch of the affected nerve, and initially result in focal demyelinating changes. If left untreated, secondary axonal injury and lasting disability can result. Read More

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MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells.

Cancer Cell Int 2021 Apr 15;21(1):213. Epub 2021 Apr 15.

Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Chemotherapy is one of the most common treatment options for breast cancer (BC) patients. However, about half of the BC patients are chemotherapeutic resistant. Doxorubicin (DOX) is considered as one of the first line drugs in the treatment of BC patients whose function is negatively affected by multi drug resistance. Read More

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