109,612 results match your criteria considered primary


Systemic therapy and prognosis of older patients with stage II/III breast cancer: A large-scale analysis of the Japanese Breast Cancer Registry.

Eur J Cancer 2021 Jul 19;154:157-166. Epub 2021 Jul 19.

Department of Breast Oncology, Aichi Cancer Center, Nagoya, Japan. Electronic address:

Aim: This study aimed at investigating the real-world prognostic impact of systemic treatment in older patients with stage II/III breast cancer (BC).

Methods: This retrospective cohort study included patients with stage II/III primary BC, aged ≥55 years, and registered in the Japanese Breast Cancer Registry from 2004 to 2011. The clinicopathological characteristics, treatments, and prognosis of patients aged ≥75 years (older) were compared to those of younger patients. Read More

View Article and Full-Text PDF

Venovenous extracorporeal membrane oxygenation during high-risk airway interventions.

Interact Cardiovasc Thorac Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

Objectives: Practice patterns for the use of extracorporeal membrane oxygenation (ECMO) during high-risk airway interventions vary, and data are limited. We aim to characterize our recent experience using ECMO for procedural support during whole-lung lavage (WLL) and high-risk bronchoscopy for central airway obstruction (CAO).

Methods: We performed a retrospective cohort study of adults who received ECMO during WLL and high-risk bronchoscopy from 1 July 2018 to 30 March 2020. Read More

View Article and Full-Text PDF

Poor adherence to lifestyle recommendations in patients with coronary heart disease: results from the EUROASPIRE surveys.

Eur J Prev Cardiol 2021 Jul 19. Epub 2021 Jul 19.

National Institute for Prevention and Cardiovascular Health, National University of Ireland, Galway, Ireland.

Aims : Despite the high use of cardioprotective medications, the risk factor control in patients with coronary heart disease (CHD) is still inadequate. Guidelines identify healthy lifestyles as equally important in secondary prevention as pharmacotherapy. Here, we describe reasons for poor lifestyle adherence from the patient's perspective. Read More

View Article and Full-Text PDF

Catch-22 in Specialized Metabolism: Balancing Defense and Growth.

J Exp Bot 2021 Jul 22. Epub 2021 Jul 22.

Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.

Plants are unsurpassed biochemists that synthesize a plethora of molecules in response to everchanging environment. The majority of these molecules considered as specialized metabolites, effectively protect the plant against pathogens and herbivores. However, this defense most likely comes at a high expense, leading to reduction of growth (known as the 'growth-defense tradeoff'). Read More

View Article and Full-Text PDF

Neither low salivary amylase activity, cooling cooked white rice, nor single nucleotide polymorphisms in starch-digesting enzymes reduce glycemic index or starch digestibility: a randomized, crossover trial in healthy adults.

Am J Clin Nutr 2021 Jul 22. Epub 2021 Jul 22.

INQUIS Clinical Research, Ltd (formerly GI Labs), Toronto, Ontario, Canada.

Background: It was suggested that low salivary-amylase activity (SAA) and cooling or stir-frying cooked starch decreases its digestibility and glycemic index.

Objective: We determined the effects of SAA, cooling, and single-nucleotide polymorphisms (SNPs) in the salivary amylase (AMY1), pancreatic amylase (AMY2A, AMY2B), maltase-glucoamylase (MGAM), and sucrase-isomaltase (SI) genes on starch digestibility and glycemic index of cooked polished rice.

Methods: Healthy subjects [pilot, n = 12; main, n = 20 with low-SAA (<50 U/mL), and n = 20 with high-SAA (>105 U/mL)] consumed test meals containing 25 g (pilot) or 50 g (main) available carbohydrate at a contract research organization using open-label (pilot) or assessor-blinded (main), randomized, crossover, Latin-square designs (trial registration: NCT03667963). Read More

View Article and Full-Text PDF

Institutional delivery and associated factors in rural communities of Central Gondar Zone, Northwest Ethiopia.

PLoS One 2021 22;16(7):e0255079. Epub 2021 Jul 22.

Department of Epidemiology and Biostatics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Institutional delivery has been considered as one of the important strategies to improve maternal and child health and significantly reduces birth-related complications. However, it is still low in developing countries though there are some improvements. Hence, the aim of this study was to assess the prevalence of institutional delivery and associated factors in the study area. Read More

View Article and Full-Text PDF

Treatment of Kyphosis Arising Secondary to Laminectomy and Irradiation in the Pediatric Population.

Orthopedics 2021 Jul-Aug;44(4):e563-e569. Epub 2021 Jul 1.

The effects of radiation therapy and laminectomy on the growing spine have been well documented. Due to compromised bone quality after irradiation, spinal fusion has a high failure rate. The aim of this study was to evaluate treatment of post-laminectomy and post-irradiation kyphosis in children using a vascularized rib graft (VRG) to augment anterior spinal fusion and posterior spinal fusion. Read More

View Article and Full-Text PDF

Variation in outcomes across surgeons meeting the Leapfrog volume standard for complex oncologic surgery.

Cancer 2021 Jul 22. Epub 2021 Jul 22.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: A large body of evidence supports regionalization of complex oncologic surgery to high-volume surgeons at high-volume hospitals. However, whether there is heterogeneity of outcomes among high-volume surgeons at high-volume hospitals remains unknown.

Methods: Patients who underwent esophagectomy, lung resection, pancreatectomy, or proctectomy for primary cancer were identified within the Medicare 100% Standard Analytic File (2013-2017). Read More

View Article and Full-Text PDF

An integrated transcriptome and metabolome approach reveals the accumulation of taste-related metabolites and gene regulatory networks during watermelon fruit development.

Planta 2021 Jul 22;254(2):35. Epub 2021 Jul 22.

Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou, 450009, China.

Main Conclusion: Accumulation patterns and gene regulatory networks of sugars and cucurbitacins and related primary and secondary metabolites during cultivated watermelon 'Cheng Lan' and wild watermelon 'PI 632,751' fruit development were identified. Metabolites are the end products of cellular regulatory processes and play important roles in fruit taste formation. However, comprehensive studies on the accumulation patterns of watermelon fruit metabolites and transcriptional regulatory networks are still scarce. Read More

View Article and Full-Text PDF

T-cell replete haploidentical stem cell transplantation with low dose anti-thymocyte globulin for relapsed/refractory Ewing sarcoma family tumors.

Cancer Rep (Hoboken) 2021 Jul 22:e1519. Epub 2021 Jul 22.

Department of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan.

Background: Despite intensive multimodal therapies, the prognosis of relapsed/ refractory Ewing sarcoma family tumors (RR-ESFTs) is dismal. Some case reports using allogeneic stem cell transplantation (allo SCT) for RR-ESFTs have been reported, however, the efficacy of allo SCT is yet to be established.

Aim: The purpose of this study was to evaluate the response and toxicity of T-cell replete haploidentical SCT (TCR-haplo-SCT) in RR-ESFTs. Read More

View Article and Full-Text PDF

Magnetic Resonance Imaging-Based Structural Covariance Changes of the Striatum in Lifelong Premature Ejaculation Patients.

J Magn Reson Imaging 2021 Jul 22. Epub 2021 Jul 22.

Life Sciences Research Center, School of Life Science and Technology, Xidian University, Xi'an, China.

Background: The striatum has been reported to be implicated in various neurological diseases, including lifelong premature ejaculation (LPE). Altered striatum-related functional connectivity was investigated in LPE patients in previous studies; however, structural abnormalities in the striatum have been less studied in LPE.

Purpose: To identify the gray matter volume (GMV) and structural covariance patterns of the striatum between LPE patients and healthy controls (HCs). Read More

View Article and Full-Text PDF

Histologic Aspect of the Curved Vomerine Mucosa in Cleft Lip and Palate.

Cleft Palate Craniofac J 2021 Jul 22:10556656211031419. Epub 2021 Jul 22.

Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel and University of Basel, Switzerland.

Background: Common surgical techniques aim to turn the entire vomerine mucosa with vomer flaps either to the oral side or to the nasal side. The latter approach is widely performed due to the similarity in color to the nasal mucosa. However, we lack a histologic description of the curved vomerine mucosa in cleft lip and palate malformations. Read More

View Article and Full-Text PDF

Talking about chronic pain: Misalignment in discussions of the body, mind and social aspects in pain clinic consultations.

Authors:
Jana Declercq

Health (London) 2021 Jul 22:13634593211032875. Epub 2021 Jul 22.

University of Groningen, Netherlands.

In Western societies, human existence and illness are mostly constructed from the perspective of mind-body dualism: body and mind are considered to function independently, and the body/the physical as primary and more real. Research shows, however, that mind-body dualism is no longer tenable, especially in healthcare contexts. This led to the rise the biopsychosocial model, in which bodily experiences, including illness, are seen an interplay of the physical and the psychological, and the social. Read More

View Article and Full-Text PDF

Developing a Culturally Responsive Lifestyle Intervention for Overweight/Obese U.S. Mexicans.

J Community Health 2021 Jul 21. Epub 2021 Jul 21.

Department of Psychiatry and Behavioral Sciences, Immigrant Health and Cancer Disparities Service, Memorial Sloan Kettering Cancer Center, 485 Lexington Ave., 2nd Floor, New York, NY, 10017, USA.

Introduction: Hispanics are the largest minority group in the United States, constituting 18 % of the population. Mexicans are the largest Hispanic subgroup and are at disproportionate risk for overweight/obesity. Lifestyle interventions targeting dietary change and physical activity have resulted in significant weight loss in several large randomized clinical trials in the general population, but few studies have tailored interventions to Mexican Americans. Read More

View Article and Full-Text PDF

Primary care-based models of care for osteoarthritis: a scoping review protocol.

HRB Open Res 2021 10;4:48. Epub 2021 May 10.

School of Physiotherapy, Royal College of Surgeons in Ireland, RCSI, University of Medicine and Health Sciences, Dublin, Ireland.

The burden of osteoarthritis (OA) to individuals and health systems is substantial and is expected to increase due to population ageing and rising prevalence of obesity and multimorbidity. Primary care-based models of care (MoCs) are being increasingly developed in response to this growing burden. However, these MoCs have yet to be formally reviewed. Read More

View Article and Full-Text PDF

Does Chronic Obstructive Pulmonary Disease Affect Workers' Health?

Authors:
Li-Peng Yao Ran Tao

Front Public Health 2021 5;9:711629. Epub 2021 Jul 5.

Qingdao Municipal Center for Disease Control and Preventation, Qingdao, China.

During recent decades, the elevation of workers' health has become the utmost point of concern since it is considered among the primary indicators of economies. The economies, especially the emerging ones, are primarily focusing on every indicator to uplift their businesses. Along with the other aspects, it is also required to assess the impact of Chronic Obstructive Pulmonary Disease (COPD) on workers' health conditions in small- and medium-scale enterprises (SMEs). Read More

View Article and Full-Text PDF

Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report.

Onco Targets Ther 2021 15;14:4201-4209. Epub 2021 Jul 15.

Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, People's Republic of China.

Background: Doublet or triplet chemotherapy plus or minus targeted drugs can achieve a high objective response rate (ORR) and are currently considered to be the backbone of conventional therapy for liver metastatic colorectal cancer (mCRC). However, current biomarkers (such as UGT1A1 and DPYD) are limited to the prediction of toxicity and there are no effective biomarkers to predict chemotherapy response. Therefore, personalized cancer chemotherapy underpinned by genomic alterations in mCRC has received increasing attention. Read More

View Article and Full-Text PDF

Effect of a Template Case Report Based on Cognitive Task Analysis on Emergency Thinking Ability of Resident Doctors in Standardized Training.

Patient Prefer Adherence 2021 15;15:1585-1591. Epub 2021 Jul 15.

Department of Emergency, Hebei General Hospital, Shijiazhuang, 050051, People's Republic of China.

Objective: To explore the effect of a template case report based on cognitive task analysis on the emergency thinking ability of resident doctors in standardized training.

Methods: The doctors were split into two groups, according to the date they joined the emergency department (n = 40, each group): the observation and control groups. In the observation group, the resident doctors' teachers in standardized training adopted the cognitive task analysis method to determine the primary links of emergency thinking, made case templates, and carried out training based on the case template report. Read More

View Article and Full-Text PDF

The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer.

Sci Rep 2021 Jul 21;11(1):14836. Epub 2021 Jul 21.

Epidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Dr., Research Triangle Park, NC, 27709, USA.

While human papillomavirus is the primary cause of cervical cancer, other factors may influence susceptibility and response to the virus. Candidates include douching and talcum powder applied in the genital area. We used Cox proportional hazards models to estimate confounder-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) in the Sister Study (2003-2009), a US cohort of women aged 35-74. Read More

View Article and Full-Text PDF

The prevalence and clinical features associated of hypothyroidism among Thai systemic sclerosis patients.

Sci Rep 2021 Jul 21;11(1):14902. Epub 2021 Jul 21.

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Thyroid disease, particularly hypothyroidism, has been reported in systemic sclerosis (SSc). Some clinical features of SSc can also present in hypothyroidism. Our aims were to determine the prevalence of, and describe clinical features associated with, hypothyroidism in SSc patients. Read More

View Article and Full-Text PDF

Interleukin-27 promotes autophagy in human serum-induced primary macrophages via an mTOR- and LC3-independent pathway.

Sci Rep 2021 Jul 21;11(1):14898. Epub 2021 Jul 21.

Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Building 550, Room 126, P.O. Box B, Frederick, MD, 21702, USA.

Interleukin-27 (IL-27) is a cytokine that suppresses human immunodeficiency virus (HIV)-1 infection in macrophages and is considered as an immunotherapeutic reagent for infectious diseases. It is reported that IL-27 suppresses autophagy in Mycobacterium tuberculosis-infected macrophages; however, a role for IL-27 on autophagy induction has been less studied. In this study, we investigated the impact of IL-27 in both autophagy induction and HIV-1 infection in macrophages. Read More

View Article and Full-Text PDF

SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells.

Sci Rep 2021 Jul 21;11(1):14880. Epub 2021 Jul 21.

Laboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000, Zagreb, Croatia.

Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs. Read More

View Article and Full-Text PDF

Nitric oxide in infertile females in the niger-delta region of Nigeria.

Niger J Clin Pract 2021 Jul;24(7):1022-1027

Department of Chemical Pathology, University of Benin Teaching Hospital, Benin City, Nigeria.

Background: Infertility is a public health challenge and it is a distressing personal tragedy for couples, more so for the female partners. Risk factors and causes of infertility vary from region to region. Reactive species is of current interest in the pathogenesis and management of infertility, especially in the Niger-Delta Region of Nigeria where environmental hazards of oil exploration exists. Read More

View Article and Full-Text PDF

Monoamine oxidase-B inhibition facilitates α-synuclein secretion and delays its aggregation in rAAV-based rat models of Parkinson's disease.

J Neurosci 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine. 2-2-2 Iida-nishi, Yamagata 990-9585, Japan.

Cell-to-cell transmission of α-synuclein (α-syn) pathology is considered to underlie the spread of neurodegeneration in Parkinson's disease. Previous studies have demonstrated that α-syn is secreted under physiological conditions in neuronal cell lines and primary neurons. However, the molecular mechanisms that regulate extracellular α-syn secretion remain unclear. Read More

View Article and Full-Text PDF

Treatment outcomes of patients with drug-sensitive tuberculosis under community-based versus facility-based directly observed treatment, short course strategy in Southwest Ethiopia: a prospective cohort study.

BMJ Open 2021 Jul 21;11(7):e048369. Epub 2021 Jul 21.

Department of Microbiology, University of Oslo, Oslo, Norway.

Objective: To compare tuberculosis (TB) treatment outcomes and associated factors among patients attending community-based versus facility-based directly observed treatment, short course (DOTS).

Design: A prospective cohort study.

Setting: The study was conducted in Southwest Ethiopia. Read More

View Article and Full-Text PDF

[Which quality of life for the sarcopenic patient?]

Geriatr Psychol Neuropsychiatr Vieil 2021 Jul 20. Epub 2021 Jul 20.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgique, Membres du Groupe Expert Nutrition en Gériatrie (GEGN) sous l'égide de la SFGG.

Sarcopenia is defined as a progressive and generalized loss of muscle strength, muscle mass and physical performance with advancing age. Among the multiple consequences of sarcopenia, the reduction in the quality of life associated with it can undeniably be considered as a major consequence. Quality of life is measured via generic or specific questionnaires. Read More

View Article and Full-Text PDF

Treatment and Outcomes of Oligometastatic Colorectal Cancer Limited to Lymph Node Metastases.

Clin Colorectal Cancer 2021 Jun 25. Epub 2021 Jun 25.

Department of Medical Oncology, Royal Hobart Hospital, Tasmania, Australia; Menzies Research Institute, Tasmania, Australia.

Introduction: The optimal management of isolated distant lymph node metastases (IDLNM) from a colorectal primary, is not clearly established. We aimed to analyze the outcomes of patients with IDLNM treated with systemic therapies plus locoregional therapy with curative intent versus systemic therapies with palliative intent.

Materials & Methods: Clinical data were collected and reviewed from the Treatment of Recurrent and Advanced Colorectal Cancer registry, a prospective, comprehensive registry for metastatic colorectal cancer (mCRC) treated at multiple tertiary hospitals across Australia. Read More

View Article and Full-Text PDF

Retrospective analysis of the clinical presentation and imaging of eight primary benign mediastinal schwannomas.

BMC Res Notes 2021 Jul 21;14(1):278. Epub 2021 Jul 21.

Department of Pathology, UMAE Hospital de Oncologia, Centro Medico Nacional Siglo XXI, IMSS, Av. Cuauhtemoc No. 330, Col. Doctores, Delegacion Cuauhtemoc, CP 06725, Mexico City, Mexico.

Objective: Mediastinal schwannomas are sometimes confused with other neoplasms during initial radiological studies, especially when there is a history of cancer in another area. In these cases, a more accurate analysis using computed tomography (CT) or even magnetic resonance (MRI) is required. Our study aimed to perform a retrospective analysis of the clinical and imaging features for a series of patients with mediastinal schwannomas that were confirmed by histology and immunohistochemistry. Read More

View Article and Full-Text PDF

Medical Assistance in Dying in patients with advanced cancer and their caregivers: a mixed methods longitudinal study protocol.

BMC Palliat Care 2021 Jul 21;20(1):117. Epub 2021 Jul 21.

Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, 620 University Avenue, 12th Floor, Toronto, Ontario, M5G 2C1, Canada.

Background: The legal criteria for medical assistance in dying (MAiD) for adults with a grievous and irremediable medical condition were established in Canada in 2016. There has been concern that potentially reversible states of depression or demoralization may contribute to the desire for death (DD) and requests for MAiD. However, little is known about the emergence of the DD in patients, its impact on caregivers, and to what extent supportive care interventions affect the DD and requests for MAiD. Read More

View Article and Full-Text PDF

Beyond chronic migraine: a systematic review and expert opinion on the off-label use of botulinum neurotoxin type-A in other primary headache disorders.

Expert Rev Neurother 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Introduction: Botulinum neurotoxin type-A (BoNTA) is licensed for the treatment of chronic migraine (CM), but it has been tested off-label as a therapeutic choice in other primary headaches (PHs). The authors aimed to provide a systematic review and expert opinion on BoNTA use in PHs, beyond CM.

Areas Covered: After providing an overview on PHs and mechanism of BoNTA action, the authors report the results of a systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, of BoNTA therapeutic trials in PHs beyond CM. Read More

View Article and Full-Text PDF