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Outcomes of surgical and/or medical treatment in patients with prolactinomas during long-term follow-up: a retrospective single-centre study.

Horm Mol Biol Clin Investig 2020 Dec 17;42(2):153-157. Epub 2020 Dec 17.

Division of Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey.

Objectives: Prolactinoma is the most common cause of pituitary tumours. Current medical guidelines recommend dopamine agonists (cabergoline or bromocriptine) as the initial therapy for prolactinoma. However, surgical removal can also be considered in selected cases, such as patients with macroadenomas with local complications (bleeding or optic chiasm pressure) or those not responding to medical treatment. Read More

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December 2020

High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials.

Mult Scler Relat Disord 2021 Jul 21;55:103159. Epub 2021 Jul 21.

Division of Neurology, Department of Medicine, St. Michael\220s Hospital, University of Toronto, ON M5B 1W8, Canada. Electronic address:

Background: Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of adenosine triphosphate (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials.

Methods: We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials. Read More

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Therapeutic plasma exchange in MS refractory relapses: Long-term outcome.

Mult Scler Relat Disord 2021 Jul 25;55:103168. Epub 2021 Jul 25.

Department of Neurology. Fleni. Buenos Aires, Argentina. Electronic address:

Introduction: Therapeutic plasma exchange (TPE) is considered a treatment option for steroid-refractory multiple sclerosis (MS) relapses. Our objective was to assess long-term clinical response to TPE in MS steroid-refractory exacerbations.

Methods: Retrospective study of relapsing remitting MS (RRMS) patients presenting intravenous methylprednisolone (IVMPS)-refractory relapses, who underwent TPE. Read More

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Should temozolomide be used on the basis of O-methylguanine DNA methyltransferase status in patients with advanced neuroendocrine tumors? A systematic review and meta-analysis.

Cancer Treat Rev 2021 Jul 22;99:102261. Epub 2021 Jul 22.

IEO, European Institute of Oncology, IRCCS, Milan, Italy. Electronic address:

Background: Temozolomide (TEM) is an active treatment in metastatic neuroendocrine tumors (NETs). Patients affected by glioblastoma multiforme or advanced melanoma treated with TEM who have deficiency of O-methylguanine DNA methyltransferase (MGMT) have a better responses and survival. However, the predictive role of MGMT in patients with NETs treated with TEM is still debated. Read More

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Characterization of a Portuguese family with Charcot-Marie-Tooth disease type 1E due to a novel point mutation in the PMP22 gene.

Clin Neurol Neurosurg 2021 Jul 21;208:106829. Epub 2021 Jul 21.

Department of Neurology, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Rua da Junqueira 126, 1349-019 Lisbon, Portugal; CEDOC Chronic Diseases Research Centre, Nova Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.

Introduction: Point mutations in the Peripheral Myelin Protein 22 (PMP22) gene comprise less than 5% of the Charcot-Marie-Tooth (CMT) type 1 cases, and individualize either the CMT 1E subtype, or Hereditary Neuropathy with Liability to Pressure Palsy. The phenotype of CMT 1E presents with a severe early-onset polyneuropathy associated with deafness, although the clinical spectrum is broad.

Case Report: We describe a novel PMP22 gene point mutation (c. Read More

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Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome.

Med Hypotheses 2021 Jul 15;154:110644. Epub 2021 Jul 15.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.

Polycystic ovarian syndrome (PCOS) is a combination of various symptoms like anovulation, hirsutism, chronic amenorrhea, infertility, obesity and polycystic ovaries. It affects over 7 million women worldwide. The current strategy to treat this disorder is based on the use of drugs that provide symptomatic relief. Read More

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Cost-Utility Analysis of Eculizumab for the Treatment of Paroxysmal Nocturnal Hemoglobinuria from the Perspective of the Brazilian Public Health System.

Value Health Reg Issues 2021 Jul 28;26:113-125. Epub 2021 Jul 28.

Instituto Nacional de Cardiologia, Rio de Janeiro, Brasil.

Objective: To perform a first cost-utility analysis of eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria from the perspective of the Brazilian Unified Health System.

Methods: A Markov decision model was developed for 35-year-old patients with symptomatic paroxysmal nocturnal hemoglobinuria. We used a cycle length of one month and a time horizon of 20 years. Read More

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Long-term outcome after midline lumbar fusion for the treatment of lumbar spine instability due to degenerative disease.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurosurgery, Tomas Bata Regional Hospital, Zlin, Czech Republic (Havlickovo nabrezi 600, 762 75 Zlin). Electronic address:

Background: New surgical techniques have been developed to minimize perioperative damage to paravertebral stabilizing musculotendinous system. Among them, midline lumbar fusion (MIDLF) shows to be a viable option. With data on MIDLF remaining scarce, we assessed its long-term clinical and radiological effects. Read More

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Analysis of factors associated with sagittal alignment deterioration after correction of degenerative scoliosis by in situ contouring.

Orthop Traumatol Surg Res 2021 Jul 28:103023. Epub 2021 Jul 28.

Service de Chirurgie du Rachis, Hôpitaux Universitaires de Strasbourg, Fédération de Médecine Translationnelle (FMTS), Université de Strasbourg, 1 Avenue Molière, 67200 Strasbourg, France.

Introduction: In situ contouring is one of the surgical techniques used for scoliosis reduction. The initial correction could change over time, with deterioration of the sagittal balance. The purpose of this study was to analyze the loss of correction after degenerative lumbar scoliosis surgery using in situ contouring. Read More

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Clin Res Hepatol Gastroenterol 2021 Jul 28:101773. Epub 2021 Jul 28.

Service d'hépato-gastroentérologie, Hôpital Saint Joseph & INSERM UMR 1252 IRD SESSTIM Aix Marseille Université, Marseille.

Diagnosis of chronic hepatitis B virus (HBV) infection, initial staging of infection and monitoring of treated and untreated patients are mainly based on clinical, biological and imaging criteria allowing a complete non-invasive management for the majority of patients. Along to the conventional virological tools, rapid diagnostic tests and blotting paper tests for HBV DNA are validated alternatives. After diagnosis, the initial work-up should include HIV, HCV and HDV serologies, HBeAg status, and HBsAg and HBV DNA quantification. Read More

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Male Sex, Cartilage Surgery, Tobacco Use, and Opioid Disorders are Associated with an Increased Risk of Infection after ACL Reconstruction.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, VA. Electronic address:

Purpose: To identify patient-related risk factors for infection following anterior cruciate ligament reconstruction (ACLR).

Methods: The Mariner database within PearlDiver was queried for patients from 2010 to 2019 undergoing primary arthroscopic ACLR. Patients undergoing ACLR with concomitant open surgery or additional ligament reconstructions were excluded. Read More

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Anterior Shoulder Instability Part III - Revision Surgery, Rehabilitation and Return to Play, and Clinical Follow-Up - An International Consensus Statement.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Purpose: The purpose of this study was to establish consensus statements via a modified Delphi process on revision surgery, rehabilitation and return to play, and clinical follow-up for anterior shoulder instability.

Methods: A consensus process on the treatment utilizing a modified Delphi technique was conducted, with 65 shoulder surgeons from 14 countries across 5 continents participating. Experts were assigned to one of 9 working groups defined by specific subtopics of interest within anterior shoulder instability. Read More

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Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma.

Biochim Biophys Acta Rev Cancer 2021 Jul 28:188598. Epub 2021 Jul 28.

Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Dublin 8, Ireland; Trinity St James's Cancer Institute, St James's Hospital, Dublin 8, Ireland. Electronic address:

Oesophageal adenocarcinoma (OAC) is a disease with an incredibly poor survival rate and a complex makeup. The growth and spread of OAC tumours are profoundly influenced by their surrounding microenvironment and the properties of the tumour itself. Constant crosstalk between the tumour and its microenvironment is key to the survival of the tumour and ultimately the death of the patient. Read More

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Functional and oncological outcomes of renal surgery for hilar tumors: informing the decisions in risk-adapted management.

Urology 2021 Jul 28. Epub 2021 Jul 28.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Objective: No consensus exists on whether renal hilar tumors should be considered for radical (RN) or partial nephrectomy (PN). In this study we aim to describe the safety and efficacy of PN for surgically managed renal hilar tumors MATERIALS AND METHODS: : we retrospectively reviewed institutional records of patients with a small (<5 cm) solitary renal (hilar or non-hilar) mass who underwent PN or RN between 2008 and 2018. Hilar tumors were defined as those at medial position, abutting the renal vessels. Read More

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X-chromosome inactivation and PCDH19-associated epileptic encephalopathy: A novel PCDH19 variant in a Chinese family.

Clin Chim Acta 2021 Jul 28. Epub 2021 Jul 28.

Kowloon West Cluster Laboratory Genetic Service, Chemical Pathology Laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong Special Administrative Region. Electronic address:

Background: Developmental and epileptic encephalopathy 9 (DEE9, MIM #300088) is an early onset seizure disorder associated with cognitive impairment and behavioral disturbances. It is caused by mutation in protocadherin 19 with an unusual X-linked inheritance selectively involving heterozygous females or mosaic hemizygous males, while hemizygous males are unaffected. Cellular interference was the postulated mechanism underlying the unusual inheritance pattern. Read More

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Using social security number to identify sub-populations vulnerable to the health impacts from extreme heat in Florida, U.S.

Environ Res 2021 Jul 28;202:111738. Epub 2021 Jul 28.

Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, NY, USA; School of Public Health, University at Albany, Rensselaer, NY, USA.

Background: Some socioeconomically vulnerable groups may experience disproportionately higher risk of extreme heat illness than other groups, but no study has utilized the presence/absence of a social security number (SSN) as a proxy for vulnerable sub-populations.

Methods: This study focused on the warm season from 2008 to 2012 in Florida, U.S. Read More

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Extreme temperature exposure and acute myocardial infarction: Elevated risk within hours?

Environ Res 2021 Jul 28;202:111691. Epub 2021 Jul 28.

Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China; School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia; School of Public Health, Institute of Environment and Population Health, Anhui Medical University, Hefei, China. Electronic address:

Day-to-day change in ambient temperature is associated with acute myocardial infarction (AMI) attacks, but evidence is scarce about the effects of extreme temperatures on the risk of AMI within hours of exposure. This study investigated the hour-level associations between extreme temperatures and AMI occurrence. State-wide data on AMI patients and temperature during winter and summer of 2013-2015 were obtained for Queensland state of Australia. Read More

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Sialendoscopy: A 4-Year Single Center Experience.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

OMFS IMPATH research group, Faculty of Medicine, Clinical intern, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium; Professor and Chairperson, Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

Purpose: Sialendoscopy is a relatively new technique designed to diagnose and treat benign obstructive salivary gland disease using a minimally invasive approach. The purpose of this study is to present our experiences regarding the use of sialendoscopy in the form of a 4-year, single center experience and to demonstrate its usefulness in oral and maxillofacial practice.

Methods: We collected data on patients who underwent sialendoscopy at the Oral-Maxillofacial Surgery Department of UZ Leuven between November 2015 and August 2019, including age, gender, sex, initial clinical presentation and symptoms, gland involvement, type of diagnostic investigations, diagnosis, localization of the obstruction, therapeutic intervention, surgeon, type of anesthesia, materials used, complications, secondary treatment, duration of follow-up, and outcome. Read More

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Single-stage tracheal transplantation-From bench to bedside.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

We read with great interest and admiration the manuscript by Genden and colleagues titled "Single-stage long-segment tracheal transplantation" (1). In adult patients, the general limits of safe tracheal resection and direct end to end re-anastomosis has always been considered to be a maximum of 5-6 cm. Long-segment tracheal resection and replacement is a challenge and has led to a century-long search for a means of tracheal replacement. Read More

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A semi-Markov model comparing the lifetime cost-effectiveness of mesh prophylaxis to prevent parastomal hernia in patients undergoing end colostomy creation for rectal cancer.

Colorectal Dis 2021 Jul 31. Epub 2021 Jul 31.

The CIPHER study group investigators.

Aim: Parastomal hernia (PSH) is a common problem following colostomy. Using prophylactic mesh during end colostomy creation may reduce PSH incidence, but concerns exist regarding the optimal type of mesh, potential long-term complications, and cost-effectiveness of its use. We evaluated the cost-effectiveness of mesh prophylaxis to prevent PSH in patients undergoing end colostomy for rectal cancer. Read More

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Quality of life in patients with Mycosis Fungoides and Sézary Syndrome: a systematic review of the literature.

J Eur Acad Dermatol Venereol 2021 Jul 31. Epub 2021 Jul 31.

Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.

Cutaneous T-cell Lymphoma's (CTCL) are a rare, heterogenous group of T-cell lymphomas that primarily manifest in the skin. Mycosis fungoides (MF) and Sézary syndrome (SS) are considered the claswsic types of CTCL. The diverse manifestation of CTCL results in a wide range of symptoms with a possible mild to severe impact on Quality of Life (QoL) depending on the disease stage. Read More

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Bariatric surgery prior to transplantation and risk of early hospital re-admission, graft failure, or death following kidney transplantation.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Hennepin County Medical Center, Division of Nephrology, Department of Medicine, USA.

Bariatric surgery has been shown to be safe in the dialysis population. Whether bariatric surgery before kidney transplantation influences post-transplant outcomes has not been examined nationally. We included severely obese (BMI>35) dialysis patients between 18-70 years who received a kidney transplant according to the US Renal Data System. Read More

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Determinants for under- and overdosing of direct oral anticoagulants and physicians' implementation of clinical pharmacists' recommendations.

Br J Clin Pharmacol 2021 Jul 31. Epub 2021 Jul 31.

Research Group Clinical Pharmacology and Clinical Pharmacy; Vrije Universiteit Brussel, Jette, Belgium.

Aim: To analyze the appropriateness of DOAC dosing and determinants for under-and overdosing as well as acceptance and implementation rates of pharmacists' interventions.

Methods: Cross-sectional study in a tertiary hospital in hospitalized patients with atrial fibrillation on DOACs in 2019 (n=1688). Primary outcome was the proportion of patients with inappropriate DOAC prescribing with identification of determinants for under-and overdosing. Read More

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Predictive performance of dynamic arterial elastance for arterial pressure response to fluid expansion in mechanically ventilated hypotensive adults: a systematic review and meta-analysis of observational studies.

Ann Intensive Care 2021 Jul 31;11(1):119. Epub 2021 Jul 31.

Department of Intensive Care Medicine, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, 315000, Zhejiang, China.

Background: Dynamic arterial elastance (Ea) has been extensively considered as a functional parameter of arterial load. However, conflicting evidence has been obtained on the ability of Ea to predict mean arterial pressure (MAP) changes after fluid expansion. This meta-analysis sought to assess the predictive performance of Ea for the MAP response to fluid expansion in mechanically ventilated hypotensive patients. Read More

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Comparison of preoperative diagnostic accuracy of fine needle aspiration and core needle biopsy in parotid gland neoplasms.

Eur Arch Otorhinolaryngol 2021 Jul 31. Epub 2021 Jul 31.

Dept of Otorhinolaryngology, University of Medical Sciences, Bagcilar Training and Research Hospital, Merkez Mahallesi, 6. Sk. Bağcilar, 34100, Istanbul, Turkey.

Background: Fine needle aspiration (FNA) and core needle biopsy (CNB) are two commonly used approaches for the diagnosis of suspected neoplastic parotid gland lesions. We aimed to compare the diagnostic efficiency of FNA and CNB performed with ultrasound guidance preoperatively for the diagnosis of parotid neoplasms.

Methods: We retrospectively analysed the preoperative specimens of 113 patients (66 FNA, 47 CNB) who underwent surgical excision at our institute between 2014 and 2017. Read More

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COVID-19 Infected Staff during the First Wave at General Out-Patient Clinic of Barau Dikko University Teaching Hospital, Kaduna: Brief Communication.

West Afr J Med 2021 Jul;38(7):705-708

Department of Family Medicine, Barau Dikko Teaching Hospital, Kaduna, Kaduna State, Nigeria.

COVID 19 viral infection is a rapidly spreading droplets infection that has a global impact. Kaduna is one of the states in Nigeria with a high number of COVID-19 infected individuals. Some staff of Barau Dikko Teaching Hospital, Kaduna (BDTH) were infected with COVID-19 during the initial period of the pandemic. Read More

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Development of prognostic models for Health-Related Quality of Life following traumatic brain injury.

Qual Life Res 2021 Jul 30. Epub 2021 Jul 30.

Department of Public Health, Center for Medical Decision Making, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Traumatic brain injury (TBI) is a leading cause of impairments affecting Health-Related Quality of Life (HRQoL). We aimed to identify predictors of and develop prognostic models for HRQoL following TBI.

Methods: We used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Core study, including patients with a clinical diagnosis of TBI and an indication for computed tomography presenting within 24 h of injury. Read More

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Diastasis recti repair with onlay mesh.

M Y Nahabedian

Hernia 2021 Jul 30. Epub 2021 Jul 30.

VCU College of Medicine-Inova Branch, National Center for Plastic Surgery, 7601 Lewinsville Rd # 400, McLean, VA, 22102, USA.

Introduction: Diastasis recti represents a midline contour abnormality of the anterior abdominal wall that is secondary to attenuation of the linea alba. Severe diastasis recti is defined as attenuation of the linea alba as well as the linea semilunaris. Treatment options are variable and include conditioning exercises and surgical repair with or without mesh. Read More

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Portal vein thrombosis following elective laparoscopic splenectomy: incidence and analysis of risk factors.

Surg Endosc 2021 Jul 30. Epub 2021 Jul 30.

Department of Surgery, Royal Brisbane and Women's Hospital, Herston, QLD, 4029, Australia.

Background: Minimally invasive splenectomy is now well established for a wide range of pathologies. Portal vein thrombosis (PVT) is increasingly being recognised as a complication of splenectomy. The aim was to determine the incidence and risk factors for PVT after laparoscopic splenectomy. Read More

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Resection of vestibular schwannomas after stereotactic radiosurgery: a systematic review.

J Neurosurg 2020 Nov 27:1-9. Epub 2020 Nov 27.

Department of Neurological Surgery, Rush University Medical Center, Chicago.

Objective: Multiple short series have evaluated the efficacy of salvage microsurgery (MS) after stereotactic radiosurgery (SRS) for treatment of vestibular schwannomas (VSs); however, there is a lack of a large volume of patient data available for interpretation and clinical adaptation. The goal of this study was to provide a comprehensive review of tumor characteristics, management, and surgical outcomes of salvage of MS after SRS for VS.

Methods: The Medline/PubMed, Scopus, CINAHL, Cochrane Library, and Google Scholar databases were queried according to PRISMA guidelines. Read More

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November 2020