43,864 results match your criteria considered sensitive


Evaluation of the Cepheid Xpert SA Nasal Complete for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in nasal swabs from pediatric patients.

Diagn Microbiol Infect Dis 2021 May 4;101(1):115417. Epub 2021 May 4.

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital; Department of Pathology, The Ohio State University, Columbus, OH; Department of Pediatrics, The Ohio State University, Columbus, OH. Electronic address:

Nasal carriers of Staphylococcus aureus (SA) are at increased risk for health-care associated infections with this organism. Timely detection of SA and Methicillin-resistant SA (MRSA) and subsequent decolonization are important components of infection control. While performance of nucleic acid amplification-based tests for detection of SA/MRSA in adults has been well-described, limited data are available in children. Read More

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Structural white matter alterations in carpal tunnel syndrome: A modified TBSS study.

Brain Res 2021 Jun 8:147558. Epub 2021 Jun 8.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Functional and structural brain alterations have been noted in carpal tunnel syndrome (CTS), the most common entrapment peripheral neuropathy. Previous studies were mainly focused on somatosensory cortices. However, the changes of white matter diffusion properties in nonsensorimotor cortices remain uninvestigated. Read More

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Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia.

Blood 2021 Jun 11. Epub 2021 Jun 11.

Washington University School of Medicine, St. Louis, Missouri, United States.

Severe congenital neutropenia (SCN) is an inborn disorder of granulopoiesis. Approximately one-third of cases do not have a known genetic cause. Exome sequencing of 104 persons with congenital neutropenia identified heterozygous missense variants of CLPB (caseinolytic peptidase B) in 5 SCN cases, with 5 more cases identified through additional sequencing efforts or clinical sequencing. Read More

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A five amino acids deletion in NKCC2 of C57BL/6 mice affects analysis of NKCC2 phosphorylation but does not impact kidney function.

Acta Physiol (Oxf) 2021 Jun 11:e13705. Epub 2021 Jun 11.

Institute of Anatomy, University of Zurich, Switzerland.

Aim: The phosphorylation level of the furosemide-sensitive Na -K -2Cl cotransporter (NKCC2) in the thick ascending limb (TAL) is used as a surrogate marker for NKCC2 activation and TAL function. However, in mice, analyses of NKCC2 phosphorylation with antibodies against phosphorylated threonines 96 and 101 (anti-pT96/pT101) give inconsistent results. We aimed (i) to elucidate these inconsistencies and (ii) to develop a phosphoform-specific antibody that ensures reliable detection of NKCC2 phosphorylation in mice. Read More

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Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?

PeerJ 2021 25;9:e11485. Epub 2021 May 25.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.

The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. Read More

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Synovial entrapment in alloplastic temporomandibular joint replacement.

Int J Oral Maxillofac Surg 2021 Jun 7. Epub 2021 Jun 7.

Instituto Português da Face, Lisboa, Portugal.

Complications of alloplastic temporomandibular joint (TMJ) prostheses can lead to stress and anxiety for the patient and the surgical team, and prosthesis substitution is sometimes required. The aim of this case report is to describe the surgical finding of synovial entrapment with interposed fibrosis in a postoperative alloplastic TMJ revision, managed effectively with adequate surgical debridement. The authors believe that synovial entrapment needs to be considered as a possible postoperative complication of total joint replacement when no clear symptoms of infection, metal hypersensitivity, osteolysis, or heterotopic bone formation are present. Read More

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Modeling and simulation of static component generation of Lamb wave propagation in a layered plate.

Ultrasonics 2021 May 28;116:106473. Epub 2021 May 28.

School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Modeling of the acoustic-radiation-induced static component (SC) generation of primary Lamb wave tone burst propagating in a layered plate is conducted. Accompanying the propagation of primary Lamb wave tone burst, there are the finite-duration SC bulk driving force in the interior of the layered plate, and the finite-duration SC traction stress on each surface/interface. According to the modal analysis approach for waveguide excitation, the function of the finite-duration SC bulk driving force and traction stress is to generate the finite-duration SC of primary Lamb wave tone burst. Read More

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C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation.

Biochem Pharmacol 2021 Jun 7:114649. Epub 2021 Jun 7.

Division of Clinical Pharmacology & Toxicology, University Hospital, Basel, Switzerland; Department of Biomedicine, University of Basel, Switzerland; Swiss Centre for Applied Human Research (SCAHT), Switzerland. Electronic address:

Statins reduce cardiovascular complications in patients with high LDL-cholesterol but are associated with myopathy. We compared the toxicity of simvastatin of C2C12 myoblasts and myotubes. Since myoblasts can proliferate and fuse to myotubes, myoblasts can be considered as satellite cells and myotubes as mature muscle fibers. Read More

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Predictions of the elastic modulus of trabecular bone in the femoral head and the intertrochanter: a solitary wave-based approach.

Biomech Model Mechanobiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Civil Infrastructure and Environmental Engineering, Khalifa University of Science and Technology, Abu Dhabi, 127788, UAE.

This paper deals with the numerical prediction of the elastic modulus of trabecular bone in the femoral head (FH) and the intertrochanteric (IT) region via site-specific bone quality assessment using solitary waves in a one-dimensional granular chain. For accurate evaluation of bone quality, high-resolution finite element models of bone microstructures in both FH and IT are generated using a topology optimization-based bone microstructure reconstruction scheme. A hybrid discrete element/finite element (DE/FE) model is then developed to study the interaction of highly nonlinear solitary waves in a granular chain with the generated bone microstructures. Read More

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Artificial Agents in Natural Moral Communities: A Brief Clarification.

Authors:
Daniel W Tigard

Camb Q Healthc Ethics 2021 Jul;30(3):455-458

Institute for History and Ethics of Medicine, Technical University of Munich, 81675Munich, Germany.

What exactly is it that makes one morally responsible? Is it a set of facts which can be objectively discerned, or is it something more subjective, a reaction to the agent or context-sensitive interaction? This debate gets raised anew when we encounter newfound examples of potentially marginal agency. Accordingly, the emergence of artificial intelligence (AI) and the idea of "novel beings" represent exciting opportunities to revisit inquiries into the nature of moral responsibility. This paper expands upon my article "Artificial Moral Responsibility: How We Can and Cannot Hold Machines Responsible" and clarifies my reliance upon two competing views of responsibility. Read More

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Cultural Sensitivity in Interventions Aiming to Reduce or Prevent Intimate Partner Violence During Pregnancy: A Scoping Review.

Trauma Violence Abuse 2021 Jun 10:15248380211021788. Epub 2021 Jun 10.

Department of Nursing and Health Promotion, Oslo Metropolitan University, Norway.

Intimate partner violence (IPV) around the time of pregnancy is a recognized global health problem. Ethnic minorities and immigrant pregnant women experiencing IPV require culturally responsive health services. The aim of this scoping review was to identify aspects of cultural sensitivity in interventions to prevent or reduce IPV among ethnic minorities and immigrant pregnant women in high-income countries. Read More

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Cost-Effectiveness Analysis of 23-Valent Pneumococcal Polysaccharide Vaccine Program for the Elderly Aged 60 Years or Older in Shanghai, China.

Front Public Health 2021 24;9:647725. Epub 2021 May 24.

School of Public Health, Fudan University, Shanghai, China.

The pneumococcal vaccine has been considered as the most effective measure to prevent pneumococcal diseases. In 2013, Shanghai launched a major public health program to vaccinate people aged 60 years or older with 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV-23) free of charge. By the end of June 2020, a total of 1. Read More

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TARGETING THE T-CELL LYMPHOMA EPIGENOME INDUCES CELL DEATH, CANCER TESTES ANTIGENS, IMMUNE MODULATORY SIGNALING PATHWAYS.

Mol Cancer Ther 2021 Jun 9. Epub 2021 Jun 9.

Dept. of Medicine,, University of Virginia

The peripheral T-cell lymphomas (PTCL) could be considered the prototypical epigenetic disease. As a disease, they are uniquely sensitive to histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors, both alone and in combination, are characterized by a host of mutations in epigenetic genes, and can develop spontaneously in genetically engineered murine models predicated on established recurring mutations in (RHOAG17V) and TET2, an epigenetic gene governing DNA methylation. Given the clinical benefit of HDAC inhibitors (HDACi) and hypomethlyation agents (HMA) alone and in combination in PTCL, we sought to explore a mechanistic basis for these agents in PTCL. Read More

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Natural environment statistics in the upper and lower visual field are reflected in mouse retinal specializations.

Curr Biol 2021 Jun 2. Epub 2021 Jun 2.

Institute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, Germany; Centre for Integrative Neuroscience (CIN), University of Tübingen, 72076 Tübingen, Germany; Bernstein Centre for Computational Neuroscience, 72076 Tübingen, Germany. Electronic address:

Pressures for survival make sensory circuits adapted to a species' natural habitat and its behavioral challenges. Thus, to advance our understanding of the visual system, it is essential to consider an animal's specific visual environment by capturing natural scenes, characterizing their statistical regularities, and using them to probe visual computations. Mice, a prominent visual system model, have salient visual specializations, being dichromatic with enhanced sensitivity to green and UV in the dorsal and ventral retina, respectively. Read More

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[What do we know about borderline personality disorder? Current aspects of etiology, diagnostics and treatment].

Nervenarzt 2021 Jun 8. Epub 2021 Jun 8.

Institut für Psychiatrische und Psychosomatische Psychotherapie, Lehrstuhl für Psychosomatische Medizin und Psychotherapie, Medizinische Fakultät Mannheim, Universität Heidelberg, Zentralinstitut für Seelische Gesundheit Mannheim, J 5, 68159, Mannheim, Deutschland.

Background: Borderline personality disorder (BPS) is considered as a severe mental disorder with a high burden for patients, family members and the healthcare system. Recent years have brought significant advances in understanding and treating BP, leading to an earlier diagnosis and better treatment outcomes.

Objective: This article outlines the current state of knowledge on the epidemiology, diagnostics, psychopathology and treatment of BPD and identifies open questions. Read More

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Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report.

Eur Heart J Case Rep 2021 Jun 5;5(6):ytab206. Epub 2021 Jun 5.

Service d'hématologie biologique, Hôpital Lariboisière, 2rue Ambroise Pare ´,75010 Paris, Université de Paris, Paris, France.

Background: Severe acute respiratory syndrome coronavirus 2 disease is strongly associated with a high incidence of thrombotic events. Anticoagulation could be a cornerstone in successfully managing severe forms of coronavirus disease 2019 (COVID-19). However, optimal anticoagulant dosing in elderly patients is challenging because of high risk of both thrombosis and bleeding. Read More

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Early diagnosis of diaphragm palsy after pediatric cardiac surgery and outcome after diaphragm plication - A single-center experience.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):178-186. Epub 2021 Feb 16.

Department of Cardiovascular and Thoracic Surgery, U.N. Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India.

Objective: The aims of our prospective observational study were to evaluate the (1) reliability of clinical signs in the early detection of diaphragm palsy (DP); (2) reliability of ultrasonography using echo machine as a bedside tool for the diagnosis of DP; and (3) does early diaphragm plication result in the improved outcome? We also sought to determine the incidence and predominant risk factors for DP and diaphragm plication at our center.

Materials And Methods: This prospective observational study included patients with suspected DP from January 2015 to December 2018. Patients with suspected DP were initially evaluated by bedside ultrasonography using echo machine and confirmed by fluoroscopy. Read More

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February 2021

Lamotrigine and its relationship with Stevens-Johnson syndrome and toxic epidermal necrolysis

Rev Med Inst Mex Seguro Soc 2020 ;58(2):202-205

Secretaría de Salud, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Dermatología, Ciudad de México, México.

Lamotrigine is an antiepileptic drug that has been widely used for epilepsy, as a mood stabilizer (for type 1 bipolar disorder) and in the management of neuropathic pain, it is used both in monotherapy and in complementary therapy. Considered relatively new, approved by the Food and Drug Administration in 1994, its benefits include a greater margin of safety compared to other anticonvulsants. However, although in a lower percentage, it causes severe adverse skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Read More

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January 2020

Perceptions of Racially and Ethnically Diverse Women at High Risk of Breast Cancer Regarding the Use of a Web-Based Decision Aid for Chemoprevention: Qualitative Study Nested Within a Randomized Controlled Trial.

J Med Internet Res 2021 Jun 8;23(6):e23839. Epub 2021 Jun 8.

Columbia University, New York, NY, United States.

Background: Chemopreventive agents such as selective estrogen receptor modulators and aromatase inhibitors have proven efficacy in reducing breast cancer risk by 41% to 79% in high-risk women. Women at high risk of developing breast cancer face the complex decision of whether to take selective estrogen receptor modulators or aromatase inhibitors for breast cancer chemoprevention. RealRisks is a patient-centered, web-based decision aid (DA) designed to promote the understanding of breast cancer risk and to engage diverse women in planning a preference-sensitive course of decision making about taking chemoprevention. Read More

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Acute arthritis, skin rash and Lofgren's syndrome.

BMJ Case Rep 2021 Jun 7;14(6). Epub 2021 Jun 7.

Department of Radiotherapy and Oncology, IGMC, Shimla, Himachal Pradesh, India.

Sarcoidosis is an autoimmune multisystem granulomatous disorder of unknown aetiology, which mainly affects the adults in the age group of 20-39 years. The disease can affect any organ in the body but mainly presents as bilateral hilar lymphadenopathy, pulmonary infiltrates, cutaneous lesions, ocular manifestations and arthropathy. Lofgren's syndrome is an uncommon initial presentation of sarcoidosis which is recognised by the classical triad of acute arthritis, erythema nodosum and bilateral hilar lymphadenopathy. Read More

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Phytoremediation potential of three terrestrial plant species for removal of atrazine, azoxystrobin, and imidacloprid.

Int J Phytoremediation 2021 Jun 7:1-9. Epub 2021 Jun 7.

Department of Crop and Soil Sciences, North Carolina State University, Raleigh, NC, USA.

Pesticides can move off-target resulting in contamination of sensitive water bodies and causing adverse effects on inhabiting species. Through best management practices, such as the implementation of vegetative buffer strips, off-target movement of pesticides can be decreased, and compound degradation can be increased via phytoremediation. In this study, blueflag iris (), broomsedge () and switchgrass () were planted in soil treated with one of three commonly used pesticides. Read More

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Hydrophilic graphene quantum dots as turn-off fluorescent nanoprobes for toxic heavy metal ions detection in aqueous media.

Chemosphere 2021 May 28;282:131019. Epub 2021 May 28.

Department of Physics, Indian Institute of Information Technology Design & Manufacturing, Kancheepuram, Chennai, 600127, India. Electronic address:

Efforts are being made to develop fast, cost-effective and sensitive sensor to detect water contamination by toxic heavy metal ions. The oxygenated functional groups decorated graphene quantum dots (GQDs) effectively enhances the aqueous solubility and considered as a more desirable and simple sensing material with high sensitivity. Here, photoluminescence (PL) property of GQDs has been employed to devise an optical nanosensor for the detection of toxic heavy metal ions in aqueous media. Read More

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Acute Effects of Training Loads on Muscle Damage Markers and Performance in Semi-elite and Elite Athletes: A Systematic Review and Meta-analysis.

Sports Med 2021 Jun 7. Epub 2021 Jun 7.

Sport and Exercise Science, James Cook University, Townsville, QLD, 4811, Australia.

Background: The relationship between exercise-induced muscle damage (EIMD) indicators and acute training loads (TL) is yet to be reviewed extensively in semi-elite and elite athlete populations.

Objectives: The objectives of this systematic review and meta-analysis were threefold: (1) to evaluate studies of EIMD following the initial period of the preseason in semi-elite and elite athletes: (2) to examine acute physiological and performance responses across two periods of the season with similar TL; and (3) to examine acute physiological and performance responses to acute changes in TL during the season.

Methods: The CINAHL, PubMed, Scopus, SPORTDiscus and Web of Science databases were systematically searched for studies that investigated: (1) semi-elite or elite athletes in team or individual sports following a periodised training programme; and (2) measured acute responses to training. Read More

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Climate-resilient strategies for sustainable management of water resources and agriculture.

Environ Sci Pollut Res Int 2021 Jun 7. Epub 2021 Jun 7.

Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam.

Warming of the earth is considered as the major adverse effect of climate change along with other abnormalities such as non-availability of water resources, decreased agriculture production, food security, rise in seawater level, glaciers melting, and loss of biodiversity. Over the years, decreased agriculture production and water quality degradation have been observed due to climatic abnormalities. Crop production is highly sensitive to climate. Read More

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Hole doping and chemical pressure effects on the strong coupling superconductor PdTe.

Phys Chem Chem Phys 2021 Jun 7. Epub 2021 Jun 7.

Graduate School of Science and Technology, Okayama University, Okayama 700-8530, Japan. and Research Institute for Interdisciplinary Science, Okayama University, Okayama 700-8530, Japan.

Chemical doping of known superconductors is a probate strategy to test and enhance our understanding of which parameters control the critical temperature Tc and the critical magnetic fields. The transition metal chalcogenide PdTe is considered a conventional type II superconductor but its resilience to magnetic Fe doping is noteworthy. Isoelectronic Ni doping has been performed, but the effects of doping charges into PdTe have been so far unexplored. Read More

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Prevalence of Allergic Sensitization in Childhood Asthma.

Cureus 2021 May 29;13(5):e15311. Epub 2021 May 29.

Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

Introduction The allergic sensitization in childhood asthma is common and the prevalence varies in different geographical locations. The data on allergen sensitization to guide clinicians on allergy avoidance is limited. Method This prospective observational study was conducted between October 2019 and April 2020 on children aged two to 14 years attending an outpatient clinic. Read More

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Lamotrigine and Stevens-Johnson Syndrome Prevention.

Psychopharmacol Bull 2021 Mar;51(2):96-114

Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.

Stevens-Johnson Syndrome (SJS) is a rare life-threatening condition characterized by severe mucocutaneous epidermal necrolysis and detachment of the epidermis. The condition centers around a delayed-type hypersensitivity reaction with a complex etiology stemming from a variety of causes. The number one cause is medication-related-common ones including sulfonamides, antiepileptics, allopurinol, and nonsteroidal anti-inflammatory drugs. Read More

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Bioremediation of polycyclic aromatic hydrocarbons in contaminated mangroves: Understanding the historical and key parameter profiles.

Mar Pollut Bull 2021 Jun 3;169:112553. Epub 2021 Jun 3.

Department of Civil Engineering, Federal University of Pernambuco (UFPE), Acadêmico Hélio Ramos Avenue, s/n, 50740-530 Recife, PE, Brazil. Electronic address:

Sensitive biomes, such as coastal ecosystems, have become increasingly susceptible to environmental impacts caused by oil logistics and storing, which, although more efficient nowadays, still cause spills. Thus, bioremediation techniques attract attention owing to their low impact on the environment. Among petroleum-based compounds, polycyclic aromatic hydrocarbons (PAHs) are known for their potential impact and persistence in the environment. Read More

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Parallel detection of SARS-CoV-2 RNA and nucleocapsid antigen in nasopharyngeal specimens from a COVID-19 patient screening cohort.

Int J Infect Dis 2021 Jun 3. Epub 2021 Jun 3.

XEMA Company, 9-ya Parkovaya st., 48, bldg. 4, Moscow, Russia.

Objectives: Reverse-transcription PCR (RT-PCR) is considered the most sensitive method in detecting severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). However, this method is relatively resource- and time-consuming. Here, we compared SARS-CoV-2 nucleocapsid antigen (N-Ag) testing using an enzyme-linked immunosorbent assay (ELISA) with SARS-CoV-2 RNA detection. Read More

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Aquaporins in insulin resistance and diabetes: More than channels!

Redox Biol 2021 May 27;44:102027. Epub 2021 May 27.

Department of Medical Biology, Medical University of Bialystok, 15-089, Bialystok, Poland. Electronic address:

Aquaporins (AQPs) are part of the family of the integral membrane proteins. Their function is dedicated to the transport of water, glycerol, ammonia, urea, HO, and other small molecules across the biological membranes. Although for many years they were scarcely considered, AQPs have a relevant role in the development of many diseases. Read More

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